This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
HA Raptor
catalog :
8513
citations: 15
Reference
Li T, Wang Q, Gao A, Li X, Sun Y, Mottis A, et al. Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation. Cell Discov. 2023;9:92 pubmed publisher
Nüchel J, Tauber M, Nolte J, Morgelin M, Türk C, Eckes B, et al. An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Mol Cell. 2021;: pubmed publisher
Majeed S, Batool A, Majeed R, Bhat N, Zargar M, Andrabi K. mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation. Cell Cycle. 2021;20:839-854 pubmed publisher
Son S, Park S, Stamatakou E, Vicinanza M, Menzies F, Rubinsztein D. Leucine regulates autophagy via acetylation of the mTORC1 component raptor. Nat Commun. 2020;11:3148 pubmed publisher
Walsh S, Simovic B, Chen L, Bastin D, Nguyen A, Stephenson K, et al. Endogenous T cells prevent tumor immune escape following adoptive T cell therapy. J Clin Invest. 2019;129:5400-5410 pubmed publisher
Antonia R, Castillo J, Herring L, Serafin D, Liu P, Graves L, et al. TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877. Sci Rep. 2019;9:13470 pubmed publisher
Son S, Park S, Lee H, Siddiqi F, Lee J, Menzies F, et al. Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Cell Metab. 2019;29:192-201.e7 pubmed publisher
Meade N, Furey C, Li H, Verma R, Chai Q, Rollins M, et al. Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit. Cell. 2018;174:1143-1157.e17 pubmed publisher
Gu Y, Albuquerque C, Braas D, Zhang W, Villa G, Bi J, et al. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017;67:128-138.e7 pubmed publisher
Brown M, Gromeier M. MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1. Cell Rep. 2017;18:1444-1457 pubmed publisher
Ruf S, Heberle A, Langelaar Makkinje M, Gelino S, Wilkinson D, Gerbeth C, et al. PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Autophagy. 2017;13:486-505 pubmed publisher
Martin R, Desponds C, Eren R, Quadroni M, Thome M, Fasel N. Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death. Cell Death Discov. 2016;2:16024 pubmed publisher
Ying Z, Jin M, Peterson L, Bernard D, Saiya Cork K, Yildiz M, et al. Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma. Clin Cancer Res. 2016;22:5383-5393 pubmed
Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed publisher
Kim D, Sarbassov D, Ali S, King J, Latek R, Erdjument Bromage H, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell. 2002;110:163-75 pubmed
product information
Catalog Number :
8513
Product Name :
HA Raptor
article :
doi10.1016/S0092-8674(02)00808-5
id220
pubmed_id12150925
bacterial resistance :
Ampicillin
cloning :
backboneprk5
backbone_mutation
backbone_origin
backbone_size4716
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
Addgene has compiled full sequence for this plasmid. Please see Notes link.
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5SalI
promoter
sequencing_primer_3SV40pA-R
sequencing_primer_5SP6
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesKOG1, Mip1
geneRPTOR
id57521
genbank_ids
mutation
nameRaptor
shRNA_sequence
size4071
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagha
resistance markers :
432
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA