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product summary
company name :
Addgene
product type :
cDNA
product name :
pcDNA3-FLAG-LKB1
catalog :
8590
citations: 18
Reference
Park J, Lee D, Kim D. Redefining the role of AMPK in autophagy and the energy stress response. Nat Commun. 2023;14:2994 pubmed publisher
Donnelly L, Hogan T, Lenahan S, Nandagopal G, Eaton J, Lebeau M, et al. Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers. Carcinogenesis. 2021;42:1428-1438 pubmed publisher
Zhang D, Ning J, Okon I, Zheng X, Satyanarayana G, Song P, et al. Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer. Cell Death Dis. 2021;12:518 pubmed publisher
Caiola E, Iezzi A, Tomanelli M, Bonaldi E, Scagliotti A, Colombo M, et al. LKB1 Deficiency Renders NSCLC Cells Sensitive to ERK Inhibitors. J Thorac Oncol. 2020;15:360-370 pubmed publisher
Yang H, Zhu L, Chao Y, Gu Y, Kong X, Chen M, et al. Hyaluronidase2 (Hyal2) modulates low shear stress-induced glycocalyx impairment via the LKB1/AMPK/NADPH oxidase-dependent pathway. J Cell Physiol. 2018;233:9701-9715 pubmed publisher
MacDonald A, Bettaieb A, Donohoe D, Alani D, Han A, Zhao Y, et al. Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties. BMC Complement Altern Med. 2018;18:188 pubmed publisher
Tarumoto Y, Lu B, Somerville T, Huang Y, Milazzo J, Wu X, et al. LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia. Mol Cell. 2018;69:1017-1027.e6 pubmed publisher
Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, et al. The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Mol Cell. 2018;69:87-99.e7 pubmed publisher
Zhang C, Xiao X, Chen M, Aldharee H, Chen Y, Long W. Liver kinase B1 restoration promotes exosome secretion and motility of lung cancer cells. Oncol Rep. 2018;39:376-382 pubmed publisher
O Farrell F, Lobert V, Sneeggen M, Jain A, Katheder N, Wenzel E, et al. Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. Nat Cell Biol. 2017;19:1412-1423 pubmed publisher
Zheng X, Chi J, Zhi J, Zhang H, Yue D, Zhao J, et al. Aurora-A-mediated phosphorylation of LKB1 compromises LKB1/AMPK signaling axis to facilitate NSCLC growth and migration. Oncogene. 2018;37:502-511 pubmed publisher
Wang P, Ma T, Guo D, Hu K, Shu Y, Xu H, et al. Metformin induces osteoblastic differentiation of human induced pluripotent stem cell-derived mesenchymal stem cells. J Tissue Eng Regen Med. 2018;12:437-446 pubmed publisher
Vaarmann A, Mandel M, Zeb A, Wareski P, Liiv J, Kuum M, et al. Mitochondrial biogenesis is required for axonal growth. Development. 2016;143:1981-92 pubmed publisher
Howe G, Xiao B, Zhao H, Al Zahrani K, Hasim M, Villeneuve J, et al. Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer. PLoS ONE. 2016;11:e0150567 pubmed publisher
Chen L, Engel B, Welsh E, Yoder S, Brantley S, Chen D, et al. A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma. J Thorac Oncol. 2016;11:838-49 pubmed publisher
Demetriades C, Plescher M, Teleman A. Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nat Commun. 2016;7:10662 pubmed publisher
Rhodes L, Tate C, Hoang V, Burks H, Gilliam D, Martin E, et al. Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1. Oncogenesis. 2015;4:e168 pubmed publisher
Shaw R, Kosmatka M, Bardeesy N, Hurley R, Witters L, Depinho R, et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004;101:3329-35 pubmed
product information
Catalog Number :
8590
Product Name :
pcDNA3-FLAG-LKB1
article :
doi10.1073/pnas.0308061100
id222
pubmed_id14985505
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5400
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3XhoI
cloning_site_5EcoRI
promoter
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed1
site_5_destroyed
entrez_gene
aliasesLKB1, PJS, hLKB1
geneSTK11
id6794
genbank_ids
Q15831
mutation
nameLKB1
shRNA_sequence
size1400
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagFLAG
resistance markers :
64
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA