This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
p-AAV-sh[SNCA]
catalog :
75437
citations: 4
Reference
Bapat O, Purimetla T, Kruessel S, Shah M, Fan R, Thum C, et al. VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity. Nat Commun. 2024;15:205 pubmed publisher
Van Laar V, Chen J, Zharikov A, Bai Q, Di Maio R, Dukes A, et al. α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo. Redox Biol. 2020;37:101695 pubmed publisher
Zharikov A, Bai Q, De Miranda B, Van Laar A, Greenamyre J, Burton E. Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration. Neurobiol Dis. 2019;125:146-153 pubmed publisher
Zharikov A, Cannon J, Tapias V, Bai Q, Horowitz M, Shah V, et al. shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model. J Clin Invest. 2015;125:2721-35 pubmed publisher
product information
Catalog Number :
75437
Product Name :
p-AAV-sh[SNCA]
article :
doi10.1172/JCI64502
id18259
pubmed_id26075822
bacterial resistance :
Ampicillin
cloning :
backbonepAAV-D(+)-U6-siRNA-CMV-GFP
backbone_mutation
backbone_origin
backbone_size
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
AAV
RNAi
growth strain :
knockdown alpha-synuclein in rat neurons
origin :
37
pi :
alt_names
Expresses GFP and shRNA targeting rat alphs-synuclein
cloning
entrez_gene
aliases
geneSnca
id29219
genbank_ids
mutation
namesnca
shRNA_sequenceGCAGTGAGGCTTATGAAAT
size
species
10116
Rattus norvegicus
tags
plasmid copy :
pAAV-D(+)-U6-siRNA-CMV-GFP was modified from pAAV-D(+)-U6-siRNA-CMV-zsGreen, which was obtained from Bing Wang, PhD, University of Pittsburgh
resistance markers :
1971
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA