This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pRK7-HA-S6K1-KR
catalog :
8985
citations: 7
Reference
Liu H, Du H, Khabibullin D, Zarei M, Wei K, Freeman G, et al. mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion. Nat Commun. 2023;14:1214 pubmed publisher
Sfakianos A, Mellor L, Pang Y, Kritsiligkou P, Needs H, Abou Hamdan H, et al. The mTOR-S6 kinase pathway promotes stress granule assembly. Cell Death Differ. 2018;25:1766-1780 pubmed publisher
Burke L, Darwish T, Cavanaugh A, Virtue S, Roth E, Morro J, et al. mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. elife. 2017;6: pubmed publisher
Glanz S, Mirsaidi A, López Fagundo C, Filliat G, Tiaden A, Richards P. Loss-of-Function of HtrA1 Abrogates All-Trans Retinoic Acid-Induced Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells Through Deficiencies in p70S6K Activation. Stem Cells Dev. 2016;25:687-98 pubmed publisher
Zhang J, Gao Z, Yin J, Quon M, Ye J. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J Biol Chem. 2008;283:35375-82 pubmed publisher
Pang C, Gao Z, Yin J, Zhang J, Jia W, Ye J. Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity. Am J Physiol Endocrinol Metab. 2008;295:E313-22 pubmed publisher
Schalm S, Blenis J. Identification of a conserved motif required for mTOR signaling. Curr Biol. 2002;12:632-9 pubmed
product information
Catalog Number :
8985
Product Name :
pRK7-HA-S6K1-KR
article :
doi10.1016/S0960-9822(02)00762-5
id344
pubmed_id11967149
bacterial resistance :
Ampicillin
cloning :
backbonepRK7
backbone_mutation
backbone_origin
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5XbaI
promoter
sequencing_primer_3
sequencing_primer_5CMV Forward
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesp70 S6K-alpha
geneRps6kb1
id83840
genbank_ids
mutationK100R, kinase-inactive
nameS6K1
shRNA_sequence
size1500
species
10116
Rattus norvegicus
tags
locationN terminal on insert
tagHA
resistance markers :
41
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA