This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCMV-SHP2 WT
catalog :
8381
citations: 9
Reference
Heynen G, Lisek K, Vogel R, Wulf Goldenberg A, Alcaniz J, Montaudon E, et al. Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors. Breast Cancer Res. 2022;24:23 pubmed publisher
Lin C, Suen K, Jeffrey P, Wieteska L, Lidster J, Bao P, et al. Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state. Mol Cell. 2022;82:1089-1106.e12 pubmed publisher
Vemulapalli V, Chylek L, Erickson A, Pfeiffer A, Gabriel K, LaRochelle J, et al. Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. elife. 2021;10: pubmed publisher
Okada Y, Zhang Y, Zhang L, Yeh L, Wang Y, Saika S, et al. Shp2-mediated MAPK pathway regulates ΔNp63 in epithelium to promote corneal innervation and homeostasis. Lab Invest. 2019;: pubmed publisher
LaRochelle J, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, et al. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun. 2018;9:4508 pubmed publisher
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed publisher
Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, et al. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun. 2017;8:2168 pubmed publisher
Beigbeder A, Chartier F, Bisson N. MPZL1 forms a signalling complex with GRB2 adaptor and PTPN11 phosphatase in HER2-positive breast cancer cells. Sci Rep. 2017;7:11514 pubmed publisher
Mamik M, Ghorpade A. Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes. PLoS ONE. 2012;7:e45596 pubmed publisher
product information
Catalog Number :
8381
Product Name :
pCMV-SHP2 WT
article :
doi
id5
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepRC/CMV
backbone_mutation
backbone_origin
backbone_size5542
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
SH-PTP2
PTPN11
PTP2C
cloning
clone_methodRestriction Enzyme
cloning_site_3XbaI
cloning_site_5HindIII
promoter
sequencing_primer_3SP6
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2
genePTPN11
id5781
genbank_ids
mutation
nameSHP2
shRNA_sequence
size2276
species
9606
Homo sapiens
tags
resistance markers :
358
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA