This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pBabe-Kras Wt
catalog :
75282
citations: 14
Reference
Gong Z, Xue L, Vlantis A, van Hasselt C, Chan J, Fang J, et al. Brusatol attenuated proliferation and invasion induced by KRAS in differentiated thyroid cancer through inhibiting Nrf2. J Endocrinol Invest. 2023;: pubmed publisher
Shin D, Jo J, Choi M, Kim K, Bae Y, Kim S. Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer. Exp Mol Med. 2023;55:2220-2237 pubmed publisher
Entrialgo Cadierno R, Cueto Ure xf1 a C, Welch C, Feliu I, Macaya I, Vera L, et al. The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer. Mol Cancer. 2023;22:86 pubmed publisher
Ricciuti B, Son J, Okoro J, Mira A, Patrucco E, Eum Y, et al. Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer. Clin Cancer Res. 2022;28:1640-1650 pubmed publisher
Sad K, Parashar P, Tripathi P, Hungyo H, Sistla R, Soni R, et al. Prochlorperazine enhances radiosensitivity of non-small cell lung carcinoma by stabilizing GDP-bound mutant KRAS conformation. Free Radic Biol Med. 2021;177:299-312 pubmed publisher
Mysore V, Zhou Z, Ambrogio C, Li L, Kapp J, Lu C, et al. A structural model of a Ras-Raf signalosome. Nat Struct Mol Biol. 2021;28:847-857 pubmed publisher
Li R, Ng T, Wang S, Prytyskach M, Rodell C, Mikula H, et al. Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. Nat Nanotechnol. 2021;16:830-839 pubmed publisher
Zhou Z, Ambrogio C, Bera A, Li Q, Li X, Li L, et al. KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer. Cancer Res. 2020;: pubmed publisher
Inoue S, Hirota Y, Ueno T, Fukui Y, Yoshida E, Hayashi T, et al. Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations. Nat Commun. 2019;10:5785 pubmed publisher
Kalvala A, Wallet P, Yang L, Wang C, Li H, Nam A, et al. Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS. J Clin Med. 2019;8: pubmed publisher
Li S, Liu S, Deng J, Akbay E, Hai J, Ambrogio C, et al. Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer. Clin Cancer Res. 2018;24:4854-4864 pubmed publisher
Ambrogio C, Köhler J, Zhou Z, Wang H, Paranal R, Li J, et al. KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS. Cell. 2018;172:857-868.e15 pubmed publisher
Zeng M, Lu J, Li L, Feru F, Quan C, Gero T, et al. Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C. Cell Chem Biol. 2017;24:1005-1016.e3 pubmed publisher
Mulcahy Levy J, Zahedi S, Griesinger A, Morin A, Davies K, Aisner D, et al. Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors. elife. 2017;6: pubmed publisher
product information
Catalog Number :
75282
Product Name :
pBabe-Kras Wt
article :
doi
id8776
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepBabe
backbone_mutation
backbone_origin
backbone_size5169
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
growth strain :
Expresses human Kras wild-type
origin :
37
pi :
alt_names
K-ras
Kras
Kirsten rat sarcoma viral oncogene homolog
cloning
clone_methodRestriction Enzyme
cloning_site_3SalI
cloning_site_5BamHI
promoter
sequencing_primer_3pBabe 3'
sequencing_primer_5pBabe 5'
site_3_destroyed
site_5_destroyed1
entrez_gene
aliases'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, K-Ras 2, KI-RAS, KRAS1, KRAS2, NS, NS3, OES, RALD, RASK2, c-Ki-ras, c-Ki-ras2
geneKRAS
id3845
genbank_ids
NC_000012.12
mutationNone. Wild-Type
nameKRAS
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationN terminal on insert
tagHA
resistance markers :
114
tags :
Unknown
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA