This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
p3868 HA-E6-AP
catalog :
8648
citations: 5
Reference
Sun J, Liu Y, Zhu G, Cato C, Hao X, Qian L, et al. PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome. Sci Rep. 2020;10:9824 pubmed publisher
Sun J, Liu Y, Jia Y, Hao X, Lin W, Tran J, et al. UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity. elife. 2018;7: pubmed publisher
Grimaldo L, Sandoval A, Garza López E, Felix R. Involvement of Parkin in the ubiquitin proteasome system-mediated degradation of N-type voltage-gated Ca2+ channels. PLoS ONE. 2017;12:e0185289 pubmed publisher
Gossan N, Zhang F, Guo B, Jin D, Yoshitane H, Yao A, et al. The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor. Nucleic Acids Res. 2014;42:5765-75 pubmed publisher
Talis A, Huibregtse J, Howley P. The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells. J Biol Chem. 1998;273:6439-45 pubmed
product information
Catalog Number :
8648
Product Name :
p3868 HA-E6-AP
article :
doi10.1074/jbc.273.11.6439
id246
pubmed_id9497376
bacterial resistance :
Ampicillin
cloning :
backbonepCMV4
backbone_mutation
backbone_origin
backbone_size4874
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
See author's map. E6-AP is missing the first 22 amino acids of isoform 1 (protein starts with MEACT NEFCA).
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3HindIII
cloning_site_5BamHI
promoter
sequencing_primer_3
sequencing_primer_5CMV Forward
site_3_destroyed
site_5_destroyed1
entrez_gene
aliasesANCR, AS, E6-AP, EPVE6AP, HPVE6A, PIX1
geneUBE3A
id7337
genbank_ids
mutation
nameE6-AP
shRNA_sequence
size2500
species
9606
Homo sapiens
tags
locationN terminal on insert
tagHA
resistance markers :
209
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA