This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
3541 pMIG Bcl-XL
catalog :
8790
citations: 8
Reference
Gazestani V, Kamath T, Nadaf N, Burris S, Rooney B, Junkkari A, et al. Early Alzheimer's disease pathology in human cortex is associated with a transient phase of distinct cell states. bioRxiv. 2023;: pubmed publisher
Erdogdu U, Dolgikh N, Laszig S, Särchen V, Meister M, Wanior M, et al. Selective BH3 mimetics synergize with BET inhibition to induce mitochondrial apoptosis in rhabdomyosarcoma cells. Neoplasia. 2022;24:109-119 pubmed publisher
Ishida S, Akiyama H, Umezawa Y, Okada K, Nogami A, Oshikawa G, et al. Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2. Oncotarget. 2018;9:26834-26851 pubmed publisher
Mai W, Gosa L, Daniëls V, Ta L, Tsang J, Higgins B, et al. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017;23:1342-1351 pubmed publisher
Chen Y, Anastassiadis K, Kranz A, Stewart A, Arndt K, Waskow C, et al. MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell. 2017;31:755-770.e6 pubmed publisher
Yu Y, Wang J, Khaled W, Burke S, Li P, Chen X, et al. Bcl11a is essential for lymphoid development and negatively regulates p53. J Exp Med. 2012;209:2467-83 pubmed publisher
Leight J, Wozniak M, Chen S, Lynch M, Chen C. Matrix rigidity regulates a switch between TGF-?1-induced apoptosis and epithelial-mesenchymal transition. Mol Biol Cell. 2012;23:781-91 pubmed publisher
Cheng E, Wei M, Weiler S, Flavell R, Mak T, Lindsten T, et al. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell. 2001;8:705-11 pubmed
product information
Catalog Number :
8790
Product Name :
3541 pMIG Bcl-XL
article :
doi10.1016/S1097-2765(01)00320-3
id289
pubmed_id11583631
bacterial resistance :
Ampicillin
cloning :
backbonepMIG
backbone_mutation
backbone_origin
backbone_size7000
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
growth notes :
Note that the GFP in this plasmid is not fused to gene. It is for selection purposes only.
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3
cloning_site_5Bgl II
promoter
sequencing_primer_3
sequencing_primer_5pLXSN 5'
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52
geneBCL2L1
id598
genbank_ids
NM_138578
mutation
nameBcl-XL
shRNA_sequence
size700
species
9606
Homo sapiens
tags
resistance markers :
264
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA