| Reference |
|---|
Chung D, Chen A, Choo C, Zhang W, Williams D, Griffis C, et al. Investigation of the functional impact of CHED- and FECD4-associated SLC4A11 mutations in human corneal endothelial cells. PLoS ONE. 2024;19:e0296928 pubmed publisher |
Kwon A, Lee N, Yu J, Choi M, Park J, Koo J. Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury. Cell Death Dis. 2024;15:51 pubmed publisher |
Lee D, Yoon E, Ham S, Lee K, Jang H, Woo D, et al. Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila. Nat Commun. 2024;15:468 pubmed publisher |
Bhattacharyya S, Oon C, Diaz L, Sandborg H, Stempinski E, Saoi M, et al. Autotaxin-lysolipid signaling suppresses a CCL11-eosinophil axis to promote pancreatic cancer progression. Nat Cancer. 2024;: pubmed publisher |
Schulz M, Teissandier A, De La Mata Santaella E, Armand M, Iranzo J, el Marjou F, et al. DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation. Nat Struct Mol Biol. 2024;: pubmed publisher |
Yu Y, Farooq M, Eberhart Meessen S, Jiang Y, Kato D, Zhan T, et al. Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ. Cell Death Dis. 2024;15:7 pubmed publisher |
Paul S, Sarraf S, Nam K, Zavar L, DeFoor N, Biswas S, et al. NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis. J Cell Biol. 2024;223: pubmed publisher |
Janer A, Morris J, Krols M, Antonicka H, Aaltonen M, Lin Z, et al. ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis. Life Sci Alliance. 2024;7: pubmed publisher |
Hariprakash J, Salviato E, La Mastra F, Sebesty xe9 n E, Tagliaferri I, Silva R, et al. Leveraging Tissue-Specific Enhancer-Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer. Cancer Res. 2024;84:133-153 pubmed publisher |
Gasimli K, Raab M, Mandal R, Kr xe4 mer A, Pe xf1 a Llopis S, Tahmasbi Rad M, et al. Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 Inhibitors. Cancers (Basel). 2023;16: pubmed publisher |
Zhang C, Chang F, Miao H, Fu Y, Tong X, Feng Y, et al. Construction and application of a multifunctional CHO cell platform utilizing Cre/lox and Dre/rox site-specific recombination systems. Front Bioeng Biotechnol. 2023;11:1320841 pubmed publisher |
Zhang J, Zhang Y, Shang Q, Cheng Y, Su Y, Zhang J, et al. Gain-of-Function KIDINS220 Variants Disrupt Neuronal Development and Cause Cerebral Palsy. Mov Disord. 2023;: pubmed publisher |
Gonzalez Salinas F, Herrera Gamboa J, Rojo R, Trevino V. Heterozygous Knockout of ARID4B Using CRISPR/Cas9 Attenuates Some Aggressive Phenotypes in a Breast Cancer Cell Line. Genes (Basel). 2023;14: pubmed publisher |
Xie B, Dean A. Noncoding function of super enhancer derived mRNA in modulating neighboring gene expression and TAD interaction. bioRxiv. 2023;: pubmed publisher |
Braun H, Xu Z, Chang F, Viceconte N, Rane G, Levin M, et al. ZNF524 directly interacts with telomeric DNA and supports telomere integrity. Nat Commun. 2023;14:8252 pubmed publisher |
Nakade K, Tsukamoto S, Nakashima K, An Y, Sato I, Li J, et al. Efficient selection of knocked-in pluripotent stem cells using a dual cassette cellular elimination system. Cell Rep Methods. 2023;3:100662 pubmed publisher |
Talbot E, Joshi L, Thornton P, Dezfouli M, Tsafou K, Perkinton M, et al. cGAS-STING signalling regulates microglial chemotaxis in genome instability. Nucleic Acids Res. 2023;: pubmed publisher |
Broadbent D, McEwan C, Tsang T, Poole D, Naylor B, Price J, et al. The formation of ubiquitin rich condensates triggers recruitment of the ATG9A lipid transfer complex to initiate basal autophagy. bioRxiv. 2023;: pubmed publisher |
Chen S, Allgayer H. Epigenetically Downregulated Breast Cancer Gene 2 through Acetyltransferase Lysine Acetyltransferase 2B Increases the Sensitivity of Colorectal Cancer to Olaparib. Cancers (Basel). 2023;15: pubmed publisher |
Papalazarou V, Newman A, Huerta Uribe A, Legrave N, Falcone M, Zhang T, et al. Phenotypic profiling of solute carriers characterizes serine transport in cancer. Nat Metab. 2023;5:2148-2168 pubmed publisher |
Thomas C, Erni R, Wu J, Fischer F, Lamers G, Grigolon G, et al. A naturally occurring polyacetylene isolated from carrots promotes health and delays signatures of aging. Nat Commun. 2023;14:8142 pubmed publisher |
Claude Taupin A, Isnard P, Bagattin A, Kuperwasser N, Roccio F, Ruscica B, et al. The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells. Nat Commun. 2023;14:8056 pubmed publisher |
Rezi C, Aslanyan M, Diwan G, Cheng T, Chamlali M, Junger K, et al. DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2. bioRxiv. 2023;: pubmed publisher |
Lemos F, de Ridder I, Bootman M, Bultynck G, Parys J. The Complex Effects of PKM2 and PKM2:IP3R Disruption on Intracellular Ca2+ Handling and Cellular Functions. Cells. 2023;12: pubmed publisher |
Shofa M, Saito A. Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation. PLoS ONE. 2023;18:e0289863 pubmed publisher |
Khandwala C, Sarkar P, Schmidt H, Ma M, Kinnebrew M, Pusapati G, et al. Direct ionic stress sensing and mitigation by the transcription factor NFAT5. bioRxiv. 2023;: pubmed publisher |
Gilmore R, Liu Y, Stoddard C, Chung M, Carmichael G, Cotney J. Identifying key underlying regulatory networks and predicting targets of orphan C/D box SNORD116 snoRNAs in Prader-Willi syndrome. bioRxiv. 2023;: pubmed publisher |
Idoko Akoh A, Goldhill D, Sheppard C, Bialy D, Quantrill J, Sukhova K, et al. Creating resistance to avian influenza infection through genome editing of the ANP32 gene family. Nat Commun. 2023;14:6136 pubmed publisher |
Mojica Perez S, Stokes K, Jaklic D, Jahagirdar S, UHLER M, Parent J, et al. Protocol for selecting single human pluripotent stem cells using a modified micropipetter. STAR Protoc. 2023;4:102629 pubmed publisher |
Nozawa T, Toh H, Iibushi J, Kogai K, Minowa Nozawa A, Satoh J, et al. Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy. Nat Commun. 2023;14:6230 pubmed publisher |
Cerdido S, S xe1 nchez Beltr xe1 n J, Lambertos A, Abrisqueta M, Padilla L, Herraiz C, et al. A Side-by-Side Comparison of Wildtype and Variant Melanocortin 1 Receptor Signaling with Emphasis on Protection against Oxidative Damage to DNA. Int J Mol Sci. 2023;24: pubmed publisher |
Lindblad A, Wu R, Persson K, Demirel I. The Role of NLRP3 in Regulation of Antimicrobial Peptides and Estrogen Signaling in UPEC-Infected Bladder Epithelial Cells. Cells. 2023;12: pubmed publisher |
Quiroga X, Walani N, Disanza A, Chavero A, Mittens A, Tebar F, et al. A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale. elife. 2023;12: pubmed publisher |
Sato A, Tsukiyama T, Komeno M, Iwatani C, Tsuchiya H, Kawamoto I, et al. Generation of a familial hypercholesterolemia model in non-human primate. Sci Rep. 2023;13:15649 pubmed publisher |
Yoshimatsu S, Okahara J, Yoshie J, Igarashi Y, Nakajima R, Sanosaka T, et al. Generation of a tyrosine hydroxylase-2A-Cre knockin non-human primate model by homology-directed-repair-biased CRISPR genome editing. Cell Rep Methods. 2023;3:100590 pubmed publisher |
Kshatri A, Rivero P xe9 rez B, Giraldez T. Subunit-specific inhibition of BK channels by piperine. Biophys J. 2023;: pubmed publisher |
Chang L, Ghosh S, Papale A, Luppino J, Miranda M, Piras V, et al. Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries. Nat Commun. 2023;14:5615 pubmed publisher |
Przybyszewska Podstawka A, Czapi x144 ski J, Ka x142 afut J, Rivero M xfc ller A. Synthetic circuits based on split Cas9 to detect cellular events. Sci Rep. 2023;13:14988 pubmed publisher |
Gilmore R, Gorka D, Stoddard C, Cotney J, Chamberlain S. Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cells. bioRxiv. 2023;: pubmed publisher |
Yu A, Yu P, Zhu Y, Zhu R, Sun R, Ye D, et al. Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development. Oncogene. 2023;42:3182-3193 pubmed publisher |
Recoules L, Tanguy Le Gac N, Moutahir F, Bystricky K, Lavigne A. Recruitment of the Histone Variant MacroH2A1 to the Pericentric Region Occurs upon Chromatin Relaxation and Is Responsible for Major Satellite Transcriptional Regulation. Cells. 2023;12: pubmed publisher |
Liu W, Wang X, Liu R, Liao Y, Peng Z, Jiang H, et al. Efficient delivery of a large-size Cas9-EGFP vector in porcine fetal fibroblasts using a Lonza 4D-Nucleofector system. BMC Biotechnol. 2023;23:29 pubmed publisher |
Keng V, Chiu A, To J, Li X, Linden M, Amin K, et al. Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma. Heliyon. 2023;9:e18774 pubmed publisher |
Nicastro R, Broh xe9 e L, Alba J, N xfc chel J, Figlia G, Kipschull S, et al. Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor. Nat Cell Biol. 2023;25:1303-1318 pubmed publisher |
Singh P, Zhou L, Shah D, Cejas R, Crossman D, Jouni M, et al. Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy. Sci Rep. 2023;13:12683 pubmed publisher |
She X, Wu Q, Rao Z, Song D, Huang C, Feng S, et al. SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle. Adv Sci (Weinh). 2023;10:e2301871 pubmed publisher |
Schuurmans I, Wu K, van Karnebeek C, Nadif Kasri N, Garanto A. Generation of an induced pluripotent stem cell line carrying biallelic deletions (SCTCi019-B) in ALDH7A1 using CRISPR/Cas9. Stem Cell Res. 2023;71:103173 pubmed publisher |
Peixoto J, Pr xed ncipe C, Pestana A, Os xf3 rio H, Pinto M, Prazeres H, et al. Using a Dual CRISPR/Cas9 Approach to Gain Insight into the Role of LRP1B in Glioblastoma. Int J Mol Sci. 2023;24: pubmed publisher |
Rasmussen M, Alvik K, Kannen V, Olafsen N, Erlingsson L, Grimaldi G, et al. Loss of PARP7 Increases Type I Interferon Signaling in EO771 Breast Cancer Cells and Prevents Mammary Tumor Growth by Increasing Antitumor Immunity. Cancers (Basel). 2023;15: pubmed publisher |
Hagkarim N, Hajkarim M, Suzuki T, Fujiwara T, Winkler G, Stewart G, et al. Disruption of the Mammalian Ccr4-Not Complex Contributes to Transcription-Mediated Genome Instability. Cells. 2023;12: pubmed publisher |
Kelly R, Parmar G, Bayat L, Maitland M, Lajoie G, Edgell D, et al. Noncanonical functions of Ku may underlie essentiality in human cells. Sci Rep. 2023;13:12162 pubmed publisher |
Zhulyn O, Rosenblatt H, Shokat L, Dai S, Kuzuoglu xd6 zt xfc rk D, Zhang Z, et al. Evolutionarily divergent mTOR remodels translatome for tissue regeneration. Nature. 2023;: pubmed publisher |
Ryder L, Arendrup F, Mart xed nez J, Snieckute G, Pecorari C, Shah R, et al. Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms. Cell Death Dis. 2023;14:467 pubmed publisher |
Park J, Woo S, Song C, Han J. Modification of surface glycan by expression of beta-1,4-N-acetyl-galactosaminyltransferase (B4GALNT2) confers resistance to multiple viruses infection in chicken fibroblast cell. Front Vet Sci. 2023;10:1160600 pubmed publisher |
van Hugte E, Lewerissa E, Wu K, Scheefhals N, Parodi G, van Voorst T, et al. SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes. Brain. 2023;: pubmed publisher |
Higashi T, Stephenson R, Schwayer C, Huljev K, Higashi A, Heisenberg C, et al. Zinc-based Ultrasensitive Microscopic Barrier Assay (ZnUMBA): a live imaging method to detect local barrier breaches. J Cell Sci. 2023;: pubmed publisher |
Hsu F, Wu Q, Fabyanic E, Wei A, Wu H, Clark A. TET1 facilitates specification of early human lineages including germ cells. iScience. 2023;26:107191 pubmed publisher |
Chung J, Park J, Lai Z, Lambert T, Richards R, Zhang J, et al. The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets. Nat Cell Biol. 2023;: pubmed publisher |
Yang Z, Johnson B, Meliopoulos V, Ju X, Zhang P, Hughes M, et al. Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication. bioRxiv. 2023;: pubmed publisher |
Kaur N, de la Ballina L, Haukaas H, Torgersen M, Radulovic M, Munson M, et al. TECPR1 is activated by damage-induced sphingomyelin exposure to mediate noncanonical autophagy. EMBO J. 2023;:e113105 pubmed publisher |
Tax G, Guay K, Sold xe0 T, Hitchman C, Hill J, Vasiljevi x107 S, et al. Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells. bioRxiv. 2023;: pubmed publisher |
Zhang X, Dan S, Pan X, Li J, Wei Q, Huang L, et al. Identification of VPS34-PI(3)P-FEN1-mediated DNA repair pathway as a potential drug target to overcome chemoresistance. Biochem Biophys Res Commun. 2023;674:27-35 pubmed publisher |
Wu M, Jin Q, Xu X, Fan J, Chen W, Miao M, et al. TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5. Adv Sci (Weinh). 2023;:e2301753 pubmed publisher |
Corkery D, Castro Gonzalez S, Knyazeva A, Herzog L, Wu Y. An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes. EMBO Rep. 2023;:e56841 pubmed publisher |
Fan M, Bao Y, Berkhout B, Herrera Carrillo E. CRISPR-Cas12b enables a highly efficient attack on HIV proviral DNA in T cell cultures. Biomed Pharmacother. 2023;165:115046 pubmed publisher |
S xe3 o Jos xe9 C, Pereira C, Ferreira M, Andr xe9 A, Os xf3 rio H, Gullo I, et al. 3D Chromatin Architecture Re-Wiring at the CDH3/CDH1 Loci Contributes to E-Cadherin to P-Cadherin Expression Switch in Gastric Cancer. Biology (Basel). 2023;12: pubmed publisher |
Cao X, Lenk G, Mikusevic V, Mindell J, Meisler M. The chloride antiporter CLCN7 is a modifier of lysosome dysfunction in FIG4 and VAC14 mutants. PLoS Genet. 2023;19:e1010800 pubmed publisher |
Modica C, Cortese M, Bersani F, Lombardi A, Napoli F, Righi L, et al. Genetic Ablation of the MET Oncogene Defines a Crucial Role of the HGF/MET Axis in Cell-Autonomous Functions Driving Tumor Dissemination. Cancers (Basel). 2023;15: pubmed publisher |
Kraus F, Goodall E, Smith I, Jiang Y, Paoli J, Adolf F, et al. PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems. EMBO Rep. 2023;:e56399 pubmed publisher |
Xu A, Molinuevo R, Fazzari E, Tom H, Zhang Z, Menendez J, et al. Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates. elife. 2023;12: pubmed publisher |
Hong H, Yoon S, Park J, Lee J, Kim H, Nam H, et al. MeCP2 dysfunction prevents proper BMP signaling and neural progenitor expansion in brain organoid. Ann Clin Transl Neurol. 2023;10:1170-1185 pubmed publisher |
Huang B, Zeng Z, Li H, Li Z, Chen X, Guo J, et al. Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids. bioRxiv. 2023;: pubmed publisher |
Ernst C, Duc J, Trono D. Efficient and sensitive profiling of RNA-protein interactions using TLC-CLIP. Nucleic Acids Res. 2023;51:e70 pubmed publisher |
Wang C, Ulryck N, Herzel L, Pythoud N, Kleiber N, Gu xe9 rineau V, et al. N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing. Nucleic Acids Res. 2023;: pubmed publisher |
Meineke B, Els xe4 sser S. Generation of Amber Suppression Cell Lines Using CRISPR-Cas9. Methods Mol Biol. 2023;2676:169-180 pubmed publisher |
Canals I, Comella Bolla A, Cepeda Prado E, Avaliani N, Crowe J, Oburoglu L, et al. Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementia. Brain Commun. 2023;5:fcad158 pubmed publisher |
Park J, Choi H, Jung K, Lee K, Shim J, Park K, et al. Production of recombinant human IgG1 Fc with beneficial N-glycosylation pattern for anti-inflammatory activity using genome-edited chickens. Commun Biol. 2023;6:589 pubmed publisher |
Peeters S, Leung T, Fornes O, Farkas R, Wasserman W, Brown C. Refining the genomic determinants underlying escape from X-chromosome inactivation. NAR Genom Bioinform. 2023;5:lqad052 pubmed publisher |
Zhu Z, Chen X, Guo A, Manzano T, Walsh P, Wills K, et al. Mitotic bookmarking by SWI/SNF subunits. Nature. 2023;618:180-187 pubmed publisher |
Alvizi L, Nani D, Brito L, Kobayashi G, Passos Bueno M, Mayor R. Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction. Nat Commun. 2023;14:2868 pubmed publisher |
Artoni F, Gr xfc tzmacher N, Demetriades C. Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor. Aging Cell. 2023;:e13888 pubmed publisher |
LIAN E, Pietrobon A, Stanford W. Differentiation and single-cell RNA-seq analyses of human pluripotent-stem-cell-derived renal organoids. STAR Protoc. 2023;4:102314 pubmed publisher |
Rubio K, Romero Olmedo A, Sarvari P, Swaminathan G, Ranvir V, Rogel Ayala D, et al. Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer. Theranostics. 2023;13:2384-2407 pubmed publisher |
Senoo N, Chinthapalli D, Baile M, Golla V, Saha B, Ogunbona O, et al. Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant. bioRxiv. 2023;: pubmed publisher |
Koob L, Friskes A, van Bergen L, Feringa F, van den Broek B, Koeleman E, et al. MND1 enables homologous recombination in somatic cells primarily outside the context of replication. Mol Oncol. 2023;17:1192-1211 pubmed publisher |
Teunissen M, Lewerissa E, van Hugte E, Wang S, Ockeloen C, Koolen D, et al. ANK2 loss-of-function variants are associated with epilepsy, and lead to impaired axon initial segment plasticity and hyperactive network activity in hiPSC-derived neuronal networks. Hum Mol Genet. 2023;32:2373-2385 pubmed publisher |
Jiménez Moreno N, Salomó Coll C, Murphy L, Wilkinson S. Signal-Retaining Autophagy Indicator as a Quantitative Imaging Method for ER-Phagy. Cells. 2023;12: pubmed publisher |
Quintanilla M, Patel H, Wu H, Sochacki K, Akamatsu M, Rotty J, et al. Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly. bioRxiv. 2023;: pubmed publisher |
Zhou L, Jia X, Shang Y, Sun Y, Liu Z, Liu J, et al. PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia. Mol Carcinog. 2023;62:1119-1135 pubmed publisher |
Patel J, Zezelic C, Rageul J, Saldanha J, Khan A, Kim H. Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe. Nucleic Acids Res. 2023;51:6246-6263 pubmed publisher |
Liu Y, Xu C, Li J, Zhang Y, Wang X, Wang Y, et al. YAP promotes AP-1 expression in tubular epithelial cells in the kidney. Am J Physiol Renal Physiol. 2023;324:F581-F589 pubmed publisher |
Lu Y, Cao Q, Yu Y, Sun Y, Jiang X, Li X. Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications. BMC Genomics. 2023;24:235 pubmed publisher |
Oudart M, Avila Gutierrez K, Moch C, Dossi E, Milior G, Boulay A, et al. The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity. Cell Rep. 2023;42:112456 pubmed publisher |
Olivas T, Wu Y, Yu S, Luan L, Choi P, Guinn E, et al. ATG9 vesicles comprise the seed membrane of mammalian autophagosomes. J Cell Biol. 2023;222: pubmed publisher |
Chapman B, Han J, Lee H, Ruud I, Kim T. Targeted Modulation of Chicken Genes In Vitro Using CRISPRa and CRISPRi Toolkit. Genes (Basel). 2023;14: pubmed publisher |
Yang S, Zhu X, Qu Z, Chen C, Wu Y, Wu Y, et al. Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skipping. In Vitro Cell Dev Biol Anim. 2023;59:241-255 pubmed publisher |
Banerjee P, Mehta A, Nirujogi R, Cooper J, James O, Nanda J, et al. Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration. Sci Adv. 2023;9:eabq0651 pubmed publisher |
Pierce C, Loh L, Steach H, Cheshenko N, Preston Hurlburt P, Zhang F, et al. HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal. J Clin Invest. 2023;133: pubmed publisher |
Wagh A, Sulakshane P, Glickman M. Alzheimer's disease-associated mutant ubiquitin (UBB+1) is secreted through an autophagosome-like vesicle-mediated unconventional pathway. Biochim Biophys Acta Gene Regul Mech. 2023;1866:194936 pubmed publisher |
Wong S, Tan Y, Loh A, Tan K, Lee H, Aziz Z, et al. RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis. EMBO Mol Med. 2023;15:e17078 pubmed publisher |
Kishita Y, Sugiura A, Onuki T, Ebihara T, Matsuhashi T, Shimura M, et al. Strategic validation of variants of uncertain significance in ECHS1 genetic testing. J Med Genet. 2023;: pubmed publisher |
Zhang Q, Yang L, Liu Y, Wilkinson J, Krainer A. Antisense oligonucleotide therapy for H3.3K27M diffuse midline glioma. Sci Transl Med. 2023;15:eadd8280 pubmed publisher |
Severin M, Pedersen E, Borre M, Axholm I, Christiansen F, Ponniah M, et al. Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia. J Cell Sci. 2023;136: pubmed publisher |
Kawamata M, Suzuki H, Kimura R, Suzuki A. Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs. Nat Biomed Eng. 2023;7:672-691 pubmed publisher |
V xf6 ing K, Michgehl U, Mertens N, Picciotto C, Maywald M, Goretzko J, et al. Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy. J Am Soc Nephrol. 2023;34:1191-1206 pubmed publisher |
Holm M, Natchiar S, Rundlet E, Myasnikov A, Watson Z, Altman R, et al. mRNA decoding in human is kinetically and structurally distinct from bacteria. Nature. 2023;617:200-207 pubmed publisher |
Ong L, Bargehr J, Knight Schrijver V, Lee J, Colzani M, Bayraktar S, et al. Epicardially secreted fibronectin drives cardiomyocyte maturation in 3D-engineered heart tissues. Stem Cell Reports. 2023;18:936-951 pubmed publisher |
Phan J, Creekmore B, Nguyen A, Bershadskaya D, Darwich N, Lee E. Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearance. bioRxiv. 2023;: pubmed publisher |
Danko C, Chivu A, Abuhashem A, Barshad G, Rice E, Leger M, et al. Evolution of promoter-proximal pausing enabled a new layer of transcription control. Res Sq. 2023;: pubmed publisher |
Cheng L, De C, Li J, Pertsinidis A. Mechanisms of transcription control by distal enhancers from high-resolution single-gene imaging. bioRxiv. 2023;: pubmed publisher |
Yu Y, Li X, Jiao R, Lu Y, Jiang X, Li X. H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development. Cell Biosci. 2023;13:66 pubmed publisher |
Sidhaye J, Trepte P, Sepke N, Novatchkova M, Schutzbier M, D xfc rnberger G, et al. Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids. elife. 2023;12: pubmed publisher |
Zhou W, Lei B, Yang C, Silva M, Xing X, Yu H, et al. Artemisia annua Extract Improves the Cognitive Deficits and Reverses the Pathological Changes of Alzheimer's Disease via Regulating YAP Signaling. Int J Mol Sci. 2023;24: pubmed publisher |
Hein J, Scholz J, K xf6 rber S, Kaufmann T, Faix J. Unleashed Actin Assembly in Capping Protein-Deficient B16-F1 Cells Enables Identification of Multiple Factors Contributing to Filopodium Formation. Cells. 2023;12: pubmed publisher |
Schuettpelz J, Janer A, Antonicka H, Shoubridge E. The role of the mitochondrial outer membrane protein SLC25A46 in mitochondrial fission and fusion. Life Sci Alliance. 2023;6: pubmed publisher |
Mesa H, Zhang E, Wang Y, Zhang Q. Human neurons lacking amyloid precursor protein exhibit cholesterol-associated developmental and presynaptic deficits. J Cell Physiol. 2023;: pubmed publisher |
Schuurmans I, Wu K, van Karnebeek C, Nadif Kasri N, Garanto A. Generation of an induced pluripotent stem cell line carrying a biallelic deletion (SCTCi019-A) in GCDH using CRISPR/Cas9. Stem Cell Res. 2023;69:103069 pubmed publisher |
Rouillon C, Eckhardt B, Kollenstart L, Gruss F, Verkennis A, Rondeel I, et al. CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands. Nucleic Acids Res. 2023;51:3770-3792 pubmed publisher |
Zhang S, Chen Y, Dong K, Zhao Y, Wang Y, Wang S, et al. BESST: a novel LncRNA knockout strategy with less genome perturbance. Nucleic Acids Res. 2023;51:e49 pubmed publisher |
Vornholz L, Isay S, Kurgyis Z, Strobl D, Loll P, Mosa M, et al. Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy. Sci Adv. 2023;9:eadd8564 pubmed publisher |
Pereira C, Stalder D, Anderson G, Shun Shion A, Houghton J, Antrobus R, et al. The exocyst complex is an essential component of the mammalian constitutive secretory pathway. J Cell Biol. 2023;222: pubmed publisher |
Tang X, Xue D, Zhang T, Nilsson Payant B, Carrau L, Duan X, et al. A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Nat Cell Biol. 2023;25:381-389 pubmed publisher |
Bai J, Koos D, Stepanian K, Fouladian Z, Shayler D, Aparicio J, et al. Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids. bioRxiv. 2023;: pubmed publisher |
Yang Y, Liu S, Wang P, Ouyang J, Zhou N, Zhang Y, et al. DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice. Nat Commun. 2023;14:1334 pubmed publisher |
Elamin M, Dumarchey A, Stoddard C, Robinson T, Cowie C, Gorka D, et al. The role of UBE3A in the autism and epilepsy-related Dup15q syndrome using patient-derived, CRISPR-corrected neurons. Stem Cell Reports. 2023;18:884-898 pubmed publisher |
Sobajima T, Kowalczyk K, Skylakakis S, Hayward D, Fulcher L, Neary C, et al. PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size. J Cell Biol. 2023;222: pubmed publisher |
Jia L, Rafiq M, Radosa L, Hortschansky P, Cunha C, Cseresny xe9 s Z, et al. Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway. Cell Host Microbe. 2023;31:373-388.e10 pubmed publisher |
de Lange W, Farrell E, Hernández J, Stempien A, Kreitzer C, Jacobs D, et al. cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities. J Gen Physiol. 2023;155: pubmed publisher |
Shimada K, Park S, Oura S, Noda T, Morohoshi A, Matzuk M, et al. TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation. Proc Natl Acad Sci U S A. 2023;120:e2221762120 pubmed publisher |
Pei H, Dai Y, Yu Y, Tang J, Cao Z, Zhang Y, et al. The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by Translated Peptide ATMLP Under the Control of m6 A Methylation. Adv Sci (Weinh). 2023;10:e2300314 pubmed publisher |
Li D, Yang J, Ma F, Malik V, Zang R, Shi X, et al. The pluripotency factor Tex10 finetunes Wnt signaling for PGC and male germline development. bioRxiv. 2023;: pubmed publisher |
Inoue S, Nishimura K, Gima S, Nakano M, Takata K. CRISPR-Cas9-Edited SNCA Knockout Human Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons and Their Vulnerability to Neurotoxicity. Biol Pharm Bull. 2023;46:517-522 pubmed publisher |
Tedesco B, Vendredy L, Adriaenssens E, Cozzi M, Asselbergh B, Crippa V, et al. HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies. Autophagy. 2023;19:2217-2239 pubmed publisher |
Li W, Berlinicke C, Huang Y, Giera S, McGrath A, Fang W, et al. High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells. iScience. 2023;26:106156 pubmed publisher |
Ramnani B, Powell S, Shetty A, Manivannan P, Hibbard B, Leaman D, et al. Viral Hemorrhagic Septicemia Virus Activates Integrated Stress Response Pathway and Induces Stress Granules to Regulate Virus Replication. Viruses. 2023;15: pubmed publisher |
Jun Y, Lee S, Ban B, Lee J, Gao F. Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis. Autophagy. 2023;19:2045-2061 pubmed publisher |
Kuribayashi S, Fukuhara S, Tsujimura G, Imanaka T, Okada K, Ueda N, et al. Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity. Reprod Med Biol. 2023;22:e12507 pubmed publisher |
Dyke E, Bijnagte Schoenmaker C, Wu K, Oudakker A, Roepman R, Nadif Kasri N. Generation of induced pluripotent stem cell line carrying frameshift variants in NPHP1 (UCSFi001-A-68) using CRISPR/Cas9. Stem Cell Res. 2023;68:103053 pubmed publisher |
Mary L, Leclerc D, Labalme A, Bellaud P, Mazaud Guittot S, Dr xe9 ano S, et al. Functional Assessment of a New PBX1 Variant in a 46,XY Fetus with Severe Syndromic Difference of Sexual Development through CRISPR-Cas9 Gene Editing. Genes (Basel). 2023;14: pubmed publisher |
Jiang H, Kong N, Liu Z, West S, Chan Y. Human Endonuclease ANKLE1 Localizes at the Midbody and Processes Chromatin Bridges to Prevent DNA Damage and cGAS-STING Activation. Adv Sci (Weinh). 2023;10:e2204388 pubmed publisher |
Liu W, Zhou X, Yao Q, Chen C, Zhang Q, Ding K, et al. In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis. J Clin Invest. 2023;133: pubmed publisher |
Venturini G, Alvim J, Padilha K, Toepfer C, Gorham J, Wasson L, et al. Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation. Front Cell Infect Microbiol. 2023;13:1098457 pubmed publisher |
St x119 pniewski J, Je x17c M, Dulak J. Generation of miR-15a/16-1 cluster-deficient human induced pluripotent stem cell line (DMBi001-A-2) using CRISPR/Cas9 gene editing. Stem Cell Res. 2023;68:103046 pubmed publisher |
Zhu T, Guo J, Wu Y, Lei T, Zhu J, Chen H, et al. The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia. iScience. 2023;26:105993 pubmed publisher |
Chien Y, Alford B, Wasik B, Weichert W, Parrish C, Daniel S. Single Particle Analysis of H3N2 Influenza Entry Differentiates the Impact of the Sialic Acids (Neu5Ac and Neu5Gc) on Virus Binding and Membrane Fusion. J Virol. 2023;97:e0146322 pubmed publisher |
Inukai K, Kise K, Hayashi Y, Jia W, Muramatsu F, Okamoto N, et al. Cancer apelin receptor suppresses vascular mimicry in malignant melanoma. Pathol Oncol Res. 2023;29:1610867 pubmed publisher |
Li Q, Chen G, Jiang H, Dai H, Li D, Zhu K, et al. ITGB3 promotes cisplatin resistance in osteosarcoma tumors. Cancer Med. 2023;12:8452-8463 pubmed publisher |
Al Adhami H, Vallet J, Schaal C, Schumacher P, Bardet A, Dumas M, et al. Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells. Nucleic Acids Res. 2023;51:3130-3149 pubmed publisher |
Wang Y, Qi T, Liu J, Yang Y, Wang Z, Wang Y, et al. A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing. Sci Adv. 2023;9:eabo6405 pubmed publisher |
Flury V, Rever xf3 n G xf3 mez N, Alcaraz N, Stewart Morgan K, Wenger A, Klose R, et al. Recycling of modified H2A-H2B provides short-term memory of chromatin states. Cell. 2023;186:1050-1065.e19 pubmed publisher |
Hajikhezri Z, Kaira Y, Schubert E, Darweesh M, Svensson C, Akusj xe4 rvi G, et al. Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism. J Virol. 2023;97:e0153922 pubmed publisher |
Diouf D, Vitale M, Z xf6 ller J, Pineau A, Klopocki E, Hamann C, et al. Generation of a ST3GAL3 null mutant induced pluripotent stem cell (iPSC) line (UKWMPi002-A-3) by CRISPR/Cas9 genome editing. Stem Cell Res. 2023;67:103038 pubmed publisher |
Ishii S, Chino H, Ode K, Kurikawa Y, Ueda H, Matsuura A, et al. CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy. Mol Biol Cell. 2023;34:ar29 pubmed publisher |
Ganesan S, Alvarez N, Steiner S, Fowler K, Corona A, Roy C. Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection. MBio. 2023;14:e0354522 pubmed publisher |
Lai S, Wang D, Sun W, Cao X. Serine/threonine-protein kinase STK24 induces tumorigenesis by regulating the STAT3/VEGFA signaling pathway. J Biol Chem. 2023;299:102961 pubmed publisher |
Forny P, Bonilla X, Lamparter D, Shao W, Plessl T, Frei C, et al. Integrated multi-omics reveals anaplerotic rewiring in methylmalonyl-CoA mutase deficiency. Nat Metab. 2023;5:80-95 pubmed publisher |
Gemmer M, Chaillet M, van Loenhout J, Cuevas Arenas R, Vismpas D, Gr xf6 llers Mulderij M, et al. Visualization of translation and protein biogenesis at the ER membrane. Nature. 2023;614:160-167 pubmed publisher |
Amada K, Hijiya N, Ikarimoto S, Yanagihara K, Hanada T, Hidano S, et al. Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor. Cancer Sci. 2023;114:2189-2202 pubmed publisher |
Adriaenssens E, Asselbergh B, Rivera Mej xed as P, Bervoets S, Vendredy L, de Winter V, et al. Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space. Nat Cell Biol. 2023;25:467-480 pubmed publisher |
Wahbeh M, Peng X, Bacharaki S, Hatzimanolis A, Dimitrakopoulos S, Wohler E, et al. A Missense Variant in CASKIN1's Proline-Rich Region Segregates with Psychosis in a Three-Generation Family. Genes (Basel). 2023;14: pubmed publisher |
Bui Q, Lee K, Fan Y, Lewis B, Deng L, Tsai Y. Disruption of CCL2 in Mesenchymal Stem Cells as an Anti-Tumor Approach against Prostate Cancer. Cancers (Basel). 2023;15: pubmed publisher |
Pavan I, Basei F, Severino M, Rosa e Silva I, Issayama L, Mancini M, et al. NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells. Cells. 2023;12: pubmed publisher |
Islam Z, Saravanan B, Walavalkar K, Farooq U, Singh A, Radhakrishnan S, et al. Active enhancers strengthen insulation by RNA-mediated CTCF binding at chromatin domain boundaries. Genome Res. 2023;33:1-17 pubmed publisher |
Hayashi T, Yano N, Kora K, Yokoyama A, Maizuru K, Kayaki T, et al. Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy. Hum Mol Genet. 2023;32:1683-1697 pubmed publisher |
Zhou C, H xe4 neke T, Rohner E, Sohlm xe9 r J, Kameneva P, Artemov A, et al. STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development. Cardiovasc Res. 2023;119:1202-1217 pubmed publisher |
Lambing S, Tan Y, Vasileiadou P, Holdenrieder S, M xfc ller P, Hagen C, et al. RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma. J Mol Cell Biol. 2023;: pubmed publisher |
Crossley M, Song C, Bocek M, Choi J, Kousorous J, Sathirachinda A, et al. R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response. Nature. 2023;613:187-194 pubmed publisher |
Tang W, Thundyil J, Lim G, Tng T, Yeow S, Nair A, et al. Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease. Hum Mol Genet. 2023;32:1466-1482 pubmed publisher |
Murphy Z, Shields D, Evrony G. Serial enrichment of heteroduplex DNA using a MutS-magnetic bead system. Biotechnol J. 2023;18:e2200323 pubmed publisher |
Wu Q, Glitscher M, Tonnemacher S, Schollmeier A, Raupach J, Zahn T, et al. Presence of Intact Hepatitis B Virions in Exosomes. Cell Mol Gastroenterol Hepatol. 2023;15:237-259 pubmed publisher |
Campostrini G, Kosmidis G, Ward van Oostwaard D, Davis R, Yiangou L, Ottaviani D, et al. Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia. Cardiovasc Res. 2023;119:167-182 pubmed publisher |
Kim Y, Park J, Choi H, Jung K, Lee K, Shim J, et al. Efficient production of recombinant human adiponectin in egg white using genome edited chickens. Front Nutr. 2022;9:1068558 pubmed publisher |
Romero J, Berlinicke C, Chow S, Duan Y, Wang Y, Chamling X, et al. Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system. Front Cell Neurosci. 2022;16:1094291 pubmed publisher |
Girardi E, Messmer M, Lopez P, Fender A, Chicher J, Chane Woon Ming B, et al. Proteomics-based determination of double stranded RNA interactome reveals known and new factors involved in Sindbis virus infection. RNA. 2022;: pubmed publisher |
He H, Zhang S, Yang H, Xu P, Kutschick I, Pfeffer S, et al. Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator. Cancers (Basel). 2022;15: pubmed publisher |
Papadakos K, Ekstr xf6 m A, Slipek P, Skourti E, Reid S, Pietras K, et al. Sushi domain-containing protein 4 binds to epithelial growth factor receptor and initiates autophagy in an EGFR phosphorylation independent manner. J Exp Clin Cancer Res. 2022;41:363 pubmed publisher |
Str xf8 msnes T, Schmidke S, Azad M, Singstad x, Gr xf8 nsberg I, Dalmo R, et al. CRISPR/Cas9-Mediated Gene Editing in Salmonids Cells and Efficient Establishment of Edited Clonal Cell Lines. Int J Mol Sci. 2022;23: pubmed publisher |
Viera Ortiz A, Cajka G, Olatunji O, Mikytuck B, Shalem O, Lee E. Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins. Brain. 2022;: pubmed publisher |
Chainarin S, Jaihan U, Tapaopong P, Kongngen P, Kunkeaw N, Cui L, et al. Overexpression of hepatocyte EphA2 enhances liver-stage infection by Plasmodium vivax. Sci Rep. 2022;12:21542 pubmed publisher |
Valton A, Venev S, Mair B, Khokhar E, Tong A, Usaj M, et al. A cohesin traffic pattern genetically linked to gene regulation. Nat Struct Mol Biol. 2022;29:1239-1251 pubmed publisher |
Wisniewski D, Liyasova M, Korrapati S, Zhang X, Ratnayake S, Chen Q, et al. Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth. J Biol Chem. 2022;299:102766 pubmed publisher |
Zhang C, Gao Y, Hung H, Zhuo Z, Grodzinsky A, Lassar A. Creb5 coordinates synovial joint formation with the genesis of articular cartilage. Nat Commun. 2022;13:7295 pubmed publisher |
Solaimuthu B, Lichtenstein M, Hayashi A, Khatib A, Plaschkes I, Nevo Y, et al. Depletion of Fumarate Hydratase, an Essential TCA Cycle Enzyme, Drives Proliferation in a Two-Step Model. Cancers (Basel). 2022;14: pubmed publisher |
Ramon C, Traversi F, B xfc rer C, Froese D, Stelling J. Cellular and computational models reveal environmental and metabolic interactions in MMUT-type methylmalonic aciduria. J Inherit Metab Dis. 2022;: pubmed publisher |
Mohibi S, Chen X, Zhang J. ZFP14 Regulates Cancer Cell Growth and Migration by Modulating p53 Protein Stability as Part of the MDM2 E3 Ubiquitin Ligase Complex. Cancers (Basel). 2022;14: pubmed publisher |
Liu S, Cao Y, Cui K, Tang Q, Zhao K. Hi-TrAC reveals division of labor of transcription factors in organizing chromatin loops. Nat Commun. 2022;13:6679 pubmed publisher |
Hagelkruys A, Horrer M, Taubenschmid Stowers J, Kavirayani A, Novatchkova M, Orthofer M, et al. The HUSH complex controls brain architecture and protocadherin fidelity. Sci Adv. 2022;8:eabo7247 pubmed publisher |
Zimmerli D, Brambillasca C, Talens F, Bhin J, Linstra R, Romanens L, et al. MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling. Nat Commun. 2022;13:6579 pubmed publisher |
Zhu X, Qi C, Wang R, Lee J, Shao J, Bei L, et al. Acute depletion of human core nucleoporin reveals direct roles in transcription control but dispensability for 3D genome organization. Cell Rep. 2022;41:111576 pubmed publisher |
Agarwal R, Wakimoto H, Paulo J, Zhang Q, Reichart D, Toepfer C, et al. Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere. Circulation. 2022;146:1674-1693 pubmed publisher |
Prophet S, Rampello A, Niescier R, Gentile J, Mallik S, Koleske A, et al. Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities. Nat Cell Biol. 2022;24:1630-1641 pubmed publisher |
Shalaby R, Diwan A, Flores Romero H, Hertlein V, García Sáez A. Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation. Cell Death Differ. 2022;:1-11 pubmed publisher |
Goff N, Breni xe8 re M, Buehl C, de Melo A, Huskova H, Ochi T, et al. Catalytically inactive DNA ligase IV promotes DNA repair in living cells. Nucleic Acids Res. 2022;50:11058-11071 pubmed publisher |
Liu X, Cui S, Qi Q, Lei H, Zhang Y, Shen W, et al. G-quadruplex-guided RNA engineering to modulate CRISPR-based genomic regulation. Nucleic Acids Res. 2022;50:11387-11400 pubmed publisher |
Liu Y, Xu P, Rivara S, Liu C, Ricci J, Ren X, et al. Clathrin-associated AP-1 controls termination of STING signalling. Nature. 2022;610:761-767 pubmed publisher |
Morizako N, Butlertanaka E, Tanaka Y, Shibata H, Okabayashi T, Mekata H, et al. Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector. Sci Rep. 2022;12:16952 pubmed publisher |
Mok R, Zhang W, Sheikh T, Pradeepan K, Fernandes I, DeJong L, et al. Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations. Transl Psychiatry. 2022;12:450 pubmed publisher |
Boland S, Swarup S, Ambaw Y, Malia P, Richards R, Fischer A, et al. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun. 2022;13:5924 pubmed publisher |
Qian Y, Li J, Zhao S, Matthews E, Adoff M, Zhong W, et al. Programmable RNA sensing for cell monitoring and manipulation. Nature. 2022;610:713-721 pubmed publisher |
S xe1 nchez Ram xed rez E, Ung T, Alarc xf3 n Del Carmen A, del Toro R xed os X, Fajardo Ordu xf1 a G, Noriega L, et al. Coordinated metabolic transitions and gene expression by NAD+ during adipogenesis. J Cell Biol. 2022;221: pubmed publisher |
Merle N, Elmsh xe4 user S, Strassheimer F, Wanzel M, K xf6 nig A, Funk J, et al. Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase. Mol Cancer. 2022;21:191 pubmed publisher |
Schmidt A, Frei J, Poetsch A, Chittka A, Zhang H, A xdf mann C, et al. MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation. Front Cell Dev Biol. 2022;10:941493 pubmed publisher |
Hernandez D, Walsh S, Saavedra Sanchez L, Dickinson M, Coers J. Interferon-Inducible E3 Ligase RNF213 Facilitates Host-Protective Linear and K63-Linked Ubiquitylation of Toxoplasma gondii Parasitophorous Vacuoles. MBio. 2022;13:e0188822 pubmed publisher |
Chen S, Roberts M, Chen C, Markmiller S, Wei H, Yeo G, et al. VPS13A and VPS13C Influence Lipid Droplet Abundance. Contact (Thousand Oaks). 2022;5: pubmed publisher |
Cai H, Agersnap S, Sj xf8 gren A, Simonsen M, Blaavand M, Jensen U, et al. In Vivo Application of CRISPR/Cas9 Revealed Implication of Foxa1 and Foxp1 in Prostate Cancer Proliferation and Epithelial Plasticity. Cancers (Basel). 2022;14: pubmed publisher |
Blackman M, Capelôa T, Rondeau J, Zampieri L, Benyahia Z, Van de Velde J, et al. Mitochondrial Protein Cox7b Is a Metabolic Sensor Driving Brain-Specific Metastasis of Human Breast Cancer Cells. Cancers (Basel). 2022;14: pubmed publisher |
Ren Z, Potenza D, Ma Y, Ajalbert G, Hoogewijs D, Ming X, et al. Role of Arginase-II in Podocyte Injury under Hypoxic Conditions. Biomolecules. 2022;12: pubmed publisher |
McKinney A, Mathur R, Stevers N, Molinaro A, Chang S, Phillips J, et al. GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer. Cell Rep. 2022;40:111344 pubmed publisher |
Lange J, Rose J, Chen C, Pichugin Y, Xie L, Tang J, et al. The evolutionary dynamics of extrachromosomal DNA in human cancers. Nat Genet. 2022;54:1527-1533 pubmed publisher |
Altgilbers S, Dierks C, Klein S, Weigend S, Kues W. Quantitative analysis of CRISPR/Cas9-mediated provirus deletion in blue egg layer chicken PGCs by digital PCR. Sci Rep. 2022;12:15587 pubmed publisher |
Glentis A, Blanch Mercader C, Balasubramaniam L, Saw T, D Alessandro J, Janel S, et al. The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces. Sci Adv. 2022;8:eabn5406 pubmed publisher |
Abuhashem A, Hadjantonakis A. Generation of knock-in degron tags for endogenous proteins in mice using the dTAG system. STAR Protoc. 2022;3:101660 pubmed publisher |
Figlia G, M xfc ller S, Hagenston A, Kleber S, Roiuk M, Quast J, et al. Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition. Nat Cell Biol. 2022;24:1407-1421 pubmed publisher |
Yang E, Huang S, Jami Alahmadi Y, McInerney G, Wohlschlegel J, Li M. Elucidation of TRIM25 ubiquitination targets involved in diverse cellular and antiviral processes. PLoS Pathog. 2022;18:e1010743 pubmed publisher |
Terrone S, Valat J, Fontrodona N, Giraud G, Claude J, Combe E, et al. RNA helicase-dependent gene looping impacts messenger RNA processing. Nucleic Acids Res. 2022;50:9226-9246 pubmed publisher |
Hu M, Li H, Huang Z, Li D, Xu Y, Xu Q, et al. Novel compound heterozygous mutation in STAMBP causes a neurodevelopmental disorder by disrupting cortical proliferation. Front Neurosci. 2022;16:963813 pubmed publisher |
Bieluszewska A, Wulfridge P, Doherty J, Ren W, Sarma K. ATRX histone binding and helicase activities have distinct roles in neuronal differentiation. Nucleic Acids Res. 2022;50:9162-9174 pubmed publisher |
Guill xe9 n Samander A, Wu Y, Pineda S, Garc xed a F, Eisen J, Leonzino M, et al. A partnership between the lipid scramblase XK and the lipid transfer protein VPS13A at the plasma membrane. Proc Natl Acad Sci U S A. 2022;119:e2205425119 pubmed publisher |
Volkmar N, Gawden Bone C, Williamson J, Nixon Abell J, West J, St George Hyslop P, et al. Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2. EMBO J. 2022;41:e110777 pubmed publisher |
Bo Z, Huang S, Li L, Chen L, Chen P, Luo X, et al. EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytes. BMC Cardiovasc Disord. 2022;22:373 pubmed publisher |
Mann G, Sulkshane P, Sadhu P, Ziv T, Glickman M, Brik A. Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1. Molecules. 2022;27: pubmed publisher |
Solinger J, Rashid H, Spang A. FERARI and cargo adaptors coordinate cargo flow through sorting endosomes. Nat Commun. 2022;13:4620 pubmed publisher |
Francis V, Alshafie W, Kumar R, Girard M, Brais B, McPherson P. The ARSACS disease protein sacsin controls lysosomal positioning and reformation by regulating microtubule dynamics. J Biol Chem. 2022;298:102320 pubmed publisher |
Goudreault M, Gagn xe9 V, Jo C, Singh S, Killoran R, Gingras A, et al. Afadin couples RAS GTPases to the polarity rheostat Scribble. Nat Commun. 2022;13:4562 pubmed publisher |
Shetty S, Kiledjian N, Copeland P. The selenoprotein P 3' untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation. PLoS ONE. 2022;17:e0271453 pubmed publisher |
Huang L, Luo J, Gao W, Song N, Tian H, Zhu L, et al. CRISPR/Cas9-Induced Knockout of miR-24 Reduces Cholesterol and Monounsaturated Fatty Acid Content in Primary Goat Mammary Epithelial Cells. Foods. 2022;11: pubmed publisher |
Kelly M, Wisniewska K, Regner M, Lewis M, Perreault A, Davis E, et al. A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer. Nat Commun. 2022;13:4247 pubmed publisher |
Mugarza E, Van Maldegem F, Boumelha J, Moore C, Rana S, Llorian Sopena M, et al. Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers. Sci Adv. 2022;8:eabm8780 pubmed publisher |
Padhy B, Xie J, Wang R, Lin F, Huang C. Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2022;33:1501-1516 pubmed publisher |
Fessenden T, Stopfer L, Chatterjee F, Zulueta J, Mesfin J, Cordero Dumit T, et al. Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins. J Immunother Cancer. 2022;10: pubmed publisher |
Kerk S, Lin L, Myers A, Sutton D, Andren A, Sajjakulnukit P, et al. Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context. elife. 2022;11: pubmed publisher |
Yang H, Liu B, Liu D, Yang Z, Zhang S, Xu P, et al. Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer. Cancers (Basel). 2022;14: pubmed publisher |
Madireddy I, Pierson Smela M. Stably Integrating an Inducible CRISPR-Cas9 to Protect Against Viral Infections in Vitro. MicroPubl Biol. 2022;2022: pubmed publisher |
Shen J, Huang Q, Jia W, Feng S, Liu L, Li X, et al. YAP1 induces invadopodia formation by transcriptionally activating TIAM1 through enhancer in breast cancer. Oncogene. 2022;: pubmed publisher |
Calhoun J, Aziz M, Happ H, Gunti J, Gleason C, Mohamed N, et al. mTORC1 functional assay reveals SZT2 loss-of-function variants and a founder in-frame deletion. Brain. 2022;145:1939-1948 pubmed publisher |
Pachano T, Rada Iglesias A. Protocol to study sufficiency of cis-regulatory elements in mouse embryonic stem cells using a CRISPR-mediated knockin approach. STAR Protoc. 2022;3:101492 pubmed publisher |
Tan H, Lu G, Dong H, Cho Y, Natalia A, Wang L, et al. A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery. Nat Commun. 2022;13:3720 pubmed publisher |
Zou L, Moch C, Graille M, Chapat C. The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex. iScience. 2022;25:104646 pubmed publisher |
Zhao C, Gao J, Wang Y, Ji L, Qin H, Hu W, et al. A Novel Rabies Vaccine Based on a Recombinant Bovine Herpes Virus Type 1 Expressing Rabies Virus Glycoprotein. Front Microbiol. 2022;13:931043 pubmed publisher |
Zhang P, Amarasinghe H, Whalley J, Tay C, Fang H, Migliorini G, et al. Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance. Genome Biol. 2022;23:136 pubmed publisher |
BOLT C, Lopez Delisle L, Hintermann A, Mascrez B, Rauseo A, Andrey G, et al. Context-dependent enhancer function revealed by targeted inter-TAD relocation. Nat Commun. 2022;13:3488 pubmed publisher |
Hong C, Schubert M, Tijhuis A, Requesens M, Roorda M, van den Brink A, et al. cGAS-STING drives the IL-6-dependent survival of chromosomally instable cancers. Nature. 2022;607:366-373 pubmed publisher |
Yamamoto M, Ong A, Shinozuka T, Sasai N. The Rx transcription factor is required for determination of the retinal lineage and regulates the timing of neuronal differentiation. Dev Growth Differ. 2022;64:318-324 pubmed publisher |
Endo Y, Groom L, Celik A, Kraeva N, Lee C, Jung S, et al. Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility. Nat Commun. 2022;13:3403 pubmed publisher |
Hong X, Wang T, Du J, Hong Y, Yang C, Xiao W, et al. ITRAQ-based quantitative proteomic analysis reveals that VPS35 promotes the expression of MCM2-7 genes in HeLa cells. Sci Rep. 2022;12:9700 pubmed publisher |
Yang H, Ting X, Geng Y, Xie Y, Nierenberg J, Huo Y, et al. The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression. Sci Adv. 2022;8:eabn3509 pubmed publisher |
Polo P, Gremke N, Stiewe T, Wanzel M. Robustness of the Autophagy Pathway to Somatic Copy Number Losses. Cells. 2022;11: pubmed publisher |
Klockner I, Schütt C, Gerhardt T, Boettger T, Braun T. Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function. Nat Commun. 2022;13:3180 pubmed publisher |
Hancock Cerutti W, Wu Z, Xu P, Yadavalli N, Leonzino M, Tharkeshwar A, et al. ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling. J Cell Biol. 2022;221: pubmed publisher |
Bortolin Cavaillé M, Quillien A, Thalalla Gamage S, Thomas J, Sas Chen A, Sharma S, et al. Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution. Nucleic Acids Res. 2022;50:6284-6299 pubmed publisher |
Chen J, Zou L, Lu G, Grinchuk O, Fang L, Ong D, et al. PFKP alleviates glucose starvation-induced metabolic stress in lung cancer cells via AMPK-ACC2 dependent fatty acid oxidation. Cell Discov. 2022;8:52 pubmed publisher |
de Almeida Magalhães T, Alencastro Veiga Cruzeiro G, Ribeiro de Sousa G, Englinger B, Peinado Nagano L, Ancliffe M, et al. Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in Supratentorial Ependymoma. Neuro Oncol. 2022;: pubmed publisher |
Sousa D, Gaspar R, Ferreira C, Baltazar F, Rodrigues L, Silva B. In Vitro CRISPR/Cas9 Transfection and Gene-Editing Mediated by Multivalent Cationic Liposome-DNA Complexes. Pharmaceutics. 2022;14: pubmed publisher |
Meng Z, Li F, Fang C, Yeoman B, Qiu Y, Wang Y, et al. The Hippo pathway mediates Semaphorin signaling. Sci Adv. 2022;8:eabl9806 pubmed publisher |
Bowness J, Nesterova T, Wei G, Rodermund L, Almeida M, Coker H, et al. Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1. Cell Rep. 2022;39:110830 pubmed publisher |
Abu Rmaileh A, Solaimuthu B, Khatib A, Lavi S, Tanna M, Hayashi A, et al. DPYSL2 interacts with JAK1 to mediate breast cancer cell migration. J Cell Biol. 2022;221: pubmed publisher |
Roboti P, Lawless C, High S. Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex. J Cell Sci. 2022;135: pubmed publisher |
Ouyang C, Lu G, He W, Bay B, Shen H. Post-translational Modification in Control of SIRT1 Stability during DNA Damage Response. Int J Biol Sci. 2022;18:2655-2669 pubmed publisher |
Smolin E, Buyan A, Lyabin D, Kulakovskiy I, Eliseeva I. RNA-Seq data of ALKBH5 and FTO double knockout HEK293T human cells. Data Brief. 2022;42:108187 pubmed publisher |
van den Broek B, Wuyts C, Sisto A, Pintelon I, Timmermans J, Somers V, et al. Oligodendroglia-derived extracellular vesicles activate autophagy via LC3B/BAG3 to protect against oxidative stress with an enhanced effect for HSPB8 enriched vesicles. Cell Commun Signal. 2022;20:58 pubmed publisher |
Wang S, Rhijn J, Akkouh I, Kogo N, Maas N, Bleeck A, et al. Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway. Cell Rep. 2022;39:110790 pubmed publisher |
Galupa R, Picard C, Servant N, Nora E, Zhan Y, van Bemmel J, et al. Inversion of a topological domain leads to restricted changes in its gene expression and affects interdomain communication. Development. 2022;149: pubmed publisher |
Obaid A, Zografou C, Vadysirisack D, Munro Sheldon B, Fichtner M, Roy B, et al. Heterogeneity of Acetylcholine Receptor Autoantibody-Mediated Complement Activity in Patients With Myasthenia Gravis. Neurol Neuroimmunol Neuroinflamm. 2022;9: pubmed publisher |
Seo J, Kim H, Min K, Kim C, Kwon Y, Zheng Z, et al. Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma. Nat Commun. 2022;13:2214 pubmed publisher |
Morale M, Tamura R, Cintra R, Araújo N, Villa L. TLR4 and SARM1 modulate survival and chemoresistance in an HPV-positive cervical cancer cell line. Sci Rep. 2022;12:6714 pubmed publisher |
Calder xf3 n K, Rojas Neyra A, Carbajal L xe9 vano B, Luj xe1 n Valenzuela L, Ticona J, Isasi Rivas G, et al. A Recombinant Turkey Herpesvirus Expressing the F Protein of Newcastle Disease Virus Genotype XII Generated by NHEJ-CRISPR/Cas9 and Cre-LoxP Systems Confers Protection against Genotype XII Challenge in Chickens. Viruses. 2022;14: pubmed publisher |
Liu X, Xiong W, Qi Q, Zhang Y, Ji H, Cui S, et al. Rational guide RNA engineering for small-molecule control of CRISPR/Cas9 and gene editing. Nucleic Acids Res. 2022;: pubmed publisher |
Kuriyama M, Hirose H, Masuda T, Shudou M, Arafiles J, Imanishi M, et al. Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells. Sci Rep. 2022;12:6322 pubmed publisher |
Nishida T, Naguro I, Ichijo H. NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress. Cell Death Discov. 2022;8:195 pubmed publisher |
Huang L, Luo J, Song N, Gao W, Zhu L, Yao W. CRISPR/Cas9-Mediated Knockout of miR-130b Affects Mono- and Polyunsaturated Fatty Acid Content via PPARG-PGC1α Axis in Goat Mammary Epithelial Cells. Int J Mol Sci. 2022;23: pubmed publisher |
Lewis M, Wisniewska K, King C, Li S, Coffey A, Kelly M, et al. Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher |
Gertler T, Cherian S, DeKeyser J, Kearney J, George A. KNa1.1 gain-of-function preferentially dampens excitability of murine parvalbumin-positive interneurons. Neurobiol Dis. 2022;168:105713 pubmed publisher |
Kovalyova Y, Bak D, Gordon E, Fung C, Shuman J, Cover T, et al. An infection-induced oxidation site regulates legumain processing and tumor growth. Nat Chem Biol. 2022;18:698-705 pubmed publisher |
Angelopoulou A, Papaspyropoulos A, Papantonis A, Gorgoulis V. CRISPR-Cas9-mediated induction of large chromosomal inversions in human bronchial epithelial cells. STAR Protoc. 2022;3:101257 pubmed publisher |
Yamauchi Y, Matsumura T, Bakse J, Holmlund H, Blanchet G, Carrot E, et al. Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility. Biol Reprod. 2022;106:1312-1326 pubmed publisher |
Bourseguin J, Cheng W, Talbot E, Hardy L, Lai J, Jeffries A, et al. Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction. Nucleic Acids Res. 2022;50:2700-2718 pubmed publisher |
Li H, Wu B, Kanchwala M, Cai J, Wang L, Xing C, et al. YAP/TAZ drives cell proliferation and tumour growth via a polyamine-eIF5A hypusination-LSD1 axis. Nat Cell Biol. 2022;24:373-383 pubmed publisher |
Sivakumar S, Qi S, Cheng N, Sathe A, Kanchwala M, Kumar A, et al. TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling. Cell Rep. 2022;38:110395 pubmed publisher |
Kwaśniak K, Czarnik Kwaśniak J, Malysheva K, Pogoda K, Korchynskyi O, Rybojad P, et al. LncCDH5-3:3 Regulates Apoptosis, Proliferation, and Aggressiveness in Human Lung Cancer Cells. Cells. 2022;11: pubmed publisher |
Yoshimatsu S, Nakajima M, Qian E, Sanosaka T, Sato T, Okano H. Homologous Recombination-Enhancing Factors Identified by Comparative Transcriptomic Analyses of Pluripotent Stem Cell of Human and Common Marmoset. Cells. 2022;11: pubmed publisher |
Stok J, Oosenbrug T, Ter Haar L, Gravekamp D, Bromley C, Zelenay S, et al. RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency. EMBO J. 2022;41:e109760 pubmed publisher |
Wu W, Tsai Y, Huang I, Cheng C, Hsu C, Cui X, et al. CRISPR genome surgery in a novel humanized model for autosomal dominant retinitis pigmentosa. Mol Ther. 2022;30:1407-1420 pubmed publisher |
Lindblad A, Johansson C, Persson K, Demirel I. The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli. Sci Rep. 2022;12:2005 pubmed publisher |
S xf8 reng K, Pankiv S, Bergsmark C, Haugsten E, Dahl A, de la Ballina L, et al. ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration. J Cell Sci. 2022;135: pubmed publisher |
Lang L, Loveless R, Dou J, Lam T, Chen A, Wang F, et al. ATAD3A mediates activation of RAS-independent mitochondrial ERK1/2 signaling, favoring head and neck cancer development. J Exp Clin Cancer Res. 2022;41:43 pubmed publisher |
Elfrink S, ter Beest M, Janssen L, Baltissen M, Jansen P, Kenyon A, et al. IRF8 is a transcriptional activator of CD37 expression in diffuse large B-cell lymphoma. Blood Adv. 2022;6:2254-2266 pubmed publisher |
Barral A, Pozo G, Ducrot L, Papadopoulos G, Sauzet S, Oldfield A, et al. SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers. Mol Cell. 2022;82:816-832.e12 pubmed publisher |
Date Y, Matsuura A, Itakura E. Disruption of actin dynamics induces autophagy of the eukaryotic chaperonin TRiC/CCT. Cell Death Discov. 2022;8:37 pubmed publisher |
Riesenberg S, Helmbrecht N, Kanis P, Maricic T, Paabo S. Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage. Nat Commun. 2022;13:489 pubmed publisher |
Wang W, Demaurex N. The mammalian trafficking chaperone protein UNC93B1 maintains the ER calcium sensor STIM1 in a dimeric state primed for translocation to the ER cortex. J Biol Chem. 2022;298:101607 pubmed publisher |
Lan B, Zeng S, Zhang S, Ren X, Xing Y, Kutschick I, et al. CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Cancers (Basel). 2022;14: pubmed publisher |
Chen Q, Ma K, Liu X, Chen S, Li P, Yu Y, et al. Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis. Cell Discov. 2022;8:3 pubmed publisher |
Sepich Poore C, Zheng Z, Schmitt E, Wen K, Zhang Z, Cui X, et al. The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation. J Biol Chem. 2022;298:101590 pubmed publisher |
Naitou Y, Nagamatsu G, Hamazaki N, Shirane K, Hayashi M, Hayashi M, et al. Dual role of Ovol2 on the germ cell lineage segregation during gastrulation in mouse embryogenesis. Development. 2022;149: pubmed publisher |
Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, et al. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. EMBO J. 2022;41:e109108 pubmed publisher |
Ambrosi G, Voloshanenko O, Eckert A, Kranz D, Nienhaus G, Boutros M. Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells. elife. 2022;11: pubmed publisher |
Yan Q, Wulfridge P, Doherty J, Fernandez Luna J, Real P, Tang H, et al. Proximity labeling identifies a repertoire of site-specific R-loop modulators. Nat Commun. 2022;13:53 pubmed publisher |
Grigolon G, Araldi E, Erni R, Wu J, Thomas C, La Fortezza M, et al. Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan. Nat Commun. 2022;13:107 pubmed publisher |
Rabelo Fern xe1 ndez R, Santiago S xe1 nchez G, Sharma R, Roche Lima A, Carrion K, Rivera R, et al. Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells. Int J Mol Sci. 2022;23: pubmed publisher |
Yoon S, Bogdanov K, Wallach D. Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes. Cell Death Differ. 2022;: pubmed publisher |
Zhu X, Pan J, Lin T, Yang Y, Huang Q, Yang S, et al. Adenine base-editing-mediated exon skipping induces gene knockout in cultured pig cells. Biotechnol Lett. 2022;44:59-76 pubmed publisher |
Devireddy S, Ferguson S. Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo. J Cell Biol. 2022;221: pubmed publisher |
Qi L, Knifley T, Chen M, O Connor K. Integrin α6β4 requires plectin and vimentin for adhesion complex distribution and invasive growth. J Cell Sci. 2022;135: pubmed publisher |
Turn R, Hu Y, Dewees S, Devi N, East M, Hardin K, et al. The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic. Mol Biol Cell. 2022;33:ar13 pubmed publisher |
Lamture G, Baer A, Fischer J, Colon Moran W, Bhattarai N. TCR-independent Activation in Presence of a Src-family Kinase Inhibitor Improves CAR-T Cell Product Attributes. J Immunother. 2022;45:139-149 pubmed publisher |
Aaltonen M, Alecu I, König T, Bennett S, Shoubridge E. Serine palmitoyltransferase assembles at ER-mitochondria contact sites. Life Sci Alliance. 2022;5: pubmed publisher |
Wu F, Xu L, Tu Y, Cheung O, Szeto L, Mok M, et al. Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis. Cancer Lett. 2022;525:115-130 pubmed publisher |
Lin S, Hirayama D, Maryu G, Matsuda K, Hino N, Deguchi E, et al. Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration. Life Sci Alliance. 2022;5: pubmed publisher |
Moroi A, Newman P. Conditional CRISPR-mediated deletion of Lyn kinase enhances differentiation and function of iPSC-derived megakaryocytes. J Thromb Haemost. 2022;20:182-195 pubmed publisher |
Taparia Y, Dolui A, Boussiba S, Khozin Goldberg I. Multiplexed Genome Editing via an RNA Polymerase II Promoter-Driven sgRNA Array in the Diatom Phaeodactylum tricornutum: Insights Into the Role of StLDP. Front Plant Sci. 2021;12:784780 pubmed publisher |
Kim S, Hong I, Kim M, Song Y, Kim K. hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons. Cells. 2021;10: pubmed publisher |
Kumawat A, Paramel G, Demirel K, Demirel I. Human Renal Fibroblasts, but Not Renal Epithelial Cells, Induce IL-1β Release during a Uropathogenic Escherichia coli Infection In Vitro. Cells. 2021;10: pubmed publisher |
Buchwalter R, Ogden S, York S, Sun L, Zheng C, Hammack C, et al. Coordination of Zika Virus Infection and Viroplasm Organization by Microtubules and Microtubule-Organizing Centers. Cells. 2021;10: pubmed publisher |
Lee R, Kang M, Kim Y, Yang B, Shim H, Kim S, et al. CTCF-mediated chromatin looping provides a topological framework for the formation of phase-separated transcriptional condensates. Nucleic Acids Res. 2021;: pubmed publisher |
Beetham H, Griffith B, Murina O, Loftus A, Parry D, Temps C, et al. Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors. Cancer Res. 2021;: pubmed publisher |
Martin Batista E, Manville R, Rivero Pérez B, Bartolomé Martín D, Alvarez de la Rosa D, Abbott G, et al. Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations. Front Mol Neurosci. 2021;14:798261 pubmed publisher |
Dobrindt K, Zhang H, Das D, Abdollahi S, Prorok T, Ghosh S, et al. Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia. Complex Psychiatry. 2021;6:68-82 pubmed publisher |
Christensen J, Kendrick A, Truong J, Aguilar Maldonado A, Adani V, Dzieciatkowska M, et al. Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes. elife. 2021;10: pubmed publisher |
Nourbakhsh K, Ferreccio A, Bernard M, Yadav S. TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. Dev Cell. 2021;56:3321-3333.e5 pubmed publisher |
Sagawa R, Sakata S, Gong B, Seto Y, Takemoto A, Takagi S, et al. Soluble PD-L1 through alternative polyadenylation works as a decoy in lung cancer immunotherapy. JCI Insight. 2021;: pubmed publisher |
Mohapatra J, Tashiro K, Beckner R, Sierra J, Kilgore J, Williams N, et al. Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. elife. 2021;10: pubmed publisher |
Robert Finestra T, Tan B, Mira Bontenbal H, Timmers E, Gontan C, Merzouk S, et al. SPEN is required for Xist upregulation during initiation of X chromosome inactivation. Nat Commun. 2021;12:7000 pubmed publisher |
Song T, Long M, Zhao H, Zou M, Fan H, Liu Y, et al. Tumor evolution selectively inactivates the core microRNA machinery for immune evasion. Nat Commun. 2021;12:7003 pubmed publisher |
Houlard M, Cutts E, Shamim M, Godwin J, Weisz D, Presser Aiden A, et al. MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface. elife. 2021;10: pubmed publisher |
Glaser L, Steiger M, Fuchs A, van Bömmel A, Einfeldt E, Chung H, et al. Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq. Nucleic Acids Res. 2021;49:12178-12195 pubmed publisher |
Luu A, Yao Z, Ramachandran S, Azzopardi S, Miles L, Schneider W, et al. A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry. Viruses. 2021;13: pubmed publisher |
Alvarez M, Molina C, de Andrea C, Fernandez Sendin M, Villalba M, Gonzalez Gomariz J, et al. Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy. J Immunother Cancer. 2021;9: pubmed publisher |
Duong E, Fessenden T, Lutz E, Dinter T, Yim L, Blatt S, et al. Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity. Immunity. 2021;: pubmed publisher |
Barroso Gomila O, Trulsson F, Muratore V, Canosa I, Merino Cacho L, Cortazar A, et al. Identification of proximal SUMO-dependent interactors using SUMO-ID. Nat Commun. 2021;12:6671 pubmed publisher |
Singh S, Quarni W, Goralski M, Wan S, Jin H, Van De Velde L, et al. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv. 2021;7:eabj5405 pubmed publisher |
Liu Z, Chen Z, Di J, Wang Z, Zhang Y, Li J, et al. Efficient mutagenesis targeting the IFNAR1 gene in mice using a combination of Cas9 protein and dual gRNAs. Am J Transl Res. 2021;13:12094-12106 pubmed |
Palma M, Tronik Le Roux D, Amin G, Castañeda S, Möbbs A, Scarafía M, et al. HLA-G gene editing in tumor cell lines as a novel alternative in cancer immunotherapy. Sci Rep. 2021;11:22158 pubmed publisher |
Schink K, Tan K, Spangenberg H, Martorana D, Sneeggen M, Stévenin V, et al. The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. Nat Commun. 2021;12:6577 pubmed publisher |
Kapetanaki S, Kumawat A, Persson K, Demirel I. The Fibrotic Effects of TMAO on Human Renal Fibroblasts Is Mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR Pathway. Int J Mol Sci. 2021;22: pubmed publisher |
Jehn U, Bayraktar S, Pollmann S, Van Marck V, Weide T, Pavenstadt H, et al. α-Galactosidase a Deficiency in Fabry Disease Leads to Extensive Dysregulated Cellular Signaling Pathways in Human Podocytes. Int J Mol Sci. 2021;22: pubmed publisher |
Adachi K, Sakurai Y, Ichinoe M, Tadehara M, Tamaki A, Kesen Y, et al. CD109 expression in tumor cells and stroma correlates with progression and prognosis in pancreatic cancer. Virchows Arch. 2021;: pubmed publisher |
Kim K, Lee J, Li W, Lee S, Jeong H, Choi J, et al. The ethanol extract of Garcinia subelliptica Merr. induces autophagy. BMC Complement Med Ther. 2021;21:280 pubmed publisher |
Rahman M, Hyodo T, Hasan M, Mihara Y, Karnan S, Ota A, et al. Flow cytometry-based quantification of targeted knock-in events in human cell lines using a GPI-anchor biosynthesis gene PIGP. Biosci Rep. 2021;41: pubmed publisher |
Nishida M, Tanaka Y, Tanaka Y, Amaya S, Tanaka N, Uyama H, et al. Human iPS cell derived RPE strips for secure delivery of graft cells at a target place with minimal surgical invasion. Sci Rep. 2021;11:21421 pubmed publisher |
Sherker A, Chaudhary N, Adam S, Heijink A, Noordermeer S, Fradet Turcotte A, et al. Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites. EMBO Rep. 2021;22:e53679 pubmed publisher |
Yu L, Zhou D, Zhang G, Ren Z, Luo X, Liu P, et al. Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence. Mol Oncol. 2021;: pubmed publisher |
Wu X, Wang H, Chen H, Lin H, Li M, Yue Z, et al. Overexpression of smad7 inhibits the TGF-β/Smad signaling pathway and EMT in NPHP1-defective MDCK cells. Biochem Biophys Res Commun. 2021;582:57-63 pubmed publisher |
Secker C, Kostova S, Niederlechner H, Beetz S, Wendland I, Liebich M, et al. CellFIE: CRISPR- and Cell Fusion-based Two-hybrid Interaction Mapping of Endogenous Proteins. J Mol Biol. 2021;433:167305 pubmed publisher |
Chirco K, Chew S, Moore A, Duncan J, Lamba D. Allele-specific gene editing to rescue dominant CRX-associated LCA7 phenotypes in a retinal organoid model. Stem Cell Reports. 2021;16:2690-2702 pubmed publisher |
Zhang K, Cloonan P, Sundaram S, Liu F, Das S, Ewoldt J, et al. Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization. Sci Adv. 2021;7:eabh3995 pubmed publisher |
Akaki K, Ogata K, Yamauchi Y, Iwai N, Tse K, Hia F, et al. IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay. elife. 2021;10: pubmed publisher |
Gao Y, Ouyang X, Zuo L, Xiao Y, Sun Y, Chang C, et al. R-2HG downregulates ERα to inhibit cholangiocarcinoma via the FTO/m6A-methylated ERα/miR16-5p/YAP1 signal pathway. Mol Ther Oncolytics. 2021;23:65-81 pubmed publisher |
Kittai A, Danilova O, Lam V, Liu T, Bruss N, Best S, et al. NEDD8-activating enzyme inhibition induces cell cycle arrest and anaphase catastrophe in malignant T-cells. Oncotarget. 2021;12:2068-2074 pubmed publisher |
Tomioka K, Miyamoto T, Akutsu S, Yanagihara H, Fujita K, Royba E, et al. NBS1 I171V variant underlies individual differences in chromosomal radiosensitivity within human populations. Sci Rep. 2021;11:19661 pubmed publisher |
Galloy M, Lachance C, Cheng X, Distéfano Gagné F, Cote J, Fradet Turcotte A. Approaches to Study Native Chromatin-Modifying Complex Activities and Functions. Front Cell Dev Biol. 2021;9:729338 pubmed publisher |
Barndt R, Ma N, Tang Y, Haugh M, Alamri L, Chan S, et al. Modeling of dilated cardiomyopathy by establishment of isogenic human iPSC lines carrying phospholamban C25T (R9C) mutation (UPITTi002-A-1) using CRISPR/Cas9 editing. Stem Cell Res. 2021;56:102544 pubmed publisher |
Lai M, Maori E, Quaranta P, Matteoli G, Maggi F, Sgarbanti M, et al. CRISPR/Cas9 Ablation of Integrated HIV-1 Accumulates Proviral DNA Circles with Reformed Long Terminal Repeats. J Virol. 2021;95:e0135821 pubmed publisher |
Hirata W, Tomoda T, Yuri S, Isotani A. Generation of the Y-chromosome linked red fluorescent protein transgenic mouse model and sexing at the preimplantation stage. Exp Anim. 2021;: pubmed publisher |
Morelli A, Tortelli T, Mancini M, Pavan I, Silva L, Severino M, et al. STAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinoma. Neoplasia. 2021;23:1048-1058 pubmed publisher |
Staller E, Sheppard C, Baillon L, Frise R, Peacock T, Sancho Shimizu V, et al. A natural variant in ANP32B impairs influenza virus replication in human cells. J Gen Virol. 2021;102: pubmed publisher |
Surve S, Watkins S, Sorkin A. EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions. J Cell Biol. 2021;220: pubmed publisher |
Jelínková S, Martyniak A, Dulak J, Stepniewski J. Derivation of human pluripotent stem cell line via CRISPR/Cas9 mediated deletion of exon 3 LAMA2 gene (DMBi001-A-1). Stem Cell Res. 2021;56:102529 pubmed publisher |
Ma X, Takahashi Y, Wu W, Liang W, Chen J, Chakraborty D, et al. ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium. J Biol Chem. 2021;297:101185 pubmed publisher |
Zhang J, Tenner B, Mehta S, Zhang J. Protocol for using fluorescent sensors targeted to endogenous proteins (FluoSTEPs) to measure microdomain-specific signaling events. STAR Protoc. 2021;2:100693 pubmed publisher |
Hong J, Kim K, Park S, Bok J, Seo J, Moon S. Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking. Mol Cells. 2021;44:591-601 pubmed publisher |
Bailey M, Tieu D, Habsid A, Tong A, Chan K, Moffat J, et al. Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2. Life Sci Alliance. 2021;4: pubmed publisher |
Pollecker K, Sylvester M, Voos W. Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation. J Biol Chem. 2021;297:101134 pubmed publisher |
Ma K, Li W, Zhu G, Sun S, Chi H, Yin Y, et al. Functionalized PDA/DEX-PEI@HA nanoparticles combined with sleeping-beauty transposons for multistage targeted delivery of CRISPR/Cas9 gene. Biomed Pharmacother. 2021;142:112061 pubmed publisher |
Janssen A, Korsten G, Nijenhuis W, Katrukha E, Kapitein L. Direct observation of aggregate-triggered selective autophagy in human cells. J Cell Sci. 2021;134: pubmed publisher |
Mariani L, Guo X, Menezes N, Drozd A, Çakal S, Wang Q, et al. A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm. Nat Commun. 2021;12:5136 pubmed publisher |
Morrow C, Porter T, Moore D. Fluorescent tagging of endogenous proteins with CRISPR/Cas9 in primary mouse neural stem cells. STAR Protoc. 2021;2:100744 pubmed publisher |
He R, Li J, Du X, Dang Y, Yang L, Huang Z, et al. LPCAT1 overexpression promotes the progression of hepatocellular carcinoma. Cancer Cell Int. 2021;21:442 pubmed publisher |
Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, et al. DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency. Nat Commun. 2021;12:5041 pubmed publisher |
Feng B, Freitas A, Gorodetski L, Wang J, Tian R, Lee Y, et al. Planar cell polarity signaling components are a direct target of β-amyloid-associated degeneration of glutamatergic synapses. Sci Adv. 2021;7: pubmed publisher |
Agarwal R, Paulo J, Toepfer C, Ewoldt J, Sundaram S, Chopra A, et al. Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation. Circ Res. 2021;129:751-766 pubmed publisher |
Weißenbruch K, Grewe J, Hippler M, Fladung M, Tremmel M, Stricker K, et al. Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics. elife. 2021;10: pubmed publisher |
Yamada D, Nakamura M, Takao T, Takihira S, Yoshida A, Kawai S, et al. Induction and expansion of human PRRX1+ limb-bud-like mesenchymal cells from pluripotent stem cells. Nat Biomed Eng. 2021;: pubmed publisher |
Arnst N, Belio Mairal P, García González L, Arnaud L, Greetham L, Nivet E, et al. Deficiency in MT5-MMP Supports Branching of Human iPSCs-Derived Neurons and Reduces Expression of GLAST/S100 in iPSCs-Derived Astrocytes. Cells. 2021;10: pubmed publisher |
Ma S, Ren N, Huang Q. rs10514231 Leads to Breast Cancer Predisposition by Altering ATP6AP1L Gene Expression. Cancers (Basel). 2021;13: pubmed publisher |
Haghighi N, Doosti A, Kiani J. Evaluation of CRISPR/Cas9 System Effects on Knocking Out NEAT1 Gene in AGS Gastric Cancer Cell Line with Therapeutic Perspective. J Gastrointest Cancer. 2021;: pubmed publisher |
Mochizuki Y, Funayama R, Shirota M, Kikukawa Y, Ohira M, Karasawa H, et al. Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer. Int J Cancer. 2021;: pubmed publisher |
Daks A, Mamontova V, Fedorova O, Petukhov A, Shuvalov O, Parfenyev S, et al. Set7/9 controls proliferation and genotoxic drug resistance of NSCLC cells. Biochem Biophys Res Commun. 2021;572:41-48 pubmed publisher |
Liu Z, Gao X, Zhou Z, Kang S, Yang Y, Liu H, et al. San1 deficiency leads to cardiomyopathy due to excessive R-loop-associated DNA damage and cardiomyocyte hypoplasia. Biochim Biophys Acta Mol Basis Dis. 2021;1867:166237 pubmed publisher |
Tsuji Tamura K, Morino Koga S, Suzuki S, Ogawa M. The canonical smooth muscle cell marker TAGLN is present in endothelial cells and is involved in angiogenesis. J Cell Sci. 2021;134: pubmed publisher |
Martyniak A, Andrysiak K, Motais B, Coste S, Podkalicka P, Ferdek P, et al. Generation of microRNA-378a-deficient hiPSC as a novel tool to study its role in human cardiomyocytes. J Mol Cell Cardiol. 2021;160:128-141 pubmed publisher |
Canals I, Ahlenius H. CRISPR/Cas9 Genome Engineering in Human Pluripotent Stem Cells for Modeling of Neurological Disorders. Methods Mol Biol. 2021;2352:237-251 pubmed publisher |
You D, Du D, Zhao X, Li X, Ying M, Hu X. Mitochondrial malic enzyme 2 promotes breast cancer metastasis via stabilizing HIF-1α under hypoxia. Chin J Cancer Res. 2021;33:308-322 pubmed publisher |
Edmondson C, Zhou Q, Liu X. Analysis of conventional and alternative CRISPR/Cas9 genome editing to enhance a single-base pair knock-in mutation. BMC Biotechnol. 2021;21:45 pubmed publisher |
Liu Q, Kong Y, Guo X, Liang B, Xie H, Hu S, et al. GSK-3β inhibitor TDZD-8 prevents reduction of aquaporin-1 expression via activating autophagy under renal ischemia reperfusion injury. FASEB J. 2021;35:e21809 pubmed publisher |
Jacquemyn J, Foroozandeh J, Vints K, Swerts J, Verstreken P, Gounko N, et al. Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms. EMBO J. 2021;:e106914 pubmed publisher |
Matsuzawa T, Morita M, Shimane A, Otsuka R, Mei Y, Irie F, et al. Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis. J Biol Chem. 2021;:101006 pubmed publisher |
Anzai T, Hara H, Chanthra N, Sadahiro T, Ieda M, Hanazono Y, et al. Generation of Efficient Knock-in Mouse and Human Pluripotent Stem Cells Using CRISPR-Cas9. Methods Mol Biol. 2021;2320:247-259 pubmed publisher |
Ying M, You D, Zhu X, Cai L, Zeng S, Hu X. Lactate and glutamine support NADPH generation in cancer cells under glucose deprived conditions. Redox Biol. 2021;46:102065 pubmed publisher |
Innamorati G, Wilkie T, Malpeli G, Paiella S, Grasso S, Rusev B, et al. Gα15 in early onset of pancreatic ductal adenocarcinoma. Sci Rep. 2021;11:14922 pubmed publisher |
King A, Songdej D, Downes D, Beagrie R, Liu S, Buckley M, et al. Reactivation of a developmentally silenced embryonic globin gene. Nat Commun. 2021;12:4439 pubmed publisher |
Yin H, Gao T, Xie J, Huang Z, Zhang X, Yang F, et al. FUBP1 promotes colorectal cancer stemness and metastasis via DVL1-mediated activation of Wnt/β-catenin signaling. Mol Oncol. 2021;: pubmed publisher |
Linda K, Lewerissa E, Verboven A, Gabriele M, Frega M, Klein Gunnewiek T, et al. Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders. Autophagy. 2021;:1-20 pubmed publisher |
Sandhu R, Sharma M, Wei D, Xu L. The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Inturi R, Jemth P. CRISPR/Cas9-based inactivation of human papillomavirus oncogenes E6 or E7 induces senescence in cervical cancer cells. Virology. 2021;562:92-102 pubmed publisher |
Boehmer D, Formisano S, de Oliveira Mann C, Mueller S, Kluge M, Metzger P, et al. OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis. Sci Immunol. 2021;6: pubmed publisher |
Sugawara T, Furuse K, Otani T, Wakayama T, Furuse M. Angulin-1 seals tricellular contacts independently of tricellulin and claudins. J Cell Biol. 2021;220: pubmed publisher |
Shepard A, Hoxha S, Troutman S, Harbaugh D, Kareta M, Kissil J. Transcriptional regulation of miR-30a by YAP impacts PTPN13 and KLF9 levels and Schwann cell proliferation. J Biol Chem. 2021;297:100962 pubmed publisher |
Zhang H, Zhang S. CRISPR/Cas9-mediated Precise SNP Editing in Human iPSC Lines. Bio Protoc. 2021;11:e4051 pubmed publisher |
Huang H, Gont A, Kee L, Dries R, Pfeifer K, Sharma B, et al. Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration. Cell Rep. 2021;36:109363 pubmed publisher |
Nüchel J, Tauber M, Nolte J, Morgelin M, Türk C, Eckes B, et al. An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Mol Cell. 2021;: pubmed publisher |
Shin J, Ding Q, Wang L, Cui Y, Baljinnyam E, Guvenek A, et al. CRISPRpas: programmable regulation of alternative polyadenylation by dCas9. Nucleic Acids Res. 2021;: pubmed publisher |
Ham S, Lee D, Xu W, Cho E, Choi S, Min S, et al. Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis. Sci Adv. 2021;7: pubmed publisher |
Subramaniam S, Ogoti Y, Hernandez I, Zogg M, Botros F, Burns R, et al. A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C). Blood Adv. 2021;5:2760-2774 pubmed publisher |
Yang X, Huang M, Zhang Q, Chen J, Li J, Han Q, et al. Metformin Antagonizes Ovarian Cancer Cells Malignancy Through MSLN Mediated IL-6/STAT3 Signaling. Cell Transplant. 2021;30:9636897211027819 pubmed publisher |
Pan J, Chao N, Zhang Y, Huang T, Chen C, Qin Q, et al. Upregulating KTN1 promotes Hepatocellular Carcinoma progression. J Cancer. 2021;12:4791-4809 pubmed publisher |
Madhavan B, Han Z, Singh B, Bordt N, Kaymak S, Bandapalli O, et al. Elevated Expression of the RAGE Variant-V in SCLC Mitigates the Effect of Chemotherapeutic Drugs. Cancers (Basel). 2021;13: pubmed publisher |
Vos E, Valdes Quezada C, Huang Y, Allahyar A, Verstegen M, Felder A, et al. Interplay between CTCF boundaries and a super enhancer controls cohesin extrusion trajectories and gene expression. Mol Cell. 2021;81:3082-3095.e6 pubmed publisher |
Martín M, Salleron L, Peyret V, Geysels R, Darrouzet E, Lindenthal S, et al. The PDZ protein SCRIB regulates sodium/iodide symporter (NIS) expression at the basolateral plasma membrane. FASEB J. 2021;35:e21681 pubmed publisher |
de Man S, Zwanenburg G, van der Wal T, Hink M, van Amerongen R. Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics. elife. 2021;10: pubmed publisher |
Enderle L, Shalaby K, Gorelik M, Weiss A, Blazer L, Paduch M, et al. A T cell redirection platform for co-targeting dual antigens on solid tumors. MAbs. 2021;13:1933690 pubmed publisher |
Sakai H, Kawakami H, Teramura T, Onodera Y, Somers E, Furuuchi K, et al. Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer. Clin Transl Med. 2021;11:e454 pubmed publisher |
Linder B, Klein C, Hoffmann M, Bonn F, Dikic I, Kogel D. BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells. J Cell Biochem. 2021;: pubmed publisher |
Sulkshane P, Ram J, Thakur A, Reis N, Kleifeld O, Glickman M. Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia. Redox Biol. 2021;45:102047 pubmed publisher |
Lu S, De Neef E, Thomas J, SABIO E, Rousseau B, Gigoux M, et al. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell. 2021;184:4032-4047.e31 pubmed publisher |
Le A, Yelland T, Paul N, Fort L, Nikolaou S, Ismail S, et al. CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation. J Cell Biol. 2021;220: pubmed publisher |
Oura S, Noda T, Morimura N, Hitoshi S, Nishimasu H, Nagai Y, et al. Precise CAG repeat contraction in a Huntington's Disease mouse model is enabled by gene editing with SpCas9-NG. Commun Biol. 2021;4:771 pubmed publisher |
Willy N, Colombo F, Huber S, Smith A, Norton E, Kural C, et al. CALM supports clathrin-coated vesicle completion upon membrane tension increase. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Zhang L, Lu S, Guo R, Ma J, Tang L, Wang J, et al. STK10 knockout inhibits cell migration and promotes cell proliferation via modulating the activity of ERM and p38 MAPK in prostate cancer cells. Exp Ther Med. 2021;22:851 pubmed publisher |
Xu S, Wu X, Wang P, Cao S, Peng B, Xu X. ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability. iScience. 2021;24:102534 pubmed publisher |
Amen T, Kaganovich D. Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability. Cell Rep. 2021;35:109237 pubmed publisher |
Zhou J, Hu M, He M, Wang X, Sun D, Huang Y, et al. TNIP3 is a novel activator of Hippo-YAP signaling protecting against hepatic ischemia/reperfusion injury. Hepatology. 2021;: pubmed publisher |
Pacini G, Dunkel I, Mages N, Mutzel V, Timmermann B, Marsico A, et al. Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution. Nat Commun. 2021;12:3638 pubmed publisher |
Weber C, Hafner A, Kirkland J, Braun S, Stanton B, Boettiger A, et al. mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nat Struct Mol Biol. 2021;28:501-511 pubmed publisher |
Dahlet T, Truss M, Frede U, Al Adhami H, Bardet A, Dumas M, et al. E2F6 initiates stable epigenetic silencing of germline genes during embryonic development. Nat Commun. 2021;12:3582 pubmed publisher |
Lubberding A, Zhang J, Lundh M, Nielsen T, Søndergaard M, Villadsen M, et al. Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V. Sci Rep. 2021;11:12253 pubmed publisher |
Bauer M, Vidal E, Zorita E, Üresin N, Pinter S, Filion G, et al. Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation. Nat Commun. 2021;12:3499 pubmed publisher |
Cabanes Creus M, Navarro R, Liao S, Baltazar G, Drouyer M, Zhu E, et al. Single amino acid insertion allows functional transduction of murine hepatocytes with human liver tropic AAV capsids. Mol Ther Methods Clin Dev. 2021;21:607-620 pubmed publisher |
Yoshimatsu S, Edamura K, Yoshii Y, Iguchi A, Kondo H, Shibuya H, et al. Non-viral derivation of a transgene-free induced pluripotent stem cell line from a male beagle dog. Stem Cell Res. 2021;53:102375 pubmed publisher |
Park J, Yang S, Zhuang W, Bera A, Liu Y, Gurbani D, et al. The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51. PLoS Biol. 2021;19:e3001281 pubmed publisher |
Ryu H, Jung Y, Lee N, Seo J, Kim S, Lee K, et al. HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation. Int J Mol Sci. 2021;22: pubmed publisher |
Michalec Wawiórka B, Czapinski J, Filipek K, Rulak P, Czerwonka A, Tchorzewski M, et al. An Improved Vector System for Homogeneous and Stable Gene Regulation. Int J Mol Sci. 2021;22: pubmed publisher |
Getachew A, Yang Z, Huang X, Wu F, Liu Y, Yan C, et al. Generation of a TLR2 homozygous knockout human embryonic stem cell line WAe001-A-64 using CRISPR/Cas9 editing. Stem Cell Res. 2021;54:102401 pubmed publisher |
Oh S, Shao J, Mitra J, Xiong F, D Antonio M, Wang R, et al. Enhancer release and retargeting activates disease-susceptibility genes. Nature. 2021;595:735-740 pubmed publisher |
Abudu Y, Shrestha B, Zhang W, Palara A, Brenne H, Larsen K, et al. SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components. J Cell Biol. 2021;220: pubmed publisher |
O Hagan D, Kruger R, Gu B, Ralston A. Efficient generation of endogenous protein reporters for mouse development. Development. 2021;148: pubmed publisher |
Matsui H, Ito J, Matsui N, Uechi T, Onodera O, Kakita A. Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease. Nat Commun. 2021;12:3101 pubmed publisher |
Ury B, Potelle S, Caligiore F, Whorton M, Bommer G. The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi. J Biol Chem. 2021;296:100789 pubmed publisher |
Roehle K, Qiang L, Ventre K, Heid D, Ali L, Lenehan P, et al. cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes. Sci Transl Med. 2021;13: pubmed publisher |
Heslop J, Pournasr B, Liu J, Duncan S. GATA6 defines endoderm fate by controlling chromatin accessibility during differentiation of human-induced pluripotent stem cells. Cell Rep. 2021;35:109145 pubmed publisher |
Tian G, Hu C, Yun Y, Yang W, Dubiel W, Cheng Y, et al. Dual roles of HSP70 chaperone HSPA1 in quality control of nascent and newly synthesized proteins. EMBO J. 2021;40:e106183 pubmed publisher |
Linder A, Bothe V, Linder N, Schwarzlmueller P, Dahlström F, Bartenhagen C, et al. Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner. Front Immunol. 2021;12:595390 pubmed publisher |
Meng D, Yang Q, Melick C, Park B, Hsieh T, Curukovic A, et al. ArfGAP1 inhibits mTORC1 lysosomal localization and activation. EMBO J. 2021;40:e106412 pubmed publisher |
Tedesco D, Maj M, Malarczyk P, Cingolani A, Zaffagnini M, Wnorowski A, et al. Application of the SMALP technology to the isolation of GPCRs from low-yielding cell lines. Biochim Biophys Acta Biomembr. 2021;1863:183641 pubmed publisher |
Oura S, Koyano T, Kodera C, Horisawa Takada Y, Matsuyama M, Ishiguro K, et al. KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice. PLoS Genet. 2021;17:e1009412 pubmed publisher |
Deliz Aguirre R, Cao F, Gerpott F, Auevechanichkul N, Chupanova M, Mun Y, et al. MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling. J Cell Biol. 2021;220: pubmed publisher |
Zocher S, Kempermann G. Generation of mouse hippocampal neural precursor cell lines with CRISPR/Cas9-mediated gene knockouts. STAR Protoc. 2021;2:100472 pubmed publisher |
Marinko J, Wright M, Schlebach J, Clowes K, Heintzman D, Plate L, et al. Glycosylation limits forward trafficking of the tetraspan membrane protein PMP22. J Biol Chem. 2021;296:100719 pubmed publisher |
Ramachandran H, Martins S, Kontarakis Z, Krutmann J, Rossi A. Fast but not furious: a streamlined selection method for genome-edited cells. Life Sci Alliance. 2021;4: pubmed publisher |
Morel K, Sheahan A, Burkhart D, Baca S, Boufaied N, Liu Y, et al. EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer. Nat Cancer. 2021;2:444-456 pubmed publisher |
Wang S, Lin C, Carleton A, Cortez C, Johnson C, Taniguchi L, et al. Spatially resolved cell polarity proteomics of a human epiblast model. Sci Adv. 2021;7: pubmed publisher |
Hu J, Bourne R, McGrath B, Lin A, Pei Z, Cavener D. Co-opting regulation bypass repair as a gene correction strategy for monogenic diseases. Mol Ther. 2021;: pubmed publisher |
Asperti M, Bellini S, Grillo E, Gryzik M, Cantamessa L, Ronca R, et al. H-ferritin suppression and pronounced mitochondrial respiration make Hepatocellular Carcinoma cells sensitive to RSL3-induced ferroptosis. Free Radic Biol Med. 2021;169:294-303 pubmed publisher |
Baldwin H, Wang C, Kanfer G, Shah H, Velayos Baeza A, Dulovic Mahlow M, et al. VPS13D promotes peroxisome biogenesis. J Cell Biol. 2021;220: pubmed publisher |
Miyahara K, Takano N, Yamada Y, Kazama H, Tokuhisa M, Hino H, et al. BRCA1 degradation in response to mitochondrial damage in breast cancer cells. Sci Rep. 2021;11:8735 pubmed publisher |
Fursova N, Turberfield A, Blackledge N, Findlater E, Lastuvkova A, Huseyin M, et al. BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome. Genes Dev. 2021;35:749-770 pubmed publisher |
Kothari V, Tang J, He Y, Kramer F, Kanter J, Bornfeldt K. ADAM17 Boosts Cholesterol Efflux and Downstream Effects of High-Density Lipoprotein on Inflammatory Pathways in Macrophages. Arterioscler Thromb Vasc Biol. 2021;41:1854-1873 pubmed publisher |
Babaei Jadidi R, Dongre A, Miller S, Castellanos Uribe M, Stewart I, Thompson Z, et al. Mast Cell Tryptase Release Contributes to Disease Progression in Lymphangioleiomyomatosis. Am J Respir Crit Care Med. 2021;: pubmed publisher |
Jegadesan N, Branzei D. DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher |
Nthiga T, Shrestha B, Bruun J, Larsen K, Lamark T, Johansen T. Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy. J Cell Biol. 2021;220: pubmed publisher |
Gao P, Dong X, Wang Y, Wei G. Optimized CRISPR/Cas9-mediated single nucleotide mutation in adherent cancer cell lines. STAR Protoc. 2021;2:100419 pubmed publisher |
Bozal Basterra L, Gonzalez Santamarta M, Muratore V, Martin Martin N, Ercilla A, Rodriguez J, et al. LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton. Front Cell Dev Biol. 2021;9:624089 pubmed publisher |
Kishimoto Y, Nishiura I, Hirata W, Yuri S, Yamamoto N, Ikawa M, et al. A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models. Sci Rep. 2021;11:8297 pubmed publisher |
Studniarek C, Tellier M, Martin P, Murphy S, Kiss T, Egloff S. The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming. Cell Rep. 2021;35:108965 pubmed publisher |
Fayad R, Rojas M, Partisani M, Finetti P, Dib S, Abélanet S, et al. EFA6B regulates a stop signal for collective invasion in breast cancer. Nat Commun. 2021;12:2198 pubmed publisher |
Ma L, Prada A, Schmidt M, Morrow E. Generation of pathogenic TPP1 mutations in human stem cells as a model for neuronal ceroid lipofuscinosis type 2 disease. Stem Cell Res. 2021;53:102323 pubmed publisher |
Sun C, Li B, Yang M, Guo R, Yuan S, Wang J, et al. Generation of GPAM knockout human embryonic stem cell line SYSUe-008-A using CRISPR/Cas9. Stem Cell Res. 2021;53:102303 pubmed publisher |
Guo G, Stirparo G, Strawbridge S, Spindlow D, Yang J, Clarke J, et al. Human naive epiblast cells possess unrestricted lineage potential. Cell Stem Cell. 2021;28:1040-1056.e6 pubmed publisher |
Shaker M, Pietrogrande G, Martin S, Lee J, Sun W, Wolvetang E. Rapid and Efficient Generation of Myelinating Human Oligodendrocytes in Organoids. Front Cell Neurosci. 2021;15:631548 pubmed publisher |
Sáenz Antoñanzas A, Moncho Amor V, Auzmendi Iriarte J, Elua Pinin A, Rizzoti K, Lovell Badge R, et al. CRISPR/Cas9 Deletion of SOX2 Regulatory Region 2 (SRR2) Decreases SOX2 Malignant Activity in Glioblastoma. Cancers (Basel). 2021;13: pubmed publisher |
Rasmussen M, Tan S, Somisetty V, Hutin D, Olafsen N, Moen A, et al. PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor α Signaling in Human Breast Cancer Cells. Cells. 2021;10: pubmed publisher |
Culver J, Mariappan M. Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins. J Cell Biol. 2021;220: pubmed publisher |
Brandão K, Grandela C, Yiangou L, Mummery C, Davis R. CRISPR/Cas9-Mediated Introduction of Specific Heterozygous Mutations in Human Induced Pluripotent Stem Cells. Methods Mol Biol. 2021;: pubmed publisher |
Kulik M, Bothe M, Kibar G, Fuchs A, Schöne S, Prekovic S, et al. Androgen and glucocorticoid receptor direct distinct transcriptional programs by receptor-specific and shared DNA binding sites. Nucleic Acids Res. 2021;49:3856-3875 pubmed publisher |
Dixon McDougall T, Brown C. Independent domains for recruitment of PRC1 and PRC2 by human XIST. PLoS Genet. 2021;17:e1009123 pubmed publisher |
Sakai H, Shiina I, Shinomiya T, Nagahara Y. BRAP2 inhibits the Ras/Raf/MEK and PI3K/Akt pathways in leukemia cells, thereby inducing apoptosis and inhibiting cell growth. Exp Ther Med. 2021;21:463 pubmed publisher |
Ramesh G, Jarzembowski L, Schwarz Y, Poth V, Konrad M, Knapp M, et al. A short isoform of STIM1 confers frequency-dependent synaptic enhancement. Cell Rep. 2021;34:108844 pubmed publisher |
Acoba M, Alpergin E, Renuse S, Fernández Del Río L, Lu Y, Khalimonchuk O, et al. The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. Cell Rep. 2021;34:108869 pubmed publisher |
Kriz A, Colognori D, Sunwoo H, Nabet B, Lee J. Balancing cohesin eviction and retention prevents aberrant chromosomal interactions, Polycomb-mediated repression, and X-inactivation. Mol Cell. 2021;81:1970-1987.e9 pubmed publisher |
De Caluwé L, Coppens S, Vereecken K, Daled S, Dhaenens M, Van Ostade X, et al. The CD147 Protein Complex Is Involved in Entry of Chikungunya Virus and Related Alphaviruses in Human Cells. Front Microbiol. 2021;12:615165 pubmed publisher |
Gunarta I, Yuliana D, Erdenebaatar P, Kishi Y, Boldbaatar J, Suzuki R, et al. c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1) attenuates curcumin-induced cell death differently from its family member, JNK-associated leucine zipper protein (JLP). Drug Discov Ther. 2021;15:66-72 pubmed publisher |
Fan H, Lee K, Chen Y, Lin L, Yang T, Lin S, et al. Wdhd1 is essential for early mouse embryogenesis. Biochim Biophys Acta Mol Cell Res. 2021;1868:119011 pubmed publisher |
Presle A, Frémont S, Salles A, Commere P, Sassoon N, Berlioz Torrent C, et al. The viral restriction factor tetherin/BST2 tethers cytokinetic midbody remnants to the cell surface. Curr Biol. 2021;31:2203-2213.e5 pubmed publisher |
Lang L, Xiong Y, Prieto Domínguez N, Loveless R, Jensen C, Shay C, et al. FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis. J Exp Clin Cancer Res. 2021;40:93 pubmed publisher |
Gil Martínez J, Macías I, Unione L, Bernardo Seisdedos G, Lopitz Otsoa F, Fernandez Ramos D, et al. Therapeutic Targeting of Fumaryl Acetoacetate Hydrolase in Hereditary Tyrosinemia Type I. Int J Mol Sci. 2021;22: pubmed publisher |
Moch M, Leube R. Hemidesmosome-Related Keratin Filament Bundling and Nucleation. Int J Mol Sci. 2021;22: pubmed publisher |
Di Stazio M, Foschi N, Athanasakis E, Gasparini P, d Adamo A. Systematic analysis of factors that improve homologous direct repair (HDR) efficiency in CRISPR/Cas9 technique. PLoS ONE. 2021;16:e0247603 pubmed publisher |
Li S, Garay J, Tubbs C, Franco H. CRISPR-based knock-in mutagenesis of the pioneer transcription factor FOXA1: optimization of strategies for multi-allelic proteins in cancer cells. FEBS Open Bio. 2021;11:1537-1551 pubmed publisher |
Ma S, Wu Z, Yang F, Zhang J, Johnson R, Rosenfeld M, et al. Hippo signalling maintains ER expression and ER+ breast cancer growth. Nature. 2021;591:E1-E10 pubmed publisher |
Zheng Z, Li Y, Fan S, An J, Luo X, Liang M, et al. WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1. Cell Death Dis. 2021;12:228 pubmed publisher |
Raza S, Jokl E, Pritchett J, Martin K, Su K, Simpson K, et al. SOX9 is required for kidney fibrosis and activates NAV3 to drive renal myofibroblast function. Sci Signal. 2021;14: pubmed publisher |
Verdina A, Di Segni M, Amoreo C, Sperduti I, Buglioni S, Mottolese M, et al. HIPK2 is a potential predictive marker of a favorable response for adjuvant chemotherapy in stage II colorectal cancer. Oncol Rep. 2021;45:899-910 pubmed publisher |
Alderson T, Adriaenssens E, Asselbergh B, Pritisanac I, Van Lent J, Gastall H, et al. A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins. EMBO J. 2021;40:e103811 pubmed publisher |
Wu B, Li Y, Li B, Zhang B, Wang Y, Li L, et al. DNMTs Play an Important Role in Maintaining the Pluripotency of Leukemia Inhibitory Factor-Dependent Embryonic Stem Cells. Stem Cell Reports. 2021;16:582-596 pubmed publisher |
Kim C, Shin Y, Choi S, Oh S, Kim K, Jeong H, et al. Extracts of Perilla frutescens var. Acuta (Odash.) Kudo Leaves Have Antitumor Effects on Breast Cancer Cells by Suppressing YAP Activity. Evid Based Complement Alternat Med. 2021;2021:5619761 pubmed publisher |
Rodriguez E, Boelaars K, Brown K, Eveline Li R, Kruijssen L, Bruijns S, et al. Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9. Nat Commun. 2021;12:1270 pubmed publisher |
Deng Z, Zhao Y, Feng J, Zhang J, Zhao H, Rau M, et al. Cryo-EM structure of a proton-activated chloride channel TMEM206. Sci Adv. 2021;7: pubmed publisher |
Fontaine V, Duboscq Bidot L, Jouve C, Hamlin M, Curjol A, Briand V, et al. Generation of iPSC line from MYH7 R403L mutation carrier with severe hypertrophic cardiomyopathy and isogenic CRISPR/Cas9 corrected control. Stem Cell Res. 2021;52:102245 pubmed publisher |
Huang Y, Su T, Wang C, Dong L, Liu S, Zhu Y, et al. Rbbp4 Suppresses Premature Differentiation of Embryonic Stem Cells. Stem Cell Reports. 2021;16:566-581 pubmed publisher |
Shen Q, Wang Y, Truong M, Mahadevan K, Wu J, Zhang H, et al. RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes. PLoS Genet. 2021;17:e1009378 pubmed publisher |
Turn R, Linnert J, Gigante E, Wolfrum U, Caspary T, Kahn R. Roles for ELMOD2 and Rootletin in ciliogenesis. Mol Biol Cell. 2021;32:800-822 pubmed publisher |
Liu L, Lauro B, Wolfe M, Selkoe D. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides. J Biol Chem. 2021;296:100393 pubmed publisher |
Lu J, Hu Z, Deng Y, Wu Q, Wu M, Song H. MEKK2 and MEKK3 orchestrate multiple signals to regulate Hippo pathway. J Biol Chem. 2021;296:100400 pubmed publisher |
Saito A, Higashi T, Fukazawa Y, Otani T, Tauchi M, Higashi A, et al. Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function. Mol Biol Cell. 2021;:mbcE20070464 pubmed publisher |
Whitton B, Okamoto H, Rose Zerilli M, Packham G, Crabb S. V-ATPase inhibition decreases mutant androgen receptor activity in castrate-resistant prostate cancer. Mol Cancer Ther. 2021;: pubmed publisher |
Kawamoto E, Nago N, Okamoto T, Gaowa A, Masui Ito A, Akama Y, et al. The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin. Biomedicines. 2021;9: pubmed publisher |
Lu P, Elmallah M, Liu Z, Wu C, Chen J, Lifshitz L, et al. Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation. J Cell Physiol. 2021;236:6407-6423 pubmed publisher |
Zhang P, Kitchen Smith I, Xiong L, Stracquadanio G, Brown K, Richter P, et al. Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response. Cancer Res. 2021;81:1667-1680 pubmed publisher |
Nitschke L, Coffin S, Xhako E, El Najjar D, Orengo J, Alcala E, et al. Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1. JCI Insight. 2021;6: pubmed publisher |
McKinzey D, Gomathinayagam S, Griffin W, Klinzing K, Jeffries E, Rajkovic A, et al. Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment. J Biol Chem. 2021;296:100355 pubmed publisher |
Xu L, Zu T, Li T, Li M, Mi J, Bai F, et al. ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells. PLoS Genet. 2021;17:e1009283 pubmed publisher |
Felce J, Parolini L, Sezgin E, Céspedes P, Korobchevskaya K, Jones M, et al. Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse. Front Cell Dev Biol. 2020;8:608484 pubmed publisher |
Qin J, Wang C, Zhu Y, Su T, Dong L, Huang Y, et al. Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates. Sci Adv. 2021;7: pubmed publisher |
Huang Z, Yu J, Cui W, Johnson B, Kim K, Pfeifer G. The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins. Sci Adv. 2021;7: pubmed publisher |
Emmer B, Sherman E, Lascuna P, Graham S, Willer C, Ginsburg D. Genome-scale CRISPR screening for modifiers of cellular LDL uptake. PLoS Genet. 2021;17:e1009285 pubmed publisher |
Chamling X, Kallman A, Fang W, Berlinicke C, Mertz J, Devkota P, et al. Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells. Nat Commun. 2021;12:652 pubmed publisher |
Wu D, Wang S, Oliveira D, Del Gaudio F, Vanlandewijck M, Lebouvier T, et al. The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression. Dis Model Mech. 2021;: pubmed publisher |
Kyryachenko S, Georges A, Yu M, Berrandou T, Guo L, Bruneval P, et al. Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci. Circ Res. 2021;: pubmed publisher |
Shao W, Hao Z, Chen Y, Du J, He Q, Ren L, et al. OIP5-AS1 specifies p53-driven POX transcription regulated by TRPC6 in glioma. J Mol Cell Biol. 2021;: pubmed publisher |
Clancy A, Heride C, Pinto Fernandez A, Elcocks H, Kallinos A, Kayser Bricker K, et al. The deubiquitylase USP9X controls ribosomal stalling. J Cell Biol. 2021;220: pubmed publisher |
Townsend A, Lora G, Engel J, Tirado Class N, Dungrawala H. DCAF14 promotes stalled fork stability to maintain genome integrity. Cell Rep. 2021;34:108669 pubmed publisher |
Barnabas G, Lee J, Shami T, Harel M, Beck L, Selitrennik M, et al. Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression. Cancer Res. 2021;81:1443-1456 pubmed publisher |
Prentzell M, Rehbein U, Cadena Sandoval M, De Meulemeester A, Baumeister R, Brohée L, et al. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell. 2021;184:655-674.e27 pubmed publisher |
Steele N, Biffi G, Kemp S, Zhang Y, Drouillard D, Syu L, et al. Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer. Clin Cancer Res. 2021;: pubmed publisher |
Vitale M, Zöller J, Jansch C, Janz A, Edenhofer F, Klopocki E, et al. Generation of induced pluripotent stem cell (iPSC) lines carrying a heterozygous (UKWMPi002-A-1) and null mutant knockout (UKWMPi002-A-2) of Cadherin 13 associated with neurodevelopmental disorders using CRISPR/Cas9. Stem Cell Res. 2021;51:102169 pubmed publisher |
Kong Y, Zhao X, Qiu M, Lin Y, Feng P, Li S, et al. Tubular Mas receptor mediates lipid-induced kidney injury. Cell Death Dis. 2021;12:110 pubmed publisher |
Han Y, Zhang J, Lee J, Mason J, Karginova O, Yoshimatsu T, et al. The BRCA1 Pseudogene Negatively Regulates Anti-Tumor Responses through Inhibition of Innate Immune Defense Mechanisms. Cancer Res. 2021;: pubmed publisher |
Cremer T, Jongsma M, Trulsson F, Vertegaal A, Neefjes J, Berlin I. The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway. Cell Rep. 2021;34:108659 pubmed publisher |
Guarnaccia A, Rose K, Wang J, Zhao B, Popay T, Wang C, et al. Impact of WIN site inhibitor on the WDR5 interactome. Cell Rep. 2021;34:108636 pubmed publisher |
Moser B, Hochreiter B, Basílio J, Gleitsmann V, Panhuber A, Pardo Garcia A, et al. The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity. Mol Cancer. 2021;20:16 pubmed publisher |
Yang Z, Yuan F, Wang N, Liu Y, Zhang J, Wei R, et al. Generation of a DKK1 homozygous knockout human embryonic stem cell line WAe001-A-21 using CRISPR/Cas9. Stem Cell Res. 2021;51:102161 pubmed publisher |
Chelmicki T, Roger E, Teissandier A, Dura M, Bonneville L, Rucli S, et al. m6A RNA methylation regulates the fate of endogenous retroviruses. Nature. 2021;: pubmed publisher |
Dai H, Hu H, Lou J, Ye A, Ba Z, Zhang X, et al. Loop extrusion mediates physiological Igh locus contraction for RAG scanning. Nature. 2021;590:338-343 pubmed publisher |
Olariu V, Yui M, Krupinski P, Zhou W, Deichmann J, Andersson E, et al. Multi-scale Dynamical Modeling of T Cell Development from an Early Thymic Progenitor State to Lineage Commitment. Cell Rep. 2021;34:108622 pubmed publisher |
Munis A, Hyde S, Gill D. A human surfactant B deficiency air-liquid interface cell culture model suitable for gene therapy applications. Mol Ther Methods Clin Dev. 2021;20:237-246 pubmed publisher |
Markiewicz Ł, Uśpieński T, Baran B, Niedziółka S, Niewiadomski P. Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus. Cell Signal. 2021;80:109907 pubmed publisher |
Ding L, Paszkowski Rogacz M, Mircetic J, Chakraborty D, Buchholz F. The Paf1 complex positively regulates enhancer activity in mouse embryonic stem cells. Life Sci Alliance. 2021;4: pubmed publisher |
Barbeito P, Tachibana Y, Martin Morales R, Moreno P, Mykytyn K, Kobayashi T, et al. HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails. Life Sci Alliance. 2021;4: pubmed publisher |
Jia X, Burugula B, Chen V, Lemons R, Jayakody S, Maksutova M, et al. Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk. Am J Hum Genet. 2021;108:163-175 pubmed publisher |
Evans L, Anglen T, Scott P, Lukasik K, Loncarek J, Holland A. ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification. EMBO J. 2020;:e105106 pubmed publisher |
Pulupa J, Prior H, Johnson D, Simon S. Conformation of the nuclear pore in living cells is modulated by transport state. elife. 2020;9: pubmed publisher |
Henninger J, Oksuz O, Shrinivas K, Sagi I, LeRoy G, Zheng M, et al. RNA-Mediated Feedback Control of Transcriptional Condensates. Cell. 2021;184:207-225.e24 pubmed publisher |
Hewitt G, Borel V, Segura Bayona S, Takaki T, Ruis P, Bellelli R, et al. Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD. Mol Cell. 2020;: pubmed publisher |
Lombardi R, Sonego M, Pucci B, Addi L, Iannelli F, Capone F, et al. HSP90 identified by a proteomic approach as druggable target to reverse platinum resistance in ovarian cancer. Mol Oncol. 2020;: pubmed publisher |
Oyama K, Baba T, Kashiwabara S. Functional characterization of testis-brain RNA-binding protein, TB-RBP/Translin, in translational regulation. J Reprod Dev. 2021;67:35-42 pubmed publisher |
Chen Q, Bian C, Wang X, Liu X, Ahmad Kassab M, Yu Y, et al. ADP-ribosylation of histone variant H2AX promotes base excision repair. EMBO J. 2021;40:e104542 pubmed publisher |
Mulholland C, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück I, et al. Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nat Commun. 2020;11:5972 pubmed publisher |
Li J, Li Y, Zhan X, Ran X, Tse H, Dang S, et al. Generation of GADD45A gene knockout human embryonic stem cell line using CRISPR/Cas9. Stem Cell Res. 2020;49:102090 pubmed publisher |
Jiang Y, Lim J, Wu K, Xu W, Suen J, Fairlie D. PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR. Br J Pharmacol. 2021;178:913-932 pubmed publisher |
Kawamoto E, Park E, Shimaoka M. Methods to Study Integrin Functions on Exosomes. Methods Mol Biol. 2021;2217:265-281 pubmed publisher |
Valsecchi C, Basilicata M, Georgiev P, Gaub A, Seyfferth J, Kulkarni T, et al. RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature. 2021;589:137-142 pubmed publisher |
Sarraf S, Shah H, Kanfer G, Pickrell A, Holtzclaw L, Ward M, et al. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Mol Cell. 2020;80:779-795.e10 pubmed publisher |
Jia R, Balligand T, Atamanyuk V, Nivarthi H, Xu E, Kutzner L, et al. Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor. Blood. 2020;: pubmed publisher |
Takeda A, Takano N, Kokuba H, Hino H, Moriya S, Abe A, et al. Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization‑associated cell death. Int J Oncol. 2020;57:1280-1292 pubmed publisher |
Park J, Jun K, Choi Y, Yoon E, Kim W, Jang Y, et al. CORO7 functions as a scaffold protein for the core kinase complex assembly of the Hippo pathway. J Biol Chem. 2021;296:100040 pubmed publisher |
Nora E, Caccianini L, Fudenberg G, So K, Kameswaran V, Nagle A, et al. Molecular basis of CTCF binding polarity in genome folding. Nat Commun. 2020;11:5612 pubmed publisher |
Mohamud Y, Shi J, Tang H, Xiang P, Xue Y, Liu H, et al. Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes. Sci Rep. 2020;10:19068 pubmed publisher |
Tunbak H, Enriquez Gasca R, Tie C, Gould P, Mlcochova P, Gupta R, et al. The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s. Nat Commun. 2020;11:5387 pubmed publisher |
Wang X, Hayes J, Xu X, Gao X, Mehta D, Lilja H, et al. Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing. Gene. 2021;768:145265 pubmed publisher |
Hattori K, Wakatsuki H, Sakauchi C, Furutani S, Sugawara S, Hatta T, et al. β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes. PLoS ONE. 2020;15:e0232645 pubmed publisher |
Gao W, Zhang Y, Luo H, Niu M, Zheng X, Hu W, et al. Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis. Cell Death Dis. 2020;11:919 pubmed publisher |
Nath A, Oak A, Chen K, Li I, Splichal R, Portis J, et al. Palmitate-Induced IRE1-XBP1-ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration. Mol Cancer Res. 2021;19:240-248 pubmed publisher |
Schene I, Joore I, Oka R, Mokry M, van Vugt A, van Boxtel R, et al. Prime editing for functional repair in patient-derived disease models. Nat Commun. 2020;11:5352 pubmed publisher |
Pfitzner C, White M, Piltz S, Scherer M, Adikusuma F, Hughes J, et al. Progress Toward Zygotic and Germline Gene Drives in Mice. CRISPR J. 2020;3:388-397 pubmed publisher |
Fujita H, Sasaki T, Miyamoto T, Akutsu S, Sato S, Mori T, et al. Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation. Aging Cell. 2020;19:e13251 pubmed publisher |
Robinson K, Teo D, Tan K, Toh G, Ong H, Lim C, et al. Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia. Science. 2020;370: pubmed publisher |
Kapitansky O, Karmon G, Sragovich S, Hadar A, Shahoha M, Jaljuli I, et al. Single Cell ADNP Predictive of Human Muscle Disorders: Mouse Knockdown Results in Muscle Wasting. Cells. 2020;9: pubmed publisher |
Li Q, Wang M, Zhang Y, Wang L, Yu W, Bao X, et al. BIX-01294-enhanced chemosensitivity in nasopharyngeal carcinoma depends on autophagy-induced pyroptosis. Acta Biochim Biophys Sin (Shanghai). 2020;52:1131-1139 pubmed publisher |
Kimura T, Flynn C, Whitton J. Hepatocytes trap and silence coxsackieviruses, protecting against systemic disease in mice. Commun Biol. 2020;3:580 pubmed publisher |
Sreevalsan S, Döring M, Paszkowski Rogacz M, Brux M, Blanck C, Meyer M, et al. MLLT6 maintains PD-L1 expression and mediates tumor immune resistance. EMBO Rep. 2020;:e50155 pubmed publisher |
Dai Y, Luo W, Yue X, Ma W, Wang J, Chang J. Identification and characterization of a new isoform of small GTPase RhoE. Commun Biol. 2020;3:572 pubmed publisher |
Bhushan J, Radke J, Perng Y, McAllaster M, Lenschow D, Virgin H, et al. ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells. MBio. 2020;11: pubmed publisher |
Griffin M, Sorum A, Miller G, Goddard W, Hsieh Wilson L. Sulfated glycans engage the Ang-Tie pathway to regulate vascular development. Nat Chem Biol. 2021;17:178-186 pubmed publisher |
Cornelissen L, Blanas A, Zaal A, van der Horst J, Kruijssen L, O Toole T, et al. Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer. Front Oncol. 2020;10:1622 pubmed publisher |
Sakakitani S, Podyma Inoue K, Takayama R, Takahashi K, Ishigami Yuasa M, Kagechika H, et al. Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells. Cancer Sci. 2020;: pubmed publisher |
Schütt C, Hallmann A, Hachim S, Klockner I, Valussi M, Atzberger A, et al. Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy. EMBO J. 2020;39:e105098 pubmed publisher |
Gremke N, Polo P, Dort A, Schneikert J, Elmshäuser S, Brehm C, et al. mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability. Nat Commun. 2020;11:4684 pubmed publisher |
Chen P, Hsueh Y, Lee Y, Tsai H, Tsai K, Chiang P. FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK. Cell Mol Life Sci. 2020;: pubmed publisher |
Darvish Ghane S, Quintana C, Beaulieu J, Martin L. D1 receptors in the anterior cingulate cortex modulate basal mechanical sensitivity threshold and glutamatergic synaptic transmission. Mol Brain. 2020;13:121 pubmed publisher |
Luo J, Zhang Y, Wang Y, Liu Q, Chen L, Zhang B, et al. Rhabdovirus Infection Is Dependent on Serine/Threonine Kinase AP2-Associated Kinase 1. Life (Basel). 2020;10: pubmed publisher |
Lobo S, Pereira C, Oliveira C, Almeida G. Skipping Exon-v6 from CD44v6-Containing Isoforms Influences Chemotherapy Response and Self-Renewal Capacity of Gastric Cancer Cells. Cancers (Basel). 2020;12: pubmed publisher |
Pournasr B, Duncan S. Generation of isogenic Propionyl-CoA carboxylase beta subunit (PCCB) deficient induced pluripotent stem cell lines. Stem Cell Res. 2020;48:101953 pubmed publisher |
Marques J, Gryder B, Pavlovic B, Chung Y, Ngo Q, Frommelt F, et al. NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency. elife. 2020;9: pubmed publisher |
Cai E, Ishikawa Y, Zhang W, Leite N, Li J, Hou S, et al. Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes. Nat Metab. 2020;2:934-945 pubmed publisher |
Gazy I, Miller C, Kim G, Usdin K. CGG Repeat Expansion, and Elevated Fmr1 Transcription and Mitochondrial Copy Number in a New Fragile X PM Mouse Embryonic Stem Cell Model. Front Cell Dev Biol. 2020;8:482 pubmed publisher |
Mulholland C, Traube F, Ugur E, Parsa E, Eckl E, Schönung M, et al. Distinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency. Sci Rep. 2020;10:12066 pubmed publisher |
Vu T, Varshavsky A. The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway. Biochemistry. 2020;: pubmed publisher |
Richard P, Feng S, Tsai Y, Li W, Rinchetti P, Muhith U, et al. SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation. Autophagy. 2020;: pubmed publisher |
Zhu X, Zhan Q, Wei Y, Yan A, Feng J, Liu L, et al. CRISPR/Cas9-mediated MSTN disruption accelerates the growth of Chinese Bama pigs. Reprod Domest Anim. 2020;: pubmed publisher |
Thornton N, Karamatic Crew V, Tilley L, Green C, Tay C, Griffiths R, et al. Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype. Nat Commun. 2020;11:3569 pubmed publisher |
Kropp K, López Muñoz A, Ritter B, Martin R, Rastrojo A, Srivaratharajan S, et al. Herpes Simplex Virus Type 2 Counteracts Neurite Outgrowth Repulsion During Infection In A Nerve Growth Factor-Dependent Manner. J Virol. 2020;: pubmed publisher |
Juszkiewicz S, Slodkowicz G, Lin Z, Freire Pritchett P, Peak Chew S, Hegde R. Ribosome collisions trigger cis-acting feedback inhibition of translation initiation. elife. 2020;9: pubmed publisher |
Cornelius R, Sharma A, Su X, Guo J, McMahon J, Ellison D, et al. A novel distal convoluted tubule-specific Cre-recombinase driven by the NaCl cotransporter gene. Am J Physiol Renal Physiol. 2020;: pubmed publisher |
Liu K, Wang Y, Zhu Q, Li P, Chen J, Tang Z, et al. Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells. Cell Death Dis. 2020;11:519 pubmed publisher |
Morinishi L, Kochanowski K, Levine R, Wu L, Altschuler S. Loss of TET2 Affects Proliferation and Drug Sensitivity through Altered Dynamics of Cell-State Transitions. Cell Syst. 2020;11:86-94.e5 pubmed publisher |
Tamming R, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, et al. Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. Cell Rep. 2020;31:107838 pubmed publisher |
Shakya M, Yildirim T, Lindberg I. Increased expression and retention of the secretory chaperone proSAAS following cell stress. Cell Stress Chaperones. 2020;: pubmed publisher |
Ryczek N, Hryhorowicz M, Lipiński D, Zeyland J, Słomski R. Evaluation of the CRISPR/Cas9 Genetic Constructs in Efficient Disruption of Porcine Genes for Xenotransplantation Purposes Along with an Assessment of the Off-Target Mutation Formation. Genes (Basel). 2020;11: pubmed publisher |
Guo Y, Ye Q, Deng P, Cao Y, He D, Zhou Z, et al. Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. Nat Commun. 2020;11:3243 pubmed publisher |
Lee H, Beilhartz G, Kucharska I, Raman S, Cui H, Lam M, et al. Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins. Cell. 2020;182:345-356.e16 pubmed publisher |
Sun J, Lu Y, Nozawa K, Xu Z, Morohoshi A, Castaneda J, et al. CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†. Biol Reprod. 2020;: pubmed publisher |
Collins M, Li Y, Bowser R. RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases. Acta Neuropathol Commun. 2020;8:91 pubmed publisher |
Bonucci M, Kuperwasser N, Barbe S, Koka V, De Villeneuve D, Zhang C, et al. mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division. Nat Commun. 2020;11:3200 pubmed publisher |
Liao Z, Lee J, Krakowiak J, Wang R, Li W. Enforced Activation of Enhancer RNAs In Situ through the dCas9 Synergistic Activation Mediator System. J Vis Exp. 2020;: pubmed publisher |
Yang Y, Yu K, Li L, Huang M, Wang Y. Proteome-wide Interrogation of Small GTPases Regulated by N6-Methyladenosine Modulators. Anal Chem. 2020;92:10145-10152 pubmed publisher |
Park S, Shimada K, Fujihara Y, Xu Z, Shimada K, Larasati T, et al. CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity. Biol Reprod. 2020;: pubmed publisher |
Dahlet T, Argüeso Lleida A, Al Adhami H, Dumas M, Bender A, Ngondo R, et al. Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity. Nat Commun. 2020;11:3153 pubmed publisher |
Cho H, Kim M, Lee J, Yoo B, Kim K, Choe K, et al. BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells. Cell Death Differ. 2020;: pubmed publisher |
Sakurai Y, Ichinoe M, Yoshida K, Nakazato Y, Saito S, Satoh M, et al. Inactivation of REV7 enhances chemosensitivity and overcomes acquired chemoresistance in testicular germ cell tumors. Cancer Lett. 2020;489:100-110 pubmed publisher |
Bozal Basterra L, Gonzalez Santamarta M, Muratore V, Bermejo Arteagabeitia A, Da Fonseca C, Barroso Gomila O, et al. LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome. elife. 2020;9: pubmed publisher |
Gajewski S, Hartwig A. PARP1 Is Required for ATM-Mediated p53 Activation and p53-Mediated Gene Expression after Ionizing Radiation. Chem Res Toxicol. 2020;33:1933-1940 pubmed publisher |
Ameur L, Marie P, Thenoz M, Giraud G, Combe E, Claude J, et al. Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1. Nat Commun. 2020;11:3045 pubmed publisher |
Perkail S, Andricovich J, Kai Y, Tzatsos A. BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Nat Commun. 2020;11:3018 pubmed publisher |
Park S, Ponce Balbuena D, Kuick R, Guerrero Serna G, Yoon J, Mellacheruvu D, et al. Kir2.1 interactome mapping uncovers PKP4 as a modulator of the Kir2.1-regulated inward rectifier potassium currents. Mol Cell Proteomics. 2020;: pubmed publisher |
Lane A, Jovanovic K, Shortall C, Ottaviani D, Panes A, Schwarz N, et al. Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids. Stem Cell Reports. 2020;15:67-79 pubmed publisher |
Kyprianou C, Christodoulou N, Hamilton R, Nahaboo W, Boomgaard D, Amadei G, et al. Basement membrane remodelling regulates mouse embryogenesis. Nature. 2020;582:253-258 pubmed publisher |
Maurissen T, Woltjen K. Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation. Nat Commun. 2020;11:2876 pubmed publisher |
Kim A, Han L, Yu K. Immunoglobulin Class Switch Recombination is initiated by rare cytosine deamination events at switch regions. Mol Cell Biol. 2020;: pubmed publisher |
Sun X, Ren Z, Cun Y, Zhao C, Huang X, Zhou J, et al. Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers. Nucleic Acids Res. 2020;48:7182-7196 pubmed publisher |
Wei Y, Zhan Q, Zhu X, Yan A, Feng J, Liu L, et al. Efficient CRISPR/Cas9-mediated gene editing in Guangdong small-ear spotted pig cells using an optimized electrotransfection method. Biotechnol Lett. 2020;: pubmed publisher |
You R, Zhou W, Li Y, Zhang Y, Huang S, Jia Z, et al. Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells. Clin Sci (Lond). 2020;134:1357-1376 pubmed publisher |
Erwood S, Laselva O, Bily T, Brewer R, Rutherford A, Bear C, et al. Allele-Specific Prevention of Nonsense-Mediated Decay in Cystic Fibrosis Using Homology-Independent Genome Editing. Mol Ther Methods Clin Dev. 2020;17:1118-1128 pubmed publisher |
Liu M, Zhu Y, Xing F, Liu S, Xia Y, Jiang Q, et al. The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters. J Biol Chem. 2020;295:9712-9724 pubmed publisher |
Carleton J, Ginley Hidinger M, Berrett K, Layer R, Quinlan A, Gertz J. Regulatory sharing between estrogen receptor α bound enhancers. Nucleic Acids Res. 2020;48:6597-6610 pubmed publisher |
Kim Nguyen N, Ohbayashi N, Kanaho Y, Funakoshi Y. TBC1D24 regulates recycling of clathrin-independent cargo proteins mediated by tubular recycling endosomes. Biochem Biophys Res Commun. 2020;528:220-226 pubmed publisher |
Min Y, Ning Y, Wang H, Deng F. A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination. J Biol Chem. 2020;295:9691-9711 pubmed publisher |
Do Y, Matsuda S, Inatomi T, Nakada K, Yasukawa T, Kang D. The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit. Mitochondrion. 2020;53:133-139 pubmed publisher |
Leng Y, Sim S, Magidson V, Wolin S. Noncoding Y RNAs regulate the levels, subcellular distribution and protein interactions of their Ro60 autoantigen partner. Nucleic Acids Res. 2020;48:6919-6930 pubmed publisher |
Weisheit I, Kroeger J, Malik R, Klimmt J, Crusius D, Dannert A, et al. Detection of Deleterious On-Target Effects after HDR-Mediated CRISPR Editing. Cell Rep. 2020;31:107689 pubmed publisher |
Dejene E, Li Y, Showkatian Z, Ling H, Seto E. Regulation of poly(A)-specific ribonuclease activity by reversible lysine acetylation. J Biol Chem. 2020;: pubmed publisher |
Yesbolatova A, Saito Y, Kanemaki M. Constructing Auxin-Inducible Degron Mutants Using an All-in-One Vector. Pharmaceuticals (Basel). 2020;13: pubmed publisher |
Gómez Domínguez D, Epifano C, Miguel F, Castaño A, Vilaplana Martí B, Martin A, et al. Consequences of Lmna Exon 4 Mutations in Myoblast Function. Cells. 2020;9: pubmed publisher |
Deng B, Jiao B, Liu Y, Li Y, Wang G. BIX-01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME-mediated pyroptosis. Cell Biol Int. 2020;: pubmed publisher |
Zhao X, Nie J, Tang Y, He W, Xiao K, Pang C, et al. Generation of Transgenic Cloned Buffalo Embryos Harboring the EGFP Gene in the Y Chromosome Using CRISPR/Cas9-Mediated Targeted Integration. Front Vet Sci. 2020;7:199 pubmed publisher |
Hecht T, Blank B, Steger M, Lopez V, Beck G, Ramazanov B, et al. Fam20C regulates protein secretion by Cab45 phosphorylation. J Cell Biol. 2020;219: pubmed publisher |
Li X, Guo S, Liu K, Zhang C, Chang H, Yang W, et al. GABRG2 Deletion Linked to Genetic Epilepsy with Febrile Seizures Plus Affects the Expression of GABAA Receptor Subunits and Other Genes at Different Temperatures. Neuroscience. 2020;438:116-136 pubmed publisher |
Luo Y, Hara T, Kawashima A, Ishido Y, Suzuki S, Ishii N, et al. Pathological role of excessive DNA as a trigger of keratinocyte proliferation in psoriasis. Clin Exp Immunol. 2020;: pubmed publisher |
Sanna S, Esposito S, Masala A, Sini P, Nieddu G, Galioto M, et al. HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo. Cell Death Dis. 2020;11:369 pubmed publisher |
Hoxha S, Shepard A, Troutman S, Diao H, Doherty J, Janiszewska M, et al. YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators. Cancer Res. 2020;80:2512-2522 pubmed publisher |
Ni W, Perez A, Schreiner S, Nicolet C, Farnham P. Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters. Nucleic Acids Res. 2020;48:5986-6000 pubmed publisher |
Xu B, Qin T, Yu J, Giordano T, Sartor M, Koenig R. Novel role of ASH1L histone methyltransferase in anaplastic thyroid carcinoma. J Biol Chem. 2020;295:8834-8845 pubmed publisher |
Zhang W, Aida T, del Rosario R, Wilde J, Ding C, Zhang X, et al. Multiplex precise base editing in cynomolgus monkeys. Nat Commun. 2020;11:2325 pubmed publisher |
Damiano Guercio J, Kurzawa L, Mueller J, Dimchev G, Schaks M, Nemethova M, et al. Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion. elife. 2020;9: pubmed publisher |
Alshafie W, Pan Y, Kreienkamp H, Stroh T. Characterization of agonist-dependent somatostatin receptor subtype 2 trafficking in neuroendocrine cells. Endocrine. 2020;: pubmed publisher |
Zu T, Wen J, Xu L, Mi J, Li H, Brakebusch C, et al. Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway. Front Oncol. 2020;10:624 pubmed publisher |
Mohammadi B, Linsenmeier L, Shafiq M, Puig B, Galliciotti G, Giudici C, et al. Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation. Mol Neurobiol. 2020;57:2812-2829 pubmed publisher |
Nijenhuis W, van Grinsven M, Kapitein L. An optimized toolbox for the optogenetic control of intracellular transport. J Cell Biol. 2020;219: pubmed publisher |
Rim E, Kinney L, Nusse R. β-catenin-mediated Wnt signal transduction proceeds through an endocytosis-independent mechanism. Mol Biol Cell. 2020;31:1425-1436 pubmed publisher |
Ryan T, Phillips E, Collier C, Jb Robinson A, Routledge D, Wood R, et al. Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles. EMBO J. 2020;39:e102539 pubmed publisher |
Kobayashi K, Endo T, Matsumura T, Lu Y, Yu Z, Matzuk M, et al. Prss55 but not Prss51 is required for male fertility in mice†. Biol Reprod. 2020;: pubmed publisher |
Guo Q, Quan M, Dong J, Bai J, Wang J, Han R, et al. The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy. Theranostics. 2020;10:4422-4436 pubmed publisher |
Ameneiro C, Moreira T, Fuentes Iglesias A, Coego A, Garcia Outeiral V, Escudero A, et al. BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells. Life Sci Alliance. 2020;3: pubmed publisher |
Fan R, Cui W, Chen J, Ma Y, Yang Z, Payne T, et al. Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples. Addict Biol. 2020;:e12898 pubmed publisher |
Willems J, de Jong A, Scheefhals N, Mertens E, Catsburg L, Poorthuis R, et al. ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons. PLoS Biol. 2020;18:e3000665 pubmed publisher |
Kim D, Kim S, Ryu J, Hong H, Chang J, Yoo T, et al. Human Embryonic Stem Cell-Derived Wilson's Disease Model for Screening Drug Efficacy. Cells. 2020;9: pubmed publisher |
Kim T, Kern C, Zhou H. Knockout of IRF7 Highlights its Modulator Function of Host Response Against Avian Influenza Virus and the Involvement of MAPK and TOR Signaling Pathways in Chicken. Genes (Basel). 2020;11: pubmed publisher |
Wang Y, Ma R, Liu B, Kong J, Lin H, Yu X, et al. SNP rs17079281 decreases lung cancer risk through creating an YY1-binding site to suppress DCBLD1 expression. Oncogene. 2020;39:4092-4102 pubmed publisher |
Xie Z, Dang Y, Wu H, He R, Ma J, Peng Z, et al. Effect of CELSR3 on the Cell Cycle and Apoptosis of Hepatocellular Carcinoma Cells. J Cancer. 2020;11:2830-2844 pubmed publisher |
Volpatti J, Endo Y, Knox J, Groom L, Brennan S, Noche R, et al. Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline. elife. 2020;9: pubmed publisher |
Zhang S, Wang M, Feng J, Chang Y, Ji S, Wu Y. Reversible promoter methylation determines fluctuating expression of acute phase proteins. elife. 2020;9: pubmed publisher |
Qiao C, Liu W, Jiang H, He M, Yang Q, Xing Y. Integrated analysis of miRNA and mRNA expression profiles in p53-edited PFF cells. Cell Cycle. 2020;19:949-959 pubmed publisher |
Szymura S, Bernal G, Wu L, Zhang Z, Crawley C, Voce D, et al. DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy. BMC Biol. 2020;18:32 pubmed publisher |
Ribeiro M, Slaats R, Schwach V, Rivera Arbelaez J, Tertoolen L, van Meer B, et al. A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness. J Mol Cell Cardiol. 2020;141:54-64 pubmed publisher |
Zhu X, Wei Y, Zhan Q, Yan A, Feng J, Liu L, et al. CRISPR/Cas9-Mediated Biallelic Knockout of IRX3 Reduces the Production and Survival of Somatic Cell-Cloned Bama Minipigs. Animals (Basel). 2020;10: pubmed publisher |
Yuan S, Natesan R, Sanchez Rivera F, Li J, Bhanu N, Yamazoe T, et al. Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression. Cancer Discov. 2020;10:854-871 pubmed publisher |
Chang Y, Shao J, Gao Y, Liu W, Gao Z, Hu Y, et al. Reporter gene knock-in into Marc-145 cells using CRISPR/Cas9-mediated homologous recombination. Biotechnol Lett. 2020;42:1317-1325 pubmed publisher |
Rohiwal S, Dvorakova N, Klima J, Vaskovicova M, Senigl F, Slouf M, et al. Polyethylenimine based magnetic nanoparticles mediated non-viral CRISPR/Cas9 system for genome editing. Sci Rep. 2020;10:4619 pubmed publisher |
Guttmann S, Nadzemova O, Grünewald I, Lenders M, Brand E, Zibert A, et al. ATP7B knockout disturbs copper and lipid metabolism in Caco-2 cells. PLoS ONE. 2020;15:e0230025 pubmed publisher |
Newton P, Thomas D, Reed S, Lau N, Xu B, Ong S, et al. Lysosomal degradation products induce Coxiella burnetii virulence. Proc Natl Acad Sci U S A. 2020;117:6801-6810 pubmed publisher |
Franke F, Slusarenko B, Engleitner T, Johannes W, Laschinger M, Rad R, et al. Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial-mesenchymal transition and colorectal cancer aggressiveness. Int J Cancer. 2020;: pubmed publisher |
Watanabe Y, Watanabe K, Fujioka D, Nakamura K, Nakamura T, Uematsu M, et al. Protein S-glutathionylation stimulate adipogenesis by stabilizing C/EBPβ in 3T3L1 cells. FASEB J. 2020;34:5827-5837 pubmed publisher |
Chen J, Li P, Song L, Bai L, Huen M, Liu Y, et al. 53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice. Cell Death Differ. 2020;: pubmed publisher |
Haberger V, Elgner F, Roos J, Bender D, Hildt E. Regulation of the Transferrin Receptor Recycling in Hepatitis C Virus-Replicating Cells. Front Cell Dev Biol. 2020;8:44 pubmed publisher |
Zhang W, Ma L, Yang M, Shao Q, Xu J, Lu Z, et al. Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes. Genes Dev. 2020;34:580-597 pubmed publisher |
Koo C, Harrison N, Noy P, Szyroka J, Matthews A, Hsia H, et al. The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. J Biol Chem. 2020;: pubmed publisher |
Morrow C, Porter T, Xu N, Arndt Z, Ako Asare K, Heo H, et al. Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit. Cell Stem Cell. 2020;26:558-568.e9 pubmed publisher |
Takahashi H, Ranjan A, Chen S, Suzuki H, Shibata M, Hirose T, et al. The role of Mediator and Little Elongation Complex in transcription termination. Nat Commun. 2020;11:1063 pubmed publisher |
Moorthy S, Byfield F, Janmey P, Klein E. Matrix stiffness regulates endosomal escape of uropathogenic E. coli. Cell Microbiol. 2020;22:e13196 pubmed publisher |
Oda Y, Sugawara T, Fukata Y, Izumi Y, Otani T, Higashi T, et al. The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts. J Biol Chem. 2020;295:4289-4302 pubmed publisher |
Horibata Y, Mitsuhashi S, Shimizu H, Maejima S, Sakamoto H, Aoyama C, et al. The phosphatidylcholine transfer protein StarD7 is important for myogenic differentiation in mouse myoblast C2C12 cells and human primary skeletal myoblasts. Sci Rep. 2020;10:2845 pubmed publisher |
Scott T, Soemardy C, Morris K. Development of a Facile Approach for Generating Chemically Modified CRISPR/Cas9 RNA. Mol Ther Nucleic Acids. 2020;19:1176-1185 pubmed publisher |
White C, Caspar B, Vanyai H, Pfleger K, Hill S. CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes. Cell Chem Biol. 2020;27:499-510.e7 pubmed publisher |
Moosburner M, Gholami P, McCarthy J, Tan M, Bielinski V, Allen A. Multiplexed Knockouts in the Model Diatom Phaeodactylum by Episomal Delivery of a Selectable Cas9. Front Microbiol. 2020;11:5 pubmed publisher |
Wamaitha S, Grybel K, Alanis Lobato G, Gerri C, Ogushi S, McCarthy A, et al. IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche. Nat Commun. 2020;11:764 pubmed publisher |
Dossin F, Pinheiro I, Zylicz J, Roensch J, Collombet S, Le Saux A, et al. SPEN integrates transcriptional and epigenetic control of X-inactivation. Nature. 2020;578:455-460 pubmed publisher |
Mejhert N, Kuruvilla L, Gabriel K, Elliott S, Guie M, Wang H, et al. Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression. Mol Cell. 2020;77:1251-1264.e9 pubmed publisher |
Dusoswa S, Verhoeff J, Abels E, Méndez Huergo S, Croci D, Kuijper L, et al. Glioblastomas exploit truncated O-linked glycans for local and distant immune modulation via the macrophage galactose-type lectin. Proc Natl Acad Sci U S A. 2020;117:3693-3703 pubmed publisher |
Yang Y, Liu S, Gao H, Wang P, Zhang Y, Zhang A, et al. Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2. Free Radic Biol Med. 2020;152:821-837 pubmed publisher |
Irie K, Nagai T, Mizuno K. Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP. J Biol Chem. 2020;295:3017-3028 pubmed publisher |
Batlle C, Yang P, Coughlin M, Messing J, Pesarrodona M, Szulc E, et al. hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation. Cell Rep. 2020;30:1117-1128.e5 pubmed publisher |
Panda S, Wigerblad G, Jiang L, Jiménez Andrade Y, Iyer V, Shen Y, et al. IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints. Proc Natl Acad Sci U S A. 2020;117:3103-3113 pubmed publisher |
Zhang B, Tang Z, Li L, Lu L. NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis. Cell Death Differ. 2020;27:2176-2190 pubmed publisher |
Morohoshi A, Miyata H, Shimada K, Nozawa K, Matsumura T, Yanase R, et al. Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. PLoS Genet. 2020;16:e1008585 pubmed publisher |
Santos M, Anderson C, Neschen S, Zumbrennen Bullough K, Romney S, Kahle Stephan M, et al. Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. Nat Commun. 2020;11:296 pubmed publisher |
Li Q, Mao F, Zhou B, Huang Y, Zou Z, Dendekker A, et al. p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells. Cell Rep. 2020;30:465-480.e6 pubmed publisher |
Tanaka M, Shiota M, Koyama M, Nakayama J, Yashiro M, Semba K, et al. Generation of Rat Monoclonal Antibodies Specific for Human Stromal Cell-Derived Factor-2. Monoclon Antib Immunodiagn Immunother. 2020;39:23-26 pubmed publisher |
Qi F, Isaji T, Duan C, Yang J, Wang Y, Fukuda T, et al. ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins. FASEB J. 2020;34:881-897 pubmed publisher |
Yamazaki H, Shirakawa K, Matsumoto T, Kazuma Y, Matsui H, Horisawa Y, et al. APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression. PLoS ONE. 2020;15:e0223463 pubmed publisher |
Li Y, Haarhuis J, Cacciatore Á, Oldenkamp R, van Ruiten M, Willems L, et al. The structural basis for cohesin-CTCF-anchored loops. Nature. 2020;: pubmed publisher |
Liu X, Li X, Tao Y, Li N, Ji M, Zhang X, et al. TCDD inhibited the osteogenic differentiation of human fetal palatal mesenchymal cells through AhR and BMP-2/TGF-β/Smad signaling. Toxicology. 2020;431:152353 pubmed publisher |
Blackledge N, Fursova N, Kelley J, Huseyin M, Feldmann A, Klose R. PRC1 Catalytic Activity Is Central to Polycomb System Function. Mol Cell. 2019;: pubmed publisher |
Coe E, Tan J, Shapiro M, Louphrasitthiphol P, Bassett A, Marques A, et al. The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor. PLoS Genet. 2019;15:e1008501 pubmed publisher |
McIlroy G, Mitchell S, Han W, Delibegovic M, Rochford J. Ablation of Bscl2/Seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy. Dis Model Mech. 2019;: pubmed publisher |
Kiełbus M, Czapinski J, Kałafut J, Woś J, Stepulak A, Rivero Muller A. Genetically Engineered Lung Cancer Cells for Analyzing Epithelial-Mesenchymal Transition. Cells. 2019;8: pubmed publisher |
Matsumoto R, Suga H, Aoi T, Bando H, Fukuoka H, Iguchi G, et al. Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells. J Clin Invest. 2019;: pubmed publisher |
Mesquita F, Arantes P, Kasai Brunswick T, Araujo D, Gubert F, Monnerat G, et al. R534C mutation in hERG causes a trafficking defect in iPSC-derived cardiomyocytes from patients with type 2 long QT syndrome. Sci Rep. 2019;9:19203 pubmed publisher |
Jonker C, Deo C, Zager P, Tkachuk A, Weinstein A, Rodriguez Boulan E, et al. Accurate measurement of fast endocytic recycling kinetics in real time. J Cell Sci. 2019;: pubmed publisher |
Yan J, Allen S, McDonald E, Das I, Mak J, Liu L, et al. MAIT Cells Promote Tumor Initiation, Growth, and Metastases via Tumor MR1. Cancer Discov. 2019;: pubmed publisher |
Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, et al. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biol. 2019;17:e3000557 pubmed publisher |
Koh C, Goh Y, Goh W. Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes. Nat Commun. 2019;10:5636 pubmed publisher |
Alansary D, Peckys D, Niemeyer B, de Jonge N. Detecting single ORAI1 proteins within the plasma membrane reveals higher order channel complexes. J Cell Sci. 2019;: pubmed publisher |
Atasoy M, Rohaim M, Munir M. Simultaneous Deletion of Virulence Factors and Insertion of Antigens into the Infectious Laryngotracheitis Virus Using NHEJ-CRISPR/Cas9 and Cre-Lox System for Construction of a Stable Vaccine Vector. Vaccines (Basel). 2019;7: pubmed publisher |
Gasiulė S, Dreize N, Kaupinis A, Razanskas R, Čiupas L, Stankevicius V, et al. miR-23b Modulates the Epithelial-Mesenchymal Transition of Colorectal Cancer Cells. J Clin Med. 2019;8: pubmed publisher |
Creed M, Baldeosingh R, Eberly C, Schlee C, Kim M, Cutler J, et al. PAX-SIX-EYA-DACH Network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis. Development. 2019;: pubmed publisher |
Qin S, Jiang C, Gao J. Transcriptional factor Nrf2 is essential for aggresome formation during proteasome inhibition. Biomed Rep. 2019;11:241-252 pubmed publisher |
Brasil A, de Carvalho M, Gerhardt E, Queiroz D, Pereira M, Outeiro T, et al. Characterization of the activity, aggregation, and toxicity of heterodimers of WT and ALS-associated mutant Sod1. Proc Natl Acad Sci U S A. 2019;116:25991-26000 pubmed publisher |
Barnard K, Wasik B, LaClair J, Buchholz D, Weichert W, Alford Lawrence B, et al. Expression of 9-O- and 7,9-O-Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses. MBio. 2019;10: pubmed publisher |
Bendriem R, Singh S, Aleem A, Antonetti D, Ross M. Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex. elife. 2019;8: pubmed publisher |
De Snoo M, Friesen E, Zhang Y, Earnshaw R, Dorval G, Kapadia M, et al. Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death. Cell Death Dis. 2019;10:907 pubmed publisher |
Boldbaatar J, Gunarta I, Suzuki R, Erdenebaatar P, Davaakhuu G, Hohjoh H, et al. Protective role of c-Jun NH2-terminal kinase-associated leucine zipper protein (JLP) in curcumin-induced cancer cell death. Biochem Biophys Res Commun. 2019;: pubmed publisher |
Xie Y, Ng N, Safrina O, Ramos C, Ess K, Schwartz P, et al. Comparisons of dual isogenic human iPSC pairs identify functional alterations directly caused by an epilepsy associated SCN1A mutation. Neurobiol Dis. 2020;134:104627 pubmed publisher |
Galupa R, Nora E, Worsley Hunt R, Picard C, Gard C, van Bemmel J, et al. A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary. Mol Cell. 2019;: pubmed publisher |
Erwood S, Brewer R, Bily T, Maino E, Zhou L, Cohn R, et al. Modeling Niemann-Pick disease type C in a human haploid cell line allows for patient variant characterization and clinical interpretation. Genome Res. 2019;29:2010-2019 pubmed publisher |
Kachamakova Trojanowska N, Stepniewski J, Dulak J. Human iPSCs-Derived Endothelial Cells with Mutation in HNF1A as a Model of Maturity-Onset Diabetes of the Young. Cells. 2019;8: pubmed publisher |
Lentsch E, Li L, Pfeffer S, Ekici A, Taher L, Pilarsky C, et al. CRISPR/Cas9-Mediated Knock-Out of KrasG12D Mutated Pancreatic Cancer Cell Lines. Int J Mol Sci. 2019;20: pubmed publisher |
Toubiana S, Gagliardi M, Papa M, Manco R, Tzukerman M, Matarazzo M, et al. Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction. elife. 2019;8: pubmed publisher |
Randolph L, Bao X, Oddo M, Lian X. Sex-dependent VEGF expression underlies variations in human pluripotent stem cell to endothelial progenitor differentiation. Sci Rep. 2019;9:16696 pubmed publisher |
Garcia B, Lee J, Edraki A, Hidalgo Reyes Y, Erwood S, Mir A, et al. Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing. Cell Rep. 2019;29:1739-1746.e5 pubmed publisher |
Sproll P, Eid W, Biason Lauber A. CBX2-dependent transcriptional landscape: implications for human sex development and its defects. Sci Rep. 2019;9:16552 pubmed publisher |
Nambiar D, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, et al. Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance. J Clin Invest. 2019;129:5553-5567 pubmed publisher |
Chung J, Wu X, Lambert T, Lai Z, Walther T, Farese R. LDAF1 and Seipin Form a Lipid Droplet Assembly Complex. Dev Cell. 2019;51:551-563.e7 pubmed publisher |
Weiterer S, Meier Soelch J, Georgomanolis T, Mizi A, Beyerlein A, Weiser H, et al. Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J. 2019;:e101533 pubmed publisher |
Busch J, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schondorf T, et al. MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Cell Rep. 2019;29:1728-1738.e9 pubmed publisher |
Cali C, Park D, Lee E. Targeted DNA methylation of neurodegenerative disease genes via homology directed repair. Nucleic Acids Res. 2019;47:11609-11622 pubmed publisher |
Yao W, Yoshida T, Hashimoto S, Takeuchi H, Strebel K, Yamaoka S. Vpu of a simian immunodeficiency virus isolated from greater spot-nosed monkey antagonizes human BST-2 via two AxxxxxxxW motifs. J Virol. 2019;: pubmed publisher |
Xu W, Hua H, Chiu Y, Li G, Zhi H, Yu Z, et al. CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways. Cell Rep. 2019;29:1311-1322.e5 pubmed publisher |
Krohn L, Ozturk T, Vanderperre B, Ouled Amar Bencheikh B, Ruskey J, Laurent S, et al. Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies. Ann Neurol. 2020;87:139-153 pubmed publisher |
Pergolizzi B, Panuzzo C, Ali M, Lo Iacono M, Levra Levron C, Ponzone L, et al. Two conserved glycine residues in mammalian and Dictyostelium Rictor are required for mTORC2 activity and integrity. J Cell Sci. 2019;132: pubmed publisher |
Grajcarek J, Monlong J, Nishinaka Arai Y, Nakamura M, Nagai M, Matsuo S, et al. Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations. Nat Commun. 2019;10:4856 pubmed publisher |
Hildebrandt A, Brüggemann M, Rücklé C, Boerner S, Heidelberger J, Busch A, et al. The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation. Genome Biol. 2019;20:216 pubmed publisher |
Hu J, Xue Y, Tang K, Fan J, Du J, Li W, et al. The protective effects of hydrogen sulfide on the myocardial ischemia via regulating Bmal1. Biomed Pharmacother. 2019;120:109540 pubmed publisher |
Klein S, Nguyen D, Bhakta V, Wong D, Chang V, Davidson T, et al. Mutations in the sonic hedgehog pathway cause macrocephaly-associated conditions due to crosstalk to the PI3K/AKT/mTOR pathway. Am J Med Genet A. 2019;179:2517-2531 pubmed publisher |
Laflamme C, McKeever P, Kumar R, Schwartz J, Kolahdouzan M, Chen C, et al. Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72. elife. 2019;8: pubmed publisher |
Yoshimatsu S, Nakamura M, Nakajima M, Nemoto A, Sato T, Sasaki E, et al. Evaluating the efficacy of small molecules for neural differentiation of common marmoset ESCs and iPSCs. Neurosci Res. 2019;: pubmed publisher |
Sümer C, Boz Er A, Dinçer T. Keratin 14 is a novel interaction partner of keratinocyte differentiation regulator: receptor-interacting protein kinase 4. Turk J Biol. 2019;43:225-234 pubmed publisher |
Khan A, White C, Pike J, Yule J, Slater A, Hill S, et al. Optimised insert design for improved single-molecule imaging and quantification through CRISPR-Cas9 mediated knock-in. Sci Rep. 2019;9:14219 pubmed publisher |
Oobatake Y, Shimizu N. Double-strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation. Genes Chromosomes Cancer. 2019;: pubmed publisher |
Chen Y, Huang Y, Kanwal M, Li G, Yang J, Niu H, et al. MUC16 in non-small cell lung cancer patients affected by familial lung cancer and indoor air pollution: clinical characteristics and cell behaviors. Transl Lung Cancer Res. 2019;8:476-488 pubmed publisher |
Yeh J, Park E, Schultz K, Griffin D. NF-κB Activation Promotes Alphavirus Replication in Mature Neurons. J Virol. 2019;93: pubmed publisher |
Schrode N, Ho S, Yamamuro K, Dobbyn A, Huckins L, Matos M, et al. Synergistic effects of common schizophrenia risk variants. Nat Genet. 2019;51:1475-1485 pubmed publisher |
Meyer K. DART-seq: an antibody-free method for global m6A detection. Nat Methods. 2019;16:1275-1280 pubmed publisher |
Mair B, Aldridge P, Atwal R, Philpott D, Zhang M, Masud S, et al. High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting. Nat Biomed Eng. 2019;3:796-805 pubmed publisher |
Giles A, Hao S, Padget M, Song H, Zhang W, Lynes J, et al. Efficient ADCC killing of meningioma by avelumab and a high-affinity natural killer cell line, haNK. JCI Insight. 2019;4: pubmed publisher |
Angarola B, Ferguson S. Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment. Mol Biol Cell. 2019;30:2750-2760 pubmed publisher |
Karakkat J, Kaimala S, Sreedharan S, Jayaprakash P, Adeghate E, Ansari S, et al. The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex. Nucleic Acids Res. 2019;47:10086-10103 pubmed publisher |
Zhu S, Wan W, Zhang Y, Shang W, Pan X, Zhang L, et al. Comprehensive Interactome Analysis Reveals that STT3B Is Required for N-Glycosylation of Lassa Virus Glycoprotein. J Virol. 2019;93: pubmed publisher |
Harel M, Ortenberg R, Varanasi S, Mangalhara K, Mardamshina M, Markovits E, et al. Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. Cell. 2019;179:236-250.e18 pubmed publisher |
van der Schoot J, Fennemann F, Valente M, Dölen Y, Hagemans I, Becker A, et al. Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering. Sci Adv. 2019;5:eaaw1822 pubmed publisher |
Gable D, Gaysinskaya V, Atik C, Talbot C, Kang B, Stanley S, et al. ZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation. Genes Dev. 2019;33:1381-1396 pubmed publisher |
Halikere A, Popova D, Scarnati M, Hamod A, Swerdel M, Moore J, et al. Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons. Mol Psychiatry. 2019;: pubmed publisher |
Fujihara Y, Noda T, Kobayashi K, Oji A, Kobayashi S, Matsumura T, et al. Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice. Proc Natl Acad Sci U S A. 2019;116:18498-18506 pubmed publisher |
BeltCappellino A, Majerciak V, Lobanov A, Lack J, Cam M, Zheng Z. CRISPR/Cas9-Mediated Knockout and In Situ Inversion of the ORF57 Gene from All Copies of the Kaposi's Sarcoma-Associated Herpesvirus Genome in BCBL-1 Cells. J Virol. 2019;93: pubmed publisher |
Turberfield A, Kondo T, Nakayama M, Koseki Y, King H, Koseki H, et al. KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity. Nucleic Acids Res. 2019;47:9005-9023 pubmed publisher |
Zhao R, Afthinos A, Zhu T, Mistriotis P, Li Y, Serra S, et al. Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Sci Adv. 2019;5:eaaw7243 pubmed publisher |
Leiria L, Wang C, Lynes M, Yang K, Shamsi F, Sato M, et al. 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metab. 2019;30:768-783.e7 pubmed publisher |
Parker M, Hao Y, Guo F, Pham B, Chase R, Platig J, et al. Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts. elife. 2019;8: pubmed publisher |
Wang S, Huang H, Xiang H, Gu B, Li W, Chen L, et al. Wnt Signaling Modulates Routes of Retinoic Acid-Induced Differentiation of Embryonic Stem Cells. Stem Cells Dev. 2019;28:1334-1345 pubmed publisher |
Miller T, Henkels K, Huddleston M, Salisbury R, Hussain S, Sasaki A, et al. Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria. J Cell Sci. 2019;132: pubmed publisher |
Manivannan P, Reddy V, Mukherjee S, Clark K, Malathi K. RNase L Induces Expression of A Novel Serine/Threonine Protein Kinase, DRAK1, to Promote Apoptosis. Int J Mol Sci. 2019;20: pubmed publisher |
Li X, Liu Z, Zhang A, Han C, Shen A, Jiang L, et al. NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance. Nat Commun. 2019;10:3251 pubmed publisher |
Agrotis A, von Chamier L, Oliver H, Kiso K, Singh T, Ketteler R. Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins. J Biol Chem. 2019;294:12610-12621 pubmed publisher |
Runwal G, Stamatakou E, Siddiqi F, Puri C, Zhu Y, Rubinsztein D. LC3-positive structures are prominent in autophagy-deficient cells. Sci Rep. 2019;9:10147 pubmed publisher |
Lindblad A, Persson K, Demirel I. IL-1RA is part of the inflammasome-regulated immune response in bladder epithelial cells and influences colonization of uropathogenic E. coli. Cytokine. 2019;123:154772 pubmed publisher |
Reimer M, Pulakanti K, Shi L, Abel A, Liang M, Malarkannan S, et al. Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression. BMC Dev Biol. 2019;19:16 pubmed publisher |
Piunti A, Smith E, Morgan M, Ugarenko M, Khaltyan N, Helmin K, et al. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. Sci Adv. 2019;5:eaax2887 pubmed publisher |
Brandsma I, Sato K, van Rossum Fikkert S, van Vliet N, Sleddens E, Reuter M, et al. HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis. Cell Rep. 2019;27:3790-3798.e7 pubmed publisher |
Tanaka H, Arima Y, Kamimura D, Tanaka Y, Takahashi N, Uehata T, et al. Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response. J Exp Med. 2019;216:1431-1449 pubmed publisher |
Soday L, Lu Y, Albarnaz J, Davies C, Antrobus R, Smith G, et al. Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist. Cell Rep. 2019;27:1920-1933.e7 pubmed publisher |
Ishiuchi T, Ohishi H, Sato T, Kamimura S, Yorino M, Abe S, et al. Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development. Cell Rep. 2019;27:1742-1754.e6 pubmed publisher |
Kalkan T, Bornelöv S, Mulas C, Diamanti E, Lohoff T, Ralser M, et al. Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency. Cell Stem Cell. 2019;24:785-801.e7 pubmed publisher |
Robertson L, Pederick D, Piltz S, White M, Nieto A, Ahladas M, et al. Expanding the RNA-Guided Endonuclease Toolkit for Mouse Genome Editing. CRISPR J. 2018;1:431-439 pubmed publisher |
Princely Abudu Y, Pankiv S, Mathai B, Håkon Lystad A, Bindesbøll C, Brenne H, et al. NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Dev Cell. 2019;49:509-525.e12 pubmed publisher |
Kilpatrick L, Alcobia D, White C, Peach C, Glenn J, Zimmerman K, et al. Complex Formation between VEGFR2 and the β2-Adrenoceptor. Cell Chem Biol. 2019;26:830-841.e9 pubmed publisher |
Valverde D, Yu S, Boggavarapu V, Kumar N, Lees J, Walz T, et al. ATG2 transports lipids to promote autophagosome biogenesis. J Cell Biol. 2019;218:1787-1798 pubmed publisher |
Swarr D, Herriges M, Li S, Morley M, Fernandes S, Sridharan A, et al. The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration. Genes Dev. 2019;33:656-668 pubmed publisher |
Li H, Petersen S, García Mariscal A, Brakebusch C. Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation. Cancer Res. 2019;79:2167-2181 pubmed publisher |
Baechler B, Bloemberg D, Quadrilatero J. Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation. Autophagy. 2019;:1-14 pubmed publisher |
Vargas J, Wang C, Bunker E, Hao L, Maric D, Schiavo G, et al. Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy. Mol Cell. 2019;74:347-362.e6 pubmed publisher |
Kumar S, Gu Y, Abudu Y, Bruun J, Jain A, Farzam F, et al. Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation. Dev Cell. 2019;: pubmed publisher |
Colognori D, Sunwoo H, Kriz A, Wang C, Lee J. Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X. Mol Cell. 2019;74:101-117.e10 pubmed publisher |
Kamieniarz Gdula K, Gdula M, Panser K, Nojima T, Monks J, Wisniewski J, et al. Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination. Mol Cell. 2019;74:158-172.e9 pubmed publisher |
Garcia Moreno M, Noerenberg M, Ni S, Järvelin A, González Almela E, Lenz C, et al. System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection. Mol Cell. 2019;74:196-211.e11 pubmed publisher |
Sugihara M, Morito D, Ainuki S, Hirano Y, Ogino K, Kitamura A, et al. The AAA+ ATPase/ubiquitin ligase mysterin stabilizes cytoplasmic lipid droplets. J Cell Biol. 2019;218:949-960 pubmed publisher |
Sakai R, Fukuda R, Unida S, Aki M, Ono Y, Endo A, et al. The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors. J Cell Sci. 2019;132: pubmed publisher |
Kant S, Freytag B, Herzog A, Reich A, Merkel R, Hoffmann B, et al. Desmoglein 2 mutation provokes skeletal muscle actin expression and accumulation at intercalated discs in murine hearts. J Cell Sci. 2019;132: pubmed publisher |
Choi S, Jeong H, Kim H, Choi D, Cho S, Seong J, et al. Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis. Autophagy. 2019;15:1069-1081 pubmed publisher |
Wimmer R, Leopoldi A, Aichinger M, Wick N, Hantusch B, Novatchkova M, et al. Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 2019;565:505-510 pubmed publisher |
Goto H, Natsume T, Kanemaki M, Kaito A, Wang S, Gabazza E, et al. Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell cycle progression. J Cell Sci. 2019;132: pubmed publisher |
Ang C, Ma Q, Wapinski O, Fan S, Flynn R, Lee Q, et al. The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders. elife. 2019;8: pubmed publisher |
Heijink A, Talens F, Jae L, van Gijn S, Fehrmann R, Brummelkamp T, et al. BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity. Nat Commun. 2019;10:100 pubmed publisher |
Liu L, Ding L, Rovere M, Wolfe M, Selkoe D. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. J Cell Biol. 2019;218:644-663 pubmed publisher |
Ishijima Y, Ohmori S, Uneme A, Aoki Y, Kobori M, Ohida T, et al. The Gata2 repression during 3T3-L1 preadipocyte differentiation is dependent on a rapid decrease in histone acetylation in response to glucocorticoid receptor activation. Mol Cell Endocrinol. 2019;483:39-49 pubmed publisher |
Hodakoski C, Hopkins B, Zhang G, Su T, Cheng Z, Morris R, et al. Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer. Cancers (Basel). 2019;11: pubmed publisher |
OZOG S, Chen C, Simpson E, Garijo O, Timberlake N, Minder P, et al. CD46 Null Packaging Cell Line Improves Measles Lentiviral Vector Production and Gene Delivery to Hematopoietic Stem and Progenitor Cells. Mol Ther Methods Clin Dev. 2019;13:27-39 pubmed publisher |
Thepparit C, Khongwichit S, Ketsuwan K, Libsittikul S, Auewarakul P, Smith D. Dengue virus requires apoptosis linked gene-2-interacting protein X (ALIX) for viral propagation. Virus Res. 2019;261:65-71 pubmed publisher |
Connelly K, Weaver T, Alpsoy A, Gu B, Musselman C, Dykhuizen E. Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association. Nucleic Acids Res. 2019;47:2289-2305 pubmed publisher |
Chen D, Liu W, Zimmerman J, Pastor W, Kim R, Hosohama L, et al. The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation. Cell Rep. 2018;25:3591-3602.e5 pubmed publisher |
Han S, Miyoshi K, Shikada S, Amano G, Wang Y, Yoshimura T, et al. TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia. Biochem Biophys Res Commun. 2018;: pubmed publisher |
Cornelissen L, Blanas A, van der Horst J, Kruijssen L, Zaal A, O Toole T, et al. Disruption of sialic acid metabolism drives tumor growth by augmenting CD8+ T cell apoptosis. Int J Cancer. 2019;144:2290-2302 pubmed publisher |
Zhang Y, Pei J, Shi S, Guo X, Cui G, Li Y, et al. CRISPR/Cas9-mediated knockout of the PDEF gene inhibits migration and invasion of human gastric cancer AGS cells. Biomed Pharmacother. 2019;111:76-85 pubmed publisher |
Sekine R, Shibata T, Ebisuya M. Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty. Nat Commun. 2018;9:5456 pubmed publisher |
Reuven N, Shanzer M, Shaul Y. Hippo Pathway Regulation by Tyrosine Kinases. Methods Mol Biol. 2019;1893:215-236 pubmed publisher |
Hryhorowicz M, Grześkowiak B, Mazurkiewicz N, Śledziński P, Lipiński D, Słomski R. Improved Delivery of CRISPR/Cas9 System Using Magnetic Nanoparticles into Porcine Fibroblast. Mol Biotechnol. 2019;61:173-180 pubmed publisher |
Forrester A, De Leonibus C, Grumati P, Fasana E, Piemontese M, Staiano L, et al. A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex. EMBO J. 2019;38: pubmed publisher |
Yiu S, Hui K, Choi C, Kao R, Ma C, Yang D, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein⁻Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers. Cancers (Basel). 2018;10: pubmed publisher |
Menzies S, Volkmar N, van den Boomen D, Timms R, Dickson A, Nathan J, et al. The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1. elife. 2018;7: pubmed publisher |
Kallimasioti Pazi E, Thelakkad Chathoth K, Taylor G, Meynert A, Ballinger T, Kelder M, et al. Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair. PLoS Biol. 2018;16:e2005595 pubmed publisher |
Sato Y, Bolzenius J, Eteleeb A, Su X, Maher C, Sehn J, et al. CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blockade. JCI Insight. 2018;3: pubmed publisher |
Zheng Y, Lin T, Lee G, Paddock M, Momb J, Cheng Z, et al. Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells. Cell. 2018;175:1546-1560.e17 pubmed publisher |
Sluch V, Chamling X, Wenger C, Duan Y, Rice D, Zack D. Highly efficient scarless knock-in of reporter genes into human and mouse pluripotent stem cells via transient antibiotic selection. PLoS ONE. 2018;13:e0201683 pubmed publisher |
Wepy J, Galligan J, Kingsley P, Xu S, Goodman M, Tallman K, et al. Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling. J Lipid Res. 2019;60:360-374 pubmed publisher |
Franke F, Muller J, Abal M, Medina E, Nitsche U, Weidmann H, et al. The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Cell Mol Gastroenterol Hepatol. 2019;7:33-53 pubmed publisher |
Gong Q, Long Z, Zhong F, Teo D, Jin Y, Yin Z, et al. Structural basis of RIP2 activation and signaling. Nat Commun. 2018;9:4993 pubmed publisher |
Choi J, Kim S, Jeong Y, Kim S, MIN K, Kim K. hnRNP Q Regulates Internal Ribosome Entry Site-Mediated fmr1 Translation in Neurons. Mol Cell Biol. 2019;39: pubmed publisher |
Gupta A, Murthy T, Paul K, Ramirez O, Fisher J, Rao S, et al. Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1). Nucleic Acids Res. 2019;47:970-980 pubmed publisher |
Haslinger D, Waltes R, Yousaf A, Lindlar S, Schneider I, Lim C, et al. Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model. Mol Autism. 2018;9:56 pubmed publisher |
Schroeder L, Barentine A, Merta H, Schweighofer S, Zhang Y, Baddeley D, et al. Dynamic nanoscale morphology of the ER surveyed by STED microscopy. J Cell Biol. 2019;218:83-96 pubmed publisher |
Chen C, Anderson N, Becker S, Schicht M, Stoddard C, Bräuer L, et al. Examining the role of the surfactant family member SFTA3 in interneuron specification. PLoS ONE. 2018;13:e0198703 pubmed publisher |
Jing R, Corbett J, Cai J, Beeson G, Beeson C, CHAN S, et al. A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome. Cell Rep. 2018;25:1469-1484.e5 pubmed publisher |
Deng Y, Pakdel M, Blank B, Sundberg E, Burd C, von Blume J. Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network. Dev Cell. 2018;47:464-478.e8 pubmed publisher |
Foster B, Stolz P, Mulholland C, Montoya A, Kramer H, Bultmann S, et al. Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin. Mol Cell. 2018;72:739-752.e9 pubmed publisher |
Zhang P, Kang B, Xie G, Li S, Gu Y, Shen Y, et al. Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer. Cancer Lett. 2018;442:53-67 pubmed publisher |
Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, et al. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene. 2019;38:1905-1919 pubmed publisher |
Deng Y, Lu J, Li W, Wu A, Zhang X, Tong W, et al. Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation. Nat Commun. 2018;9:4564 pubmed publisher |
Chen J, Wang C, Kuang S. Transdifferentiation of Muscle Satellite Cells to Adipose Cells Using CRISPR/Cas9-Mediated Targeting of MyoD. Methods Mol Biol. 2019;1889:25-41 pubmed publisher |
Mohamed A, Shah N, Hettmer S, Vargesson N, Wackerhage H. Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma. Sci Rep. 2018;8:15674 pubmed publisher |
Murthy T, Paul K, MINELLA A, Pillai M. The Development and Use of Scalable Systems for Studying Aberrant Splicing in SF3B1-Mutant CLL. Methods Mol Biol. 2019;1881:83-99 pubmed publisher |
Song Y, Cyburt D, Lucas T, Gregory D, Lyddon T, Johnson M. βTrCP is Required for HIV-1 Vpu Modulation of CD4, GaLV Env, and BST-2/Tetherin. Viruses. 2018;10: pubmed publisher |
Chen L, He X, Xie Y, Huang Y, Wolff D, Abel P, et al. Up-regulated miR-133a orchestrates epithelial-mesenchymal transition of airway epithelial cells. Sci Rep. 2018;8:15543 pubmed publisher |
Finelli M, Aprile D, Castroflorio E, Jeans A, Moschetta M, Chessum L, et al. The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons. Hum Mol Genet. 2019;28:584-597 pubmed publisher |
Mahpour A, Scruggs B, Smiraglia D, Ouchi T, Gelman I. A methyl-sensitive element induces bidirectional transcription in TATA-less CpG island-associated promoters. PLoS ONE. 2018;13:e0205608 pubmed publisher |
Hackett J, Huang Y, Günesdogan U, Gretarsson K, Kobayashi T, Surani M. Tracing the transitions from pluripotency to germ cell fate with CRISPR screening. Nat Commun. 2018;9:4292 pubmed publisher |
Inoko A, Yano T, Miyamoto T, Matsuura S, Kiyono T, Goshima N, et al. Albatross/FBF1 contributes to both centriole duplication and centrosome separation. Genes Cells. 2018;23:1023-1042 pubmed publisher |
Janssen A, Katrukha E, van Straaten W, Verlhac P, Reggiori F, Kapitein L. Probing aggrephagy using chemically-induced protein aggregates. Nat Commun. 2018;9:4245 pubmed publisher |
Idoko Akoh A, Taylor L, Sang H, McGrew M. High fidelity CRISPR/Cas9 increases precise monoallelic and biallelic editing events in primordial germ cells. Sci Rep. 2018;8:15126 pubmed publisher |
Bamford C, Aranday Cortes E, Filipe I, Sukumar S, Mair D, Filipe A, et al. A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages. PLoS Pathog. 2018;14:e1007307 pubmed publisher |
Guo Y, Perez A, Hazelett D, Coetzee G, Rhie S, Farnham P. CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops. Genome Biol. 2018;19:160 pubmed publisher |
Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, et al. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018;47:248-256.e4 pubmed publisher |
Kutsche L, Gysi D, Fallmann J, Lenk K, Petri R, Swiersy A, et al. Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis. Cell Syst. 2018;7:438-452.e8 pubmed publisher |
Pasupala N, Morrow M, Que L, Malynn B, Ma A, Wolberger C. OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination. J Biol Chem. 2018;293:18285-18295 pubmed publisher |
Onodera Y, Teramura T, Takehara T, Itokazu M, Mori T, Fukuda K. Inflammation-associated miR-155 activates differentiation of muscular satellite cells. PLoS ONE. 2018;13:e0204860 pubmed publisher |
Luttrell L, Wang J, Plouffe B, Smith J, Yamani L, Kaur S, et al. Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Sci Signal. 2018;11: pubmed publisher |
Emmer B, Hesketh G, Kotnik E, Tang V, Lascuna P, Xiang J, et al. The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. elife. 2018;7: pubmed publisher |
Zielke S, Meyer N, Mari M, Abou El Ardat K, Reggiori F, van Wijk S, et al. Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Cell Death Dis. 2018;9:994 pubmed publisher |
Parola C, Mason D, Zingg A, Neumeier D, Reddy S. Genome Engineering of Hybridomas to Generate Stable Cell Lines for Antibody Expression. Methods Mol Biol. 2018;1850:79-111 pubmed publisher |
Hikita T, Miyata M, Watanabe R, Oneyama C. Sensitive and rapid quantification of exosomes by fusing luciferase to exosome marker proteins. Sci Rep. 2018;8:14035 pubmed publisher |
Spille J, Hecht M, Grube V, Cho W, Lee C, Cisse I. A CRISPR/Cas9 platform for MS2-labelling of single mRNA in live stem cells. Methods. 2019;153:35-45 pubmed publisher |
Paul S, Dansithong W, Figueroa K, Scoles D, Pulst S. Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration. Nat Commun. 2018;9:3648 pubmed publisher |
Valsecchi C, Basilicata M, Semplicio G, Georgiev P, Gutierrez N, Akhtar A. Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells. Nat Commun. 2018;9:3626 pubmed publisher |
Nowak K, Taubert R, Haberecht S, Venz S, Krüger E. Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition. Biosci Rep. 2018;38: pubmed publisher |
Mohamud Y, Qu J, Xue Y, Liu H, Deng H, Luo H. CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation. Cell Death Differ. 2019;26:1062-1076 pubmed publisher |
Zhu X, Zhong Y, Ge Y, Lu K, Lu S. CRISPR/Cas9-Mediated Generation of Guangxi Bama Minipigs Harboring Three Mutations in ?-Synuclein Causing Parkinson's Disease. Sci Rep. 2018;8:12420 pubmed publisher |
Mann B, Wadsworth P. Distribution of Eg5 and TPX2 in mitosis: Insight from CRISPR tagged cells. Cytoskeleton (Hoboken). 2018;: pubmed publisher |
Chen Q, Kassab M, Dantzer F, Yu X. PARP2 mediates branched poly ADP-ribosylation in response to DNA damage. Nat Commun. 2018;9:3233 pubmed publisher |
Liu G, Lu Y, Thulasi Raman S, Xu F, Wu Q, Li Z, et al. Nuclear-resident RIG-I senses viral replication inducing antiviral immunity. Nat Commun. 2018;9:3199 pubmed publisher |
Ibba G, Piu C, Uleri E, Serra C, Dolei A. Disruption by SaCas9 Endonuclease of HERV-Kenv, a Retroviral Gene with Oncogenic and Neuropathogenic Potential, Inhibits Molecules Involved in Cancer and Amyotrophic Lateral Sclerosis. Viruses. 2018;10: pubmed publisher |
Fang D, Wang H, Zhang Z. Probing the Function of Oncohistones Using Mutant Transgenes and Knock-In Mutations. Methods Mol Biol. 2018;1832:339-356 pubmed publisher |
Kemp J, Brieher W. The actin filament bundling protein α-actinin-4 actually suppresses actin stress fibers by permitting actin turnover. J Biol Chem. 2018;293:14520-14533 pubmed publisher |
Høye A, Tolstrup S, Horton E, Nicolau M, Frost H, Woo J, et al. Tumor endothelial marker 8 promotes cancer progression and metastasis. Oncotarget. 2018;9:30173-30188 pubmed publisher |
Gupta N, Susa K, Yoda Y, Bonventre J, Valerius M, Morizane R. CRISPR/Cas9-based Targeted Genome Editing for the Development of Monogenic Diseases Models with Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2018;45:e50 pubmed publisher |
Dhar S, Bakthavatchalu V, Dhar B, Chen J, Tadahide I, Zhu H, et al. DNA polymerase gamma (Polγ) deficiency triggers a selective mTORC2 prosurvival autophagy response via mitochondria-mediated ROS signaling. Oncogene. 2018;37:6225-6242 pubmed publisher |
Ardelt M, Frohlich T, Martini E, Muller M, Kanitz V, Atzberger C, et al. Inhibition of Cyclin-Dependent Kinase 5: A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy. Hepatology. 2019;69:376-393 pubmed publisher |
Schafer A, Cheng H, Xiong R, Soloveva V, Retterer C, Mo F, et al. Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics. Antiviral Res. 2018;157:47-56 pubmed publisher |
Soto Velasquez M, Hayes M, Alpsoy A, Dykhuizen E, Watts V. A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and cAMP Signaling. Mol Pharmacol. 2018;94:963-972 pubmed publisher |
Alshudukhi A, Zhu J, Huang D, Jama A, Smith J, Wang Q, et al. Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle. FASEB J. 2018;:fj201800374 pubmed publisher |
Murakami T, Kim J, Li Y, Green G, Shikanov A, Ono A. Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions. Nat Commun. 2018;9:2436 pubmed publisher |
Singh K, Sripada L, Lipatova A, Roy M, Prajapati P, Gohel D, et al. NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation. Biochim Biophys Acta Mol Cell Res. 2018;1865:1260-1276 pubmed publisher |
Li D, Wenger T, Seiler C, March M, Gutierrez Uzquiza A, Kao C, et al. Pathogenic variant in EPHB4 results in central conducting lymphatic anomaly. Hum Mol Genet. 2018;27:3233-3245 pubmed publisher |
Stoletov K, Willetts L, Paproski R, Bond D, Raha S, Jovel J, et al. Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis. Nat Commun. 2018;9:2343 pubmed publisher |
Zenke K, Muroi M, Tanamoto K. IRF1 supports DNA binding of STAT1 by promoting its phosphorylation. Immunol Cell Biol. 2018;96:1095-1103 pubmed publisher |
Choi J, Min W, Gopal J, Lee Y, Muthu M, Chun S, et al. Silver nanoparticle-induced hormesis of astroglioma cells: A Mu-2-related death-inducing protein-orchestrated modus operandi. Int J Biol Macromol. 2018;117:1147-1156 pubmed publisher |
Yanik M, Ponnam S, Wimmer T, Trimborn L, Müller C, Gambert I, et al. Development of a Reporter System to Explore MMEJ in the Context of Replacing Large Genomic Fragments. Mol Ther Nucleic Acids. 2018;11:407-415 pubmed publisher |
Oldoni F, van Capelleveen J, Dalila N, Wolters J, Heeren J, Sinke R, et al. Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans. Arterioscler Thromb Vasc Biol. 2018;38:1440-1453 pubmed publisher |
Dimitrova E, Kondo T, Feldmann A, Nakayama M, Koseki Y, Konietzny R, et al. FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment. elife. 2018;7: pubmed publisher |
Li W, Tanikawa T, Kryczek I, Xia H, Li G, Wu K, et al. Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer. Cell Metab. 2018;28:87-103.e6 pubmed publisher |
Lambrus B, Moyer T, Holland A. Applying the auxin-inducible degradation system for rapid protein depletion in mammalian cells. Methods Cell Biol. 2018;144:107-135 pubmed publisher |
Zhang P, Xia J, Zhu J, Gao P, Tian Y, Du M, et al. High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing. Nat Commun. 2018;9:2022 pubmed publisher |
Kong Y, Liang Q, Chen Y, Yang P, Liu X, Li Y, et al. Hyaluronan negatively regulates vascular calcification involving BMP2 signaling. Lab Invest. 2018;98:1320-1332 pubmed publisher |
Ahmed W, Lingner J. PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase. Genes Dev. 2018;32:658-669 pubmed publisher |
Andrews J, Conway W, Cho W, Narayanan A, Spille J, Jayanth N, et al. qSR: a quantitative super-resolution analysis tool reveals the cell-cycle dependent organization of RNA Polymerase I in live human cells. Sci Rep. 2018;8:7424 pubmed publisher |
Copeland S, McRae A, Guarguaglini G, Trinkle Mulcahy L, Copeland J. Actin-dependent regulation of cilia length by the inverted formin FHDC1. Mol Biol Cell. 2018;29:1611-1627 pubmed publisher |
Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam A, Sattentau Q, Meinhart A, et al. RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Mol Cell. 2018;70:650-662.e8 pubmed publisher |
Khlghatyan J, Evstratova A, Chamberland S, Marakhovskaia A, Bahremand A, Toth K, et al. Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission. Front Mol Neurosci. 2018;11:119 pubmed publisher |
Ge J, Burnier L, Adamopoulou M, Kwa M, Schaks M, Rottner K, et al. RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells. J Biol Chem. 2018;293:9358-9369 pubmed publisher |
Indra I, Choi J, Chen C, Troyanovsky R, Shapiro L, Honig B, et al. Spatial and temporal organization of cadherin in punctate adherens junctions. Proc Natl Acad Sci U S A. 2018;115:E4406-E4415 pubmed publisher |
Wang W, Zheng W, Hu F, He X, Wu D, Zhang W, et al. Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9. ACS Synth Biol. 2018;7:1259-1268 pubmed publisher |
Kato Inui T, Takahashi G, Hsu S, Miyaoka Y. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair. Nucleic Acids Res. 2018;46:4677-4688 pubmed publisher |
Lee K, Chatterjee P, Choi E, Sung M, Oh J, Won H, et al. Selection on the regulation of sympathetic nervous activity in humans and chimpanzees. PLoS Genet. 2018;14:e1007311 pubmed publisher |
Demirel I, Persson A, Brauner A, Särndahl E, Kruse R, Persson K. Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells. Front Cell Infect Microbiol. 2018;8:81 pubmed publisher |
Yu X, Zhang Y, Ma X, Pertsemlidis A. miR-195 potentiates the efficacy of microtubule-targeting agents in non-small cell lung cancer. Cancer Lett. 2018;427:85-93 pubmed publisher |
Beyer T, Bolz S, Junger K, Horn N, Moniruzzaman M, Wissinger Y, et al. CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement. Mol Cell Proteomics. 2018;17:1285-1294 pubmed publisher |
Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, et al. Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs. Endocr Relat Cancer. 2018;25:619-631 pubmed publisher |
Kwasna D, Abdul Rehman S, Natarajan J, Matthews S, Madden R, De Cesare V, et al. Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability. Mol Cell. 2018;70:150-164.e6 pubmed publisher |
Poppelreuther M, Sander S, Minden F, Dietz M, Exner T, Du C, et al. The metabolic capacity of lipid droplet localized acyl-CoA synthetase 3 is not sufficient to support local triglyceride synthesis independent of the endoplasmic reticulum in A431 cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:614-624 pubmed publisher |
Johnson B, Vanblargan L, Xu W, White J, Shan C, Shi P, et al. Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity. 2018;48:487-499.e5 pubmed publisher |
Jung J, Eggleton P, Robinson A, Wang J, Gutowski N, Holley J, et al. Calnexin is necessary for T cell transmigration into the central nervous system. JCI Insight. 2018;3: pubmed publisher |
Zhao N, Cao J, Xu L, Tang Q, Dobrolecki L, Lv X, et al. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018;128:1283-1299 pubmed publisher |
Paul M, Zelensky A, Wyman C, Kanaar R. Single-Molecule Dynamics and Localization of DNA Repair Proteins in Cells. Methods Enzymol. 2018;600:375-406 pubmed publisher |
Ringer K, Roth M, Garey M, Piorczynski T, Suli A, Hansen J, et al. Comparative analysis of lipid-mediated CRISPR-Cas9 genome editing techniques. Cell Biol Int. 2018;42:849-858 pubmed publisher |
Arnhold V, Schmelz K, Proba J, Winkler A, W nschel J, Toedling J, et al. Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma. Oncotarget. 2018;9:2304-2319 pubmed publisher |
Yu X, Zhang Y, Cavazos D, Ma X, Zhao Z, Du L, et al. miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer. Cell Death Dis. 2018;9:193 pubmed publisher |
Josipovic I, Pflüger B, Fork C, Vasconez A, Oo J, Hitzel J, et al. Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell function. J Mol Cell Cardiol. 2018;116:57-68 pubmed publisher |
Youn J, Dunham W, Hong S, Knight J, Bashkurov M, Chen G, et al. High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Mol Cell. 2018;69:517-532.e11 pubmed publisher |
Gupta D, Lin B, Cowan A, Heinen C. ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage. Proc Natl Acad Sci U S A. 2018;115:1523-1528 pubmed publisher |
Dufour C, Claudel A, Joubarne N, Merindol N, Maisonnet T, Masroori N, et al. Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1. PLoS ONE. 2018;13:e0191709 pubmed publisher |
Abbasi F, Miyata H, Ikawa M. Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR/Cas9. Reprod Med Biol. 2018;17:3-10 pubmed publisher |
Sharma A, Toepfer C, Ward T, WASSON L, Agarwal R, Conner D, et al. CRISPR/Cas9-Mediated Fluorescent Tagging of Endogenous Proteins in Human Pluripotent Stem Cells. Curr Protoc Hum Genet. 2018;96:21.11.1-21.11.20 pubmed publisher |
Lin H, Wei S, Hurt E, Green M, Zhao L, Vatan L, et al. Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression. J Clin Invest. 2018;128:805-815 pubmed publisher |
Kim W, Lee S, Kim H, Song M, Cha Y, Kim Y, et al. Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth. Genome Res. 2018;: pubmed publisher |
Kosmidou C, Efstathiou N, Hoang M, Notomi S, Konstantinou E, Hirano M, et al. Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Sci Rep. 2018;8:461 pubmed publisher |
Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh J, et al. The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. EMBO J. 2018;37: pubmed publisher |
Stepniewski J, Pacholczak T, Skrzypczyk A, Ciesla M, Szade A, Szade K, et al. Heme oxygenase-1 affects generation and spontaneous cardiac differentiation of induced pluripotent stem cells. IUBMB Life. 2018;70:129-142 pubmed publisher |
Mita P, Wudzinska A, Sun X, Andrade J, Nayak S, Kahler D, et al. LINE-1 protein localization and functional dynamics during the cell cycle. elife. 2018;7: pubmed publisher |
Steyer B, Bu Q, Cory E, Jiang K, Duong S, Sinha D, et al. Scarless Genome Editing of Human Pluripotent Stem Cells via Transient Puromycin Selection. Stem Cell Reports. 2018;10:642-654 pubmed publisher |
Smith M, Harley M, Kemp A, Wills J, Lee M, Arends M, et al. CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis. Dev Cell. 2018;44:217-232.e11 pubmed publisher |
Tajai P, Fedeles B, Suriyo T, Navasumrit P, Kanitwithayanun J, Essigmann J, et al. An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity. Free Radic Biol Med. 2018;116:64-72 pubmed publisher |
Tang N, Zhang Y, Pedrera M, Chang P, Baigent S, Moffat K, et al. A simple and rapid approach to develop recombinant avian herpesvirus vectored vaccines using CRISPR/Cas9 system. Vaccine. 2018;36:716-722 pubmed publisher |
Corsinotti A, Wong F, Tatar T, Szczerbinska I, Halbritter F, Colby D, et al. Distinct SoxB1 networks are required for naïve and primed pluripotency. elife. 2017;6: pubmed publisher |
Zhang X, Saarinen A, Hitosugi T, Wang Z, Wang L, Ho T, et al. Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia. elife. 2017;6: pubmed publisher |
Chung E, Efstathiou N, Konstantinou E, Maidana D, Miller J, Young L, et al. AICAR suppresses TNF-α-induced complement factor B in RPE cells. Sci Rep. 2017;7:17651 pubmed publisher |
Zenke K, Muroi M, Tanamoto K. AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner. Cell Signal. 2018;43:32-39 pubmed publisher |
Weigert M, Binks A, Dowson S, Leung E, Athineos D, Yu X, et al. RIPK3 promotes adenovirus type 5 activity. Cell Death Dis. 2017;8:3206 pubmed publisher |
He M, Ye W, Wang W, Sison E, Jan Y, Jan L. Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis. Proc Natl Acad Sci U S A. 2017;114:E11161-E11169 pubmed publisher |
Van Itallie C, Tietgens A, Aponte A, Gucek M, Cartagena Rivera A, Chadwick R, et al. MARCKS-related protein regulates cytoskeletal organization at cell-cell and cell-substrate contacts in epithelial cells. J Cell Sci. 2018;131: pubmed publisher |
Adikusuma F, Pfitzner C, Thomas P. Versatile single-step-assembly CRISPR/Cas9 vectors for dual gRNA expression. PLoS ONE. 2017;12:e0187236 pubmed publisher |
Christie K, Courtney D, DeDionisio L, Shern C, De Majumdar S, Mairs L, et al. Towards personalised allele-specific CRISPR gene editing to treat autosomal dominant disorders. Sci Rep. 2017;7:16174 pubmed publisher |
Das S, Senapati P, Chen Z, Reddy M, Ganguly R, Lanting L, et al. Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells. Nat Commun. 2017;8:1467 pubmed publisher |
Akaike T, Ida T, Wei F, Nishida M, Kumagai Y, Alam M, et al. Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Nat Commun. 2017;8:1177 pubmed publisher |
Zaucker A, Nagorska A, Kumari P, Hecker N, Wang Y, Huang S, et al. Translational co-regulation of a ligand and inhibitor by a conserved RNA element. Nucleic Acids Res. 2018;46:104-119 pubmed publisher |
Schmidt N, Kollewe A, Constantin C, Henrich S, Ritzau Jost A, Bildl W, et al. Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca2+-ATPases and Key Regulators of Ca2+ Clearance. Neuron. 2017;96:827-838.e9 pubmed publisher |
Vaites L, Paulo J, Huttlin E, Harper J. Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux. Mol Cell Biol. 2018;38: pubmed publisher |
Distasio A, Driver A, Sund K, Donlin M, Muraleedharan R, Pooya S, et al. Copb2 is essential for embryogenesis and hypomorphic mutations cause human microcephaly. Hum Mol Genet. 2017;26:4836-4848 pubmed publisher |
Sluch V, Chamling X, Liu M, Berlinicke C, Cheng J, Mitchell K, et al. Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells. Stem Cells Transl Med. 2017;6:1972-1986 pubmed publisher |
Schubert L, Ho T, Hoffmann S, Haahr P, Guérillon C, Mailand N. RADX interacts with single-stranded DNA to promote replication fork stability. EMBO Rep. 2017;18:1991-2003 pubmed publisher |
Onodera Y, Teramura T, Takehara T, Obora K, Mori T, Fukuda K. miR-155 induces ROS generation through downregulation of antioxidation-related genes in mesenchymal stem cells. Aging Cell. 2017;16:1369-1380 pubmed publisher |
Carleton J, Berrett K, Gertz J. Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor α-Bound Enhancers. Cell Syst. 2017;5:333-344.e5 pubmed publisher |
Fredriksson Lidman K, Van Itallie C, Tietgens A, Anderson J. Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. PLoS ONE. 2017;12:e0185448 pubmed publisher |
Rhodes J, Haarhuis J, Grimm J, Rowland B, Lavis L, Nasmyth K. Cohesin Can Remain Associated with Chromosomes during DNA Replication. Cell Rep. 2017;20:2749-2755 pubmed publisher |
Rhodes J, Mazza D, Nasmyth K, Uphoff S. Scc2/Nipbl hops between chromosomal cohesin rings after loading. elife. 2017;6: pubmed publisher |
Galloway C, Dalvi S, Hung S, MacDonald L, Latchney L, Wong R, et al. Drusen in patient-derived hiPSC-RPE models of macular dystrophies. Proc Natl Acad Sci U S A. 2017;114:E8214-E8223 pubmed publisher |
Takahara T, Inoue K, Arai Y, Kuwata K, Shibata H, Maki M. The calcium-binding protein ALG-2 regulates protein secretion and trafficking via interactions with MISSL and MAP1B proteins. J Biol Chem. 2017;292:17057-17072 pubmed publisher |
Hezroni H, Ben Tov Perry R, Meir Z, Housman G, Lubelsky Y, Ulitsky I. A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes. Genome Biol. 2017;18:162 pubmed publisher |
Bluhm B, Ehlen H, Holzer T, Georgieva V, Heilig J, Pitzler L, et al. miR-322 stabilizes MEK1 expression to inhibit RAF/MEK/ERK pathway activation in cartilage. Development. 2017;144:3562-3577 pubmed publisher |
Rocchi A, Yamamoto S, Ting T, Fan Y, SADLEIR K, Wang Y, et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017;13:e1006962 pubmed publisher |
Cui Y, Wu B, Flamini V, Evans B, Zhou D, Jiang W. Knockdown of EPHA1 Using CRISPR/CAS9 Suppresses Aggressive Properties of Ovarian Cancer Cells. Anticancer Res. 2017;37:4415-4424 pubmed |
Flack J, Mieszczanek J, Novcic N, Bienz M. Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Mol Cell. 2017;67:181-193.e5 pubmed publisher |
Zelensky A, Schimmel J, Kool H, Kanaar R, Tijsterman M. Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA. Nat Commun. 2017;8:66 pubmed publisher |
Jiang P, Li Y, Poleshko A, Medvedeva V, Baulina N, Zhang Y, et al. The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network. EBioMedicine. 2017;22:28-43 pubmed publisher |
Pousinha P, Mouska X, Raymond E, Gwizdek C, Dhib G, Poupon G, et al. Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein. elife. 2017;6: pubmed publisher |
Zhang C, Lai M, Khandan L, Lee L, Chen Z, Junge H. Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function. Nat Commun. 2017;8:16050 pubmed publisher |
Malpotra S, Vats A, Kumar S, Gautam D, De S. Generation of Genomic Deletions (of Rig-I GENE) in Goat Primary Cell Culture Using CRISPR/CAS9 Method. Anim Biotechnol. 2018;29:142-152 pubmed publisher |
Lai M, Zhang C, Shi J, Johnson V, Khandan L, McVey J, et al. TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling. Cell Rep. 2017;19:2809-2822 pubmed publisher |
Noda T, Oji A, Ikawa M. Genome Editing in Mouse Zygotes and Embryonic Stem Cells by Introducing SgRNA/Cas9 Expressing Plasmids. Methods Mol Biol. 2017;1630:67-80 pubmed publisher |
Hindriksen S, Bramer A, Truong M, Vromans M, Post J, Verlaan Klink I, et al. Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. PLoS ONE. 2017;12:e0179514 pubmed publisher |
Song F, Stieger K. Optimizing the DNA Donor Template for Homology-Directed Repair of Double-Strand Breaks. Mol Ther Nucleic Acids. 2017;7:53-60 pubmed publisher |
Mohsen Z, Sim H, García Galiano D, Han X, Bellefontaine N, Saunders T, et al. Sexually dimorphic distribution of Prokr2 neurons revealed by the Prokr2-Cre mouse model. Brain Struct Funct. 2017;222:4111-4129 pubmed publisher |
Inoue T, Tsai B. Regulated Erlin-dependent release of the B12 transmembrane J-protein promotes ER membrane penetration of a non-enveloped virus. PLoS Pathog. 2017;13:e1006439 pubmed publisher |
Skvarova Kramarzova K, Osborn M, Webber B, Defeo A, McElroy A, Kim C, et al. CRISPR/Cas9-Mediated Correction of the FANCD1 Gene in Primary Patient Cells. Int J Mol Sci. 2017;18: pubmed publisher |
Gong F, Clouaire T, Aguirrebengoa M, Legube G, Miller K. Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair. J Cell Biol. 2017;216:1959-1974 pubmed publisher |
Lalonde S, Stone O, Lessard S, Lavertu A, Desjardins J, Beaudoin M, et al. Frameshift indels introduced by genome editing can lead to in-frame exon skipping. PLoS ONE. 2017;12:e0178700 pubmed publisher |
Beautrait A, Paradis J, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017;8:15054 pubmed publisher |
Pennington M, Van De Walle G. Electric Cell-Substrate Impedance Sensing To Monitor Viral Growth and Study Cellular Responses to Infection with Alphaherpesviruses in Real Time. mSphere. 2017;2: pubmed publisher |
Lo C, Greben A, Chen B. Generating stable cell lines with quantifiable protein production using CRISPR/Cas9-mediated knock-in. Biotechniques. 2017;62:165-174 pubmed publisher |
Hahn F, Schmalen A, Setz C, Friedrich M, Schlößer S, Kölle J, et al. Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner. PLoS ONE. 2017;12:e0174254 pubmed publisher |
Pradeepa M, McKenna F, Taylor G, Bengani H, Grimes G, Wood A, et al. Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip. PLoS Genet. 2017;13:e1006677 pubmed publisher |
Takayama K, Matsuura A, Itakura E. Dissection of ubiquitinated protein degradation by basal autophagy. FEBS Lett. 2017;591:1199-1211 pubmed publisher |
Aktas T, Avşar Ilık İ, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G, et al. DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature. 2017;544:115-119 pubmed publisher |
McFarland A, Luo S, Ahmed Qadri F, Zuck M, Thayer E, Goo Y, et al. Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State. Immunity. 2017;46:433-445 pubmed publisher |
Han D, Chen Q, Shi J, Zhang F, Yu X. CTCF participates in DNA damage response via poly(ADP-ribosyl)ation. Sci Rep. 2017;7:43530 pubmed publisher |
Zhang Y, Schmid B, Nikolaisen N, Rasmussen M, Aldana B, Agger M, et al. Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B. Stem Cell Reports. 2017;8:648-658 pubmed publisher |
Walter D, Venancio O, Buza E, Tobias J, Deshpande C, Gudiel A, et al. Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma. Cancer Res. 2017;77:1719-1729 pubmed publisher |
Fujii K, Shi Z, Zhulyn O, Denans N, Barna M. Pervasive translational regulation of the cell signalling circuitry underlies mammalian development. Nat Commun. 2017;8:14443 pubmed publisher |
Dietsch F, Donzeau M, Cordonnier A, Weiss E, Chatton B, Vigneron M. A fast method for analyzing essential protein mutants in human cells. Biotechniques. 2017;62:80-82 pubmed publisher |
Carter H, Marty R, Hofree M, Gross A, Jensen J, Fisch K, et al. Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. Cancer Discov. 2017;7:410-423 pubmed publisher |
Damiani E, Puebla Osorio N, Lege B, Liu J, Neelapu S, Ullrich S. Platelet activating factor-induced expression of p21 is correlated with histone acetylation. Sci Rep. 2017;7:41959 pubmed publisher |
Hummel B, Hansen E, Yoveva A, Aprile Garcia F, Hussong R, Sawarkar R. The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses. Nat Struct Mol Biol. 2017;24:234-242 pubmed publisher |
Bai X, Mangum K, Dee R, Stouffer G, Lee C, Oni Orisan A, et al. Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. J Clin Invest. 2017;127:670-680 pubmed publisher |
Günaltay S, Ghiboub M, Hultgren O, Hörnquist E. Reduced IL-37 Production Increases Spontaneous Chemokine Expressions in Colon Epithelial Cells. Dig Dis Sci. 2017;62:1204-1215 pubmed publisher |
Van Nostrand E, Gelboin Burkhart C, Wang R, Pratt G, Blue S, Yeo G. CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins. Methods. 2017;118-119:50-59 pubmed publisher |
Latomanski E, Newton P, Khoo C, Newton H. The Effector Cig57 Hijacks FCHO-Mediated Vesicular Trafficking to Facilitate Intracellular Replication of Coxiella burnetii. PLoS Pathog. 2016;12:e1006101 pubmed publisher |
Moon S, Kim W, Kim S, Kim Y, Song Y, Bilousov O, et al. Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization. EMBO Rep. 2017;18:61-71 pubmed publisher |
Van Itallie C, Tietgens A, Anderson J. Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1. Mol Biol Cell. 2017;28:524-534 pubmed publisher |
Nimsanor N, Poulsen U, Rasmussen M, Clausen C, Mau Holzmann U, Nielsen J, et al. Generation of an isogenic, gene-corrected iPSC line from a pre-symptomatic 28-year-old woman with an R406W mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Res. 2016;17:600-602 pubmed publisher |
Nimsanor N, Poulsen U, Rasmussen M, Clausen C, Mau Holzmann U, Nielsen J, et al. Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Res. 2016;17:576-579 pubmed publisher |
Yu H, Zhang H, Dong M, Wu Z, Shen Z, Xie Y, et al. Metabolic reprogramming and AMPK?1 pathway activation by caulerpin in colorectal cancer cells. Int J Oncol. 2017;50:161-172 pubmed publisher |
Yasuda H, Oh C, Chen D, de Crombrugghe B, Kim J. A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6. J Biol Chem. 2017;292:528-538 pubmed publisher |
Noordstra I, Liu Q, Nijenhuis W, Hua S, Jiang K, Baars M, et al. Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7. J Cell Sci. 2016;129:4278-4288 pubmed |
Nimsanor N, Kitiyanant N, Poulsen U, Rasmussen M, Clausen C, Mau Holzmann U, et al. Generation of an isogenic, gene-corrected iPSC line from a symptomatic 57-year-old female patient with frontotemporal dementia caused by a P301L mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Res. 2016;17:556-559 pubmed publisher |
Poon A, Schmid B, Pires C, Nielsen T, Hjermind L, Nielsen J, et al. Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1. Stem Cell Res. 2016;17:466-469 pubmed publisher |
Cho W, Jayanth N, Mullen S, Tan T, Jung Y, Cissé I. Super-resolution imaging of fluorescently labeled, endogenous RNA Polymerase II in living cells with CRISPR/Cas9-mediated gene editing. Sci Rep. 2016;6:35949 pubmed publisher |
Haahr P, Hoffmann S, Tollenaere M, Ho T, Toledo L, Mann M, et al. Activation of the ATR kinase by the RPA-binding protein ETAA1. Nat Cell Biol. 2016;18:1196-1207 pubmed publisher |
Yuen K, Chan C, Kok K, Jin D. Mutagenesis and Genome Engineering of Epstein-Barr Virus in Cultured Human Cells by CRISPR/Cas9. Methods Mol Biol. 2017;1498:23-31 pubmed |
Prior K, Leisegang M, Josipovic I, Löwe O, Shah A, Weissmann N, et al. CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity. Redox Biol. 2016;9:287-295 pubmed publisher |
Zhang Y, Schmid B, Nielsen T, Nielsen J, Clausen C, Hyttel P, et al. Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B. Stem Cell Res. 2016;17:151-153 pubmed publisher |
Zhang Y, Schmid B, Nielsen T, Nielsen J, Clausen C, Hyttel P, et al. Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B. Stem Cell Res. 2016;17:148-150 pubmed publisher |
Santos D, Kiskinis E, Eggan K, Merkle F. Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2016;38:5B.6.1-5B.6.60 pubmed publisher |
Walton J, Blagih J, Ennis D, Leung E, Dowson S, Farquharson M, et al. CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma. Cancer Res. 2016;76:6118-6129 pubmed |
Xiao A, Zhang B. Generation of Targeted Genomic Deletions Through CRISPR/Cas System in Zebrafish. Methods Mol Biol. 2016;1451:65-79 pubmed publisher |
Rickels R, Hu D, Collings C, Woodfin A, Piunti A, Mohan M, et al. An Evolutionary Conserved Epigenetic Mark of Polycomb Response Elements Implemented by Trx/MLL/COMPASS. Mol Cell. 2016;63:318-328 pubmed publisher |
Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, et al. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. EMBO Mol Med. 2016;8:992-1004 pubmed publisher |
Du J, Leung A, Trac C, Lee M, Parks B, Lusis A, et al. Chromatin variation associated with liver metabolism is mediated by transposable elements. Epigenetics Chromatin. 2016;9:28 pubmed publisher |
Zhang R, Miner J, Gorman M, Rausch K, Ramage H, White J, et al. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature. 2016;535:164-8 pubmed |
Hung S, Chrysostomou V, Li F, Lim J, Wang J, Powell J, et al. AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo. Invest Ophthalmol Vis Sci. 2016;57:3470-6 pubmed publisher |
Dam S, Kracht M, Pleschka S, Schmitz M. The Influenza A Virus Genotype Determines the Antiviral Function of NF-?B. J Virol. 2016;90:7980-90 pubmed publisher |
Madureira P, Bharadwaj A, Bydoun M, Garant K, O Connell P, Lee P, et al. Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10. Oncotarget. 2016;7:47720-47737 pubmed publisher |
Cho H, Kim M, Jang Y. The BRPF2/BRD1-MOZ complex is involved in retinoic acid-induced differentiation of embryonic stem cells. Exp Cell Res. 2016;346:30-9 pubmed publisher |
Hung S, McCaughey T, Swann O, Pebay A, Hewitt A. Genome engineering in ophthalmology: Application of CRISPR/Cas to the treatment of eye disease. Prog Retin Eye Res. 2016;53:1-20 pubmed publisher |
Vad Nielsen J, Lin L, Bolund L, Nielsen A, Luo Y. Golden Gate Assembly of CRISPR gRNA expression array for simultaneously targeting multiple genes. Cell Mol Life Sci. 2016;73:4315-4325 pubmed |
Watanabe Y, Murdoch C, Sano S, Ido Y, Bachschmid M, Cohen R, et al. Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1α and improve limb revascularization. Proc Natl Acad Sci U S A. 2016;113:6011-6 pubmed publisher |
Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, et al. Tumour resistance in induced pluripotent stem cells derived from naked mole-rats. Nat Commun. 2016;7:11471 pubmed publisher |
Kaczmarczyk L, Mende Y, Zevnik B, Jackson W. Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9. PLoS ONE. 2016;11:e0154604 pubmed publisher |
Josipovic I, Fork C, Preussner J, Prior K, Iloska D, Vasconez A, et al. PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells. Acta Physiol (Oxf). 2016;218:13-27 pubmed publisher |
Karnan S, Ota A, Konishi Y, Wahiduzzaman M, Hosokawa Y, Konishi H. Improved methods of AAV-mediated gene targeting for human cell lines using ribosome-skipping 2A peptide. Nucleic Acids Res. 2016;44:e54 pubmed publisher |
Van Itallie C, Tietgens A, Krystofiak E, Kachar B, Anderson J. A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction. Mol Biol Cell. 2015;26:2769-87 pubmed publisher |
Ran F, Hsu P, Wright J, Agarwala V, Scott D, Zhang F. Genome engineering using the CRISPR-Cas9 system. Nat Protoc. 2013;8:2281-2308 pubmed publisher |
