This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
CaV1.3e[8a,11,31b, 32, 42a]
catalog :
49332
citations: 5
Reference
Jeong S, Rhee J, Lee J. Snapin Specifically Up-Regulates Cav1.3 Ca2+ Channel Variant with a Long Carboxyl Terminus. Int J Mol Sci. 2021;22: pubmed publisher
Li B, He X, Dong Z, Xuan K, Sun W, Gao L, et al. Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca2+ channel internalization in mesenchymal stem cells. Bone Res. 2020;8:19 pubmed publisher
Bellono N, Leitch D, Julius D. Molecular basis of ancestral vertebrate electroreception. Nature. 2017;543:391-396 pubmed publisher
Moreno C, Dixon R, Tajada S, Yuan C, Opitz Araya X, Binder M, et al. Ca(2+) entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels. elife. 2016;5: pubmed publisher
Xu W, Lipscombe D. Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. J Neurosci. 2001;21:5944-51 pubmed
product information
Catalog Number :
49332
Product Name :
CaV1.3e[8a,11,31b, 32, 42a]
article :
doi
id3699
pubmed_id11487617
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA6/V5-His ABC
backbone_mutation
backbone_originInvitrogen
backbone_size5100
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
Isolated from superior cervical ganglia. For more information about this plasmid: http://neuroscience.brown.edu/LipscombeLab/homepage/otherpages/clonespage/clonespage1.htm
growth strain :
Repaired Addgene #26577 to agree with the rat ref sequence. Repairs are @: nt 6224 (GCC->GTC) [Ala->Val]; nt 3310 (GTG->GCG) [Val->Ala]; nt 731 (TCA->GGA) [Ser->Gly].
inserts :
Top10F'
origin :
30
pi :
alt_names
calcium channel, voltage-dependent, L type, alpha 1D subunit
Cav1.3
cloning
clone_methodRestriction Enzyme
cloning_site_3SacI
cloning_site_5NheI
promoterCMV
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-Fwd
site_3_destroyed
site_5_destroyed
entrez_gene
aliases
geneCacna1d
id29716
genbank_ids
mutationContains exons 8a, 11, and 31b.Exons 32 and 42a are deleted. Exon 42a was replaced by exons 42 & 49.
nameCACNA1D
shRNA_sequence
size6400
species
10116
Rattus norvegicus
tags
resistance markers :
813
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA