This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pBabe-Kras G12C
catalog :
58901
citations: 6
Reference
Shin D, Jo J, Choi M, Kim K, Bae Y, Kim S. Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer. Exp Mol Med. 2023;55:2220-2237 pubmed publisher
Huynh M, Parsonage D, Forshaw T, Chirasani V, Hobbs G, Wu H, et al. Oncogenic KRAS G12C: Kinetic and Redox Characterization of Covalent Inhibition. J Biol Chem. 2022;:102186 pubmed publisher
Sad K, Parashar P, Tripathi P, Hungyo H, Sistla R, Soni R, et al. Prochlorperazine enhances radiosensitivity of non-small cell lung carcinoma by stabilizing GDP-bound mutant KRAS conformation. Free Radic Biol Med. 2021;177:299-312 pubmed publisher
Liu J, Sun M, Cho K, Gao X, Guo B. A CRISPR-Cas9 repressor for epigenetic silencing of KRAS. Pharmacol Res. 2021;164:105304 pubmed publisher
Inoue S, Hirota Y, Ueno T, Fukui Y, Yoshida E, Hayashi T, et al. Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations. Nat Commun. 2019;10:5785 pubmed publisher
Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely C, et al. RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Nat Med. 2015;21:1038-47 pubmed publisher
product information
Catalog Number :
58901
Product Name :
pBabe-Kras G12C
article :
doi
id8776
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepBabe-puro
backbone_mutation
backbone_originunknown
backbone_size5169
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
growth strain :
Expresses human Kras with a G12C mutation
origin :
37
pi :
alt_names
K-Ras2A
RASK2
cloning
entrez_gene
aliases'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, K-Ras 2, KI-RAS, KRAS1, KRAS2, NS, NS3, OES, RALD, RASK2, c-Ki-ras, c-Ki-ras2
geneKRAS
id3845
genbank_ids
NM_004985.4
NP_004976.2
mutationG12C mutation
nameKRAS
shRNA_sequence
size600
species
9606
Homo sapiens
tags
locationN terminal on insert
tagHA
resistance markers :
114
tags :
Unknown
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA