This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pLC-RFP657-CASP8
catalog :
75164
citations: 2
Reference
Elmallah M, Cogo S, Constantinescu A, Elifio Esposito S, Abdelfattah M, Micheau O. Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP. Cells. 2020;9: pubmed publisher
McComb S, Aguadé Gorgorió J, Harder L, Marovca B, Cario G, Eckert C, et al. Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL. Sci Transl Med. 2016;8:339ra70 pubmed publisher
product information
Catalog Number :
75164
Product Name :
pLC-RFP657-CASP8
article :
doi10.1126/scitranslmed.aad2986
id18541
pubmed_id27194728
bacterial resistance :
Ampicillin
cloning :
backbonelentiCRISPRv1
backbone_mutationSwap puromycin resistance for tagBFP
backbone_origin
backbone_size
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Lentiviral
CRISPR
growth strain :
LentiCRISPR-RFP657 with sgRNA targeting human Caspase-8
origin :
37
pi :
alt_names
Caspase-8
cloning
clone_methodRestriction Enzyme
cloning_site_3BsmBI (Esp3I)
cloning_site_5BsmBI (Esp3I)
promoterU6
sequencing_primer_3AAACTTGCGGAATGTAGTCCAGGCC
sequencing_primer_5GACTATCATATGCTTACCGT
site_3_destroyed1
site_5_destroyed1
entrez_gene
aliasesALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
geneCASP8
id841
genbank_ids
NG_007497.1
mutation
nameCASP8 sgRNA
shRNA_sequenceGCCTGGACTACATTCCGCAA
size
species
9606
Homo sapiens
tags
resistance markers :
2810
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA