This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pBABE-FLAG-KD LKB1
catalog :
8593
citations: 8
Reference
Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, et al. ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Nat Cancer. 2021;2:503-514 pubmed publisher
Ren Y, Chen J, Chen P, Hao Q, Cheong L, Tang M, et al. Oxidative stress-mediated AMPK inactivation determines the high susceptibility of LKB1-mutant NSCLC cells to glucose starvation. Free Radic Biol Med. 2021;166:128-139 pubmed publisher
Hermanova I, Z iga Garc a P, Caro Maldonado A, Fernandez Ruiz S, Salvador F, Mart n Mart n N, et al. Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer. J Exp Med. 2020;217: pubmed publisher
Lee Y, Kim N, Cho E, Yang J, Cha Y, Kang H, et al. Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner. Nat Commun. 2018;9:2301 pubmed publisher
Hai J, Liu S, Bufe L, Do K, Chen T, Wang X, et al. Synergy of WEE1 and mTOR Inhibition in Mutant KRAS-Driven Lung Cancers. Clin Cancer Res. 2017;23:6993-7005 pubmed publisher
Cooper J, Ou Y, McMillan E, Vaden R, Zaman A, Bodemann B, et al. TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer. Cancer Res. 2017;77:5077-5094 pubmed publisher
Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, et al. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature. 2017;546:168-172 pubmed publisher
Shaw R, Kosmatka M, Bardeesy N, Hurley R, Witters L, Depinho R, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004;101:3329-35 pubmed
product information
Catalog Number :
8593
Product Name :
pBABE-FLAG-KD LKB1
article :
doi10.1073/pnas.0308061100
id222
pubmed_id14985505
bacterial resistance :
Ampicillin
cloning :
backbonepBABE-puro
backbone_mutation
backbone_origin
backbone_size5169
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3SalI
cloning_site_5BamHI
promoter
sequencing_primer_3
sequencing_primer_5pBABE 5'
site_3_destroyed
site_5_destroyed1
entrez_gene
aliasesLKB1, PJS, hLKB1
geneSTK11
id6794
genbank_ids
Q15831
mutationK78I: lysine 78 mutated to isoleucine; kinase dead
nameLKB1
shRNA_sequence
size1400
species
9606
Homo sapiens
tags
locationN terminal on insert
tagFLAG
resistance markers :
64
tags :
High Copy
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA