This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pcDNA3-FLAG-KD LKB1
catalog :
8591
citations: 5
Reference
Park J, Lee D, Kim D. Redefining the role of AMPK in autophagy and the energy stress response. Nat Commun. 2023;14:2994 pubmed publisher
Donnelly L, Hogan T, Lenahan S, Nandagopal G, Eaton J, Lebeau M, et al. Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers. Carcinogenesis. 2021;42:1428-1438 pubmed publisher
Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, et al. The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Mol Cell. 2018;69:87-99.e7 pubmed publisher
Wang P, Ma T, Guo D, Hu K, Shu Y, Xu H, et al. Metformin induces osteoblastic differentiation of human induced pluripotent stem cell-derived mesenchymal stem cells. J Tissue Eng Regen Med. 2018;12:437-446 pubmed publisher
Shaw R, Kosmatka M, Bardeesy N, Hurley R, Witters L, Depinho R, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004;101:3329-35 pubmed
product information
Catalog Number :
8591
Product Name :
pcDNA3-FLAG-KD LKB1
article :
doi10.1073/pnas.0308061100
id222
pubmed_id14985505
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5400
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3XhoI
cloning_site_5EcoRI
promoter
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed1
site_5_destroyed
entrez_gene
aliasesLKB1, PJS, hLKB1
geneSTK11
id6794
genbank_ids
Q15831
NM_000455.4
mutationK78I: lysine 78 mutated to isoleucine; kinase dead
nameLKB1
shRNA_sequence
size1400
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagFLAG
resistance markers :
64
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA