This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCMV HA hRB-wt
catalog :
58905
citations: 6
Reference
De Rosa P, Severi F, Zadran S, Russo M, Aloisi S, Rigamonti A, et al. MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors' Efficacy in Neuroblastoma Cells. Int J Mol Sci. 2023;24: pubmed publisher
Koch J, Schober S, Hindupur S, Sch xf6 ning C, Klein F, Mantwill K, et al. Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus. Nat Commun. 2022;13:4689 pubmed publisher
Yang W, Jiang X, Zhao X, Mao P. Treatment of RB-deficient retinoblastoma with Aurora-A kinase inhibitor. Kaohsiung J Med Sci. 2021;: pubmed publisher
Kuganesan N, Dlamini S, Tillekeratne L, Taylor W. Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F. J Biol Chem. 2021;297:101365 pubmed publisher
Bollaert E, Johanns M, Herinckx G, de Rocca Serra A, Vandewalle V, Havelange V, et al. HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation. Cell Signal. 2018;44:158-170 pubmed publisher
Narasimha A, Kaulich M, Shapiro G, Choi Y, Sicinski P, Dowdy S. Cyclin D activates the Rb tumor suppressor by mono-phosphorylation. elife. 2014;3: pubmed publisher
product information
Catalog Number :
58905
Product Name :
pCMV HA hRB-wt
article :
doi10.7554/eLife.02872
id8750
pubmed_id24876129
bacterial resistance :
Ampicillin
cloning :
backbonepCMV
backbone_mutation
backbone_originClontech
backbone_size
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth strain :
mammalian expression of wild type human Rb
origin :
37
pi :
alt_names
retinoblastoma tumor suppressor protein
cloning
clone_methodUnknown
cloning_site_3
cloning_site_5
promoterCMV
sequencing_primer_3EBV-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesOSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb, pp110
geneRB1
id5925
genbank_ids
mutation
nameRb
shRNA_sequence
size2787
species
9606
Homo sapiens
tags
locationN terminal on insert
tagHA
resistance markers :
1187
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA