This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pOTTC293 - pAAV EF1a V5-synuclein (WT)
catalog :
60057
citations: 6
Reference
Cui H, Kilpeläinen T, Zouzoula L, Auno S, Trontti K, Kurvonen S, et al. Prolyl oligopeptidase inhibition reduces alpha-synuclein aggregation in a cellular model of multiple system atrophy. J Cell Mol Med. 2021;25:9634-9646 pubmed publisher
Julku U, Jäntti M, Svarcbahs R, Myöhänen T. Prolyl Oligopeptidase Regulates Dopamine Transporter Oligomerization and Phosphorylation in a PKC- and ERK-Independent Manner. Int J Mol Sci. 2021;22: pubmed publisher
Bäck S, Dossat A, Parkkinen I, Koivula P, Airavaara M, Richie C, et al. Neuronal Activation Stimulates Cytomegalovirus Promoter-Driven Transgene Expression. Mol Ther Methods Clin Dev. 2019;14:180-188 pubmed publisher
Bäck S, Necarsulmer J, Whitaker L, Coke L, Koivula P, Heathward E, et al. Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Neuron. 2019;102:105-119.e8 pubmed publisher
Svarcbahs R, Julku U, Norrbacka S, Myöhänen T. Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo. Sci Rep. 2018;8:1552 pubmed publisher
Savolainen M, Richie C, Harvey B, Mannisto P, Maguire Zeiss K, Myöhänen T. The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse. Neurobiol Dis. 2014;68:1-15 pubmed publisher
product information
Catalog Number :
60057
Product Name :
pOTTC293 - pAAV EF1a V5-synuclein (WT)
article :
doi10.1016/j.nbd.2014.04.003
id9019
pubmed_id24746855
bacterial resistance :
Ampicillin
cloning :
backbonepAAV-EF1a-double floxed-hChR2(H134R)-mCherry-WPRE-HGHpA (Addgene 20297)
backbone_mutation
backbone_originKarl Deisseroth
backbone_size
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
AAV
growth strain :
An AAV packaging vector that expresses wildtype alpha-synuclein under control of the EF1a promoter.
origin :
30
pi :
alt_names
SCNA
cloning
clone_methodLigation Independent Cloning
cloning_site_3
cloning_site_5
promoterEF1a
sequencing_primer_3WPRE_R1
sequencing_primer_5EF1a_F1
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesNACP, PARK1, PARK4, PD1
geneSNCA
id6622
genbank_ids
NM_000345
mutation
namealpha-synuclein
shRNA_sequence
size423
species
9606
Homo sapiens
32644
Other
human
tags
locationN terminal on insert
tagV5
resistance markers :
1684
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA