This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
Hs.HRAS Q61L
catalog :
83186
citations: 8
Reference
Long C, Yuan L, Wei W, Li J. Overcoming chemoresistance in glioblastoma by fluvastatin via prenylation-dependent inhibition of Ras signaling. Hum Exp Toxicol. 2022;41:9603271221125934 pubmed publisher
Wan W, Xiao W, Pan W, Chen L, Liu Z, Xu J. Isoprenylcysteine carboxyl methyltransferase is critical for glioblastoma growth and survival by activating Ras/Raf/Mek/Erk. Cancer Chemother Pharmacol. 2022;89:401-411 pubmed publisher
Lu H, Zhou L, Zuo H, Le W, Hu J, Zhang T, et al. Overriding sorafenib resistance via blocking lipid metabolism and Ras by sphingomyelin synthase 1 inhibition in hepatocellular carcinoma. Cancer Chemother Pharmacol. 2021;87:217-228 pubmed publisher
Dai S, Zhang X, Zhang P, Zheng X, Pang Q. Fentanyl inhibits acute myeloid leukemia differentiated cells and committed progenitors via opioid receptor-independent suppression of Ras and STAT5 pathways. Fundam Clin Pharmacol. 2020;: pubmed publisher
Zheng Q, Peng X, Zhang Y. Cytotoxicity of amide-linked local anesthetics on melanoma cells via inhibition of Ras and RhoA signaling independent of sodium channel blockade. BMC Anesthesiol. 2020;20:43 pubmed publisher
Wang C, Liu X, He R, Li J, Pan R. Prenylation-dependent Ras inhibition by pamidronate inhibits pediatric acute myeloid leukemia stem and differentiated cell growth and survival. Biochem Biophys Res Commun. 2019;517:439-444 pubmed publisher
Liu Q, Chen J, Fu B, Dai J, Zhao Y, Lai L. Isoprenylcysteine carboxylmethyltransferase regulates ovarian cancer cell response to chemotherapy and Ras activation. Biochem Biophys Res Commun. 2018;501:556-562 pubmed publisher
Pan Q, Liu R, Banu H, Ma L, Li H. Inhibition of isoprenylcysteine carboxylmethyltransferase sensitizes common chemotherapies in cervical cancer via Ras-dependent pathway. Biomed Pharmacother. 2018;99:169-175 pubmed publisher
product information
Catalog Number :
83186
Product Name :
Hs.HRAS Q61L
article :
doi
id22172
pubmed_id
bacterial resistance :
Spectinomycin
cloning :
backbonepDonor-255
backbone_mutation
backbone_origin
backbone_size2693
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Other
Gateway Entry Clone
growth strain :
Gateway ORF Entry clone of human HRAS [NM_005343.2 ] with stop codon (for native or N-terminal fusions), Q61L mutation
origin :
37
pi :
alt_names
cloning
clone_methodGateway Cloning
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3attLR 23-mer (5'-TAACATCAGAGATTTTGAGACAC)
sequencing_primer_5M13F 23-mer (5'-CCCAGTCACGACGTTGTAAAACG)
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesC-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras
geneHRAS
id3265
genbank_ids
NM_005343.2
mutationQ61L
nameHRAS
shRNA_sequence
size570
species
9606
Homo sapiens
tags
resistance markers :
139
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA