pCMV HA hRb delta CDK | Addgene 58906 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Addgene

product type :

cDNA

product name :

pCMV HA hRb delta CDK

catalog :

58906

citations: 3

Reference
De Rosa P, Severi F, Zadran S, Russo M, Aloisi S, Rigamonti A, et al. MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors' Efficacy in Neuroblastoma Cells. Int J Mol Sci. 2023;24: pubmed publisher
Voigt E, Wallenburg M, Wollenzien H, Thompson E, Kumar K, Feiner J, et al. Sox2 Is an Oncogenic Driver of Small-Cell Lung Cancer and Promotes the Classic Neuroendocrine Subtype. Mol Cancer Res. 2021;19:2015-2025 pubmed publisher
Narasimha A, Kaulich M, Shapiro G, Choi Y, Sicinski P, Dowdy S. Cyclin D activates the Rb tumor suppressor by mono-phosphorylation. elife. 2014;3: pubmed publisher

product information

Catalog Number :

58906

Product Name :

pCMV HA hRb delta CDK

article :

doi	10.7554/eLife.02872
id	8750
pubmed_id	24876129

bacterial resistance :

Ampicillin

cloning :

backbone

pCMV

backbone_mutation

backbone_origin

Clontech

backbone_size

promoter

sequencing_primer_3

sequencing_primer_5

vector_types

Mammalian Expression

growth strain :

mammalian expression of human Rb with all Ser/Thr Cdk acceptor sites removed

origin :

pi :

alt_names

retinoblastoma tumor suppressor protein

cloning

clone_method	Unknown
cloning_site_3
cloning_site_5
promoter	CMV
sequencing_primer_3	EBV-rev
sequencing_primer_5	CMV-F
site_3_destroyed
site_5_destroyed

entrez_gene

aliases	OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb, pp110
gene	RB1
id	5925

genbank_ids

mutation

all 15 Ser/Thr Cdk acceptor sites changed to Ala, with Ser567 left unaltered (T5, S230A, S249A, T252A, T356A, T373A, S608A, S612A, S780A, S788A, S795A, S807A, S811A, T821A, T826A)

name

shRNA_sequence

size

2787

species

9606

Homo sapiens