This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCMV-SHP2 CS
catalog :
8382
citations: 4
Reference
Heynen G, Lisek K, Vogel R, Wulf Goldenberg A, Alcaniz J, Montaudon E, et al. Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors. Breast Cancer Res. 2022;24:23 pubmed publisher
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed publisher
Mamik M, Ghorpade A. Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes. PLoS ONE. 2012;7:e45596 pubmed publisher
Fujita Y, Takashima R, Endo S, Takai T, Yamashita T. The p75 receptor mediates axon growth inhibition through an association with PIR-B. Cell Death Dis. 2011;2:e198 pubmed publisher
product information
Catalog Number :
8382
Product Name :
pCMV-SHP2 CS
article :
doi
id5
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepRC/CMV
backbone_mutation
backbone_origin
backbone_size5542
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
SH-PTP2
PTPN11
PTP2C
cloning
clone_methodRestriction Enzyme
cloning_site_3XbaI
cloning_site_5HindIII
promoter
sequencing_primer_3SP6
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
genePTPN11
id5781
genbank_ids
mutationC459S, mutation of essential catalytic cysteine
nameSHP2
shRNA_sequence
size2276
species
9606
Homo sapiens
tags
locationC terminal on insert
tagHA
resistance markers :
358
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA