This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
SHP2(WT)@pLKO-Trex-SBP
catalog :
85457
citations: 2
Reference
Buckarma E, Werneberg N, Conboy C, Kabashima A, O Brien D, Wang C, et al. The YAP-Interacting Phosphatase SHP2 Can Regulate Transcriptional Co-activity and Modulate Sensitivity to Chemotherapy in Cholangiocarcinoma. Mol Cancer Res. 2020;: pubmed publisher
Chen Y, LaMarche M, Chan H, Fekkes P, García Fortanet J, Acker M, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016;535:148-52 pubmed
product information
Catalog Number :
85457
Product Name :
SHP2(WT)@pLKO-Trex-SBP
article :
doi10.1038/nature18621
id22687
pubmed_id27362227
bacterial resistance :
Ampicillin
cloning :
backbonepLKO-trex-SBP-DEST-Neo
backbone_mutation
backbone_origin
backbone_size9600
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Lentiviral
growth strain :
Gene expression
origin :
37
pi :
alt_names
PTPN11
cloning
clone_methodGateway Cloning
cloning_site_3
cloning_site_5
promoterRSV
sequencing_primer_3TCATCTGAAACTTTTCTGCTGTTGC
sequencing_primer_5ATGACATCGCGGAGATGGTTTCACC
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
genePTPN11
id5781
genbank_ids
mutation
nameSHP2
shRNA_sequence
size2200
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagSBP Tag
resistance markers :
3154
tags :
Unknown
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA