This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
MELOPS
catalog :
80151
citations: 3
Reference
Wu W, Wang Y, Liu Y, Guo H, Li Z, Zou W, et al. TRPA1 promotes UVB-induced skin pigmentation by regulating melanosome luminal pH. Exp Dermatol. 2022;: pubmed publisher
Quiroz F, Fiore V, Levorse J, Polak L, Wong E, Pasolli H, et al. Liquid-liquid phase separation drives skin barrier formation. Science. 2020;367: pubmed publisher
Ambrosio A, Boyle J, Aradi A, Christian K, Di Pietro S. TPC2 controls pigmentation by regulating melanosome pH and size. Proc Natl Acad Sci U S A. 2016;113:5622-7 pubmed publisher
product information
Catalog Number :
80151
Product Name :
MELOPS
article :
doi10.1073/pnas.1600108113
id18764
pubmed_id27140606
bacterial resistance :
Ampicillin
cloning :
backbonepCR3
backbone_mutation
backbone_originInvitrogen
backbone_size5537
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth strain :
Genetically encoded melanosome-localized pH sensor.
origin :
37
pi :
alt_names
P Protein
cloning
clone_methodRestriction Enzyme
cloning_site_3XhoI
cloning_site_5BamHI
promoterCMV
sequencing_primer_3CACCTTCCAGGGTCAAGGA
sequencing_primer_5CGCAAATGGGCGGTAGGCGTG
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesBEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, P, PED, SHEP1
geneOCA2
id4948
genbank_ids
NM_000275
mutationnonpathologic polymorphism D257A, pore mutation V443I
nameOCA2
shRNA_sequence
size2517
species
9606
Homo sapiens
tags
location
tagmNectarine in first luminal loop
plasmid copy :
This plasmid was derived from pCR3/OCA2-HA (Sitaram A, et al. (2009) Localization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 function. Mol Biol Cell 20(5):1464 1477)
resistance markers :
2926
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA