This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
1236 pcDNA3 Myr HA Akt3
catalog :
9017
citations: 13
Reference
Lu W, Omari R, Ray H, Wang J, Williams I, Jacobs C, et al. AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation. FEBS J. 2022;289:3876-3893 pubmed publisher
Zhao J, Zhu L, Wijesekera N, Jones C. Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency. J Virol. 2020;94: pubmed publisher
McDougald D, Papp T, Zezulin A, Zhou S, Bennett J. AKT3 Gene Transfer Promotes Anabolic Reprogramming and Photoreceptor Neuroprotection in a Pre-clinical Model of Retinitis Pigmentosa. Mol Ther. 2019;: pubmed publisher
Workman A, Zhu L, Keel B, Smith T, Jones C. The Wnt Signaling Pathway Is Differentially Expressed during the Bovine Herpesvirus 1 Latency-Reactivation Cycle: Evidence That Two Protein Kinases Associated with Neuronal Survival, Akt3 and BMPR2, Are Expressed at Higher Levels during Latency. J Virol. 2018;92: pubmed publisher
Figlia G, Norrmen C, Pereira J, Gerber D, Suter U. Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system. elife. 2017;6: pubmed publisher
Bhardwaj A, Singh H, Rajapakshe K, Tachibana K, Ganesan N, Pan Y, et al. Regulation of miRNA-29c and its downstream pathways in preneoplastic progression of triple-negative breast cancer. Oncotarget. 2017;8:19645-19660 pubmed publisher
Miao L, Yang L, Huang H, Liang F, Ling C, Hu Y. mTORC1 is necessary but mTORC2 and GSK3? are inhibitory for AKT3-induced axon regeneration in the central nervous system. elife. 2016;5:e14908 pubmed publisher
Shi Q, Hoffman B, Liu Q. PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs. Virology. 2016;490:99-108 pubmed publisher
Ye Y, Ge Y, Xiao M, Guo L, Li Q, Hao J, et al. Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt. J Gastroenterol. 2016;51:230-40 pubmed publisher
Greene M, Loeser R. Function of the chondrocyte PI-3 kinase-Akt signaling pathway is stimulus dependent. Osteoarthritis Cartilage. 2015;23:949-56 pubmed publisher
Elloul S, Kedrin D, Knoblauch N, Beck A, Toker A. The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration. Mol Cancer Res. 2014;12:464-76 pubmed publisher
Ye Y, Jin L, Wilmott J, Hu W, Yosufi B, Thorne R, et al. PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma. Nat Commun. 2013;4:1508 pubmed publisher
Calleja V, Laguerre M, Parker P, Larijani B. Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. PLoS Biol. 2009;7:e17 pubmed publisher
product information
Catalog Number :
9017
Product Name :
1236 pcDNA3 Myr HA Akt3
article :
doi
id349
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5446
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
The sequence of the HA tag in this plasmid is YAYDVPDYA instead of YPYDVPDYA. Not all HA antibodies will recognize this sequence. Cell Signaling Technology's HA antibody #2367 will work.
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5HindIII
promoter
sequencing_primer_3
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesMPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
geneAKT3
id10000
genbank_ids
mutation
nameAkt3
shRNA_sequence
size1500
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagMyr
locationN terminal on backbone
tagHA
resistance markers :
455
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA