This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
3I91
catalog :
62514
citations: 4
Reference
Wang S, Denton K, Hobbs K, Weaver T, McFarlane J, Connelly K, et al. Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. ACS Chem Biol. 2020;15:112-131 pubmed publisher
Connelly K, Weaver T, Alpsoy A, Gu B, Musselman C, Dykhuizen E. Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association. Nucleic Acids Res. 2019;47:2289-2305 pubmed publisher
Milosevich N, Gignac M, McFarlane J, Simhadri C, Horvath S, Daze K, et al. Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family. ACS Med Chem Lett. 2016;7:139-44 pubmed publisher
Kaustov L, Ouyang H, Amaya M, Lemak A, Nady N, Duan S, et al. Recognition and specificity determinants of the human cbx chromodomains. J Biol Chem. 2011;286:521-9 pubmed publisher
product information
Catalog Number :
62514
Product Name :
3I91
article :
doi10.1074/jbc.M110.191411
id9620
pubmed_id21047797
bacterial resistance :
Kanamycin
cloning :
backbonepET28-MHL
backbone_mutation
backbone_originSGC (Addgene Plasmid # 26096)
backbone_size7325
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Bacterial Expression
growth notes :
For more information, please see: http://www.thesgc.org/structures/3i91/ http://www.thesgc.org/structures/5EQ0/
growth strain :
Bacterial expression plasmid for use in structural determination.
origin :
37
pi :
alt_names
chromobox homolog 8
PDB IDs: 3I91, 5EQ0
cloning
clone_methodLigation Independent Cloning
cloning_site_3
cloning_site_5
promoterT7
sequencing_primer_3T7-term
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesPC3, RC1
geneCBX8
id57332
genbank_ids
mutation
nameCBX8
shRNA_sequence
size162
species
9606
Homo sapiens
tags
locationN terminal on backbone
tag6xHis
locationN terminal on backbone
tagTEV cleavage
resistance markers :
732
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA