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product summary
company name :
Addgene
product type :
cDNA
product name :
TMPRSS2
catalog :
53887
citations: 25
Reference
Pastorio C, Noettger S, Nchioua R, Zech F, Sparrer K, Kirchhoff F. Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization. iScience. 2023;26:108299 pubmed publisher
Saunders N, Fernandez I, Planchais C, Michel V, Rajah M, Baquero Salazar E, et al. TMPRSS2 is a functional receptor for human coronavirus HKU1. Nature. 2023;624:207-214 pubmed publisher
Garc xed a Murria M, Gadea Salom L, Moreno S, Rius Salvador M, Zaragoza O, Brun A, et al. Identification of small molecules capable of enhancing viral membrane fusion. Virol J. 2023;20:99 pubmed publisher
Wettstein L, Immenschuh P, Weil T, Conzelmann C, Almeida Hern xe1 ndez Y, Hoffmann M, et al. Native and activated antithrombin inhibits TMPRSS2 activity and SARS-CoV-2 infection. J Med Virol. 2023;95:e28124 pubmed publisher
Harte J, Wakerlin S, Lindsay A, McCarthy J, Coleman Vaughan C. Metalloprotease-Dependent S2'-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2. Viruses. 2022;14: pubmed publisher
Fuchs E, Rudnik Jansen I, Dinesen A, Selnihhin D, Mandrup O, Thiam K, et al. An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension. Acta Biomater. 2022;153:411-418 pubmed publisher
Su P, Zhai D, Wong A, Liu F. Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice. Mol Brain. 2022;15:71 pubmed publisher
Roelle S, Shukla N, Pham A, Bruchez A, Matreyek K. Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains. PLoS Biol. 2022;20:e3001738 pubmed publisher
Wettstein L, Knaff P, Kersten C, Muller P, Weil T, Conzelmann C, et al. Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture. Commun Biol. 2022;5:681 pubmed publisher
Tortorici M, Walls A, Joshi A, Park Y, Eguia R, Miranda M, et al. Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein. Cell. 2022;185:2279-2291.e17 pubmed publisher
Fraser B, Beldar S, Seitova A, Hutchinson A, Mannar D, Li Y, et al. Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation. Nat Chem Biol. 2022;: pubmed publisher
Mahalingam G, Rachamalla H, Arjunan P, Periyasami Y, M S, Thangavel S, et al. Optimization of SARS-CoV-2 Pseudovirion Production in Lentivirus Backbone With a Novel Liposomal System. Front Pharmacol. 2022;13:840727 pubmed publisher
Lee S, Kim D, Jung Y. Construction of SARS-CoV-2 spike-pseudotyped retroviral vector inducing syncytia formation. Virus Genes. 2022;58:172-179 pubmed publisher
David A, Parkinson N, Peacock T, Pairo Castineira E, Khanna T, Cobat A, et al. A common TMPRSS2 variant has a protective effect against severe COVID-19. Curr Res Transl Med. 2022;70:103333 pubmed publisher
Balachandran H, Phetsouphanh C, Agapiou D, Adhikari A, Rodrigo C, Hammoud M, et al. Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses. Cell Rep. 2022;38:110345 pubmed publisher
Valero J, Civit L, Dupont D, Selnihhin D, Reinert L, Idorn M, et al. A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Liu X, Luongo C, Matsuoka Y, Park H, Santos C, Yang L, et al. A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Ashhurst A, Tang A, Fajtová P, Yoon M, Aggarwal A, Bedding M, et al. Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. J Med Chem. 2021;: pubmed publisher
Cecon E, Burridge M, Cao L, Carter L, Ravichandran R, Dam J, et al. SARS-COV-2 spike binding to ACE2 in living cells monitored by TR-FRET. Cell Chem Biol. 2021;: pubmed publisher
Colson A, Depoix C, Dessilly G, Baldin P, Danhaive O, Hubinont C, et al. Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2. Am J Pathol. 2021;191:1610-1623 pubmed publisher
Peacock T, Goldhill D, Zhou J, Baillon L, Frise R, Swann O, et al. The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets. Nat Microbiol. 2021;6:899-909 pubmed publisher
Wettstein L, Weil T, Conzelmann C, Müller J, Groß R, Hirschenberger M, et al. Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection. Nat Commun. 2021;12:1726 pubmed publisher
Wang R, Simoneau C, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi J, et al. Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses. Cell. 2021;184:106-119.e14 pubmed publisher
Dieterle M, Haslwanter D, Bortz R, Wirchnianski A, Lasso G, Vergnolle O, et al. A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition. bioRxiv. 2020;: pubmed publisher
Edie S, Zaghloul N, Leitch C, Klinedinst D, Lebron J, Thole J, et al. Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio. G3 (Bethesda). 2018;8:2215-2223 pubmed publisher
product information
Catalog Number :
53887
Product Name :
TMPRSS2
article :
doi10.1534/g3.118.200144
id8419
pubmed_id29760202
bacterial resistance :
Ampicillin
cloning :
backbonepCSDest
backbone_mutation
backbone_originLawson Lab (Addgene Plasmid 22423)
backbone_size4095
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
NM_005656
growth strain :
Expression of TMPRSS2
origin :
37
pi :
alt_names
cloning
clone_methodGateway Cloning
cloning_site_3
cloning_site_5
promoterSP6 and CMV
sequencing_primer_3EBV-Rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesPRSS10
geneTMPRSS2
id7113
genbank_ids
mutation
nameTMPRSS2
shRNA_sequence
size1479
species
9606
Homo sapiens
tags
resistance markers :
1972
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA