pLPC-Progerin | Addgene 69061 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Addgene

product type :

cDNA

product name :

pLPC-Progerin

catalog :

69061

citations: 3

Reference
Coll Bonfill N, Mahajan U, Shashkova E, Lin C, Mecham R, Gonzalo S. Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature. GeroScience. 2022;: pubmed publisher
Aguado J, Sola Carvajal A, Cancila V, Revêchon G, Ong P, Jones Weinert C, et al. Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome. Nat Commun. 2019;10:4990 pubmed publisher
Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed publisher

product information

Catalog Number :

69061

Product Name :

pLPC-Progerin

article :

doi	10.1080/15384101.2015.1053671
id	15627
pubmed_id	26029982

bacterial resistance :

Ampicillin

cloning :

backbone

pLPC

backbone_mutation

backbone_origin

backbone_size

5493

promoter

sequencing_primer_3

sequencing_primer_5

vector_types

Mammalian Expression

Retroviral

growth strain :

encodes the lamin A mutant with a 50 amino acids deletion responsible for the Hutchinson-Gilford Progeria Syndrome

origin :

pi :

alt_names

cloning

clone_method	Unknown
cloning_site_3
cloning_site_5
promoter	CMV
sequencing_primer_3	acctgtaggtttggcaag
sequencing_primer_5	taggcgtgtacggtggga
site_3_destroyed
site_5_destroyed

entrez_gene

aliases	CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, MADA, PRO1
gene	LMNA
id	4000

genbank_ids

mutation

name

Progerin

shRNA_sequence

size

1845

species

9606

Homo sapiens