This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pcDNA3-Flag-IDH1-R132H
catalog :
62907
citations: 5
Reference
Kramer M, Zhang Q, Sprung R, Day R, Erdmann Gilmore P, Li Y, et al. Proteomic and phosphoproteomic landscapes of acute myeloid leukemia. Blood. 2022;140:1533-1548 pubmed publisher
Fukunaga T, Fujita Y, Kishima H, Yamashita T. Methylation dependent down-regulation of G0S2 leads to suppression of invasion and improved prognosis of IDH1-mutant glioma. PLoS ONE. 2018;13:e0206552 pubmed publisher
Avellaneda Matteo D, Wells G, Luna L, Grunseth A, Zagnitko O, Scott D, et al. Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants. Biochem J. 2018;475:3221-3238 pubmed publisher
Sun X, Zhu M. Butyrate Inhibits Indices of Colorectal Carcinogenesis via Enhancing α-Ketoglutarate-Dependent DNA Demethylation of Mismatch Repair Genes. Mol Nutr Food Res. 2018;62:e1700932 pubmed publisher
Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009;324:261-5 pubmed publisher
product information
Catalog Number :
62907
Product Name :
pcDNA3-Flag-IDH1-R132H
article :
doi10.1126/science.1170944
id9724
pubmed_id19359588
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5473
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth strain :
Expresses R132 mutant IDH1 in mammalian cells
origin :
37
pi :
alt_names
Isocitrate Dehydrogenase
cloning
entrez_gene
aliasesHEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD
geneIDH1
id3417
genbank_ids
NG_023319.2
mutationDeleted Arg132 (R132)
nameIDH1
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagFlag
resistance markers :
593
tags :
Unknown
terms :
Other
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA