This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pcDNA3.1 SIRT6_H133Y
catalog :
53149
citations: 5
Reference
Zhang L, Bai L, Ren Q, Sun G, Si Y. Protective effects of SIRT6 against lipopolysaccharide (LPS) are mediated by deacetylation of Ku70. Mol Immunol. 2018;101:312-318 pubmed publisher
Wang L, Guo W, Ma J, Dai W, Liu L, Guo S, et al. Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling. Autophagy. 2018;14:518-533 pubmed publisher
Tao N, Ren J, Tang H, Ran L, Zhou H, Liu B, et al. Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma. Biochem Biophys Res Commun. 2017;485:713-719 pubmed publisher
Chen W, Chen X, Sun Y. WITHDRAWN: SIRT6 protects against lipopolysaccharide (LPS)-induced apoptosis in human dental pulp cells by deacetylation of Ku70. Biochem Biophys Res Commun. 2016;: pubmed publisher
Michishita E, McCord R, Berber E, Kioi M, Padilla Nash H, Damian M, et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature. 2008;452:492-6 pubmed publisher
product information
Catalog Number :
53149
Product Name :
pcDNA3.1 SIRT6_H133Y
article :
doi10.1038/nature06736
id8268
pubmed_id18337721
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3.1
backbone_mutation
backbone_originInvitrogen
backbone_size5428
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth strain :
expression vector for catalyitc inactive human Sirtuin6
origin :
37
pi :
alt_names
sirtuin 6
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5EcoRI
promoterCMV
sequencing_primer_3BGHrev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesSIR2L6, hSIRT6
geneSIRT6
id51548
genbank_ids
AK225567
AK074810
mutationH133Y, catalytic inactive
nameSirt6
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on backbone
tagFLAG
resistance markers :
1936
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA