Reference |
---|
Celli L, Gasparini P, Biino G, Zannini L, Cardano M. CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome. Cell Biosci. 2024;14:15 pubmed publisher
|
Eshchenko N, Sergeeva M, Zhuravlev E, Kudria K, Goncharova E, Komissarov A, et al. A Knockout of the IFITM3 Gene Increases the Sensitivity of WI-38 VA13 Cells to the Influenza A Virus. Int J Mol Sci. 2024;25: pubmed publisher
|
Rickman O, Guignard E, Chabanon T, Bertoldi G, Auberson M, Hummler E. Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport. Life Sci Alliance. 2024;7: pubmed publisher
|
Flinois A, M xe9 an I, Mutero Maeda A, Guillemot L, Citi S. Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization. J Cell Sci. 2024;137: pubmed publisher
|
King A, Reichl P, Metson J, Parker R, Munro D, Oliveira C, et al. Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice. bioRxiv. 2023;: pubmed publisher
|
Zhang C, Chang F, Miao H, Fu Y, Tong X, Feng Y, et al. Construction and application of a multifunctional CHO cell platform utilizing Cre/lox and Dre/rox site-specific recombination systems. Front Bioeng Biotechnol. 2023;11:1320841 pubmed publisher
|
Huth T, Dreher E, Lemke S, Fritzsche S, Sugiyanto R, Castven D, et al. Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer. Sci Adv. 2023;9:eadh1442 pubmed publisher
|
De Pace R, Maroofian R, Paimboeuf A, Zamani M, Zaki M, Sadeghian S, et al. Biallelic BORCS8 variants cause an infantile-onset neurodegenerative disorder with altered lysosome dynamics. Brain. 2023;: pubmed publisher
|
Lee J, Lee H, Lee H, Shin M, Shin M, Seo J, et al. ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells. Nat Commun. 2023;14:8463 pubmed publisher
|
Voon H, Hii L, Garvie A, Udugama M, Krug B, Russo C, et al. Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies. Genome Biol. 2023;24:284 pubmed publisher
|
Maltseva E, Vasil eva I, Moor N, Kim D, Dyrkheeva N, Kutuzov M, et al. Cas9 is mostly orthogonal to human systems of DNA break sensing and repair. PLoS ONE. 2023;18:e0294683 pubmed publisher
|
Edrei Y, Levy R, Kaye D, Marom A, Radlwimmer B, Hellman A. Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation. Genome Biol. 2023;24:264 pubmed publisher
|
Ruiz Pastor M, S xe1 nchez S xe1 ez X, Kutsyr O, Albertos Arranz H, S xe1 nchez Castillo C, Ortu xf1 o Lizar xe1 n I, et al. Prph2 knock-in mice recapitulate human central areolar choroidal dystrophy retinal degeneration and exhibit aberrant synaptic remodeling and microglial activation. Cell Death Dis. 2023;14:711 pubmed publisher
|
Khandwala C, Sarkar P, Schmidt H, Ma M, Kinnebrew M, Pusapati G, et al. Direct ionic stress sensing and mitigation by the transcription factor NFAT5. bioRxiv. 2023;: pubmed publisher
|
Firth W, Robb J, Stewart D, Pye K, Bamford R, Oguro Ando A, et al. Regulation of astrocyte metabolism by mitochondrial translocator protein 18kDa. bioRxiv. 2023;: pubmed publisher
|
Pathak T, Benson J, Johnson M, Xin P, Abdelnaby A, Walter V, et al. Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway. bioRxiv. 2023;: pubmed publisher
|
Dubaić M, Peskova L, Hampl M, Weissová K, Celiker C, Shylo N, et al. Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid. Life Sci Alliance. 2023;6: pubmed publisher
|
Yi K, Kong H, Zheng C, Zhuo C, Jin Y, Zhong Q, et al. A LIGHTFUL nanomedicine overcomes EGFR-mediated drug resistance for enhanced tyrosine-kinase-inhibitor-based hepatocellular carcinoma therapy. Biomaterials. 2023;302:122349 pubmed publisher
|
Xu J, Dai Y, Gao Y, Chai R, Lu C, Yu B, et al. RAD51D Secondary Mutation-Mediated Resistance to PARP-Inhibitor-Based Therapy in HGSOC. Int J Mol Sci. 2023;24: pubmed publisher
|
Lau M, Hu Z, Zhao X, Tan Y, Liu J, Huang H, et al. Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription. Nat Commun. 2023;14:6464 pubmed publisher
|
Li J, Krause G, Gui Q, Kaushik S, Róna G, Zhang Q, et al. A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion. Sci Adv. 2023;9:eadh1134 pubmed publisher
|
Idoko Akoh A, Goldhill D, Sheppard C, Bialy D, Quantrill J, Sukhova K, et al. Creating resistance to avian influenza infection through genome editing of the ANP32 gene family. Nat Commun. 2023;14:6136 pubmed publisher
|
Kim J, Diaz L, Miller M, Leadem B, Krivega I, Dean A. An enhancer RNA recruits MLL1 to regulate transcription of Myb. bioRxiv. 2023;: pubmed publisher
|
Ausejo Mauleon I, Labiano S, de la Nava D, Laspidea V, Zalacain M, Marrod xe1 n L, et al. TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory. Cancer Cell. 2023;41:1911-1926.e8 pubmed publisher
|
Huang X, Yao J, Liu L, Chen J, Mei L, Huangfu J, et al. S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy. Mol Cell. 2023;83:3485-3501.e11 pubmed publisher
|
Clancy A, Rusilowicz Jones E, Wallace I, Swatek K, Urb xe9 S, Clague M. ISGylation-independent protection of cell growth by USP18 following interferon stimulation. Biochem J. 2023;480:1571-1581 pubmed publisher
|
Ying P, Chen C, Lu Z, Chen S, Zhang M, Cai Y, et al. Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk. Nat Commun. 2023;14:5958 pubmed publisher
|
Ra E, Kim M, Lee G. Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson's disease pathology. STAR Protoc. 2023;4:102609 pubmed publisher
|
Jo A, Deniz S, Xu J, Duvoisin R, DeVries S, Zhu Y. A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina. Nat Commun. 2023;14:5937 pubmed publisher
|
O Neill M, Yang T, Laudeman J, Calandranis M, Solus J, Roden D, et al. ParSE-seq: A Calibrated Multiplexed Assay to Facilitate the Clinical Classification of Putative Splice-altering Variants. medRxiv. 2023;: pubmed publisher
|
Oh M, Jang S, Lee J, Kim J, Jung Y, Kim J, et al. The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism. Nat Commun. 2023;14:5728 pubmed publisher
|
Ang H, Sutiman N, Deng X, Liu A, Cerda Smith C, Hutchinson H, et al. Cooperative regulation of coupled oncoprotein synthesis and stability in triple-negative breast cancer by EGFR and CDK12/13. Proc Natl Acad Sci U S A. 2023;120:e2221448120 pubmed publisher
|
Gonz xe1 lez Romero E, Mart xed nez Valiente C, Garc xed a Garc xed a G, Rosal Vela A, Mill xe1 n J, Sanz M, et al. PCR-Based Strategy for Introducing CRISPR/Cas9 Machinery into Hematopoietic Cell Lines. Cancers (Basel). 2023;15: pubmed publisher
|
Recoules L, Tanguy Le Gac N, Moutahir F, Bystricky K, Lavigne A. Recruitment of the Histone Variant MacroH2A1 to the Pericentric Region Occurs upon Chromatin Relaxation and Is Responsible for Major Satellite Transcriptional Regulation. Cells. 2023;12: pubmed publisher
|
Ei Z, Mutirangura A, Arunmanee W, Chanvorachote P. The Role of Box A of HMGB1 in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-aging Therapy. In Vivo. 2023;37:2006-2017 pubmed publisher
|
Verboom L, Anderson C, Jans M, Petta I, Blancke G, Martens A, et al. OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection. Cell Death Dis. 2023;14:534 pubmed publisher
|
Han S, Lee M, Shin Y, Giovanni R, Chakrabarty R, Herrerias M, et al. Mitochondrial integrated stress response controls lung epithelial cell fate. Nature. 2023;620:890-897 pubmed publisher
|
Hoffmann T, H xf6 rmann A, Corcokovic M, Zmajkovic J, Hinterndorfer M, Salkanovic J, et al. Precision RNAi using synthetic shRNAmir target sites. elife. 2023;12: pubmed publisher
|
Singh P, Ali S, Kumar S, Mohanty A. CRISPR-Cas9 based knockout of S100A8 in mammary epithelial cells enhances cell proliferation and triggers oncogenic transformation via the PI3K-Akt pathway: Insights from a deep proteomic analysis. J Proteomics. 2023;288:104981 pubmed publisher
|
Park S, Kulkarni A, Konopka G. FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells. PLoS Biol. 2023;21:e3001852 pubmed publisher
|
Ploeg E, Britsch I, van Wijngaarden A, Ke X, Hendriks M, Samplonius D, et al. A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer. Cancers (Basel). 2023;15: pubmed publisher
|
Rodencal J, Kim N, Li V, He A, Lange M, He J, et al. A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2. bioRxiv. 2023;: pubmed publisher
|
Lin C, Chang T, Wang Y, Guo L, Gao Y, Bikorimana E, et al. Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Res Sq. 2023;: pubmed publisher
|
Kelly R, Parmar G, Bayat L, Maitland M, Lajoie G, Edgell D, et al. Noncanonical functions of Ku may underlie essentiality in human cells. Sci Rep. 2023;13:12162 pubmed publisher
|
Serrano Benítez A, Wells S, Drummond Clarke L, Russo L, Thomas J, Leal G, et al. Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity. EMBO J. 2023;:e113190 pubmed publisher
|
Gupta N, Yakhou L, Albert J, Azogui A, Ferry L, Kirsh O, et al. A genome-wide screen reveals new regulators of the 2-cell-like cell state. Nat Struct Mol Biol. 2023;: pubmed publisher
|
Zheng D, Mao Y, Gao Y, He F, Ma J. Daughter cell fate choice instructed preemptively by mother cells facing nutrient limitation. iScience. 2023;26:107198 pubmed publisher
|
Karnan S, Ota A, Murakami H, Rahman M, Wahiduzzaman M, Hasan M, et al. CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma. Cell Death Discov. 2023;9:257 pubmed publisher
|
Yamakawa T, Zhang G, Najjar L, Li C, Itakura K. The uncharacterized transcript KIAA0930 confers a cachexic phenotype on cancer cells. Oncotarget. 2023;14:723-737 pubmed publisher
|
Wang Z, Zhang N, Zhang M, Jiang Y, Ng A, Bridges E, et al. GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner. Cancer Res. 2023;: pubmed publisher
|
Nigam N, Bernard B, Sevilla S, Kim S, Dar M, Tsai D, et al. SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck. Cell Rep. 2023;42:112823 pubmed publisher
|
Shibata T, Sato R, Taoka M, Saitoh S, Komine M, Yamaguchi K, et al. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. J Exp Med. 2023;220: pubmed publisher
|
Ohkawa Y, Kanto N, Nakano M, Fujinawa R, Kizuka Y, Johnson E, et al. Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model. J Biol Chem. 2023;:105052 pubmed publisher
|
Wa x17c y x144 ska M, Butera R, Requesens M, Plat A, Zarganes Tzitzikas T, Neochoritis C, et al. Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. J Med Chem. 2023;66:9577-9591 pubmed publisher
|
Wang F, Cali Daylan A, Deng L, Yang J, Sharma J, Su C, et al. Heterogeneous Expression of PD-L1, B7x, B7-H3, and HHLA2 in Pulmonary Sarcomatoid Carcinoma and the Related Regulatory Signaling Pathways. Cancers (Basel). 2023;15: pubmed publisher
|
Dom xed nguez Zorita S, Romero Carrami xf1 ana I, Santacatterina F, Esparza Molt xf3 P, Sim xf3 C, del Arco A, et al. IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype. Cell Death Dis. 2023;14:413 pubmed publisher
|
Gracia Diaz C, Zhou Y, Yang Q, Maroofian R, Espana Bonilla P, Lee C, et al. Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders. Nat Commun. 2023;14:4109 pubmed publisher
|
Xu M, Chen J, Xu Y, Zhang J, Zhou Y, He J, et al. Generation of Centromere-Associated Protein-E CENP-E-/- Knockout Cell Lines using the CRISPR/Cas9 System. J Vis Exp. 2023;: pubmed publisher
|
Zhang W, Pan X, Xu Y, Guo H, Zheng M, Chen X, et al. Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA. Acta Pharm Sin B. 2023;13:2585-2600 pubmed publisher
|
Kado S, Bein K, Castañeda A, Pouraryan A, Garrity N, Ishihara Y, et al. Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer. Cells. 2023;12: pubmed publisher
|
Isozaki H, Sakhtemani R, Abbasi A, Nikpour N, Stanzione M, Oh S, et al. Therapy-induced APOBEC3A drives evolution of persistent cancer cells. Nature. 2023;: pubmed publisher
|
Yuan H, Ren Q, Du Y, Ma Y, Gu L, Zhou J, et al. LncRNA miR663AHG represses the development of colon cancer in a miR663a-dependent manner. Cell Death Discov. 2023;9:220 pubmed publisher
|
Canale F, Neumann J, von Renesse J, Loggi E, Pecoraro M, Vogel I, et al. Proteomics of immune cells from liver tumors reveals immunotherapy targets. Cell Genom. 2023;3:100331 pubmed publisher
|
Dave B, Chen X, McCready F, Charton C, Morley R, Tailor J, et al. Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis. Development. 2023;150: pubmed publisher
|
Corral Serrano J, Sladen P, Ottaviani D, Rezek O, Athanasiou D, Jovanovic K, et al. Eupatilin Improves Cilia Defects in Human CEP290 Ciliopathy Models. Cells. 2023;12: pubmed publisher
|
You G, Li W, Wang Y, Cao H, Li X, Gao L, et al. Reduced NR2F2 Expression in the Host Response to Infectious Bursal Disease Virus Infection Suppressed Viral Replication by Enhancing Type I Interferon Expression by Targeting SOCS5. J Virol. 2023;97:e0066423 pubmed publisher
|
Chornyi S, Costa C, IJlst L, Fransen M, Wanders R, van Roermund C, et al. Human peroxisomal NAD+/NADH homeostasis is regulated by two independent NAD(H) shuttle systems. Free Radic Biol Med. 2023;206:22-32 pubmed publisher
|
Dong F, Amlal H, Venkatakrishnan J, Zhang J, Fry M, Yuan Y, et al. The gene therapy for corneal pathology with novel nonsense cystinosis mouse lines created by CRISPR Gene Editing. Ocul Surf. 2023;29:432-443 pubmed publisher
|
Wojnacki J, Lujan A, Brouwers N, Aranda Vallejo C, Bigliani G, Rodriguez M, et al. Tetraspanin-8 sequesters syntaxin-2 to control biphasic release propensity of mucin granules. Nat Commun. 2023;14:3710 pubmed publisher
|
Minet N, Boschat A, Lane R, Laughton D, Beer P, Asnagli H, et al. Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation. Life Sci Alliance. 2023;6: pubmed publisher
|
Onda M, Ota A, Ito K, Ono T, Karnan S, Kato M, et al. Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma. Cancer Med. 2023;: pubmed publisher
|
Kim M, Ra E, Kweon S, Seo B, Ko H, Oh Y, et al. Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. Cell Stem Cell. 2023;30:973-986.e11 pubmed publisher
|
Loftus D, Bae B, Whilden C, Whipple A. Allelic chromatin structure primes imprinted expression of Kcnk9 during neurogenesis. bioRxiv. 2023;: pubmed publisher
|
Lopez Robles C, Scaramuzza S, Astorga Simón E, Ishida M, Williamson C, Ba xf1 os Mateos S, et al. Architecture of the ESCPE-1 membrane coat. Nat Struct Mol Biol. 2023;30:958-969 pubmed publisher
|
Trivedi P, Steele C, Au F, Alexandrov L, Cleveland D. Mitotic tethering enables inheritance of shattered micronuclear chromosomes. Nature. 2023;618:1049-1056 pubmed publisher
|
Berber M, Leng S, Wengi A, Winter D, Odermatt A, Beuschlein F, et al. Calcineurin regulates aldosterone production via dephosphorylation of NFATC4. JCI Insight. 2023;8: pubmed publisher
|
Ma F, Plazyo O, Billi A, Tsoi L, Xing X, Wasikowski R, et al. Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis. Nat Commun. 2023;14:3455 pubmed publisher
|
Zhou J, Sturtevant D, Love C, Kulkarni A, Biyani N, Kathad U, et al. LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair. Oncotarget. 2023;14:597-611 pubmed publisher
|
Owen L, Rainger J, Bengani H, Kilanowski F, Fitzpatrick D, Papanastasiou A. Characterization of an eye field-like state during optic vesicle organoid development. Development. 2023;: pubmed publisher
|
Kim S, Ong Q, Liao Y, Ding Z, Tan A, Lim L, et al. Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling. Int J Mol Sci. 2023;24: pubmed publisher
|
Vatandaslar H, Garzia A, Meyer C, Godbersen S, Brandt L, Griesbach E, et al. In vivo PAR-CLIP (viP-CLIP) of liver TIAL1 unveils targets regulating cholesterol synthesis and secretion. Nat Commun. 2023;14:3386 pubmed publisher
|
Nishi W, Wakamatsu E, Machiyama H, Matsushima R, Saito K, Yoshida Y, et al. Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters. Nat Commun. 2023;14:3157 pubmed publisher
|
Moriya K, Nakano T, Honda Y, Tsumura M, Ogishi M, Sonoda M, et al. Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity. J Exp Med. 2023;220: pubmed publisher
|
Haldrup J, Weiss S, Schmidt L, S xf8 rensen K. Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome-wide CRISPR/Cas9 screening. Sci Rep. 2023;13:9043 pubmed publisher
|
Yuan T, Tang H, Xu X, Shao J, Wu G, Cho Y, et al. Inflammation conditional genome editing mediated by the CRISPR-Cas9 system. iScience. 2023;26:106872 pubmed publisher
|
Pecori R, Ren W, Pirmoradian M, Wang X, Liu D, Berglund M, et al. ADAR1-mediated RNA editing promotes B cell lymphomagenesis. iScience. 2023;26:106864 pubmed publisher
|
Ala Nisula T, Sah Teli S, Ronkainen V, Dimova E, Koivunen P. Human phytanoyl-CoA dioxygenase domain-containing 1 (PHYHD1) is a putative oxygen sensor associated with RNA and carbohydrate metabolism. FEBS Lett. 2023;597:1651-1666 pubmed publisher
|
Fujii S, Ushioda R, Nagata K. Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A. 2023;120:e2216857120 pubmed publisher
|
Wang Y, Guo Y, Song Y, Zou W, Zhang J, Yi Q, et al. A pan-cancer analysis of the expression and molecular mechanism of DHX9 in human cancers. Front Pharmacol. 2023;14:1153067 pubmed publisher
|
Maier C, Hartmann O, Prieto Garcia C, Al Shami K, Schlicker L, Vogel F, et al. USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer. Cell Death Differ. 2023;30:1710-1725 pubmed publisher
|
Healy M, McNally K, Butkovi x10d R, Chilton M, Kato K, Sacharz J, et al. Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Cell. 2023;186:2219-2237.e29 pubmed publisher
|
Tal A, Aguilera J, Bren I, Strauss C, Schlesinger S. Differential effect of histone H3.3 depletion on retroviral repression in embryonic stem cells. Clin Epigenetics. 2023;15:83 pubmed publisher
|
Ma Z, Zhang F, Liu A, Lin H, Liu C. Somatic-to-primordial germ cell-like transformation is critical in tumor initiation of mouse breast tumor 4T1 cells. Am J Cancer Res. 2023;13:1471-1485 pubmed
|
Pu J, Lin L, Jiang H, Hu Z, Li H, Yan Z, et al. Parkin Maintains Robust Pacemaking in Human Induced Pluripotent Stem Cell-Derived A9 Dopaminergic Neurons. Mov Disord. 2023;38:1273-1281 pubmed publisher
|
Peker E, Weiss K, Song J, Zarges C, Gerlich S, Boehm V, et al. A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis. J Cell Biol. 2023;222: pubmed publisher
|
Donati G, Nicoli P, Verrecchia A, Vallelonga V, Croci O, Rodighiero S, et al. Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC-driven lymphoma. EMBO Mol Med. 2023;15:e16910 pubmed publisher
|
Shi Y, Liao Y, Liu Q, Ni Z, Zhang Z, Shi M, et al. BRD4-targeting PROTAC as a unique tool to study biomolecular condensates. Cell Discov. 2023;9:47 pubmed publisher
|
Lei X, Tian X, Wang H, Xu X, Li G, Liu W, et al. Noncoding SNP at rs1663689 represses ADGRG6 via interchromosomal interaction and reduces lung cancer progression. EMBO Rep. 2023;24:e56212 pubmed publisher
|
Conrad S, Mays J, Hearn C, Dunn J. Targeted Ablation of Exon 2 of the Avian Leukosis Virus-A (ALV-A) Receptor Gene in a Chicken Fibroblast Cell Line by CRISPR Abrogates ALV-A Infection. Avian Dis. 2023;67:102-107 pubmed publisher
|
Zhang J, Hu Z, Chung H, Tian Y, Lau K, Ser Z, et al. Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. Nat Commun. 2023;14:2439 pubmed publisher
|
Olivas T, Wu Y, Yu S, Luan L, Choi P, Guinn E, et al. ATG9 vesicles comprise the seed membrane of mammalian autophagosomes. J Cell Biol. 2023;222: pubmed publisher
|
Elcocks H, Brazel A, McCarron K, Kaulich M, Husnjak K, Mortiboys H, et al. FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels. EMBO J. 2023;42:e112799 pubmed publisher
|
Long T, Bhattacharyya T, Repele A, Naylor M, Nooti S, Krueger S, et al. The contributions of DNA accessibility and transcription factor occupancy to enhancer activity during cellular differentiation. bioRxiv. 2023;: pubmed publisher
|
Mudumbi K, Burns E, Schodt D, Petrova Z, Kiyatkin A, Kim L, et al. Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes. bioRxiv. 2023;: pubmed publisher
|
Gupta A, Li Y, Chen S, Papas B, Martin N, Morgan M. TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication. Commun Biol. 2023;6:438 pubmed publisher
|
Pawlak J, Hsu J, Xia H, Han P, Suh H, Grove T, et al. CMPK2 restricts Zika virus replication by inhibiting viral translation. PLoS Pathog. 2023;19:e1011286 pubmed publisher
|
Lee D, Choi C, Sanders D, Beckers L, Riback J, Brangwynne C, et al. Size distributions of intracellular condensates reflect competition between coalescence and nucleation. Nat Phys. 2023;19:586-596 pubmed publisher
|
Im J, Duic I, Yoshimura S, Onomoto K, Yoneyama M, Kato H, et al. Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I. Sci Rep. 2023;13:6318 pubmed publisher
|
Bi H, Tranell J, Harper D, Lin W, Li J, Hellstr xf6 m A, et al. A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken. PLoS Genet. 2023;19:e1010724 pubmed publisher
|
Dinter J, Friedrich R, Yang H, Pilarsky C, Mangge H, P xf6 ttler M, et al. Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids. Materials (Basel). 2023;16: pubmed publisher
|
Bhatia V, Kamat N, Pariva T, Wu L, Tsao A, Sasaki K, et al. Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy. Nat Commun. 2023;14:2041 pubmed publisher
|
Xu L, Xiang Y, Hu J. Molecular basis of Climp63-mediated ER lumen spacing. J Cell Sci. 2023;136: pubmed publisher
|
Bogomiakova M, Sekretova E, Anufrieva K, Khabarova P, Kazakova A, Bobrovsky P, et al. iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors. Stem Cell Res Ther. 2023;14:77 pubmed publisher
|
Chen L, Shi K, Ditzel N, Qiu W, Figeac F, Nielsen L, et al. KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration. Nat Commun. 2023;14:2016 pubmed publisher
|
Garg V, Yang Y, Nowotschin S, Setty M, Kuo Y, Sharma R, et al. Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticities. bioRxiv. 2023;: pubmed publisher
|
Weigert R, Hetzel S, Bailly N, Haggerty C, Ilik I, Yung P, et al. Dynamic antagonism between key repressive pathways maintains the placental epigenome. Nat Cell Biol. 2023;25:579-591 pubmed publisher
|
Li S, Zhang R, Lavrijsen M, van den Bosch T, Peppelenbosch M, Smits R. Issues with RNF43 antibodies to reliably detect intracellular location. PLoS ONE. 2023;18:e0283894 pubmed publisher
|
D Augustin O, Gaudon V, Siberchicot C, Smith R, Chapuis C, Depagne J, et al. Identification of key residues of the DNA glycosylase OGG1 controlling efficient DNA sampling and recruitment to oxidized bases in living cells. Nucleic Acids Res. 2023;51:4942-4958 pubmed publisher
|
Dorard C, Madry C, Buhard O, Toifl S, Didusch S, Ratovomanana T, et al. RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status. Oncogene. 2023;42:1649-1660 pubmed publisher
|
Ruminski K, Celis Gutierrez J, Jarmuzynski N, Maturin E, Audebert S, Malissen M, et al. Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway. Front Immunol. 2023;14:1139123 pubmed publisher
|
Delaney J, La Spada A. Protocol for mapping double-stranded DNA break sites across the genome with translocation capture sequencing. STAR Protoc. 2023;4:102205 pubmed publisher
|
Chornyi S, Ofman R, Koster J, Waterham H. The origin of long-chain fatty acids required for de novo ether lipid/plasmalogen synthesis. J Lipid Res. 2023;64:100364 pubmed publisher
|
Sidhaye J, Trepte P, Sepke N, Novatchkova M, Schutzbier M, D xfc rnberger G, et al. Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids. elife. 2023;12: pubmed publisher
|
Perdig xe3 o P, Ollington B, Sai H, Leung A, Sacristán Reviriego A, van der Spuy J. Retinal Organoids from an AIPL1 CRISPR/Cas9 Knockout Cell Line Successfully Recapitulate the Molecular Features of LCA4 Disease. Int J Mol Sci. 2023;24: pubmed publisher
|
Dyrkheeva N, Malakhova A, Zakharenko A, Okorokova L, Shtokalo D, Pavlova S, et al. Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor. Int J Mol Sci. 2023;24: pubmed publisher
|
Bader S, W xfc rfel T, Jahner T, Nothdurfter C, Rupprecht R, Milenkovic V, et al. Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells. Cells. 2023;12: pubmed publisher
|
Nieddu V, Melocchi V, Battistini C, Franciosa G, Lupia M, Stellato C, et al. Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer. Cell Death Dis. 2023;14:220 pubmed publisher
|
Ngo A, Puschnik A. Genome-Scale Analysis of Cellular Restriction Factors That Inhibit Transgene Expression from Adeno-Associated Virus Vectors. J Virol. 2023;97:e0194822 pubmed publisher
|
Jeon W, Jung S, Lee C, Kim W, Kim H, Jang K, et al. Evaluation of Radiation Sensitivity Differences in Mouse Liver Tumor Organoids Using CRISPR/Cas9-Mediated Gene Mutation. Technol Cancer Res Treat. 2023;22:15330338231165125 pubmed publisher
|
Li R, Huang D, Zhao Y, Yuan Y, Sun X, Dai Z, et al. PR-DUB safeguards Polycomb repression through H2AK119ub1 restriction. Cell Prolif. 2023;:e13457 pubmed publisher
|
Meng X, Liu S, Deng T, Li D, You L, Hong H, et al. Loss of Histone Methyltransferase KMT2D Attenuates Angiogenesis in the Ischemic Heart by Inhibiting the Transcriptional Activation of VEGF-A. J Cardiovasc Transl Res. 2023;: pubmed publisher
|
Hu Y, Sun H, Sakurai M, Jones A, Liu L, Cheng T, et al. RNA Sensing and Innate Immunity Constitutes a Barrier for Interspecies Chimerism. bioRxiv. 2023;: pubmed publisher
|
Wei Y, Zhang E, Yu L, Ci B, Guo L, Sakurai M, et al. Dissecting embryonic and extra-embryonic lineage crosstalk with stem cell co-culture. bioRxiv. 2023;: pubmed publisher
|
Jaiswal A, Wang Z, Xudong Z, Ju Z. Unraveling the connection between calreticulin and myeloproliferative neoplasms via calcium signaling. Cell Biol Int. 2023;47:1229-1246 pubmed publisher
|
Heylen E, Verstraete P, Van Aerschot L, Geeraerts S, Venken T, Timcheva K, et al. Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer. Br J Cancer. 2023;128:1862-1878 pubmed publisher
|
Baughn M, Melamed Z, L xf3 pez Erauskin J, Beccari M, Ling K, Zuberi A, et al. Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies. Science. 2023;379:1140-1149 pubmed publisher
|
Aimola G, Wight D, Flamand L, Kaufer B. Excision of Integrated Human Herpesvirus 6A Genomes Using CRISPR/Cas9 Technology. Microbiol Spectr. 2023;11:e0076423 pubmed publisher
|
Lambuta R, Nanni L, Liu Y, Diaz Miyar J, Iyer A, Tavernari D, et al. Whole-genome doubling drives oncogenic loss of chromatin segregation. Nature. 2023;615:925-933 pubmed publisher
|
Killarney S, Washart R, Soderquist R, Hoj J, Lebhar J, Lin K, et al. Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis. Nat Commun. 2023;14:1399 pubmed publisher
|
Russo S, Scotto di Carlo F, Maurizi A, Fortunato G, Teti A, Licastro D, et al. A mutation in the ZNF687 gene that is responsible for the severe form of Paget's disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model. Bone Res. 2023;11:16 pubmed publisher
|
Silginer M, Papa E, Szab xf3 E, Vasella F, Pruschy M, Stroh C, et al. Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition. Acta Neuropathol Commun. 2023;11:41 pubmed publisher
|
Bonjoch L, Fernández Rozadilla C, Álvarez Barona M, Lopez Novo A, Herrera Pariente C, Amigo J, et al. BMPR2 as a Novel Predisposition Gene for Hereditary Colorectal Polyposis. Gastroenterology. 2023;165:162-172.e5 pubmed publisher
|
Szwarc M, Guarnieri A, Joshi M, Duc H, Laird M, Pandey A, et al. FAM193A is a positive regulator of p53 activity. Cell Rep. 2023;42:112230 pubmed publisher
|
Qiao Y, Sun Q, Chen X, He L, Wang D, Su R, et al. Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export. elife. 2023;12: pubmed publisher
|
Mao L, Su S, Li J, Yu S, Gong Y, Chen C, et al. Development of Engineered CAR T Cells Targeting Tumor-Associated Glycoforms of MUC1 for the Treatment of Intrahepatic Cholangiocarcinoma. J Immunother. 2023;46:89-95 pubmed publisher
|
Li B, Zhao H, Tu Z, Yang W, Han R, Wang L, et al. CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate. Cell Discov. 2023;9:27 pubmed publisher
|
Zhang J, Pan L, Zhang Q, Zhao Y, Wang W, Lin N, et al. MFN2 deficiency affects calcium homeostasis in lung adenocarcinoma cells via downregulation of UCP4. FEBS Open Bio. 2023;13:1107-1124 pubmed publisher
|
Huynh D, Hu J, Schneider J, Tsolova K, Soderblom E, Watson A, et al. O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations. bioRxiv. 2023;: pubmed publisher
|
Radford B, Zhao X, Glazer T, Eaton M, Blackwell D, Mohammad S, et al. Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease. Nat Commun. 2023;14:1174 pubmed publisher
|
Przanowski P, Przanowska R, Guertin M. ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation. Commun Biol. 2023;6:231 pubmed publisher
|
Norris M, Mendell J. Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein. Genes Dev. 2023;37:191-203 pubmed publisher
|
Adell M, Klockner T, H xf6 fler R, Wallner L, Schmid J, Markovic A, et al. Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies. Genes Dev. 2023;37:171-190 pubmed publisher
|
Poverennaya E, Pyatnitskiy M, Dolgalev G, Arzumanian V, Kiseleva O, Kurbatov I, et al. Exploiting Multi-Omics Profiling and Systems Biology to Investigate Functions of TOMM34. Biology (Basel). 2023;12: pubmed publisher
|
Bademosi A, Decet M, Kuenen S, Calatayud C, Swerts J, Gallego S, et al. EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation. Neuron. 2023;111:1402-1422.e13 pubmed publisher
|
Tanushi X, Pinna G, Vandamme M, Siberchicot C, D Augustin O, Di Guilmi A, et al. OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression. Front Cell Dev Biol. 2023;11:1124960 pubmed publisher
|
Chai A, Cui M, Chemello F, Li H, Chen K, Tan W, et al. Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice. Nat Med. 2023;29:401-411 pubmed publisher
|
Collignon E, Cho B, Fothergill Robinson J, Furlan G, Ross R, Limbach P, et al. m 6 A RNA methylation orchestrates transcriptional dormancy during developmental pausing. bioRxiv. 2023;: pubmed publisher
|
Chen A, Lee Y, Ruan H, Huang W, Fong S, Tian S, et al. Expanded Potential Stem Cells from Human Embryos Have an Open Chromatin Configuration with Enhanced Trophoblast Differentiation Ability. Adv Sci (Weinh). 2023;10:e2204797 pubmed publisher
|
Vallverd xfa Prats M, Carreras D, P xe9 rez G, Campuzano O, Brugada R, Alcalde M. Alterations in Calcium Handling Are a Common Feature in an Arrhythmogenic Cardiomyopathy Cell Model Triggered by Desmosome Genes Loss. Int J Mol Sci. 2023;24: pubmed publisher
|
Reyes Ballista J, Miazgowicz K, Acciani M, Jimenez A, Belloli R, Havranek K, et al. Chikungunya virus entry and infectivity is primarily facilitated through cell line dependent attachment factors in mammalian and mosquito cells. Front Cell Dev Biol. 2023;11:1085913 pubmed publisher
|
Rosspopoff O, Cazottes E, Huret C, Loda A, Collier A, Casanova M, et al. Species-specific regulation of XIST by the JPX/FTX orthologs. Nucleic Acids Res. 2023;51:2177-2194 pubmed publisher
|
Li Y, Lian D, Wang J, Zhao Y, Li Y, Liu G, et al. MDM2 antagonists promote CRISPR/Cas9-mediated precise genome editing in sheep primary cells. Mol Ther Nucleic Acids. 2023;31:309-323 pubmed publisher
|
Dema A, Charafeddine R, Rahgozar S, van Haren J, Wittmann T. Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant. elife. 2023;12: pubmed publisher
|
Du Y, Chang W, Gao L, Deng L, Ji W. Tex2 is required for lysosomal functions at TMEM55-dependent ER membrane contact sites. J Cell Biol. 2023;222: pubmed publisher
|
K xf6 ster K, Duque Escobar J, Fietkau A, Toledo R, Oetjen E. Increase of c-FOS promoter transcriptional activity by the dual leucine zipper kinase. Naunyn Schmiedebergs Arch Pharmacol. 2023;396:1223-1233 pubmed publisher
|
Yang J, Chen J, Liu Y, Chen K, Baraban J, Qiu Z. Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA. Neuron. 2023;111:1104-1117.e6 pubmed publisher
|
Bredeck G, Busch M, Rossi A, Stahlmecke B, Fomba K, Herrmann H, et al. Inhalable Saharan dust induces oxidative stress, NLRP3 inflammasome activation, and inflammatory cytokine release. Environ Int. 2023;172:107732 pubmed publisher
|
Tatsumi M, Kishi T, Ishida S, Kawana H, Uwamizu A, Ono Y, et al. Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels. PLoS ONE. 2023;18:e0280448 pubmed publisher
|
Toledano S, Sabag A, Ilan N, Liburkin Dan T, Kessler O, Neufeld G. Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells. Cell Death Dis. 2023;14:41 pubmed publisher
|
Storchova R, Palek M, Palkova N, Veverka P, Brom T, Hofr C, et al. Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres. Nucleic Acids Res. 2023;51:1154-1172 pubmed publisher
|
Edginton White B, Maytum A, Kellaway S, Goode D, Keane P, Pagnuco I, et al. A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification. Nat Commun. 2023;14:267 pubmed publisher
|
Zhou C, H xe4 neke T, Rohner E, Sohlm xe9 r J, Kameneva P, Artemov A, et al. STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development. Cardiovasc Res. 2023;119:1202-1217 pubmed publisher
|
Briukhovetska D, Suarez Gosalvez J, Voigt C, Markota A, Giannou A, Sch xfc bel M, et al. T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis. Immunity. 2023;56:143-161.e11 pubmed publisher
|
Tandon V, Moreno R, Allmeroth K, Quinn J, Wiley S, Nicely L, et al. Dual inhibition of HSF1 and DYRK2 impedes cancer progression. Biosci Rep. 2023;43: pubmed publisher
|
Irazoki A, Gordaliza Alaguero I, Frank E, Giakoumakis N, Seco J, Palac xed n M, et al. Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation. Nat Commun. 2023;14:108 pubmed publisher
|
Ohkawa Y, Kitano M, Maeda K, Nakano M, Kanto N, Kizuka Y, et al. Core Fucosylation Is Required for the Secretion of and the Enzymatic Activity of SOD3 in Nonsmall-Cell Lung Cancer Cells. Antioxid Redox Signal. 2023;38:1201-1211 pubmed publisher
|
Zhao D, Yuan H, Fang Y, Gao J, Li H, Li M, et al. Histone Methyltransferase KMT2B Promotes Metastasis and Angiogenesis of Cervical Cancer by Upregulating EGF Expression. Int J Biol Sci. 2023;19:34-49 pubmed publisher
|
Bruno P, Timms R, Abdelfattah N, Leng Y, Lélis F, Wesemann D, et al. High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform. Nat Biotechnol. 2023;41:980-992 pubmed publisher
|
Serrano R, Feyen D, Bruyneel A, Hnatiuk A, Vu M, Amatya P, et al. A deep learning platform to assess drug proarrhythmia risk. Cell Stem Cell. 2023;30:86-95.e4 pubmed publisher
|
Ott J, Sehr J, Schmidt N, Schliebs W, Erdmann R. Comparison of human PEX knockout cell lines suggests a dual role of PEX1 in peroxisome biogenesis. Biol Chem. 2023;404:209-219 pubmed publisher
|
Kl xfc mper N, Ralser D, Ellinger J, Roghmann F, Albrecht J, Below E, et al. Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance. Clin Cancer Res. 2023;29:1496-1505 pubmed publisher
|
Demin D, Murashko M, Uvarova A, Stasevich E, Shyrokova E, Gorlachev G, et al. Adversary of DNA integrity: A long non-coding RNA stimulates driver oncogenic chromosomal rearrangement in human thyroid cells. Int J Cancer. 2023;152:1452-1462 pubmed publisher
|
Ngai H, Barragan G, Tian G, Balzeau J, Zhang C, Courtney A, et al. LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells. Cancer Immunol Res. 2023;11:171-183 pubmed publisher
|
Clava xed n L, Fern xe1 ndez Pisonero I, Movilla N, Lorenzo Mart xed n L, Nieto B, Abad A, et al. Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors. Oncogene. 2023;42:389-405 pubmed publisher
|
Ustiugova A, Ekaterina D, Nataliya M, Alexey D, Dmitry K, Marina A. CRISPR/Cas9 genome editing demonstrates functionality of the autoimmunity-associated SNP rs12946510. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166599 pubmed publisher
|
Czaplinska D, Ialchina R, Andersen H, Yao J, Stigliani A, Dannesboe J, et al. Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness. Int J Cancer. 2023;152:1210-1225 pubmed publisher
|
Ma Z, Bai J, Jiang C, Zhu H, Liu D, Pan M, et al. Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy. Autophagy. 2023;19:1512-1532 pubmed publisher
|
Vu Hong A, Bourg N, Sanatine P, Poupiot J, Charton K, Gicquel E, et al. Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions in the dystrophic muscle in Duchenne muscular dystrophy. Life Sci Alliance. 2023;6: pubmed publisher
|
Hattori T, Maso L, Araki K, Koide A, Hayman J, Akkapeddi P, et al. Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy. Cancer Discov. 2023;13:132-145 pubmed publisher
|
Kim D, Weller B, Lin C, Sheykhkarimli D, Knapp J, Dugied G, et al. A proteome-scale map of the SARS-CoV-2-human contactome. Nat Biotechnol. 2023;41:140-149 pubmed publisher
|
Christians A, Kesdiren E, Hennies I, Hofmann A, Trowe M, Brand F, et al. Heterozygous variants in the DVL2 interaction region of DACT1 cause CAKUT and features of Townes-Brocks syndrome 2. Hum Genet. 2023;142:73-88 pubmed publisher
|
Prahl J, Pierce S, van der Schans E, Coetzee G, Tyson T. The Parkinson's disease variant rs356182 regulates neuronal differentiation independently from alpha-synuclein. Hum Mol Genet. 2023;32:1-14 pubmed publisher
|
Pecori R, Chill xf3 n I, Lo Giudice C, Arnold A, W xfc st S, Binder M, et al. ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts. Front Cell Dev Biol. 2022;10:1080626 pubmed publisher
|
Park J, Park G, Lee J, Park J, Kim S, Kim E, et al. ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth. Front Mol Biosci. 2022;9:1030725 pubmed publisher
|
Kol A, Fan X, Ważyńska M, van Duijnhoven S, Giesen D, Plat A, et al. Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration. J Immunother Cancer. 2022;10: pubmed publisher
|
Leung A, Yiu T, Liu L, Tam H, Gu S, Tu J, et al. Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells. Cell Biosci. 2022;12:212 pubmed publisher
|
Pu L, Xie L, Chen J, Sun H, Huang Z, Xu T, et al. Tracking the dynamics of female germ cell development during peri-hatch periods using a gene-edited chicken model. Poult Sci. 2022;102:102377 pubmed publisher
|
Jiang X, Isogai T, Chi J, Danuser G. Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes. PLoS Comput Biol. 2022;18:e1009667 pubmed publisher
|
Wu Y, Kram H, Gempt J, Liesche Starnecker F, Wu W, Schlegel J. ALDH1-Mediated Autophagy Sensitizes Glioblastoma Cells to Ferroptosis. Cells. 2022;11: pubmed publisher
|
Ho B, Pang J, Chen Y, Loh Y, An O, Yang H, et al. Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases. Stem Cell Res Ther. 2022;13:529 pubmed publisher
|
Griess K, Rieck M, M xfc ller N, Karsai G, Hartwig S, Pelligra A, et al. Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nat Cell Biol. 2022;: pubmed publisher
|
Clarke M, Marsoner T, Adell M, Ravichandran M, Campbell C. Adaptation to high rates of chromosomal instability and aneuploidy through multiple pathways in budding yeast. EMBO J. 2022;:e111500 pubmed publisher
|
Pan Y, Han H, Hu H, Wang H, Song Y, Hao Y, et al. KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Cancer Cell. 2022;: pubmed publisher
|
Iwai M, Kajino T, Nakatochi M, Yanagisawa K, Hosono Y, Isomura H, et al. Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer. Oncogene. 2022;: pubmed publisher
|
Heller Trulli D, Liu H, Mukherjee S, Moore C. UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells. Mol Cell Biol. 2022;42:e0017422 pubmed publisher
|
Karpov D, Demidova N, Kulagin K, Shuvalova A, Kovalev M, Simonov R, et al. Complete and Prolonged Inhibition of Herpes Simplex Virus Type 1 Infection In Vitro by CRISPR/Cas9 and CRISPR/CasX Systems. Int J Mol Sci. 2022;23: pubmed publisher
|
Viegas J, Azad G, Lv Y, Fishman L, Paltiel T, Pattabiraman S, et al. RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2. Dev Cell. 2022;57:2731-2744.e5 pubmed publisher
|
Takahashi G, Kondo D, Maeda M, Morishita Y, Miyaoka Y. Genome editing is induced in a binary manner in single human cells. iScience. 2022;25:105619 pubmed publisher
|
Niu Y, Ferreira Azevedo C, Li X, Kamali E, Haagen Nielsen O, Storgaard S xf8 rensen C, et al. Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select. Nat Genet. 2022;54:1983-1993 pubmed publisher
|
Solaimuthu B, Lichtenstein M, Hayashi A, Khatib A, Plaschkes I, Nevo Y, et al. Depletion of Fumarate Hydratase, an Essential TCA Cycle Enzyme, Drives Proliferation in a Two-Step Model. Cancers (Basel). 2022;14: pubmed publisher
|
Nishiyama T, Zhang Y, Cui M, Li H, Sanchez Ortiz E, McAnally J, et al. Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy. Sci Transl Med. 2022;14:eade1633 pubmed publisher
|
Liu Y, Azizian N, Sullivan D, Li Y. mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resistant persisters. Nat Commun. 2022;13:7047 pubmed publisher
|
Di Paola S, Matarese M, Barretta M, Dathan N, Colanzi A, Corda D, et al. PARP10 Mediates Mono-ADP-Ribosylation of Aurora-A Regulating G2/M Transition of the Cell Cycle. Cancers (Basel). 2022;14: pubmed publisher
|
Geiller H, Harvey A, Jones R, Grimstead J, Cleal K, Hendrickson E, et al. ATRX modulates the escape from a telomere crisis. PLoS Genet. 2022;18:e1010485 pubmed publisher
|
Heijink A, Stok C, Porubský D, Manolika E, de Kanter J, Kok Y, et al. Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51. Nat Commun. 2022;13:6722 pubmed publisher
|
Hanzl A, Casement R, Imrichová H, Hughes S, Barone E, Testa A, et al. Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. Nat Chem Biol. 2022;: pubmed publisher
|
Zimmerli D, Brambillasca C, Talens F, Bhin J, Linstra R, Romanens L, et al. MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling. Nat Commun. 2022;13:6579 pubmed publisher
|
Chen H, Ho Y, Mezzadra R, Adrover J, Smolkin R, Zhu C, et al. Senescence rewires microenvironment sensing to facilitate anti-tumor immunity. Cancer Discov. 2022;: pubmed publisher
|
Galiani S, Reglinski K, Carravilla P, Barbotin A, Urban x10d i x10d I, Ott J, et al. Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5. Biophys Rep (N Y). 2022;2:None pubmed publisher
|
Brooks R, Monzy J, Aaron B, Zhang X, Kossenkov A, Hayden J, et al. Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis. Cell Rep. 2022;41:111514 pubmed publisher
|
Hou G, Zhou T, Xu N, Yin Z, Zhu X, Zhang Y, et al. Integrative functional genomics identifies SLE causal genetic variant in the IRF5 risk locus. Arthritis Rheumatol. 2022;: pubmed publisher
|
Winkler R, Quaas M, Glasmacher S, Wolfrum U, Thalheim T, Galle J, et al. The Adhesion G-Protein-Coupled Receptor GPR115/ADGRF4 Regulates Epidermal Differentiation and Associates with Cytoskeletal KRT1. Cells. 2022;11: pubmed publisher
|
Kokate S, Ciuba K, Tran V, Kumari R, Tojkander S, Engel U, et al. Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments. Nat Commun. 2022;13:6032 pubmed publisher
|
Novakova Z, Milosevic M, Kutil Z, Ondrakova M, Havlinova B, Kaspárek P, et al. Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene. Sci Rep. 2022;12:17081 pubmed publisher
|
Zhang J, Wang B, Gao X, Peng C, Shan C, Johnson S, et al. RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy. Nat Commun. 2022;13:6007 pubmed publisher
|
Blomberg E, Silginer M, Roth P, Weller M. Programmed death ligand 1 gene silencing in murine glioma models reveals cell line-specific modulation of tumor growth in vivo. Neurooncol Adv. 2022;4:vdac148 pubmed publisher
|
Fern xe1 ndez Vizarra E, L xf3 pez Calcerrada S, Sierra Magro A, P xe9 rez P xe9 rez R, Formosa L, Hock D, et al. Two independent respiratory chains adapt OXPHOS performance to glycolytic switch. Cell Metab. 2022;34:1792-1808.e6 pubmed publisher
|
Ras xe9 V, Hayward R, Haughian J, Pullen N. Th17, Th22, and Myeloid-Derived Suppressor Cell Population Dynamics and Response to IL-6 in 4T1 Mammary Carcinoma. Int J Mol Sci. 2022;23: pubmed publisher
|
Hutter K, R xfc licke T, Szabó T, Andersen L, Villunger A, Herzog S. The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression. Front Immunol. 2022;13:967914 pubmed publisher
|
Zhao X, Wang P, Diedrich J, Smart B, Reyes N, Yoshimura S, et al. Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia. Nat Commun. 2022;13:5401 pubmed publisher
|
Glentis A, Blanch Mercader C, Balasubramaniam L, Saw T, D Alessandro J, Janel S, et al. The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces. Sci Adv. 2022;8:eabn5406 pubmed publisher
|
Van Royen T, Sedeyn K, Moschonas G, Toussaint W, Vuylsteke M, Van Haver D, et al. An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25. J Virol. 2022;96:e0129722 pubmed publisher
|
Kim Y, Potashnikova D, Gisina A, Kholodenko I, Kopylov A, Tikhonova O, et al. TRIM28 Is a Novel Regulator of CD133 Expression Associated with Cancer Stem Cell Phenotype. Int J Mol Sci. 2022;23: pubmed publisher
|
Damkham N, Lorthongpanich C, Klaihmon P, Lueangamornnara U, Kheolamai P, Trakarnsanga K, et al. YAP and TAZ play a crucial role in human erythrocyte maturation and enucleation. Stem Cell Res Ther. 2022;13:467 pubmed publisher
|
Bridges J, Safina C, Pirard B, Brown K, Filuta A, Panchanathan R, et al. Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism. elife. 2022;11: pubmed publisher
|
van Schendel R, Schimmel J, Tijsterman M. SIQ: easy quantitative measurement of mutation profiles in sequencing data. NAR Genom Bioinform. 2022;4:lqac063 pubmed publisher
|
Colicchia V, H xe4 ggblad M, Sirozh O, Porebski B, Balan M, Li X, et al. New regulators of the tetracycline-inducible gene expression system identified by chemical and genetic screens. FEBS Open Bio. 2022;12:1896-1908 pubmed publisher
|
Harlow C, Gandawijaya J, Bamford R, Martin E, Wood A, van der Most P, et al. Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies. Am J Hum Genet. 2022;109:1638-1652 pubmed publisher
|
Makaryan V, Kelley M, Fletcher B, Archibald I, Poulsen T, Dale D. Comparison of Gene Editing versus a Neutrophil Elastase Inhibitor as Potential Therapies for ELANE Neutropenia. J Cell Immunol. 2022;4:19-28 pubmed publisher
|
Shi M, McCracken K, Patel A, Zhang W, Ester L, Valerius M, et al. Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types. Nat Biotechnol. 2022;: pubmed publisher
|
Zhdanova P, Lomzov A, Prokhorova D, Stepanov G, Chernonosov A, Koval V. Thermodynamic Swings: How Ideal Complex of Cas9-RNA/DNA Forms. Int J Mol Sci. 2022;23: pubmed publisher
|
Vanneste D, Staal J, Haegman M, Driege Y, Carels M, Van Nuffel E, et al. CARD14 Signalling Ensures Cell Survival and Cancer Associated Gene Expression in Prostate Cancer Cells. Biomedicines. 2022;10: pubmed publisher
|
Busch M, Bredeck G, Waag F, Rahimi K, Ramachandran H, Bessel T, et al. Assessing the NLRP3 Inflammasome Activating Potential of a Large Panel of Micro- and Nanoplastics in THP-1 Cells. Biomolecules. 2022;12: pubmed publisher
|
Ibarra I, Ratnu V, Gordillo L, Hwang I, Mariani L, Weinand K, et al. Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements. Mol Syst Biol. 2022;18:e10473 pubmed publisher
|
Liu H, Heller Trulli D, Moore C. Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal. iScience. 2022;25:104804 pubmed publisher
|
De Angeli P, Reuter P, Hauser S, Sch xf6 ls L, Stingl K, Wissinger B, et al. Effective splicing restoration of a deep-intronic ABCA4 variant in cone photoreceptor precursor cells by CRISPR/SpCas9 approaches. Mol Ther Nucleic Acids. 2022;29:511-524 pubmed publisher
|
Cumin C, Huang Y, Rossdam C, Ruoff F, C xe9 spedes S, Liang C, et al. Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways. Cell Rep. 2022;40:111181 pubmed publisher
|
Khateb M, Perovanovic J, Ko K, Jiang K, Feng X, Acevedo Luna N, et al. Transcriptomics, regulatory syntax, and enhancer identification in mesoderm-induced ESCs at single-cell resolution. Cell Rep. 2022;40:111219 pubmed publisher
|
Groen K, van Nieuwkoop S, Lamers M, Fouchier R, van den Hoogen B. Evidence against the Human Metapneumovirus G, SH, and M2-2 Proteins as Bona Fide Interferon Antagonists. J Virol. 2022;96:e0072322 pubmed publisher
|
Blessing C, Apelt K, van den Heuvel D, González Leal C, Rother M, van der Woude M, et al. XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair. Nat Commun. 2022;13:4762 pubmed publisher
|
Gerardo Ram xed rez M, Keggenhoff F, Giam V, Becker D, Groth M, Hartmann N, et al. CD44 Contributes to the Regulation of MDR1 Protein and Doxorubicin Chemoresistance in Osteosarcoma. Int J Mol Sci. 2022;23: pubmed publisher
|
Lebeau B, Zhao K, Jangal M, Zhao T, Guerra M, Greenwood C, et al. Single base-pair resolution analysis of DNA binding motif with MoMotif reveals an oncogenic function of CTCF zinc-finger 1 mutation. Nucleic Acids Res. 2022;50:8441-8458 pubmed publisher
|
Solinger J, Rashid H, Spang A. FERARI and cargo adaptors coordinate cargo flow through sorting endosomes. Nat Commun. 2022;13:4620 pubmed publisher
|
Yousefi M, Lee W, Yan B, Cui L, Yong C, Yap X, et al. TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection. PLoS Pathog. 2022;18:e1010763 pubmed publisher
|
Wang J, Zhang Z, Jiang J, Tang L, Wang X, Wang Z, et al. KDM2A plays a dual role in regulating the expression of malignancy-related genes in esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 2022;624:53-58 pubmed publisher
|
Pfromm J, Bonillo M, Dauletbekov D, Bucher K, Fischer M. Plasmid-mediated gene transfer of Cas9 induces vector-related but not SpCas9-related immune responses in human retinal pigment epithelial cells. Sci Rep. 2022;12:13202 pubmed publisher
|
Bolgi O, Silva Garcia M, Ross B, Pilla E, Kari V, Killisch M, et al. Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. EMBO Rep. 2022;23:e54136 pubmed publisher
|
Na Z, Dai X, Zheng S, Bryant C, Loh K, Su H, et al. Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID. Mol Cell. 2022;82:2900-2911.e7 pubmed publisher
|
Feng H, Lane K, Roumeliotis T, Jeggo P, Somaiah N, Choudhary J, et al. PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance. Genes Dev. 2022;36:790-806 pubmed publisher
|
Gómez Navarro N, Maldutyte J, Poljak K, Peak Chew S, Orme J, Bisnett B, et al. Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export. Proc Natl Acad Sci U S A. 2022;119:e2202080119 pubmed publisher
|
Moya J xf3 dar M, Coppiello G, Rodr xed guez Madoz J, Abizanda G, Barlab xe9 P, Vilas Zornoza A, et al. One-Step In Vitro Generation of ETV2-Null Pig Embryos. Animals (Basel). 2022;12: pubmed publisher
|
Mugarza E, Van Maldegem F, Boumelha J, Moore C, Rana S, Llorian Sopena M, et al. Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers. Sci Adv. 2022;8:eabm8780 pubmed publisher
|
Slusher A, Kim J, Ribick M, Pollens Voigt J, Bankhead A, Palmbos P, et al. Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non-Small Cell Lung Cancer. Mol Cancer Res. 2022;20:1574-1588 pubmed publisher
|
Fu H, Wang T, Kong X, Yan K, Yang Y, Cao J, et al. A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells. Nat Commun. 2022;13:3984 pubmed publisher
|
Kim H, Moon S, Hong S, Won H, Kim J. DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300. Nucleic Acids Res. 2022;: pubmed publisher
|
Feng Z, Hom M, Bearrood T, Rosenthal Z, Fernandez D, Ondrus A, et al. Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. Nat Chem Biol. 2022;: pubmed publisher
|
Cheng J, Clayton J, Acemel R, Zheng Y, Taylor R, Kele x15f S, et al. Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer. Front Immunol. 2022;13:901747 pubmed publisher
|
Rinzema N, Sofiadis K, Tjalsma S, Verstegen M, Oz Y, Valdes Quezada C, et al. Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes. Nat Struct Mol Biol. 2022;29:563-574 pubmed publisher
|
Rahimi H, Zaboli K, Thekkiniath J, Mousavi S, Johari B, Hashemi M, et al. BSA-PEI Nanoparticle Mediated Efficient Delivery of CRISPR/Cas9 into MDA-MB-231 Cells. Mol Biotechnol. 2022;64:1376-1387 pubmed publisher
|
Hancock Cerutti W, Wu Z, Xu P, Yadavalli N, Leonzino M, Tharkeshwar A, et al. ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling. J Cell Biol. 2022;221: pubmed publisher
|
Nguyen T, Ramachandran H, Martins S, Krutmann J, Rossi A. Identification of genome edited cells using CRISPRnano. Nucleic Acids Res. 2022;: pubmed publisher
|
Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, et al. Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022;24:954-967 pubmed publisher
|
Sousa D, Gaspar R, Ferreira C, Baltazar F, Rodrigues L, Silva B. In Vitro CRISPR/Cas9 Transfection and Gene-Editing Mediated by Multivalent Cationic Liposome-DNA Complexes. Pharmaceutics. 2022;14: pubmed publisher
|
Gangopadhyay A, Devi S, Tenguria S, Carrière J, Nguyen H, Jäger E, et al. NLRP3 licenses NLRP11 for inflammasome activation in human macrophages. Nat Immunol. 2022;23:892-903 pubmed publisher
|
Kim Y, Nomakuchi T, Papaleonidopoulou F, Yang L, Zhang Q, Krainer A. Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy. Nat Commun. 2022;13:2978 pubmed publisher
|
Zhu D, Han F, Sun L, Agnihotri S, Hu Y, Bueler H. Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission. Front Oncol. 2022;12:893396 pubmed publisher
|
Schlo xdf hauer J, Cavak N, Zemella A, Thoring L, Kubick S. Cell Engineering and Cultivation of Chinese Hamster Ovary Cells for the Development of Orthogonal Eukaryotic Cell-free Translation Systems. Front Mol Biosci. 2022;9:832379 pubmed publisher
|
Gao Q, Wang S, Li F, Lian J, Cheng S, Yue D, et al. High Mobility Group Protein B1 Decreases Surface Localization of PD-1 to Augment T-cell Activation. Cancer Immunol Res. 2022;10:844-855 pubmed publisher
|
Duclaux Loras R, Lebreton C, Berthelet J, Charbit Henrion F, Nicolle O, Revenu de Courtils C, et al. UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking. J Clin Invest. 2022;132: pubmed publisher
|
Fernandez R, Gardner Z, Slovik K, Liberti D, Estep K, Yang W, et al. GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells. elife. 2022;11: pubmed publisher
|
Reticker Flynn N, Zhang W, Belk J, Basto P, Escalante N, Pilarowski G, et al. Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Cell. 2022;185:1924-1942.e23 pubmed publisher
|
Liu J, Knopp K, Rackaityte E, Wang C, Laurie M, Sunshine S, et al. Genome-Wide Knockout Screen Identifies Human Sialomucin CD164 as an Essential Entry Factor for Lymphocytic Choriomeningitis Virus. MBio. 2022;13:e0020522 pubmed publisher
|
Kappel S, Ross Kaschitza D, Hauert B, Rother K, Peinelt C. p53 alters intracellular Ca2+ signaling through regulation of TRPM4. Cell Calcium. 2022;104:102591 pubmed publisher
|
Hanna M, Suen P, Wu Y, Reinisch K, De Camilli P. SHIP164 is a chorein motif lipid transfer protein that controls endosome-Golgi membrane traffic. J Cell Biol. 2022;221: pubmed publisher
|
Mockly S, Houbron É, Seitz H. A rationalized definition of general tumor suppressor microRNAs excludes miR-34a. Nucleic Acids Res. 2022;: pubmed publisher
|
Zakharova V, Magnitov M, Del Maestro L, Ulianov S, Glentis A, Uyanik B, et al. SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties. Nucleic Acids Res. 2022;: pubmed publisher
|
Zhang X, Jiang Y, Wang Q, An W, Zhang X, Xu M, et al. Atypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis. Invest Ophthalmol Vis Sci. 2022;63:17 pubmed publisher
|
Wu L, Shukla V, Yadavalli A, Dinesh R, Xu D, Rao A, et al. HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation. Genes Dev. 2022;36:433-450 pubmed publisher
|
Llimos G, Gardeux V, Koch U, Kribelbauer J, Hafner A, Alpern D, et al. A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation. Nat Commun. 2022;13:2042 pubmed publisher
|
Daoud M, Broxtermann P, Schorn F, Werthenbach J, Seeger J, Schiffmann L, et al. XIAP promotes melanoma growth by inducing tumour neutrophil infiltration. EMBO Rep. 2022;23:e53608 pubmed publisher
|
Rylee J, Nin Velez A, Mahato S, Helms K, Wade M, Zentner G, et al. Generating and testing the efficacy of transgenic Cas9 in Tribolium castaneum. Insect Mol Biol. 2022;31:543-550 pubmed publisher
|
Pokusaeva V, Diez A, Espinar L, Pérez A, Filion G. Strand asymmetry influences mismatch resolution during a single-strand annealing. Genome Biol. 2022;23:93 pubmed publisher
|
Bordeira Carriço R, Teixeira J, Duque M, Galhardo M, Ribeiro D, Acemel R, et al. Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers. Nat Commun. 2022;13:1945 pubmed publisher
|
Pladevall Morera D, Castejón Griñán M, Aguilera P, Gaardahl K, Ingham A, Brosnan Cashman J, et al. ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors. Cancers (Basel). 2022;14: pubmed publisher
|
V xe1 squez Limeta A, Lukasik K, Kong D, Sullenberger C, Luvsanjav D, Sahabandu N, et al. CPAP insufficiency leads to incomplete centrioles that duplicate but fragment. J Cell Biol. 2022;221: pubmed publisher
|
Mishra T, Bhardwaj V, Ahuja N, Gadgil P, Ramdas P, Shukla S, et al. Improved loss-of-function CRISPR-Cas9 genome editing in human cells concomitant with inhibition of TGF-β signaling. Mol Ther Nucleic Acids. 2022;28:202-218 pubmed publisher
|
Rubio Ramos A, Bernabé Rubio M, Labat de Hoz L, Casares Arias J, Kremer L, Correas I, et al. MALL, a membrane-tetra-spanning proteolipid overexpressed in cancer, is present in membraneless nuclear biomolecular condensates. Cell Mol Life Sci. 2022;79:236 pubmed publisher
|
Zhou T, Zhu X, Ye Z, Wang Y, Yao C, Xu N, et al. Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery. Nat Commun. 2022;13:1855 pubmed publisher
|
Liu Z, Wu A, Wu Z, Wang T, Pan Y, Li B, et al. TOX4 facilitates promoter-proximal pausing and C-terminal domain dephosphorylation of RNA polymerase II in human cells. Commun Biol. 2022;5:300 pubmed publisher
|
Di Minin G, Holzner M, Grison A, Dumeau C, Chan W, Monfort A, et al. TMED2 binding restricts SMO to the ER and Golgi compartments. PLoS Biol. 2022;20:e3001596 pubmed publisher
|
Adpaikar A, Zhang S, Kim H, Kim K, Moon S, Lee J, et al. Fine-tuning of epithelial taste bud organoid to promote functional recapitulation of taste reactivity. Cell Mol Life Sci. 2022;79:211 pubmed publisher
|
Angelopoulou A, Papaspyropoulos A, Papantonis A, Gorgoulis V. CRISPR-Cas9-mediated induction of large chromosomal inversions in human bronchial epithelial cells. STAR Protoc. 2022;3:101257 pubmed publisher
|
Miki S, Koga T, McKinney A, Parisian A, Tadokoro T, Vadla R, et al. TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo. Neuro Oncol. 2022;: pubmed publisher
|
Maharaj A, Guran T, Buonocore F, Achermann J, Metherell L, Prasad R, et al. Insights From Long-term Follow-up of a Girl With Adrenal Insufficiency and Sphingosine-1-Phosphate Lyase Deficiency. J Endocr Soc. 2022;6:bvac020 pubmed publisher
|
Guo X, Zhao Y, Kim J, Dean A. Hemogen/BRG1 cooperativity modulates promoter and enhancer activation during erythropoiesis. Blood. 2022;139:3532-3545 pubmed publisher
|
Fung T, Chakrabarti R, Kollasser J, Rottner K, Stradal T, Kage F, et al. Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria. Curr Biol. 2022;32:1577-1592.e8 pubmed publisher
|
Aouida M, Aljogol D, Ali R, Ramotar D. A simple protocol to isolate a single human cell PRDX1 knockout generated by CRISPR-Cas9 system. STAR Protoc. 2022;3:101216 pubmed publisher
|
Li C, Ogawa H, Ng S, Chen X, Kishimoto E, Sakabe K, et al. Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency. JHEP Rep. 2022;4:100446 pubmed publisher
|
Zamberlan M, Boeckx A, Muller F, Vinelli F, Ek O, Vianello C, et al. Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth. J Exp Clin Cancer Res. 2022;41:95 pubmed publisher
|
Stormo A, Shavarebi F, FitzGibbon M, Earley E, Ahrendt H, Lum L, et al. The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. J Cell Biol. 2022;221: pubmed publisher
|
Arnold P, Jackson B, Paras K, Brunner J, Hart M, Newsom O, et al. A non-canonical tricarboxylic acid cycle underlies cellular identity. Nature. 2022;603:477-481 pubmed publisher
|
Lee D, Apelt K, Lee S, Chan H, Luijsterburg M, Leung J, et al. ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination. Nucleic Acids Res. 2022;50:3922-3943 pubmed publisher
|
Ishihara S, Sato T, Fujikado N, Miyazaki H, Yoshimoto T, Yamamoto H, et al. Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling. Commun Biol. 2022;5:206 pubmed publisher
|
Cujba A, Alvarez Fallas M, Pedraza Arevalo S, Laddach A, Shepherd M, Hattersley A, et al. An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function. Cell Rep. 2022;38:110425 pubmed publisher
|
D Annibale O, Koppes E, Sethuraman M, Bloom K, Mohsen A, Vockley J. Characterization of exonic variants of uncertain significance in very long-chain acyl-CoA dehydrogenase identified through newborn screening. J Inherit Metab Dis. 2022;45:529-540 pubmed publisher
|
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, et al. Low-dose metformin targets the lysosomal AMPK pathway through PEN2. Nature. 2022;603:159-165 pubmed publisher
|
Nataraj N, Noronha A, Lee J, Ghosh S, Mohan Raju H, Sekar A, et al. Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. Cell Rep. 2022;38:110418 pubmed publisher
|
Sivakumar S, Qi S, Cheng N, Sathe A, Kanchwala M, Kumar A, et al. TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling. Cell Rep. 2022;38:110395 pubmed publisher
|
Kim H, Jang S, Lee Y. The m6A(m)-independent role of FTO in regulating WNT signaling pathways. Life Sci Alliance. 2022;5: pubmed publisher
|
Sreenivasan L, Li L, Leclair P, Lim C. Targeting the gp130/STAT3 Axis Attenuates Tumor Microenvironment Mediated Chemoresistance in Group 3 Medulloblastoma Cells. Cells. 2022;11: pubmed publisher
|
Umansky C, Morellato A, Rieckher M, Scheidegger M, Martinefski M, Fernández G, et al. Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity. Nat Commun. 2022;13:745 pubmed publisher
|
Pan Y, Shao M, Li P, Xu C, Nie J, Zhang K, et al. Polyaminoglycoside-mediated cell reprogramming system for the treatment of diabetes mellitus. J Control Release. 2022;343:420-433 pubmed publisher
|
Meinhardt A, Munkhbaatar E, Höckendorf U, Dietzen M, Dechant M, Anton M, et al. The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner. Oncogene. 2022;41:1376-1382 pubmed publisher
|
Rodríguez Caparrós A, Álvarez Santiago J, López Castellanos L, Ruiz Rodríguez C, Valle Pastor M, López Ros J, et al. Differently Regulated Gene-Specific Activity of Enhancers Located at the Boundary of Subtopologically Associated Domains: TCRα Enhancer. J Immunol. 2022;208:910-928 pubmed publisher
|
Riesenberg S, Helmbrecht N, Kanis P, Maricic T, Paabo S. Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage. Nat Commun. 2022;13:489 pubmed publisher
|
Siqueira E, Obiols Guardia A, Jorge Torres O, Oliveira Mateos C, Soler M, Ramesh Kumar D, et al. Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome. Mol Ther Nucleic Acids. 2022;27:621-644 pubmed publisher
|
Uceda Castro R, van Asperen J, Vennin C, Sluijs J, van Bodegraven E, Margarido A, et al. GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence. Sci Rep. 2022;12:424 pubmed publisher
|
Ajore R, Niroula A, Pertesi M, Cafaro C, Thodberg M, Went M, et al. Functional dissection of inherited non-coding variation influencing multiple myeloma risk. Nat Commun. 2022;13:151 pubmed publisher
|
Cacho Navas C, Reglero Real N, Colás Algora N, Barroso S, de Rivas G, Stamatakis K, et al. Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells. Cell Mol Life Sci. 2022;79:61 pubmed publisher
|
Vogeley C, Sondermann N, Woeste S, Momin A, Gilardino V, Hartung F, et al. Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response. Environ Int. 2022;158:106989 pubmed publisher
|
Wang Z, Lv J, Yu P, Qu Y, Zhou Y, Zhou L, et al. SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages. Cell Mol Immunol. 2022;: pubmed publisher
|
Ishikawa M, Osaki M, Uno N, Ohira T, Kugoh H, Okada F. MTA1, a metastasis‑associated protein, in endothelial cells is an essential molecule for angiogenesis. Mol Med Rep. 2022;25: pubmed publisher
|
Wu F, Xu L, Tu Y, Cheung O, Szeto L, Mok M, et al. Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis. Cancer Lett. 2022;525:115-130 pubmed publisher
|
Millarte V, Schlienger S, Kälin S, Spiess M. Rabaptin5 targets autophagy to damaged endosomes and Salmonella vacuoles via FIP200 and ATG16L1. EMBO Rep. 2022;23:e53429 pubmed publisher
|
Leon F, Seshacharyulu P, Nimmakayala R, Chugh S, Karmakar S, Nallasamy P, et al. Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and metastasis in pancreatic cancer. Oncogene. 2022;41:57-71 pubmed publisher
|
Yin Y, Yan F, Zhou R, Li M, Ma J, Liu Z, et al. Single-domain antibody screening by isPLA-seq. Life Sci Alliance. 2022;5: pubmed publisher
|
Huhn D, Marti Rodrigo P, Mouron S, Hansel C, Tschapalda K, Porebski B, et al. Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells. Mol Oncol. 2022;16:148-165 pubmed publisher
|
Naakka E, Barros Filho M, Adnan Awad S, Al Samadi A, Marchi F, Kuasne H, et al. miR-22 and miR-205 Drive Tumor Aggressiveness of Mucoepidermoid Carcinomas of Salivary Glands. Front Oncol. 2021;11:786150 pubmed publisher
|
López Muneta L, Linares J, Casis O, Martínez Ibáñez L, González Miqueo A, Bezunartea J, et al. Generation of NKX2.5GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts. Front Cell Dev Biol. 2021;9:797927 pubmed publisher
|
Tsortouktzidis D, Tröscher A, Schulz H, Opitz T, Schoch S, Becker A, et al. A Versatile Clustered Regularly Interspaced Palindromic Repeats Toolbox to Study Neurological CaV3.2 Channelopathies by Promoter-Mediated Transcription Control. Front Mol Neurosci. 2021;14:667143 pubmed publisher
|
Deng C, Hu F, Zhao Z, Zhou Y, Liu Y, Zhang T, et al. The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance. Front Cell Dev Biol. 2021;9:797005 pubmed publisher
|
Shafaattalab S, Li A, Gunawan M, Kim B, Jayousi F, Maaref Y, et al. Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant I79N. Front Cell Dev Biol. 2021;9:787581 pubmed publisher
|
Kaku H, Ludlow A, Gutknecht M, Rothstein T. Fas Apoptosis Inhibitory Molecule Blocks and Dissolves Pathological Amyloid-β Species. Front Mol Neurosci. 2021;14:750578 pubmed publisher
|
Lange K, Best S, Tsiropoulou S, Berry I, Johnson C, Blacque O. Interpreting ciliopathy-associated missense variants of uncertain significance (VUS) in Caenorhabditis elegans. Hum Mol Genet. 2021;: pubmed publisher
|
Koslová A, Trefil P, Mucksová J, Krchlíková V, Plachy J, Krijt J, et al. Knock-Out of Retrovirus Receptor Gene Tva in the Chicken Confers Resistance to Avian Leukosis Virus Subgroups A and K and Affects Cobalamin (Vitamin B12)-Dependent Level of Methylmalonic Acid. Viruses. 2021;13: pubmed publisher
|
Guha J, Chari R. Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells. Vaccines (Basel). 2021;9: pubmed publisher
|
Kaiser F, Morawski M, Krohn K, Rayes N, Hsiao C, Quaas M, et al. Adhesion GPCR GPR56 Expression Profiling in Human Tissues. Cells. 2021;10: pubmed publisher
|
Hirayama H, Tachida Y, Seino J, Suzuki T. A method for assaying peptide: N-glycanase/N-Glycanase 1 activities in crude extracts using an N-glycosylated cyclopeptide. Glycobiology. 2021;: pubmed publisher
|
Sun X, Bai J, Xu J, Xi X, Gu M, Zhu C, et al. Multiple DSB Resection Activities Redundantly Promote Alternative End Joining-Mediated Class Switch Recombination. Front Cell Dev Biol. 2021;9:767624 pubmed publisher
|
Rovelet Lecrux A, Feuillette S, Miguel L, Schramm C, Pernet S, Quenez O, et al. Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease. Acta Neuropathol Commun. 2021;9:196 pubmed publisher
|
Ma K, Fokkens M, van Laar T, Verbeek D. Systematic analysis of PINK1 variants of unknown significance shows intact mitophagy function for most variants. NPJ Parkinsons Dis. 2021;7:113 pubmed publisher
|
Poetz F, Corbo J, Levdansky Y, Spiegelhalter A, Lindner D, Magg V, et al. RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation. Nat Commun. 2021;12:7175 pubmed publisher
|
Griffiths S, Schwab R, El Omari K, Bishop B, Iverson E, Malinauskas T, et al. Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun. 2021;12:7171 pubmed publisher
|
Jacobs Catane L, Moshel O, Smith Y, Davidson B, Reich R. Splice-Variant Knock-Out of TGFβ Receptors Perturbates the Proteome of Ovarian Carcinoma Cells. Int J Mol Sci. 2021;22: pubmed publisher
|
Miyake M, Zhang J, Yasue A, Hisanaga S, Tsugawa K, Sakaue H, et al. Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity. iScience. 2021;24:103448 pubmed publisher
|
Magdy T, Jouni M, Kuo H, Weddle C, Lyra Leite D, Fonoudi H, et al. Identification of Drug Transporter Genomic Variants and Inhibitors that Protect Against Doxorubicin-Induced Cardiotoxicity. Circulation. 2021;: pubmed publisher
|
Jiang H, Alahmad A, Fu S, Fu X, Liu Z, Han X, et al. Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency. J Inherit Metab Dis. 2021;: pubmed publisher
|
Mauthe M, Dinesh Kumar N, Verlhac P, van de Beek N, Reggiori F. HSBP1 Is a Novel Interactor of FIP200 and ATG13 That Promotes Autophagy Initiation and Picornavirus Replication. Front Cell Infect Microbiol. 2021;11:745640 pubmed publisher
|
Kim E, Liu P, Zhang S, Donahue K, Wang Y, Schehr J, et al. BAF155 methylation drives metastasis by hijacking super-enhancers and subverting anti-tumor immunity. Nucleic Acids Res. 2021;49:12211-12233 pubmed publisher
|
Reisman B, Guo H, Ramsey H, Wright M, Reinfeld B, Ferrell P, et al. Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase. Nat Chem Biol. 2021;: pubmed publisher
|
Robert Finestra T, Tan B, Mira Bontenbal H, Timmers E, Gontan C, Merzouk S, et al. SPEN is required for Xist upregulation during initiation of X chromosome inactivation. Nat Commun. 2021;12:7000 pubmed publisher
|
Donnelly L, Hogan T, Lenahan S, Nandagopal G, Eaton J, Lebeau M, et al. Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers. Carcinogenesis. 2021;42:1428-1438 pubmed publisher
|
Adhikari B, Narain A, Wolf E. Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells. STAR Protoc. 2021;2:100949 pubmed publisher
|
Podinovskaia M, Prescianotto Baschong C, Buser D, Spang A. A novel live-cell imaging assay reveals regulation of endosome maturation. elife. 2021;10: pubmed publisher
|
Feng Y, Li C, Stewart J, Barbulescu P, Desivo N, Alvarez Quilón A, et al. FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature. 2021;600:324-328 pubmed publisher
|
Kim D, Lee J, Lee E, Jang H, Han S, Kim H, et al. O-GlcNAcylation of Sox2 at threonine 258 regulates the self-renewal and early cell fate of embryonic stem cells. Exp Mol Med. 2021;53:1759-1768 pubmed publisher
|
King R, Lin Z, Balbin Cuesta G, Myers G, Friedman A, Zhu G, et al. SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II. Sci Adv. 2021;7:eabj5293 pubmed publisher
|
Adamowicz M, Hailstone R, Demin A, Komulainen E, Hanzlikova H, Brazina J, et al. XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. Nat Cell Biol. 2021;23:1287-1298 pubmed publisher
|
Dara M, Razban V, Mazloomrezaei M, Ranjbar M, Nourigorji M, Dianatpour M. Dystrophin gene editing by CRISPR/Cas9 system in human skeletal muscle cell line (HSkMC). Iran J Basic Med Sci. 2021;24:1153-1158 pubmed publisher
|
Mailler E, Guardia C, Bai X, Jarnik M, Williamson C, Li Y, et al. The autophagy protein ATG9A enables lipid mobilization from lipid droplets. Nat Commun. 2021;12:6750 pubmed publisher
|
Song Y, Hou G, Diep J, Ooi Y, Akopyants N, Beverley S, et al. Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation. Nucleic Acids Res. 2021;49:12706-12715 pubmed publisher
|
Lyu P, Hoang T, Santiago C, Thomas E, Timms A, Appel H, et al. Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina. Cell Rep. 2021;37:109994 pubmed publisher
|
Lee H, Lee J, Park N, Dubey S, Kim T, Ruan K, et al. Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS. Nat Neurosci. 2021;24:1673-1685 pubmed publisher
|
Earley A, Burbulla L, Krainc D, Awatramani R. Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons. Sci Rep. 2021;11:22257 pubmed publisher
|
Gorrell L, Omari S, Makareeva E, Leikin S. Noncanonical ER-Golgi trafficking and autophagy of endogenous procollagen in osteoblasts. Cell Mol Life Sci. 2021;78:8283-8300 pubmed publisher
|
Schink K, Tan K, Spangenberg H, Martorana D, Sneeggen M, Stévenin V, et al. The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. Nat Commun. 2021;12:6577 pubmed publisher
|
Smith J, Banerjee R, Waly R, Urbano A, Gimenez G, Day R, et al. Locus-Specific DNA Methylation Editing in Melanoma Cell Lines Using a CRISPR-Based System. Cancers (Basel). 2021;13: pubmed publisher
|
Dyrkheeva N, Filimonov A, Luzina O, Orlova K, Chernyshova I, Kornienko T, et al. New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1. Int J Mol Sci. 2021;22: pubmed publisher
|
Han S, Lee H, Lee A, Kim S, Jung I, Koh G, et al. CHD4 Conceals Aberrant CTCF-Binding Sites at TAD Interiors by Regulating Chromatin Accessibility in Mouse Embryonic Stem Cells. Mol Cells. 2021;44:805-829 pubmed publisher
|
Rahman M, Hyodo T, Hasan M, Mihara Y, Karnan S, Ota A, et al. Flow cytometry-based quantification of targeted knock-in events in human cell lines using a GPI-anchor biosynthesis gene PIGP. Biosci Rep. 2021;41: pubmed publisher
|
Mirzaei R, Gordon A, Zemp F, Kumar M, Sarkar S, Luchman H, et al. PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway. Sci Adv. 2021;7:eabh2148 pubmed publisher
|
Mózsik L, Pohl C, Meyer V, Bovenberg R, Nygård Y, Driessen A. Modular Synthetic Biology Toolkit for Filamentous Fungi. ACS Synth Biol. 2021;10:2850-2861 pubmed publisher
|
Kim J, Jeon Y, Lim S, Ryu J, Lee J, Chang I, et al. Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation. Cell Death Dis. 2021;12:1013 pubmed publisher
|
Aronson B, Scourzic L, Shah V, Swanzey E, Kloetgen A, Polyzos A, et al. A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus. Dev Cell. 2021;56:3052-3065.e5 pubmed publisher
|
Xu F, Wang N, Li G, Tian D, Shi X. ANGPTL8/Betatrophin Improves Glucose Tolerance in Older Mice and Metabolomic Analysis Reveals Its Role in Insulin Resistance in HepG2 Cells. Diabetes Metab Syndr Obes. 2021;14:4209-4221 pubmed publisher
|
Radaszkiewicz T, Nosková M, Gömöryová K, Vondálová Blanárová O, Radaszkiewicz K, Pícková M, et al. RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy. elife. 2021;10: pubmed publisher
|
Liniger M, Gerber M, Renzullo S, García Nicolás O, Ruggli N. TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent. Viruses. 2021;13: pubmed publisher
|
Tamura N, Sakai S, Martorell L, Colome R, Mizuike A, Goto A, et al. Intellectual-disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution. J Biol Chem. 2021;297:101338 pubmed publisher
|
Schuster J, de Guidi C, Fatima A, Sobol M, Dahl N. Syndromic RNA polymerase II insufficiency: Generation of a human induced pluripotent stem cell line (UUIGPi002A-5) with a heterozygous disruption of POLR2A. Stem Cell Res. 2021;57:102577 pubmed publisher
|
Romano E, Trionfini P, Giampietro R, Benigni A, Tomasoni S. Generation of a homozygous CIITA knockout iPS cell line using the CRISPR-Cas9 system. Stem Cell Res. 2021;57:102580 pubmed publisher
|
Duan S, Moro L, Qu R, Simoneschi D, Cho H, Jiang S, et al. Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis. Cell Rep. 2021;37:109870 pubmed publisher
|
Li Z, Liu W, Fu J, Cheng S, Xu Y, Wang Z, et al. Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11. Nature. 2021;599:290-295 pubmed publisher
|
Averina O, Permyakov O, Grigorieva O, Starshin A, Mazur A, Prokhortchouk E, et al. Comparative Analysis of Genome Editors Efficiency on a Model of Mice Zygotes Microinjection. Int J Mol Sci. 2021;22: pubmed publisher
|
Donati G, Ravà M, Filipuzzi M, Nicoli P, Cassina L, Verrecchia A, et al. Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma. Mol Oncol. 2021;: pubmed publisher
|
Karvelis T, Druteika G, Bigelyte G, Budre K, Zedaveinyte R, Silanskas A, et al. Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease. Nature. 2021;599:692-696 pubmed publisher
|
Sluysmans S, Méan I, Xiao T, Boukhatemi A, Ferreira F, Jond L, et al. PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis. Mol Biol Cell. 2021;32:ar34 pubmed publisher
|
Bai W, Zhu G, Xu J, Chen P, Meng F, Xue H, et al. The 3'-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching. Cell Rep. 2021;36:109756 pubmed publisher
|
Liang R, Yung M, He F, Jiao P, Chan K, Ngan H, et al. The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment. Cancers (Basel). 2021;13: pubmed publisher
|
Spek C, Aberson H, Butler J, de Vos A, Duitman J. CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs. Cells. 2021;10: pubmed publisher
|
Biber G, Ben Shmuel A, Noy E, Joseph N, Puthenveetil A, Reiss N, et al. Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies. Nat Commun. 2021;12:5581 pubmed publisher
|
Kohela A, van Kampen S, Moens T, Wehrens M, Molenaar B, Boogerd C, et al. Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy. Sci Transl Med. 2021;13:eabf2750 pubmed publisher
|
Smith L, Ladner J, Hodara V, Parodi L, Harris R, Callery J, et al. Multiplexed Simian Immunodeficiency Virus-Specific Paired RNA-Guided Cas9 Nickases Inactivate Proviral DNA. J Virol. 2021;95:e0088221 pubmed publisher
|
D Annibale O, Koppes E, Alodaib A, Kochersperger C, Karunanidhi A, Mohsen A, et al. Characterization of variants of uncertain significance in isovaleryl-CoA dehydrogenase identified through newborn screening: An approach for faster analysis. Mol Genet Metab. 2021;134:29-36 pubmed publisher
|
Kim D, Kulishova L, Torgasheva N, Melentyev V, Dianov G, Medvedev S, et al. Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line. PLoS ONE. 2021;16:e0257473 pubmed publisher
|
Soblechero Martin P, Albiasu Arteta E, Anton Martinez A, de la Puente Ovejero L, Garcia Jimenez I, González Iglesias G, et al. Duchenne muscular dystrophy cell culture models created by CRISPR/Cas9 gene editing and their application in drug screening. Sci Rep. 2021;11:18188 pubmed publisher
|
Temocin O, Regele D, Sathianathan M, Überbacher C, Hartl M, Edenhofer F, et al. Generation of an hiPSC-1 knock-in line expressing TY1-tagged MNX1-protein together with mScarlet. Stem Cell Res. 2021;56:102522 pubmed publisher
|
Tromans Coia C, Sanchi A, Moeller G, Timinszky G, Lopes M, Ahel I. TARG1 protects against toxic DNA ADP-ribosylation. Nucleic Acids Res. 2021;49:10477-10492 pubmed publisher
|
Yue X, Qian Y, Zhu L, Gim B, Bao M, Jia J, et al. ACBD3 modulates KDEL receptor interaction with PKA for its trafficking via tubulovesicular carrier. BMC Biol. 2021;19:194 pubmed publisher
|
Šikrová D, Cadar V, Ariyurek Y, Laros J, Balog J, van der Maarel S. Adenine base editing of the DUX4 polyadenylation signal for targeted genetic therapy in facioscapulohumeral muscular dystrophy. Mol Ther Nucleic Acids. 2021;25:342-354 pubmed publisher
|
Santiago F, Li Y, Khachigian L. Serine 26 in Early Growth Response-1 Is Critical for Endothelial Proliferation, Migration, and Network Formation. J Am Heart Assoc. 2021;10:e020521 pubmed publisher
|
Redman Rivera L, Shaver T, Jin H, Marshall C, Schafer J, Sheng Q, et al. Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes. Nat Commun. 2021;12:5184 pubmed publisher
|
Lai X, Liu J, Zou Z, Wang Y, Wang Y, Liu X, et al. SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells. Cell Death Dis. 2021;12:814 pubmed publisher
|
Mariani L, Guo X, Menezes N, Drozd A, Çakal S, Wang Q, et al. A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm. Nat Commun. 2021;12:5136 pubmed publisher
|
Pierre M, Djemai M, Poulin H, Chahine M. NaV1.5 knockout in iPSCs: a novel approach to study NaV1.5 variants in a human cardiomyocyte environment. Sci Rep. 2021;11:17168 pubmed publisher
|
Guardia C, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino J. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Mol Biol Cell. 2021;32:ar25 pubmed publisher
|
Morrow C, Porter T, Moore D. Fluorescent tagging of endogenous proteins with CRISPR/Cas9 in primary mouse neural stem cells. STAR Protoc. 2021;2:100744 pubmed publisher
|
Li P, Li S, Gao S, Dong D. CRISPR/Cas9-mediated gene editing on Sox2ot promoter leads to its truncated expression and does not influence neural tube closure and embryonic development in mice. Biochem Biophys Res Commun. 2021;573:107-111 pubmed publisher
|
Li X, Chen M, Liu B, Lu P, Lv X, Zhao X, et al. Transcriptional silencing of fetal hemoglobin expression by NonO. Nucleic Acids Res. 2021;49:9711-9723 pubmed publisher
|
Geurts M, de Poel E, Pleguezuelos Manzano C, Oka R, Carrillo L, Andersson Rolf A, et al. Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids. Life Sci Alliance. 2021;4: pubmed publisher
|
Stanton C, Findlay A, Drake C, Mustafa M, Gautier P, McKie L, et al. A Mouse Model of Brittle Cornea Syndrome caused by mutation in Zfp469. Dis Model Mech. 2021;: pubmed publisher
|
Cui Z, Dabas H, Leonard B, Shiah J, Grandis J, Johnson D. Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction. Cell Death Dis. 2021;12:775 pubmed publisher
|
Ramakrishnan A, Chen L, Burby P, Cadigan K. Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif. Nucleic Acids Res. 2021;: pubmed publisher
|
Dyrkheeva N, Filimonov A, Luzina O, Zakharenko A, Ilina E, Malakhova A, et al. New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. Biomolecules. 2021;11: pubmed publisher
|
Hellwig C, Delgado M, Skoko J, Dyck L, Hanna C, Wentges A, et al. Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol. Cell Death Differ. 2021;: pubmed publisher
|
Ring S, Cupovic J, Onder L, Lütge M, Perez Shibayama C, Gil Cruz C, et al. Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nat Commun. 2021;12:4734 pubmed publisher
|
Nuebel E, Morgan J, Fogarty S, Winter J, Lettlova S, Berg J, et al. The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder. EMBO Rep. 2021;:e51991 pubmed publisher
|
Anderson C, Medina C, Barron B, Karvelyte L, Aaes T, Lambertz I, et al. Microbes exploit death-induced nutrient release by gut epithelial cells. Nature. 2021;596:262-267 pubmed publisher
|
Gao C, Wu P, Yu L, Liu L, Liu H, Tan X, et al. The application of CRISPR/Cas9 system in cervical carcinogenesis. Cancer Gene Ther. 2021;: pubmed publisher
|
Liu R, Li J, Shao J, Lee J, Qiu X, Xiao Y, et al. Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair. Cell Metab. 2021;: pubmed publisher
|
Gautheron J, Morisseau C, Chung W, Zammouri J, Auclair M, Baujat G, et al. EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. elife. 2021;10: pubmed publisher
|
Cui J, Duizer C, Bouwman L, van Rooijen K, Voogdt C, van Putten J, et al. The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells. PLoS Pathog. 2021;17:e1009787 pubmed publisher
|
Willms A, Schupp H, Poelker M, Adawy A, Debus J, Hartwig T, et al. TRAIL-receptor 2-a novel negative regulator of p53. Cell Death Dis. 2021;12:757 pubmed publisher
|
Becker J, Clifford G, Bonnet C, Groth A, Wilson M, Chapman J. BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination. Nature. 2021;: pubmed publisher
|
Saric A, Freeman S, Williamson C, Jarnik M, Guardia C, Fernandopulle M, et al. SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum. Nat Commun. 2021;12:4552 pubmed publisher
|
Brandt M, Kim Hellmuth S, Ziosi M, Gokden A, Wolman A, Lam N, et al. An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?. PLoS Genet. 2021;17:e1009684 pubmed publisher
|
Escrevente C, Falcão A, Hall M, Lopes da Silva M, Antas P, Mesquita M, et al. Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction. Invest Ophthalmol Vis Sci. 2021;62:39 pubmed publisher
|
Hattersley K, Carosi J, Hein L, Bensalem J, Sargeant T. PICALM regulates cathepsin D processing and lysosomal function. Biochem Biophys Res Commun. 2021;570:103-109 pubmed publisher
|
Anzai T, Hara H, Chanthra N, Sadahiro T, Ieda M, Hanazono Y, et al. Generation of Efficient Knock-in Mouse and Human Pluripotent Stem Cells Using CRISPR-Cas9. Methods Mol Biol. 2021;2320:247-259 pubmed publisher
|
Neguembor M, Martin L, Castells Garcia A, Gomez Garcia P, Vicario C, Carnevali D, et al. Transcription-mediated supercoiling regulates genome folding and loop formation. Mol Cell. 2021;81:3065-3081.e12 pubmed publisher
|
McAndrews K, Xiao F, Chronopoulos A, LeBleu V, Kugeratski F, Kalluri R. Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer. Life Sci Alliance. 2021;4: pubmed publisher
|
Stefanovic B, Stefanovic L, Manojlovic Z. Imaging of type I procollagen biosynthesis in cells reveals biogenesis in highly organized bodies; Collagenosomes. Matrix Biol Plus. 2021;12:100076 pubmed publisher
|
Bianchi G, Czarnecki P, Ho M, Roccaro A, Sacco A, Kawano Y, et al. ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment. Blood Cancer Discov. 2021;2:338-353 pubmed publisher
|
Yu J, LeRoy G, Bready D, Frenster J, Saldaña Meyer R, Jin Y, et al. The H3K36me2 writer-reader dependency in H3K27M-DIPG. Sci Adv. 2021;7: pubmed publisher
|
Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kucukkose C, et al. Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery. Nat Commun. 2021;12:4284 pubmed publisher
|
Duan Z, Baughn L, Wang X, Zhang Y, Gupta V, MacCarthy T, et al. Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
|
Cassioli C, Onnis A, Finetti F, Capitani N, Brunetti J, Compeer E, et al. The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly. J Cell Sci. 2021;: pubmed publisher
|
Wang W, Lu G, Liu H, Xiong Z, Leung H, Cao R, et al. Pten Regulates Cardiomyocyte Differentiation by Modulating Non-CG Methylation via Dnmt3. Adv Sci (Weinh). 2021;:e2100849 pubmed publisher
|
Kumar D, Rains A, Herranz Pérez V, Lu Q, Shi X, Swaney D, et al. A ciliopathy complex builds distal appendages to initiate ciliogenesis. J Cell Biol. 2021;220: pubmed publisher
|
Bogomiakova M, Sekretova E, Eremeev A, Shuvalova L, Bobrovsky P, Zerkalenkova E, et al. Derivation of induced pluripotent stem cells line (RCPCMi007-A-1) with inactivation of the beta-2-microglobulin gene by CRISPR/Cas9 genome editing. Stem Cell Res. 2021;55:102451 pubmed publisher
|
Ruiz E, Lan L, Diefenbacher M, Riising E, Da Costa C, Chakraborty A, et al. JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. JCI Insight. 2021;6: pubmed publisher
|
Serifi I, Besta S, Karetsou Z, Giardoglou P, Beis D, Niewiadomski P, et al. Targeting of SET/I2PP2A oncoprotein inhibits Gli1 transcription revealing a new modulator of Hedgehog signaling. Sci Rep. 2021;11:13940 pubmed publisher
|
Chu X, Jaeger M, Beumer J, Bakker O, Aguirre Gamboa R, Oosting M, et al. Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease. Genome Biol. 2021;22:198 pubmed publisher
|
Barile M, Imaz Rosshandler I, Inzani I, Ghazanfar S, Nichols J, Marioni J, et al. Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation. Genome Biol. 2021;22:197 pubmed publisher
|
Berthelsen M, Riedel M, Cai H, Skaarup S, Alstrup A, Dagnæs Hansen F, et al. The CRISPR/Cas9 Minipig-A Transgenic Minipig to Produce Specific Mutations in Designated Tissues. Cancers (Basel). 2021;13: pubmed publisher
|
Bownes L, Williams A, Marayati R, Quinn C, Hutchins S, Stewart J, et al. Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma Cell Lines. Cancers (Basel). 2021;13: pubmed publisher
|
Kuzuoğlu Öztürk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang G, et al. Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Cell Rep. 2021;35:109321 pubmed publisher
|
Conway E, Rossi F, Fernandez Perez D, Ponzo E, Ferrari K, Zanotti M, et al. BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation. Mol Cell. 2021;: pubmed publisher
|
Park S, Bennett Baker P, Ahmed S, Arlt M, Ljungman M, Glover T, et al. Locus-specific transcription silencing at the FHIT gene suppresses replication stress-induced copy number variant formation and associated replication delay. Nucleic Acids Res. 2021;49:7507-7524 pubmed publisher
|
Zhou J, Gelot C, Pantelidou C, Li A, Yücel H, Davis R, et al. A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. Nat Cancer. 2021;2:598-610 pubmed publisher
|
Zhang H, Zhang Y, Williams R, Smyth H. Development of PEGylated chitosan/CRISPR-Cas9 dry powders for pulmonary delivery via thin-film freeze-drying. Int J Pharm. 2021;605:120831 pubmed publisher
|
Perez García V, Lea G, Lopez Jimenez P, Okkenhaug H, Burton G, Moffett A, et al. BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion. elife. 2021;10: pubmed publisher
|
Szanto A, Aguilar R, Kesner B, Blum R, Wang D, Cifuentes Rojas C, et al. A disproportionate impact of G9a methyltransferase deficiency on the X chromosome. Genes Dev. 2021;35:1035-1054 pubmed publisher
|
Jamalpoor A, van Gelder C, Yousef Yengej F, Zaal E, Berlingerio S, Veys K, et al. Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis. EMBO Mol Med. 2021;13:e13067 pubmed publisher
|
Li P, Walsh J, Lopez K, Isidan A, Zhang W, Chen A, et al. Genetic engineering of porcine endothelial cell lines for evaluation of human-to-pig xenoreactive immune responses. Sci Rep. 2021;11:13131 pubmed publisher
|
Leung E, Patel J, Hollywood J, Zafar A, Tomek P, Barker D, et al. Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. Oncol Ther. 2021;: pubmed publisher
|
Corvaisier M, Zhou J, Malycheva D, Cornella N, Chioureas D, Gustafsson N, et al. The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells. Commun Biol. 2021;4:767 pubmed publisher
|
Chen D, Gregory A, Li X, Wei J, Burton C, Gibson G, et al. RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease. JCI Insight. 2021;6: pubmed publisher
|
Martens Y, Xu S, Tait R, Li G, Zhao X, Lu W, et al. Generation and validation of APOE knockout human iPSC-derived cerebral organoids. STAR Protoc. 2021;2:100571 pubmed publisher
|
Nieto Torres J, Shanahan S, Chassefeyre R, Chaiamarit T, Zaretski S, Landeras Bueno S, et al. LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Curr Biol. 2021;31:3440-3449.e7 pubmed publisher
|
Liu Y, Du M, Lin H. Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization. J Cell Mol Med. 2021;25:7690-7708 pubmed publisher
|
Shah A, Ratkowski M, Rosa A, Feinstein P, Bozza T. Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers. Nat Commun. 2021;12:3797 pubmed publisher
|
Kaufman M, Goodson N, Park K, Schwanke M, Office E, Schneider S, et al. Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity. Development. 2021;148: pubmed publisher
|
Xu S, Wu X, Wang P, Cao S, Peng B, Xu X. ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability. iScience. 2021;24:102534 pubmed publisher
|
Gažová I, Lefèvre L, Bush S, Rojo R, Hume D, Lengeling A, et al. CRISPR-Cas9 Editing of Human Histone Deubiquitinase Gene USP16 in Human Monocytic Leukemia Cell Line THP-1. Front Cell Dev Biol. 2021;9:679544 pubmed publisher
|
González Acosta D, Blanco Romero E, Ubieto Capella P, Mutreja K, Míguez S, Llanos S, et al. PrimPol-mediated repriming facilitates replication traverse of DNA interstrand crosslinks. EMBO J. 2021;40:e106355 pubmed publisher
|
Ma K, Fokkens M, Reggiori F, Mari M, Verbeek D. Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy. Transl Neurodegener. 2021;10:19 pubmed publisher
|
Mercer T, Ohashi Y, Boeing S, Jefferies H, De Tito S, Flynn H, et al. Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy. EMBO J. 2021;40:e105985 pubmed publisher
|
Bansal A, Pandey M, Barham W, Liu X, Harrington S, Lucien F, et al. Non-invasive immunoPET imaging of PD-L1 using anti-PD-L1-B11 in breast cancer and melanoma tumor model. Nucl Med Biol. 2021;100-101:4-11 pubmed publisher
|
Kimura H, Sada R, Takada N, Harada A, Doki Y, Eguchi H, et al. The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers. Oncogene. 2021;40:4486-4502 pubmed publisher
|
Dahlet T, Truss M, Frede U, Al Adhami H, Bardet A, Dumas M, et al. E2F6 initiates stable epigenetic silencing of germline genes during embryonic development. Nat Commun. 2021;12:3582 pubmed publisher
|
Weems J, Slaughter B, Unruh J, Weaver K, Miller B, Delventhal K, et al. A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription. J Biol Chem. 2021;297:100862 pubmed publisher
|
Tan K, Nähse V, Campsteijn C, Brech A, Schink K, Stenmark H. JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes. J Cell Sci. 2021;134: pubmed publisher
|
Xiong F, Wang R, Lee J, Li S, Chen S, Liao Z, et al. RNA m6A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability. Cell Res. 2021;31:861-885 pubmed publisher
|
van der Weegen Y, de Lint K, van den Heuvel D, Nakazawa Y, Mevissen T, van Schie J, et al. ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation. Nat Cell Biol. 2021;23:595-607 pubmed publisher
|
Xu J, Xu K, Jung S, Conte A, Lieberman J, Muecksch F, et al. Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants. Nature. 2021;595:278-282 pubmed publisher
|
Yao J, Wang Y, Cao C, Song R, Bi D, Zhang H, et al. CRISPR/Cas9-mediated correction of MITF homozygous point mutation in a Waardenburg syndrome 2A pig model. Mol Ther Nucleic Acids. 2021;24:986-999 pubmed publisher
|
Gisina A, NOVIKOVA S, Kim Y, Sidorov D, Bykasov S, Volchenko N, et al. CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells. Cancer Biomark. 2021;: pubmed publisher
|
Varone A, Amoruso C, Monti M, Patheja M, Greco A, Auletta L, et al. The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function. Cell Commun Signal. 2021;19:64 pubmed publisher
|
Wei C, Luo Q, Wang B, Long Y, Zhang M, Shan W, et al. Generation of a FTO gene knockout human embryonic stem cell line using CRISPR/Cas9 editing. Stem Cell Res. 2021;53:102362 pubmed publisher
|
Kato H, Maezawa Y, Ouchi Y, Takayama N, Sone M, Sone K, et al. Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome. Stem Cell Res. 2021;53:102360 pubmed publisher
|
Yamamoto Y, Chino H, Tsukamoto S, Ode K, Ueda H, Mizushima N. NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA. Nat Commun. 2021;12:3292 pubmed publisher
|
Liu R, Lee J, Li J, Yu R, Tan L, Xia Y, et al. Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. Mol Cell. 2021;81:2722-2735.e9 pubmed publisher
|
Ryu H, Jung Y, Lee N, Seo J, Kim S, Lee K, et al. HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation. Int J Mol Sci. 2021;22: pubmed publisher
|
Liedtke V, Schröder C, Roggenbuck D, Weiss R, Stohwasser R, Schierack P, et al. LEDGF/p75 Is Required for an Efficient DNA Damage Response. Int J Mol Sci. 2021;22: pubmed publisher
|
Ord T, Ord D, Kaikkonen M, Ord T. Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib. Cancers (Basel). 2021;13: pubmed publisher
|
Rook M, Miaro M, Couch T, Kneisley D, Musgaard M, MacLean D. Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1. J Gen Physiol. 2021;153: pubmed publisher
|
Zhao Q, Kong Y, Kittredge A, Li Y, Shen Y, Zhang Y, et al. Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations. elife. 2021;10: pubmed publisher
|
Torres Fernandez L, Emich J, Port Y, Mitschka S, Wöste M, Schneider S, et al. TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility. Front Cell Dev Biol. 2021;9:658966 pubmed publisher
|
Xuan Y, Sheng Y, Zhang D, Zhang K, Zhang Z, Ping Y, et al. Targeting CD276 by CAR-T cells induces regression of esophagus squamous cell carcinoma in xenograft mouse models. Transl Oncol. 2021;14:101138 pubmed publisher
|
Karnan S, Hanamura I, Ota A, Takasugi S, Nakamura A, Takahashi M, et al. CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia. Cell Death Discov. 2021;7:121 pubmed publisher
|
Li L, Galichon P, Xiao X, Figueroa Ramirez A, Tamayo D, Lee J, et al. Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. EMBO Rep. 2021;22:e51169 pubmed publisher
|
Muller I, Moroni A, Shlyueva D, Sahadevan S, Schoof E, Radzisheuskaya A, et al. MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells. Nat Commun. 2021;12:3034 pubmed publisher
|
Junyent S, Reeves J, Szczerkowski J, Garcin C, Trieu T, Wilson M, et al. Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division. elife. 2021;10: pubmed publisher
|
Mosig R, Castaneda A, Deslauriers J, Frazier L, He K, Maghzian N, et al. Natural antisense transcript of Period2, Per2AS, regulates the amplitude of the mouse circadian clock. Genes Dev. 2021;35:899-913 pubmed publisher
|
Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, et al. High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts. EMBO Mol Med. 2021;13:e13579 pubmed publisher
|
Servetto A, Kollipara R, Formisano L, Lin C, Lee K, Sudhan D, et al. Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer. Clin Cancer Res. 2021;27:4379-4396 pubmed publisher
|
Ostojic J, Yoon Y, Sonntag T, Nguyen B, Vaughan J, Shokhirev M, et al. Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways. Cell Rep. 2021;35:109136 pubmed publisher
|
Rasmussen K, Helin K. ChIP-Sequencing of TET Proteins. Methods Mol Biol. 2021;2272:251-262 pubmed publisher
|
Cuello F, Knaust A, Saleem U, Loos M, Raabe J, Mosqueira D, et al. Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation. EMBO Mol Med. 2021;13:e13074 pubmed publisher
|
Weinberg D, Rosenbaum P, Chen X, Barrows D, Horth C, Marunde M, et al. Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands. Nat Genet. 2021;53:794-800 pubmed publisher
|
Wan Y, Anastasakis D, Rodriguez J, Palangat M, Gudla P, Zaki G, et al. Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and stochastic splice site selection. Cell. 2021;184:2878-2895.e20 pubmed publisher
|
Lee M, Shorthouse D, Mahen R, Hall B, Venkitaraman A. Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance. Nucleic Acids Res. 2021;49:5588-5604 pubmed publisher
|
Mylonas C, Lee C, Auld A, Cisse I, Boyer L. A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation. Nat Struct Mol Biol. 2021;28:435-442 pubmed publisher
|
Akbaba H, Erel Akbaba G, Senturk S. Special Focus Issue Part II: Recruitment of solid lipid nanoparticles for the delivery of CRISPR/Cas9: primary evaluation of anticancer gene editing. Nanomedicine (Lond). 2021;16:963-978 pubmed publisher
|
Zhang R, He H, Yuan B, Wu Z, Wang X, Du Y, et al. An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development. Neurosci Bull. 2021;37:1091-1106 pubmed publisher
|
Venkatesan S, Angelova M, Puttick C, Zhai H, Caswell D, Lu W, et al. Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution. Cancer Discov. 2021;: pubmed publisher
|
Morello G, Cancila V, La Rosa M, Germano G, Lecis D, Amodio V, et al. T Cells Expressing Receptor Recombination/Revision Machinery Are Detected in the Tumor Microenvironment and Expanded in Genomically Over-unstable Models. Cancer Immunol Res. 2021;9:825-837 pubmed publisher
|
Simoes Eugénio M, Faurez F, Kara Ali G, Lagarrigue M, Uhart P, Bonnet M, et al. TRIM21, a New Component of the TRAIL-Induced Endogenous Necrosome Complex. Front Mol Biosci. 2021;8:645134 pubmed publisher
|
Noort R, Christopher G, Esseltine J. Pannexin 1 Influences Lineage Specification of Human iPSCs. Front Cell Dev Biol. 2021;9:659397 pubmed publisher
|
Woodley C, Romer A, Wang J, Guarnaccia A, Elion D, Maxwell J, et al. Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. Oncogene. 2021;40:3593-3609 pubmed publisher
|
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al. Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12:2482 pubmed publisher
|
Chemello F, Chai A, Li H, Rodriguez Caycedo C, Sanchez Ortiz E, Atmanli A, et al. Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing. Sci Adv. 2021;7: pubmed publisher
|
Li Y, Wang Y, Du X, Zhang T, Mak H, Hancock S, et al. TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine. J Cell Biol. 2021;220: pubmed publisher
|
Shi X, Wen Z, Wang Y, Liu Y, Shi K, Jiu Y. Feedback-Driven Mechanisms Between Phosphorylated Caveolin-1 and Contractile Actin Assemblies Instruct Persistent Cell Migration. Front Cell Dev Biol. 2021;9:665919 pubmed publisher
|
Dahou H, Minati M, Jacquemin P, Assi M. Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells. Antioxidants (Basel). 2021;10: pubmed publisher
|
Nagaraj S, Want A, Laskowska Kaszub K, Fesiuk A, Vaz S, Logarinho E, et al. Candidate Alzheimer's Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression. Int J Mol Sci. 2021;22: pubmed publisher
|
Grochowska M, Carreras Mascaro A, Boumeester V, Natale D, Breedveld G, Geut H, et al. LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Acta Neuropathol. 2021;142:117-137 pubmed publisher
|
Lin Y, Liang Y, Wang H, Tung L, Forster M, Subramani P, et al. Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1. Front Immunol. 2021;12:626418 pubmed publisher
|
Thrun A, Garzia A, Kigoshi Tansho Y, Patil P, Umbaugh C, Dallinger T, et al. Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing. Mol Cell. 2021;81:2112-2122.e7 pubmed publisher
|
Dannenmann B, Klimiankou M, Oswald B, Solovyeva A, Mardan J, Nasri M, et al. iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia. Cell Stem Cell. 2021;28:906-922.e6 pubmed publisher
|
Barger C, Chee L, Albahrani M, Munoz Trujillo C, Boghean L, Branick C, et al. Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer. elife. 2021;10: pubmed publisher
|
Formosa L, Reljic B, Sharpe A, Hock D, Muellner Wong L, Stroud D, et al. Optic atrophy-associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
|
Rivera O, Mallory M, Quesnel Vallieres M, Chatrikhi R, Schultz D, Carroll M, et al. Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
|
Low H, Wong Z, Wu B, Kong L, Png C, Cho Y, et al. DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death. Nat Commun. 2021;12:2284 pubmed publisher
|
Simoneschi D, Róna G, Zhou N, Jeong Y, Jiang S, Milletti G, et al. CRL4AMBRA1 is a master regulator of D-type cyclins. Nature. 2021;592:789-793 pubmed publisher
|
Wang M, Liu J, Tu Y, Zhao Z, Qu J, Chen K, et al. RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling. J Biol Chem. 2021;296:100109 pubmed publisher
|
Fayad R, Rojas M, Partisani M, Finetti P, Dib S, Abélanet S, et al. EFA6B regulates a stop signal for collective invasion in breast cancer. Nat Commun. 2021;12:2198 pubmed publisher
|
Lester E, Ooi F, Bakkar N, Ayers J, Woerman A, Wheeler J, et al. Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. 2021;109:1675-1691.e9 pubmed publisher
|
Mehta G, Angus S, Khella C, Tong K, Khanna P, Dixon S, et al. SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2. NPJ Breast Cancer. 2021;7:40 pubmed publisher
|
Tran D, Kesavan R, Rion H, Soflaee M, Solmonson A, Bezwada D, et al. Mitochondrial NADP+ is essential for proline biosynthesis during cell growth. Nat Metab. 2021;3:571-585 pubmed publisher
|
Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, et al. Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia. Nat Genet. 2021;53:672-682 pubmed publisher
|
Aoto K, Kato M, Akita T, Nakashima M, Mutoh H, Akasaka N, et al. ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice. Nat Commun. 2021;12:2107 pubmed publisher
|
Day K, Kago G, Wang L, Richter J, Hayden C, Lafer E, et al. Liquid-like protein interactions catalyse assembly of endocytic vesicles. Nat Cell Biol. 2021;23:366-376 pubmed publisher
|
Ho K, Luo H, Zhu W, Tang Y. Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress. Sci Rep. 2021;11:7502 pubmed publisher
|
Wang W, Liu P, Lavrijsen M, Li S, Zhang R, Li S, et al. Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines. Sci Rep. 2021;11:7470 pubmed publisher
|
Meira W, Daher B, Parks S, Cormerais Y, Durivault J, Tambutte E, et al. A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCTKO Pancreatic Ductal Adenocarcinoma Cells. Cancers (Basel). 2021;13: pubmed publisher
|
Pellanda P, Dalsass M, Filipuzzi M, Loffreda A, Verrecchia A, Castillo Cano V, et al. Integrated requirement of non-specific and sequence-specific DNA binding in Myc-driven transcription. EMBO J. 2021;40:e105464 pubmed publisher
|
Cho E, Lou H, Kuruvilla L, Calderwood D, Turk B. PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. Cell Rep. 2021;34:108928 pubmed publisher
|
Gowrishankar S, Lyons L, Rafiq N, Roczniak Ferguson A, De Camilli P, Ferguson S. Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons. Mol Biol Cell. 2021;32:1094-1103 pubmed publisher
|
Nguyen T, Padman B, Zellner S, Khuu G, Uoselis L, Lam W, et al. ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system. Mol Cell. 2021;81:2013-2030.e9 pubmed publisher
|
Ahmed R, Sarwar S, Hu J, Cardin V, Qiu L, Zapata G, et al. Transgenic mice with an R342X mutation in Phf6 display clinical features of Börjeson-Forssman-Lehmann Syndrome. Hum Mol Genet. 2021;30:575-594 pubmed publisher
|
Okawa F, Hama Y, Zhang S, Morishita H, Yamamoto H, Levine T, et al. Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1. J Cell Sci. 2021;134: pubmed publisher
|
Macrae T, Ramalho Santos M. The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development. Nat Commun. 2021;12:1865 pubmed publisher
|
Benito Kwiecinski S, Giandomenico S, Sutcliffe M, Riis E, Freire Pritchett P, Kelava I, et al. An early cell shape transition drives evolutionary expansion of the human forebrain. Cell. 2021;184:2084-2102.e19 pubmed publisher
|
Vogel C, Lazennec G, Kado S, Dahlem C, He Y, Castañeda A, et al. Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development. Front Immunol. 2021;12:625346 pubmed publisher
|
Burckhardt C, Minna J, Danuser G. SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt. Dev Cell. 2021;56:1164-1181.e12 pubmed publisher
|
Villa E, Sahu U, O Hara B, Ali E, Helmin K, Asara J, et al. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. Mol Cell. 2021;81:2076-2093.e9 pubmed publisher
|
Westervelt N, Yoest A, Sayed S, Von Zimmerman M, Kaps K, Chadwick B. Deletion of the XIST promoter from the human inactive X chromosome compromises polycomb heterochromatin maintenance. Chromosoma. 2021;: pubmed publisher
|
Owa M, DYNLACHT B. A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division. Commun Biol. 2021;4:358 pubmed publisher
|
Kulsuptrakul J, Wang R, Meyers N, Ott M, Puschnik A. A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection. Cell Rep. 2021;34:108859 pubmed publisher
|
Zhang X, Wang X, Yuan Z, Radford S, Liu C, Libutti S, et al. Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis. Cell Rep. 2021;34:108830 pubmed publisher
|
Fernandez Vizarra E, López Calcerrada S, Formosa L, Pérez Pérez R, Ding S, Fearnley I, et al. SILAC-based complexome profiling dissects the structural organization of the human respiratory supercomplexes in SCAFIKO cells. Biochim Biophys Acta Bioenerg. 2021;1862:148414 pubmed publisher
|
Fan H, Lee K, Chen Y, Lin L, Yang T, Lin S, et al. Wdhd1 is essential for early mouse embryogenesis. Biochim Biophys Acta Mol Cell Res. 2021;1868:119011 pubmed publisher
|
Baxley R, Leung W, Schmit M, Matson J, Yin L, Oram M, et al. Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening. Nat Commun. 2021;12:1626 pubmed publisher
|
Sanchez Vazquez R, Martinez P, Blasco M. AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. PLoS Genet. 2021;17:e1009410 pubmed publisher
|
Bartoschek M, Ugur E, Nguyen T, Rodschinka G, Wierer M, Lang K, et al. Identification of permissive amber suppression sites for efficient non-canonical amino acid incorporation in mammalian cells. Nucleic Acids Res. 2021;49:e62 pubmed publisher
|
Dorrington M, Bradfield C, Lack J, Lin B, Liang J, Starr T, et al. Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol. PLoS Pathog. 2021;17:e1009395 pubmed publisher
|
Du R, Sullivan D, Azizian N, Liu Y, Li Y. Inhibition of ERAD synergizes with FTS to eradicate pancreatic cancer cells. BMC Cancer. 2021;21:237 pubmed publisher
|
Zhang X, SABIO E, Krishna C, Ma X, Wang J, Jiang H, et al. Qa-1b Modulates Resistance to Anti-PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing. Mol Cancer Res. 2021;19:1076-1084 pubmed publisher
|
Song H, Yang Y, Chien Y, Lai W, Lin Y, Chou S, et al. Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation. Int J Mol Sci. 2021;22: pubmed publisher
|
Di Stazio M, Foschi N, Athanasakis E, Gasparini P, d Adamo A. Systematic analysis of factors that improve homologous direct repair (HDR) efficiency in CRISPR/Cas9 technique. PLoS ONE. 2021;16:e0247603 pubmed publisher
|
Azami Y, Tsuyama N, Abe Y, Sugai Takahashi M, Kudo K, Ota A, et al. Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells. Sci Rep. 2021;11:5216 pubmed publisher
|
Emrich S, Yoast R, Xin P, Arige V, Wagner L, Hempel N, et al. Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling. Cell Rep. 2021;34:108760 pubmed publisher
|
Berthelsen M, Leknes S, Riedel M, Pedersen M, Joseph J, Hager H, et al. Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9. Cancers (Basel). 2021;13: pubmed publisher
|
Zhu S, Ding W, Chen Y, Wang W, Xu R, Liu C, et al. High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells. Genomics Proteomics Bioinformatics. 2021;: pubmed publisher
|
Alambeladi S, Hosseiny S, Jafarinia M, Dianatpour M. Use of dual-transfection for programmed death cell protein 1 disruption mediated by CRISPR-Cas9 in human peripheral blood mononuclear cells. Iran J Basic Med Sci. 2021;24:44-50 pubmed publisher
|
Nair Gill E, Bonora M, Zhong X, Liu A, Miranda A, Stewart N, et al. Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases. EMBO J. 2021;40:e104888 pubmed publisher
|
Tigano M, Vargas D, Tremblay Belzile S, Fu Y, Sfeir A. Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance. Nature. 2021;591:477-481 pubmed publisher
|
Milewski D, Shukla S, Gryder B, Pradhan A, Donovan J, Sudha P, et al. FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. Oncogene. 2021;40:2182-2199 pubmed publisher
|
Bloemberg D, Sosa Miranda C, Nguyen T, Weeratna R, McComb S. Self-Cutting and Integrating CRISPR Plasmids Enable Targeted Genomic Integration of Genetic Payloads for Rapid Cell Engineering. CRISPR J. 2021;4:104-119 pubmed publisher
|
Krall A, Mullen P, Surjono F, Momcilovic M, Schmid E, Halbrook C, et al. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metab. 2021;33:1013-1026.e6 pubmed publisher
|
Augereau A, Mariotti M, Pousse M, Filipponi D, Libert F, Beck B, et al. Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen. Sci Adv. 2021;7: pubmed publisher
|
Omarjee O, Mathieu A, Quiniou G, Moreews M, Ainouze M, Frachette C, et al. LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages. J Exp Med. 2021;218: pubmed publisher
|
Naetar N, Georgiou K, Knapp C, Bronshtein I, Zier E, Fichtinger P, et al. LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior. elife. 2021;10: pubmed publisher
|
Liu Q, Chen X, Novak M, Zhang S, Hu W. Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs. elife. 2021;10: pubmed publisher
|
Li M, Soder R, Abhyankar S, Abdelhakim H, Braun M, Trinidad C, et al. WJMSC-derived small extracellular vesicle enhance T cell suppression through PD-L1. J Extracell Vesicles. 2021;10:e12067 pubmed publisher
|
Sinha A, Fan V, Ramakrishnan A, Engelhardt N, KENNELL J, Cadigan K. Repression of Wnt/β-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2. Sci Adv. 2021;7: pubmed publisher
|
Perrin Cocon L, Vidalain P, Jacquemin C, Aublin Gex A, Olmstead K, Panthu B, et al. A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity. Commun Biol. 2021;4:217 pubmed publisher
|
Mann N, Mzoughi S, Schneider R, Kühl S, Schanze D, Klämbt V, et al. Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome. J Am Soc Nephrol. 2021;32:580-596 pubmed publisher
|
Srivastava S, Sahu U, Zhou Y, Hogan A, Sathyan K, Bodner J, et al. NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia. Sci Adv. 2021;7: pubmed publisher
|
Maglitto A, Mariani S, de Pater E, Rodríguez Seoane C, Vink C, Piao X, et al. Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation. Blood Adv. 2021;5:829-842 pubmed publisher
|
Girbig M, Misiaszek A, Vorländer M, Lafita A, Grötsch H, Baudin F, et al. Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Nat Struct Mol Biol. 2021;28:210-219 pubmed publisher
|
Hakala M, Wioland H, Tolonen M, Kotila T, Jégou A, Romet Lemonne G, et al. Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks. Nat Cell Biol. 2021;23:147-159 pubmed publisher
|
Brandel A, Aigal S, Lagies S, Schlimpert M, Meléndez A, Xu M, et al. The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa. Cell Mol Life Sci. 2021;78:3637-3656 pubmed publisher
|
Fan X, Masamsetti V, Sun J, Engholm Keller K, Osteil P, Studdert J, et al. TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. elife. 2021;10: pubmed publisher
|
Kim T, Piao J, Koo S, Kriks S, Chung S, Betel D, et al. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell Stem Cell. 2021;28:343-355.e5 pubmed publisher
|
Geusz R, Wang A, Chiou J, Lancman J, Wetton N, Kefalopoulou S, et al. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. elife. 2021;10: pubmed publisher
|
Dolskiy A, Bodnev S, Nazarenko A, Smirnova A, Pyankova O, Matveeva A, et al. Deletion of BST2 Cytoplasmic and Transmembrane N-Terminal Domains Results in SARS-CoV, SARS-CoV-2, and Influenza Virus Production Suppression in a Vero Cell Line. Front Mol Biosci. 2020;7:616798 pubmed publisher
|
Zhu S, Chen W, Wang J, Qi L, Pan H, Feng Z, et al. SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing. Theranostics. 2021;11:3359-3375 pubmed publisher
|
Alonso Curbelo D, Ho Y, Burdziak C, Mååg J, Morris J, Chandwani R, et al. A gene-environment-induced epigenetic program initiates tumorigenesis. Nature. 2021;: pubmed publisher
|
Simpson C, Tokito M, Uppala R, Sarkar M, Gudjonsson J, Holzbaur E. NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation. Cell Rep. 2021;34:108689 pubmed publisher
|
Mueller A, Piper M, Goodspeed A, Bhuvane S, Williams J, Bhatia S, et al. Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer. Cancer Res. 2021;81:3255-3269 pubmed publisher
|
Masalmeh R, Taglini F, Rubio Ramon C, Musialik K, Higham J, Davidson Smith H, et al. De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands. Nat Commun. 2021;12:694 pubmed publisher
|
Kamali E, Rahbarizadeh F, Hojati Z, Frodin M. CRISPR/Cas9-mediated knockout of clinically relevant alloantigenes in human primary T cells. BMC Biotechnol. 2021;21:9 pubmed publisher
|
Ortiz Cordero C, Magli A, Dhoke N, Kuebler T, Selvaraj S, Oliveira N, et al. NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes. elife. 2021;10: pubmed publisher
|
Zheng C, Hu Y, Sakurai M, Pinzon Arteaga C, Li J, Wei Y, et al. Cell Competition Constitutes a Barrier for Interspecies Chimerism. Nature. 2021;: pubmed publisher
|
Suzuki T, Katada E, Mizuoka Y, Takagi S, Kazuki Y, Oshimura M, et al. A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing. Nucleic Acids Res. 2021;: pubmed publisher
|
Alizada A, Khyzha N, Wang L, Antounians L, Chen X, Khor M, et al. Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals. Nat Commun. 2021;12:567 pubmed publisher
|
Papa G, Mallery D, Albecka A, Welch L, Cattin Ortolá J, Lupták J, et al. Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion. PLoS Pathog. 2021;17:e1009246 pubmed publisher
|
Kressler C, Gasparoni G, Nordstrom K, Hamo D, Salhab A, Dimitropoulos C, et al. Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype. Front Immunol. 2020;11:609891 pubmed publisher
|
Zhang Y, Sun Y, Zhang Y, Miao Q, Wang Q, Yang B, et al. Nuclear factor Y participates in alcoholic liver disease by activating SREBP1 expression in mice. Biochem Biophys Res Commun. 2021;541:90-94 pubmed publisher
|
Unsicker C, Cristian F, von Hahn M, Eckstein V, Rappold G, Berkel S. SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differentiation in SH-SY5Y cells. Sci Rep. 2021;11:2128 pubmed publisher
|
Harris E, Zimmerman D, Warga E, Bamezai A, Elmer J. Nonviral gene delivery to T cells with Lipofectamine LTX. Biotechnol Bioeng. 2021;118:1693-1706 pubmed publisher
|
Han Y, Zhang J, Lee J, Mason J, Karginova O, Yoshimatsu T, et al. The BRCA1 Pseudogene Negatively Regulates Anti-Tumor Responses through Inhibition of Innate Immune Defense Mechanisms. Cancer Res. 2021;: pubmed publisher
|
Liu S, Liao Y, Chen B, Chen Y, Yu Z, Wei H, et al. Critical role of Syk-dependent STAT1 activation in innate antiviral immunity. Cell Rep. 2021;34:108627 pubmed publisher
|
Hao M, Yeo S, Turner K, Harold A, Yang Y, Zhang X, et al. Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles. Dev Cell. 2021;56:341-355.e5 pubmed publisher
|
Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, et al. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy. 2021;:1-20 pubmed publisher
|
Challagulla A, Jenkins K, O Neil T, Shi S, Morris K, Wise T, et al. In Vivo Inhibition of Marek's Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4. Microorganisms. 2021;9: pubmed publisher
|
Mohamud Y, Xue Y, Liu H, Ng C, Bahreyni A, Jan E, et al. The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy. Biochem Biophys Res Commun. 2021;540:75-82 pubmed publisher
|
Roliński M, Montaldo N, Aksu M, Fordyce Martin S, Brambilla A, Kunath N, et al. Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation. Nucleic Acids Res. 2021;: pubmed publisher
|
Ji Z, Li Y, Liu S, Sharrocks A. The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation. Nucleic Acids Res. 2021;49:1345-1363 pubmed publisher
|
Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, et al. Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells. Nat Protoc. 2021;16:919-936 pubmed publisher
|
Tsyklauri O, Niederlova V, Forsythe E, Prasai A, Drobek A, Kaspárek P, et al. Bardet-Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance. EMBO Rep. 2021;22:e50785 pubmed publisher
|
Harland L, Simon C, Senft A, Costello I, Greder L, Imaz Rosshandler I, et al. The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors. Nat Cell Biol. 2021;23:61-74 pubmed publisher
|
Jung H, Lee K, Choi J. Comprehensive characterisation of intronic mis-splicing mutations in human cancers. Oncogene. 2021;40:1347-1361 pubmed publisher
|
Hou G, Harley I, Lu X, Zhou T, Xu N, Yao C, et al. SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression. Nat Commun. 2021;12:135 pubmed publisher
|
Gori I, George R, Purkiss A, Strohbuecker S, Randall R, Ogrodowicz R, et al. Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization. elife. 2021;10: pubmed publisher
|
Berg J, Perfler B, Hatzl S, Mayer M, Wurm S, Uhl B, et al. Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia. Clin Epigenetics. 2021;13:1 pubmed publisher
|
Wu J, Zhao K, Du Z, Chen Y, Zhang F, Jiang W, et al. Systemic effect of FHL1 on neuromuscular junction and myotube formation via insulin-like growth factor and myostatin signaling pathways. Biochem Biophys Res Commun. 2021;537:125-131 pubmed publisher
|
Ho R, Workman M, Mathkar P, Wu K, Kim K, O Rourke J, et al. Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures. Cell Syst. 2021;12:159-175.e9 pubmed publisher
|
Alberts A, Klingberg A, Hoffmeister L, Wessig A, Brand K, Pich A, et al. Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures. Front Immunol. 2020;11:596103 pubmed publisher
|
Jia X, Burugula B, Chen V, Lemons R, Jayakody S, Maksutova M, et al. Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk. Am J Hum Genet. 2021;108:163-175 pubmed publisher
|
Cui H, Kapur M, Diedrich J, Iii J, Ackerman S, Schimmel P. Regulation of ex-translational activities is the primary function of the multi-tRNA synthetase complex. Nucleic Acids Res. 2020;: pubmed publisher
|
Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, et al. MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway. Cancer Cell. 2021;39:109-121.e5 pubmed publisher
|
Wang R, Simoneau C, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi J, et al. Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses. Cell. 2021;184:106-119.e14 pubmed publisher
|
Hewitt G, Borel V, Segura Bayona S, Takaki T, Ruis P, Bellelli R, et al. Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD. Mol Cell. 2020;: pubmed publisher
|
Lin S, Wu H, Yeh L, Yang C, Kao S, Chang K. Activation of the miR-371/372/373 miRNA Cluster Enhances Oncogenicity and Drug Resistance in Oral Carcinoma Cells. Int J Mol Sci. 2020;21: pubmed publisher
|
Gally F, Sasse S, Kurche J, Gruca M, Cardwell J, Okamoto T, et al. The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. JCI Insight. 2021;6: pubmed publisher
|
Apelt K, White S, Kim H, Yeo J, Kragten A, Wondergem A, et al. ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients. J Exp Med. 2021;218: pubmed publisher
|
Guibentif C, Griffiths J, Imaz Rosshandler I, Ghazanfar S, Nichols J, Wilson V, et al. Diverse Routes toward Early Somites in the Mouse Embryo. Dev Cell. 2021;56:141-153.e6 pubmed publisher
|
Sun X, Hou W, Liu X, Chai J, Guo H, Yu J. Targeting REV7 effectively reverses 5-FU and oxaliplatin resistance in colorectal cancer. Cancer Cell Int. 2020;20:580 pubmed publisher
|
Huang T, Fang L, He R, Weng H, Chen X, Ye Q, et al. Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels. Aging (Albany NY). 2020;13:77-88 pubmed publisher
|
Suzuki R, Murata M, Manguso N, Watanabe T, Mouakkad Montoya L, Igari F, et al. The fragility of a structurally diverse duplication block triggers recurrent genomic amplification. Nucleic Acids Res. 2021;49:244-256 pubmed publisher
|
Inderbitzin A, Kok Y, Jörimann L, Kelley A, Neumann K, Heinzer D, et al. HIV-1 promoter is gradually silenced when integrated into BACH2 in Jurkat T-cells. Peerj. 2020;8:e10321 pubmed publisher
|
Sreenivasan L, Wang H, Yap S, Leclair P, Tam A, Lim C. Autocrine IL-6/STAT3 signaling aids development of acquired drug resistance in Group 3 medulloblastoma. Cell Death Dis. 2020;11:1035 pubmed publisher
|
Ucuncu E, Rajamani K, Wilson M, Medina Cano D, Altin N, David P, et al. MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Nat Commun. 2020;11:6087 pubmed publisher
|
Ho H, Bigliardi P, Stelmashenko O, Ramasamy S, Postlethwaite M, Bigliardi Qi M. Functionally expressed bitter taste receptor TAS2R14 in human epidermal keratinocytes serves as a chemosensory receptor. Exp Dermatol. 2021;30:216-225 pubmed publisher
|
Canals Hernaez D, Hughes M, Dean P, Bergqvist P, Samudio I, Blixt O, et al. PODO447: a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin. J Immunother Cancer. 2020;8: pubmed publisher
|
Mulholland C, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück I, et al. Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nat Commun. 2020;11:5972 pubmed publisher
|
Keren Kaplan T, Bonifacino J. ARL8 Relieves SKIP Autoinhibition to Enable Coupling of Lysosomes to Kinesin-1. Curr Biol. 2021;31:540-554.e5 pubmed publisher
|
Harutyunyan A, Chen H, Lu T, Horth C, Nikbakht H, Krug B, et al. H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation. Cell Rep. 2020;33:108390 pubmed publisher
|
Ma H, Jeppesen J, Jaenisch R. Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction. Cell Rep Med. 2020;1:100097 pubmed publisher
|
Knyazeva A, Khudiakov A, Vaz R, Muravyev A, Sukhareva K, Sejersen T, et al. FLNC Expression Level Influences the Activity of TEAD-YAP/TAZ Signaling. Genes (Basel). 2020;11: pubmed publisher
|
Chua X, Aballo T, Elnemer W, Tran M, Salomon A. Quantitative Interactomics of Lck-TurboID in Living Human T Cells Unveils T Cell Receptor Stimulation-Induced Proximal Lck Interactors. J Proteome Res. 2021;20:715-726 pubmed publisher
|
Han J, LaVigne C, Jones B, Zhang H, Gillett F, Mendell J. A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming. Science. 2020;370: pubmed publisher
|
Buffet A, Zhang J, Rebel H, Corssmit E, Jansen J, Hensen E, et al. Germline DLST Variants Promote Epigenetic Modifications in Pheochromocytoma-Paraganglioma. J Clin Endocrinol Metab. 2021;106:459-471 pubmed publisher
|
Pattabiraman S, Azad G, Amen T, Brielle S, Park J, Sze S, et al. Vimentin protects differentiating stem cells from stress. Sci Rep. 2020;10:19525 pubmed publisher
|
Nemeth J, Schundner A, Quast K, Winkelmann V, Frick M. A Novel Fibroblast Reporter Cell Line for in vitro Studies of Pulmonary Fibrosis. Front Physiol. 2020;11:567675 pubmed publisher
|
Kong H, Reczek C, McElroy G, Steinert E, Wang T, Sabatini D, et al. Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species. Sci Adv. 2020;6: pubmed publisher
|
Fan H, Lu J, Guo Y, Li D, Zhang Z, Tsai Y, et al. BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nat Genet. 2020;52:1384-1396 pubmed publisher
|
Wang X, Hayes J, Xu X, Gao X, Mehta D, Lilja H, et al. Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing. Gene. 2021;768:145265 pubmed publisher
|
Sakamoto H, Yamasaki T, Sumiyoshi T, Takeda M, Shibasaki N, Utsunomiya N, et al. Functional and genomic characterization of patient-derived xenograft model to study the adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma. Cancer Med. 2021;10:119-134 pubmed publisher
|
Nath A, Oak A, Chen K, Li I, Splichal R, Portis J, et al. Palmitate-Induced IRE1-XBP1-ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration. Mol Cancer Res. 2021;19:240-248 pubmed publisher
|
Sreevalsan S, Döring M, Paszkowski Rogacz M, Brux M, Blanck C, Meyer M, et al. MLLT6 maintains PD-L1 expression and mediates tumor immune resistance. EMBO Rep. 2020;:e50155 pubmed publisher
|
Møller T, Pedersen M, van Senten J, Seiersen S, Mathiesen J, Bouvier M, et al. Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells. Sci Rep. 2020;10:17395 pubmed publisher
|
Sarangi P, Clairmont C, Galli L, Moreau L, D Andrea A. p31comet promotes homologous recombination by inactivating REV7 through the TRIP13 ATPase. Proc Natl Acad Sci U S A. 2020;117:26795-26803 pubmed publisher
|
Shi X, Fan C, Jiu Y. Unidirectional Regulation of Vimentin Intermediate Filaments to Caveolin-1. Int J Mol Sci. 2020;21: pubmed publisher
|
Fedele C, Li S, Teng K, Foster C, Peng D, Ran H, et al. SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling. J Exp Med. 2021;218: pubmed publisher
|
Shinozawa T, Kimura M, Cai Y, Saiki N, Yoneyama Y, Ouchi R, et al. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids. Gastroenterology. 2021;160:831-846.e10 pubmed publisher
|
Kwon S, Jang H, Shen S, Baek S, Kim K, Yang J, et al. ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8. Nucleic Acids Res. 2020;48:11097-11112 pubmed publisher
|
Liu B, Liu Z, Chen S, Ki M, Erickson C, Reis Filho J, et al. Mutant SF3B1 promotes AKT- and NF-κB-driven mammary tumorigenesis. J Clin Invest. 2021;131: pubmed publisher
|
Kok Y, Guerrero Llobet S, Schoonen P, Everts M, Bhattacharya A, Fehrmann R, et al. Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors. Oncogenesis. 2020;9:88 pubmed publisher
|
Brinck Andersen N, Jørgensen S, Skipper K, Larsen S, Heinz J, Thomsen M, et al. Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient. Autophagy. 2020;:1-16 pubmed publisher
|
Guo L, Cui C, Wang J, Yuan J, Yang Q, Zhang P, et al. PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth. Nat Commun. 2020;11:4913 pubmed publisher
|
Tishchenko A, Azorín D, Vidal Brime L, Muñoz M, Arenas P, Pearce C, et al. Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells. Cancers (Basel). 2020;12: pubmed publisher
|
Zhang H, Zhang Y, Zhou X, Wright S, Hyle J, Zhao L, et al. Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen. elife. 2020;9: pubmed publisher
|
Quagliano A, Gopalakrishnapillai A, Kolb E, Barwe S. CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia. Blood Adv. 2020;4:4393-4405 pubmed publisher
|
Levitas A, Muhammad E, Zhang Y, Perea Gil I, Serrano R, Diaz N, et al. A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy. PLoS Genet. 2020;16:e1009000 pubmed publisher
|
Fox S, Myers J, Davidson C, Getman M, Kingsley P, Frankiewicz N, et al. Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function. Nat Commun. 2020;11:4544 pubmed publisher
|
Chen F, Zhang W, Xie D, Gao T, Dong Z, Lu X. Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters. Nucleic Acids Res. 2020;48:10211-10225 pubmed publisher
|
Galdos F, Darsha A, Paige S, Wu S. Purification of Pluripotent Stem Cell-Derived Cardiomyocytes Using CRISPR/Cas9-Mediated Integration of Fluorescent Reporters. Methods Mol Biol. 2021;2158:223-240 pubmed publisher
|
Shi H, Tao T, Abraham B, Durbin A, Zimmerman M, Kadoch C, et al. ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression. Sci Adv. 2020;6:eaaz3440 pubmed publisher
|
Lee M, Yun S, Lee B, Jeong E, Yoon G, Kim K, et al. Association of TIM-3 expression with glucose metabolism in Jurkat T cells. BMC Immunol. 2020;21:48 pubmed publisher
|
Lv L, Chen P, Cao L, Li Y, Zeng Z, Cui Y, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. elife. 2020;9: pubmed publisher
|
Staal J, Driege Y, Haegman M, Kreike M, Iliaki S, Vanneste D, et al. Defining the combinatorial space of PKC::CARD-CC signal transduction nodes. FEBS J. 2021;288:1630-1647 pubmed publisher
|
Nur Patria Y, Stenta T, Lilianty J, Rowley L, Stanley E, Elefanty A, et al. CRISPR/Cas9 gene editing of a SOX9 reporter human iPSC line to produce two TRPV4 patient heterozygous missense mutant iPSC lines, MCRIi001-A-3 (TRPV4 p.F273L) and MCRIi001-A-4 (TRPV4 p.P799L). Stem Cell Res. 2020;48:101942 pubmed publisher
|
Sato T, Ishihara S, Marui R, Takagi J, Katagiri K. Dissection of α4β7 integrin regulation by Rap1 using novel conformation-specific monoclonal anti-β7 antibodies. Sci Rep. 2020;10:13221 pubmed publisher
|
Prasai A, Schmidt Cernohorska M, Ruppova K, Niederlova V, Andelova M, Dráber P, et al. The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cells. J Biol Chem. 2020;295:14279-14290 pubmed publisher
|
Blayney J, Foster E, Jagielowicz M, Kreuzer M, Morotti M, Reglinski K, et al. Unexpectedly High Levels of Inverted Re-Insertions Using Paired sgRNAs for Genomic Deletions. Methods Protoc. 2020;3: pubmed publisher
|
Diem K, Fauler M, Fois G, Hellmann A, Winokurow N, Schumacher S, et al. Mechanical stretch activates piezo1 in caveolae of alveolar type I cells to trigger ATP release and paracrine stimulation of surfactant secretion from alveolar type II cells. FASEB J. 2020;34:12785-12804 pubmed publisher
|
Zhang K, Chooi W, Liu S, Chin J, Murray A, Nizetic D, et al. Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering. Biomaterials. 2020;256:120225 pubmed publisher
|
Lerner T, Kluesner M, Tasakis R, Moriarity B, Papavasiliou F, Pecori R. C-to-U RNA Editing: From Computational Detection to Experimental Validation. Methods Mol Biol. 2021;2181:51-67 pubmed publisher
|
Feyen D, McKeithan W, Bruyneel A, Spiering S, Hörmann L, Ulmer B, et al. Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. Cell Rep. 2020;32:107925 pubmed publisher
|
Butt L, Unnersjö Jess D, Höhne M, EDWARDS A, Binz Lotter J, Reilly D, et al. A molecular mechanism explaining albuminuria in kidney disease. Nat Metab. 2020;2:461-474 pubmed publisher
|
Jiménez Gutiérrez G, Mondragón González R, Soto Ponce L, Gómez Monsiváis W, García Aguirre I, Pacheco Rivera R, et al. Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability. Int J Mol Sci. 2020;21: pubmed publisher
|
Qi Y, Liu J, Chao J, Greer P, Li S. PTEN dephosphorylates Abi1 to promote epithelial morphogenesis. J Cell Biol. 2020;219: pubmed publisher
|
Löber J, Hitzing C, Münchhalfen M, Engels N. Vav family proteins constitute disparate branching points for distinct BCR signaling pathways. Eur J Immunol. 2020;: pubmed publisher
|
Bandaru S, Tsuji M, Shimizu Y, Usami K, Lee S, Takei N, et al. Structure-based design of gRNA for Cas13. Sci Rep. 2020;10:11610 pubmed publisher
|
Yin Q, Jian Y, Xu M, Huang X, Wang N, Liu Z, et al. CDK4/6 regulate lysosome biogenesis through TFEB/TFE3. J Cell Biol. 2020;219: pubmed publisher
|
Morrison E, Wegner T, Zucchetti A, Alvaro Benito M, Zheng A, Kliche S, et al. Dynamic palmitoylation events following T-cell receptor signaling. Commun Biol. 2020;3:368 pubmed publisher
|
Shrestha A, Bruckmueller H, Kildalsen H, Kaur G, Gaestel M, Wetting H, et al. Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38MAPK-MK2 axis and affects NF-κB-mediated transcription. Sci Rep. 2020;10:11388 pubmed publisher
|
Brannvoll A, Xue X, Kwon Y, Kompocholi S, Simonsen A, Viswalingam K, et al. The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells. Cell Rep. 2020;32:107849 pubmed publisher
|
Inde Z, Forcina G, Denton K, Dixon S. Kinetic Heterogeneity of Cancer Cell Fractional Killing. Cell Rep. 2020;32:107845 pubmed publisher
|
Ikeda M, Taniguchi Ikeda M, Kato T, Shinkai Y, Tanaka S, Hagiwara H, et al. Unexpected Mutations by CRISPR-Cas9 CTG Repeat Excision in Myotonic Dystrophy and Use of CRISPR Interference as an Alternative Approach. Mol Ther Methods Clin Dev. 2020;18:131-144 pubmed publisher
|
Rusilowicz Jones E, Jardine J, Kallinos A, Pinto Fernandez A, Guenther F, Giurrandino M, et al. USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation. Life Sci Alliance. 2020;3: pubmed publisher
|
Osei Amponsa V, Sridharan V, Tandon M, Evans C, Klarmann K, Cheng K, et al. Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity. Mol Cell Biol. 2020;: pubmed publisher
|
Busse D, Habgood Coote D, Clare S, Brandt C, Bassano I, Kaforou M, et al. Interferon-induced Protein-44 and Interferon-induced Protein 44-like restrict replication of Respiratory Syncytial Virus. J Virol. 2020;: pubmed publisher
|
Yan P, Patel H, Sharma S, Corben A, Wang T, Panchal P, et al. Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone. Cell Rep. 2020;31:107840 pubmed publisher
|
Goldspink D, Lu V, Miedzybrodzka E, Smith C, Foreman R, Billing L, et al. Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture. Cell Rep. 2020;31:107833 pubmed publisher
|
Krishn S, Salem I, Quaglia F, Naranjo N, Agarwal E, Liu Q, et al. The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis. J Extracell Vesicles. 2020;9:1763594 pubmed publisher
|
Zhou T, Damsky W, Weizman O, McGeary M, Hartmann K, Rosen C, et al. IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature. 2020;583:609-614 pubmed publisher
|
Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, Inoko A, et al. Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Nat Commun. 2020;11:3175 pubmed publisher
|
Vergara Mendoza M, Gomez Quiroz L, Miranda Labra R, Fuentes Romero L, Romero Rodríguez D, González Ruiz J, et al. Regulation of Cas9 by viral proteins Tat and Rev for HIV-1 inactivation. Antiviral Res. 2020;180:104856 pubmed publisher
|
Murai N, Mitalipova M, Jaenisch R. Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell-derived microglia-like cells. Eur J Neurosci. 2020;: pubmed publisher
|
Laptev I, Shvetsova E, Levitskii S, Serebryakova M, Rubtsova M, Zgoda V, et al. METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue. Nucleic Acids Res. 2020;: pubmed publisher
|
Tian Y, Liu Q, Yu S, Chu Q, Chen Y, Wu K, et al. NRF2-Driven KEAP1 Transcription in Human Lung Cancer. Mol Cancer Res. 2020;: pubmed publisher
|
Stephan T, Brüser C, Deckers M, Steyer A, Balzarotti F, Barbot M, et al. MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation. EMBO J. 2020;39:e104105 pubmed publisher
|
Schilling M, Bridgeman A, Gray N, Hertzog J, Hublitz P, Kohl A, et al. RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death. Cells. 2020;9: pubmed publisher
|
Younis S, Naboulsi R, Wang X, Cao X, Larsson M, Sargsyan E, et al. The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells. FASEB J. 2020;: pubmed publisher
|
Gao C, Song Q, Zhang M, Li J, Miao Y, Li Z, et al. Generation, ex vivo expansion and safety of engineered PD1-knockout primary T cells from cynomolgus macaques. Mol Immunol. 2020;124:100-108 pubmed publisher
|
Shvets E, Mendoza Topaz C. Tagging and Deleting of Endogenous Caveolar Components Using CRISPR/Cas9 Technology. Methods Mol Biol. 2020;2169:149-166 pubmed publisher
|
Liu J, Zuo Z, Sastalla I, Liu C, Jang J, Sekine Y, et al. Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors. Cell Host Microbe. 2020;: pubmed publisher
|
Knights A, Vohralik E, Houweling P, Stout E, Norton L, Alexopoulos S, et al. Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3). Nat Commun. 2020;11:2922 pubmed publisher
|
Dirac Svejstrup A, Walker J, Faull P, Encheva V, Akimov V, Puglia M, et al. DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1. Mol Cell. 2020;79:332-341.e7 pubmed publisher
|
Cenni V, Squarzoni S, Loi M, Mattioli E, Lattanzi G, Capanni C. Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization. Cells. 2020;9: pubmed publisher
|
Charlton J, Jung E, Mattei A, Bailly N, Liao J, Martin E, et al. TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers. Nat Genet. 2020;: pubmed publisher
|
Zhang F, Liu R, Liu C, Zhang H, Lu Y. Nanos3, a cancer-germline gene, promotes cell proliferation, migration, chemoresistance, and invasion of human glioblastoma. Cancer Cell Int. 2020;20:197 pubmed publisher
|
Cassinari K, Rovelet Lecrux A, Tury S, Quenez O, Richard A, Charbonnier C, et al. Haploinsufficiency of the Primary Familial Brain Calcification Gene SLC20A2 Mediated by Disruption of a Regulatory Element. Mov Disord. 2020;: pubmed publisher
|
Kuhny M, Forbes L, Çakan E, Vega Loza A, Kostiuk V, Dinesh R, et al. Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID. J Clin Invest. 2020;: pubmed publisher
|
Pinch B, Doctor Z, Nabet B, Browne C, Seo H, Mohardt M, et al. Identification of a potent and selective covalent Pin1 inhibitor. Nat Chem Biol. 2020;: pubmed publisher
|
Zhang X, Zhu B, Chen L, Xie L, Yu W, Wang Y, et al. Dual base editor catalyzes both cytosine and adenine base conversions in human cells. Nat Biotechnol. 2020;38:856-860 pubmed publisher
|
Xiong L, Zhao K, Cao Y, Guo H, Pan J, Yang X, et al. Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency. PLoS Biol. 2020;18:e3000731 pubmed publisher
|
Malankhanova T, Sorokin M, Medvedev S, Zakian S, Malakhova A. Introducing an Expanded Trinucleotide Repeat Tract into the Human Genome for Huntington's Disease Modeling In Vitro. Curr Protoc Hum Genet. 2020;106:e100 pubmed publisher
|
Dang L, Glanowska K, Iffland Ii P, Barnes A, Baybis M, Liu Y, et al. Multimodal Analysis of STRADA Function in Brain Development. Front Cell Neurosci. 2020;14:122 pubmed publisher
|
Lilianty J, Nur Patria Y, Stanley E, Elefanty A, Bateman J, Lamande S. Generation of a heterozygous COL2A1 (p.R989C) spondyloepiphyseal dysplasia congenita mutation iPSC line, MCRIi001-B, using CRISPR/Cas9 gene editing. Stem Cell Res. 2020;45:101843 pubmed publisher
|
Montico B, Colizzi F, Giurato G, Rizzo A, Salvati A, Baboci L, et al. Loss of Spry1 reduces growth of BRAFV600-mutant cutaneous melanoma and improves response to targeted therapy. Cell Death Dis. 2020;11:392 pubmed publisher
|
Stöhr D, Schmid J, Beigl T, Mack A, Maichl D, Cao K, et al. Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death Differ. 2020;: pubmed publisher
|
Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati G, McKenna J, et al. R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling. elife. 2020;9: pubmed publisher
|
Singhal J, Chikara S, Horne D, Awasthi S, Salgia R, Singhal S. Targeting RLIP with CRISPR/Cas9 controls tumor growth. Carcinogenesis. 2020;: pubmed publisher
|
Rodríguez González C, Lin S, Arkan S, Hansen C. Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation. Sci Rep. 2020;10:8130 pubmed publisher
|
Yu H, Ding J, Zhu H, Jing Y, Zhou H, Tian H, et al. LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2. Cell Death Differ. 2020;: pubmed publisher
|
Wrona D, Pastukhov O, Pritchard R, Raimondi F, Tchinda J, Jinek M, et al. CRISPR-Directed Therapeutic Correction at the NCF1 Locus Is Challenged by Frequent Incidence of Chromosomal Deletions. Mol Ther Methods Clin Dev. 2020;17:936-943 pubmed publisher
|
Nielsen C, Zhang T, Barisic M, Kalitsis P, Hudson D. Topoisomerase IIα is essential for maintenance of mitotic chromosome structure. Proc Natl Acad Sci U S A. 2020;117:12131-12142 pubmed publisher
|
Chen T, Zhang W, Huang B, Chen X, Huang C. UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway. Cells. 2020;9: pubmed publisher
|
Collins M, Stransky L, Forgac M. AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells. J Biol Chem. 2020;295:9433-9444 pubmed publisher
|
Zurli V, Montecchi T, Heilig R, Poschke I, Volkmar M, Wimmer G, et al. Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells. Sci Signal. 2020;13: pubmed publisher
|
Halder L, Jo E, Hasan M, Ferreira Gomes M, Krüger T, Westermann M, et al. Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles. Nat Commun. 2020;11:2331 pubmed publisher
|
Agosto M, Wensel T. LRRTM4 is a member of the transsynaptic complex between rod photoreceptors and bipolar cells. J Comp Neurol. 2020;: pubmed publisher
|
Pinzon Arteaga C, Snyder M, Lazzarotto C, Moreno N, Juras R, Raudsepp T, et al. Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9. Sci Rep. 2020;10:7411 pubmed publisher
|
Liu C, Huang C, Chen H, Lu H, Hsieh P, Lee J. Generation of a gene corrected human isogenic IBMS-iPSC-014-C from polycystic-kidney-disease induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2020;45:101784 pubmed publisher
|
Liu Q, Li A, Wang L, He W, Zhao L, Wu C, et al. Stomatin-like Protein 2 Promotes Tumor Cell Survival by Activating the JAK2-STAT3-PIM1 Pathway, Suggesting a Novel Therapy in CRC. Mol Ther Oncolytics. 2020;17:169-179 pubmed publisher
|
Liu Y, Huang X, Nguyen D, Shammas M, Wu B, Dombi E, et al. Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations. Hum Mol Genet. 2020;29:1547-1567 pubmed publisher
|
Yang F, Sun S, Wang C, Haas M, Yeo S, Guan J. Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation. Br J Cancer. 2020;122:1791-1802 pubmed publisher
|
Waaler J, Mygland L, Tveita A, Strand M, Solberg N, Olsen P, et al. Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Commun Biol. 2020;3:196 pubmed publisher
|
Jin H, Lee B, Luo Y, Choi Y, Choi E, Jin H, et al. FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku. Nat Commun. 2020;11:2010 pubmed publisher
|
Grosch M, Ittermann S, Rusha E, Greisle T, Ori C, Truong D, et al. Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation. BMC Biol. 2020;18:42 pubmed publisher
|
Tu J, Wan C, Zhang F, Cao L, Law P, Tian Y, et al. Genetic correction of Werner syndrome gene reveals impaired pro-angiogenic function and HGF insufficiency in mesenchymal stem cells. Aging Cell. 2020;19:e13116 pubmed publisher
|
Lee E, Yu J, Paek A, Lee S, Jang H, Cho S, et al. Targeting TJP1 attenuates cell-cell aggregation and modulates chemosensitivity against doxorubicin in leiomyosarcoma. J Mol Med (Berl). 2020;98:761-773 pubmed publisher
|
Hock D, Reljic B, Ang C, Muellner Wong L, Mountford H, Compton A, et al. HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV. Mol Cell Proteomics. 2020;19:1145-1160 pubmed publisher
|
Morita K, He S, Nowak R, Wang J, Zimmerman M, Fu C, et al. Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2. Cell. 2020;181:702-715.e20 pubmed publisher
|
Lee Y, Lee E, Choi B, Jang H, Myung J, You H. The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability. Mol Cells. 2020;43:459-468 pubmed publisher
|
Stojic L, Lun A, Mascalchi P, Ernst C, Redmond A, Mangei J, et al. A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Nat Commun. 2020;11:1851 pubmed publisher
|
Vyhlídalová B, Krasulová K, Pecinkova P, Marcalíková A, Vrzal R, Zemankova L, et al. Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization. Int J Mol Sci. 2020;21: pubmed publisher
|
Deng X, Iwagawa T, Fukushima M, Watanabe S. Characterization of human-induced pluripotent stem cells carrying homozygous RB1 gene deletion. Genes Cells. 2020;25:510-517 pubmed publisher
|
Yao S, Ye J, Yin M, Yu R. DMAMCL exerts antitumor effects on hepatocellular carcinoma both in vitro and in vivo. Cancer Lett. 2020;483:87-97 pubmed publisher
|
Grosshans H, Fischer T, Steinle J, Brill A, Ehrlich B. Neuronal Calcium Sensor 1 is up-regulated in response to stress to promote cell survival and motility in cancer cells. Mol Oncol. 2020;14:1134-1151 pubmed publisher
|
Witte A, Rohlfing A, Dannenmann B, Dicenta V, Nasri M, Kolb K, et al. The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4. Cardiovasc Res. 2020;: pubmed publisher
|
Vanderboor C, Thibeault P, Nixon K, Gros R, Kramer J, Ramachandran R. Proteinase-Activated Receptor 4 Activation Triggers Cell Membrane Blebbing through RhoA and β-Arrestin. Mol Pharmacol. 2020;97:365-376 pubmed publisher
|
Wang Z, Xu C, Diplas B, Moure C, Chen C, Chen L, et al. Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib. Mol Cancer Res. 2020;18:968-980 pubmed publisher
|
Knights A, Yang L, Shah M, Norton L, Green G, Stout E, et al. Krüppel-like factor 3 (KLF3) suppresses NF-κB-driven inflammation in mice. J Biol Chem. 2020;295:6080-6091 pubmed publisher
|
Viol L, Hata S, Pastor Peidro A, Neuner A, Murke F, Wuchter P, et al. Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis. J Cell Biol. 2020;219: pubmed publisher
|
Fatima A, Schuster J, Akram T, Sobol M, Hoeber J, Dahl N. Generation of a human Neurochondrin deficient iPSC line KICRi002-A-3 using CRISPR/Cas9. Stem Cell Res. 2020;44:101758 pubmed publisher
|
Hollywood J, Przepiorski A, D Souza R, Sreebhavan S, Wolvetang E, Harrison P, et al. Use of Human Induced Pluripotent Stem Cells and Kidney Organoids To Develop a Cysteamine/mTOR Inhibition Combination Therapy for Cystinosis. J Am Soc Nephrol. 2020;31:962-982 pubmed publisher
|
Yu L, Wang L, Yi H, Wu X. LRP6-CRISPR prevents activation of hepatic stellate cells and liver fibrogenesis in rats. Am J Transl Res. 2020;12:397-408 pubmed
|
Pirouzfar M, Amiri F, Dianatpour M, Takhshid M. CRISPR/Cas9-mediated knockout of MLL5 enhances apoptotic effect of cisplatin in HeLa cells in vitro. EXCLI J. 2020;19:170-182 pubmed publisher
|
Li K, Zhang Y, Liu X, Liu Y, Gu Z, Cao H, et al. Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies. Cancer Discov. 2020;10:724-745 pubmed publisher
|
Xu Y, Fulciniti M, Samur M, Ho M, Deng S, Liu L, et al. YWHAE/14-3-3ε expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma. Blood. 2020;136:468-479 pubmed publisher
|
Renema P, Hardy K, Housley N, Dunbar G, Annamdevula N, Britain A, et al. cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection. Am J Physiol Lung Cell Mol Physiol. 2020;318:L1074-L1083 pubmed publisher
|
Fan X, Waardenberg A, Demuth M, Osteil P, Sun J, Loebel D, et al. TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation. Mol Cell Biol. 2020;40: pubmed publisher
|
Kanasugi J, Hanamura I, Ota A, Karnan S, Lam V, Mizuno S, et al. Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells. Cancer Sci. 2020;111:1663-1675 pubmed publisher
|
Kaku H, Rothstein T. FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With Accumulation of Stress-Induced Protein Aggregates. Front Mol Biosci. 2020;7:32 pubmed publisher
|
Yang P, Wang Y, Tang W, Sun W, Ma Y, Lin S, et al. Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice. Sci Rep. 2020;10:4701 pubmed publisher
|
Koyama S, Tsuchiya H, Amisaki M, Sakaguchi H, Honjo S, Fujiwara Y, et al. NEAT1 is Required for the Expression of the Liver Cancer Stem Cell Marker CD44. Int J Mol Sci. 2020;21: pubmed publisher
|
Brenner E, Schörg B, Ahmetlić F, Wieder T, Hilke F, Simon N, et al. Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours. Nat Commun. 2020;11:1335 pubmed publisher
|
Dubois M, Meller A, Samandi S, Brunelle M, Frion J, Brunet M, et al. UBB pseudogene 4 encodes functional ubiquitin variants. Nat Commun. 2020;11:1306 pubmed publisher
|
Martin E, Minet N, Boschat A, Sanquer S, Sobrino S, Lenoir C, et al. Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation. JCI Insight. 2020;5: pubmed publisher
|
Sun C, Liu M, Chang J, Yang D, Zhao B, Wang H, et al. Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region. J Virol. 2020;94: pubmed publisher
|
Liang J, Lingeman E, Luong T, Ahmed S, Muhar M, Nguyen T, et al. A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation. Cell. 2020;180:1160-1177.e20 pubmed publisher
|
Verschuren E, Rigalli J, Castenmiller C, Rohrbach M, Bindels R, Peters D, et al. Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease. FASEB J. 2020;34:6382-6398 pubmed publisher
|
Buel G, Chen X, Chari R, O Neill M, Ebelle D, Jenkins C, et al. Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10. Nat Commun. 2020;11:1291 pubmed publisher
|
Pu J, Gao T, Zheng R, Fang Y, Ruan Y, Jin C, et al. Parkin mutation decreases neurite complexity and maturation in neurons derived from human fibroblasts. Brain Res Bull. 2020;159:9-15 pubmed publisher
|
Apelt K, Zoutendijk I, Gout D, Wondergem A, van den Heuvel D, Luijsterburg M. Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair. Sci Rep. 2020;10:4332 pubmed publisher
|
Cao J, Chen X, Jiang L, Lu B, Yuan M, Zhu D, et al. DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase. Nat Commun. 2020;11:1251 pubmed publisher
|
Zheng Z, Anurag M, Lei J, Cao J, Singh P, Peng J, et al. Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer. Cancer Cell. 2020;37:387-402.e7 pubmed publisher
|
He B, Yang N, Man C, Ng N, Cher C, Leung H, et al. Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia. EMBO Mol Med. 2020;12:e10895 pubmed publisher
|
Fatima A, Schuster J, Akram T, González C, Sobol M, Hoeber J, et al. Incontinentia pigmenti: Generation of an IKBKG deficient human iPSC line (KICRi002-A-1) on a 46,XY background using CRISPR/Cas9. Stem Cell Res. 2020;44:101739 pubmed publisher
|
Sato H, Schoenfeld A, Siau E, Lu Y, Tai H, Suzawa K, et al. MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by ROS1 Fusions. Clin Cancer Res. 2020;26:2932-2945 pubmed publisher
|
Cao Y, Wang X, Tang L, Li Y, Song X, Liu X, et al. Engrailed-2 promotes a malignant phenotype of esophageal squamous cell carcinoma through upregulating the expression of pro-oncogenic genes. Peerj. 2020;8:e8662 pubmed publisher
|
Gao X, Jin Z, Tan X, Zhang C, Zou C, Zhang W, et al. Hyperbranched poly(β-amino ester) based polyplex nanopaticles for delivery of CRISPR/Cas9 system and treatment of HPV infection associated cervical cancer. J Control Release. 2020;321:654-668 pubmed publisher
|
Morrow C, Porter T, Xu N, Arndt Z, Ako Asare K, Heo H, et al. Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit. Cell Stem Cell. 2020;26:558-568.e9 pubmed publisher
|
Smolina N, Khudiakov A, Knyazeva A, Zlotina A, Sukhareva K, Kondratov K, et al. Desmin mutations result in mitochondrial dysfunction regardless of their aggregation properties. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165745 pubmed publisher
|
Takahashi H, Ranjan A, Chen S, Suzuki H, Shibata M, Hirose T, et al. The role of Mediator and Little Elongation Complex in transcription termination. Nat Commun. 2020;11:1063 pubmed publisher
|
Dimchev G, Amiri B, Humphries A, Schaks M, Dimchev V, Stradal T, et al. Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation. J Cell Sci. 2020;133: pubmed publisher
|
Wu W, Wu Y, Mayer K, von Rosenstiel C, Schecker J, Baur S, et al. Lipid Peroxidation Plays an Important Role in Chemotherapeutic Effects of Temozolomide and the Development of Therapy Resistance in Human Glioblastoma. Transl Oncol. 2020;13:100748 pubmed publisher
|
Sawahata M, Mori D, Arioka Y, Kubo H, Kushima I, Kitagawa K, et al. Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia. Psychiatry Clin Neurosci. 2020;74:318-327 pubmed publisher
|
Jin J, Xu Y, Huo L, Ma L, Scott A, Pizzi M, et al. An improved strategy for CRISPR/Cas9 gene knockout and subsequent wildtype and mutant gene rescue. PLoS ONE. 2020;15:e0228910 pubmed publisher
|
Park J, Burckhardt C, Lazcano R, Solis L, Isogai T, Li L, et al. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature. 2020;578:621-626 pubmed publisher
|
Wang W, Lu G, Su X, Tang C, Li H, Xiong Z, et al. Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells. Cell Death Dis. 2020;11:107 pubmed publisher
|
Pimenova A, Goate A. Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations. Neurobiol Dis. 2020;138:104785 pubmed publisher
|
Xu X, Xin S, Mao H, Zhang H, Chen L, Li L, et al. SHOX CNE9/10 Knockout in U2OS Osteosarcoma Cells and Its Effects on Cell Growth and Apoptosis. Med Sci Monit. 2020;26:e921233 pubmed publisher
|
Ruegenberg S, Horn M, Pichlo C, Allmeroth K, Baumann U, Denzel M. Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun. 2020;11:687 pubmed publisher
|
Nguyen C, Sawangarun W, Mandasari M, Morita K, Harada H, Kayamori K, et al. AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression. PLoS ONE. 2020;15:e0222689 pubmed publisher
|
Li Y, Zhang M, Wang X, Liu W, Wang H, Yang Y. Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice. Nat Commun. 2020;11:581 pubmed publisher
|
Ballabio C, Anderle M, Gianesello M, Lago C, Miele E, Cardano M, et al. Modeling medulloblastoma in vivo and with human cerebellar organoids. Nat Commun. 2020;11:583 pubmed publisher
|
Momoi Y, Nishikimi A, Du G, Kataoka T, Katagiri K. Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration. Biochem Biophys Res Commun. 2020;524:325-331 pubmed publisher
|
Koga T, Chaim I, Benitez J, Markmiller S, Parisian A, Hevner R, et al. Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nat Commun. 2020;11:550 pubmed publisher
|
Komatsu T, Shimizu T, Kanoh M, Miyakawa T, Satta Y, Yasukochi Y, et al. Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion. Immunogenetics. 2020;72:143-153 pubmed publisher
|
Koslová A, Trefil P, Mucksová J, Reinisová M, Plachy J, Kalina J, et al. Precise CRISPR/Cas9 editing of the NHE1 gene renders chickens resistant to the J subgroup of avian leukosis virus. Proc Natl Acad Sci U S A. 2020;117:2108-2112 pubmed publisher
|
Montaño A, Ordóñez J, Alonso Pérez V, Hernández Sánchez J, Santos S, Gonzalez T, et al. ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia. Cells. 2020;9: pubmed publisher
|
Deng W, Bates J, Wei H, Bartoschek M, Conradt B, Leonhardt H. Tunable light and drug induced depletion of target proteins. Nat Commun. 2020;11:304 pubmed publisher
|
Dubey R, Stivala C, Nguyen H, Goo Y, Paul A, Carette J, et al. Lipid droplets can promote drug accumulation and activation. Nat Chem Biol. 2020;16:206-213 pubmed publisher
|
Li R, Zeng W, Ma M, Wei Z, Liu H, Liu X, et al. Precise editing of myostatin signal peptide by CRISPR/Cas9 increases the muscle mass of Liang Guang Small Spotted pigs. Transgenic Res. 2020;29:149-163 pubmed publisher
|
Mithal A, Capilla A, Heinze D, Berical A, Villacorta Martin C, Vedaie M, et al. Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nat Commun. 2020;11:215 pubmed publisher
|
Omi J, Watanabe Takahashi M, Igai K, Shimizu E, Tseng C, Miyasaka T, et al. The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection. Nat Commun. 2020;11:162 pubmed publisher
|
Prieto Bermejo R, Romo González M, Pérez Fernández A, García Tuñón I, Sanchez Martin M, Hernández Hernández A. Cyba-deficient mice display an increase in hematopoietic stem cells and an overproduction of immunoglobulins. Haematologica. 2020;: pubmed publisher
|
Clairmont C, Sarangi P, Ponnienselvan K, Galli L, Csete I, Moreau L, et al. TRIP13 regulates DNA repair pathway choice through REV7 conformational change. Nat Cell Biol. 2020;22:87-96 pubmed publisher
|
Qi F, Isaji T, Duan C, Yang J, Wang Y, Fukuda T, et al. ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins. FASEB J. 2020;34:881-897 pubmed publisher
|
Peters Hall J, Min J, Tedone E, Sho S, Siteni S, Mender I, et al. Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings. FASEB J. 2020;34:386-398 pubmed publisher
|
Okuyama Y, Nagashima H, Ushio Fukai M, Croft M, Ishii N, So T. IQGAP1 restrains T-cell cosignaling mediated by OX40. FASEB J. 2020;34:540-554 pubmed publisher
|
Duan C, Fukuda T, Isaji T, Qi F, Yang J, Wang Y, et al. Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system. FASEB J. 2020;34:3239-3252 pubmed publisher
|
Abe H, Alavattam K, Hu Y, Pang Q, Andreassen P, Hegde R, et al. The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Curr Biol. 2019;: pubmed publisher
|
Moskal N, Riccio V, Bashkurov M, Taddese R, Datti A, Lewis P, et al. ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway. Nat Commun. 2020;11:88 pubmed publisher
|
Wang H, Zhu N, Ye X, Wang L, Wang B, Shan W, et al. PTPN21-CDSlong isoform inhibits the response of acute lymphoblastic leukemia cells to NK-mediated lysis via the KIR/HLA-I axis. J Cell Biochem. 2020;121:3298-3312 pubmed publisher
|
Burke J, Lester E, Tauber D, Parker R. RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules. J Biol Chem. 2020;295:1426-1438 pubmed publisher
|
Thibeault P, LeSarge J, Arends D, Fernandes M, Chidiac P, Stathopulos P, et al. Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4). J Biol Chem. 2020;295:2520-2540 pubmed publisher
|
Brydon E, Bronstein R, Buskin A, Lako M, Pierce E, Fernandez Godino R. AAV-Mediated Gene Augmentation Therapy Restores Critical Functions in Mutant PRPF31+/- iPSC-Derived RPE Cells. Mol Ther Methods Clin Dev. 2019;15:392-402 pubmed publisher
|
Nur Patria Y, Lilianty J, Elefanty A, Stanley E, Labonne T, Bateman J, et al. Generation of a SOX9-tdTomato reporter human iPSC line, MCRIi001-A-2, using CRISPR/Cas9 editing. Stem Cell Res. 2019;42:101689 pubmed publisher
|
Tamburri S, Lavarone E, Fernandez Perez D, Conway E, Zanotti M, Manganaro D, et al. Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression. Mol Cell. 2019;: pubmed publisher
|
Bode K, Bujupi F, Link C, Hein T, Zimmermann S, Peiris D, et al. Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2. Cell Rep. 2019;29:4435-4446.e9 pubmed publisher
|
Peng Y, Yang T, Tang X, Chen F, Wang S. Construction of an Inducible CRISPR/Cas9 System for CXCR4 Gene and Demonstration of its Effects on MKN-45 Cells. Cell Biochem Biophys. 2019;: pubmed publisher
|
Park E, Scott P, Clutario K, Cassidy K, Zhan K, Gerber S, et al. WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. J Cell Biol. 2020;219: pubmed publisher
|
Ulloa Navas M, García Tárraga P, Garcia Verdugo J, Herranz Pérez V. Immunogold Labeling to Detect Streptococcus pyogenes Cas9 in Cell Culture and Tissues by Electron Microscopy. CRISPR J. 2019;2:395-405 pubmed publisher
|
Senigl F, Maman Y, Dinesh R, Alinikula J, Seth R, Pecnova L, et al. Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. Cell Rep. 2019;29:3902-3915.e8 pubmed publisher
|
Matsumoto R, Suga H, Aoi T, Bando H, Fukuoka H, Iguchi G, et al. Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells. J Clin Invest. 2019;: pubmed publisher
|
Wu C, Cho S, Huang H, Lu C, Russ J, Cruz L, et al. MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation. Sci Adv. 2019;5:eaaw1715 pubmed publisher
|
Valderrama J, Kulkarni S, Nizet V, Bier E. A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. Nat Commun. 2019;10:5726 pubmed publisher
|
García Tuñón I, Vuelta E, Lozano L, Herrero M, Mendez L, Palomero Hernandez J, et al. Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology. Mol Biol Rep. 2020;47:1381-1391 pubmed publisher
|
Xie L, Sun J, Mo L, Xu T, Shahzad Q, Chen D, et al. HMEJ-mediated efficient site-specific gene integration in chicken cells. J Biol Eng. 2019;13:90 pubmed publisher
|
Uezu A, Hisey E, Kobayashi Y, Gao Y, Bradshaw T, Devlin P, et al. Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice. elife. 2019;8: pubmed publisher
|
Liao K, Chuo V, Fagg W, Bradrick S, Pompon J, Garcia Blanco M. The RNA binding protein Quaking represses host interferon response by downregulating MAVS. RNA Biol. 2019;:1-15 pubmed publisher
|
Casanova M, Moscatelli M, Chauvière L, Huret C, Samson J, Liyakat Ali T, et al. A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Nat Commun. 2019;10:5652 pubmed publisher
|
Moyer C, Ivanovich J, Gillespie J, Doberstein R, Radke M, Richardson M, et al. Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer. Cancer Res. 2020;80:857-867 pubmed publisher
|
Abe H, Satoh J, Shirasaka Y, Kogure A, Kato H, Ito S, et al. Priming Phosphorylation of TANK-Binding Kinase 1 by IκB Kinase β Is Essential in Toll-Like Receptor 3/4 Signaling. Mol Cell Biol. 2020;40: pubmed publisher
|
Yang J, Isaji T, Zhang G, Qi F, Duan C, Fukuda T, et al. EpCAM associates with integrin and regulates cell adhesion in cancer cells. Biochem Biophys Res Commun. 2020;522:903-909 pubmed publisher
|
Ysselstein D, Nguyen M, Young T, Severino A, Schwake M, Merchant K, et al. LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. Nat Commun. 2019;10:5570 pubmed publisher
|
Czech Sioli M, Siebels S, Radau S, Zahedi R, Schmidt C, Dobner T, et al. The Ubiquitin-Specific Protease Usp7, a Novel Merkel Cell Polyomavirus Large T-Antigen Interaction Partner, Modulates Viral DNA Replication. J Virol. 2020;94: pubmed publisher
|
Liu P, Zhao L, Loos F, Marty C, Xie W, Martins I, et al. Immunosuppression by Mutated Calreticulin Released from Malignant Cells. Mol Cell. 2019;: pubmed publisher
|
Montaldo N, Bordin D, Brambilla A, Rösinger M, Fordyce Martin S, Bjørås K, et al. Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression. Nat Commun. 2019;10:5460 pubmed publisher
|
Warmerdam D, Alonso de Vega I, Wiegant W, van den Broek B, Rother M, Wolthuis R, et al. PHF6 promotes non-homologous end joining and G2 checkpoint recovery. EMBO Rep. 2019;:e48460 pubmed publisher
|
Filippova J, Matveeva A, Zhuravlev E, Balakhonova E, Prokhorova D, Malanin S, et al. Are Small Nucleolar RNAs "CRISPRable"? A Report on Box C/D Small Nucleolar RNA Editing in Human Cells. Front Pharmacol. 2019;10:1246 pubmed publisher
|
Huang C, Wang H, Wang M, Hsu M, Wu Y, Jiang Y, et al. Kisspeptin-Activated Autophagy Independently Suppresses Non-Glucose-Stimulated Insulin Secretion from Pancreatic β-Cells. Sci Rep. 2019;9:17451 pubmed publisher
|
Hochberg Laufer H, Neufeld N, Brody Y, Nadav Eliyahu S, Ben Yishay R, Shav Tal Y. Availability of splicing factors in the nucleoplasm can regulate the release of mRNA from the gene after transcription. PLoS Genet. 2019;15:e1008459 pubmed publisher
|
Chappidi N, Nascakova Z, Boleslavska B, Zellweger R, Isik E, Andrs M, et al. Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops. Mol Cell. 2019;: pubmed publisher
|
Morales C, Ruiz Torres M, Rodriguez Acebes S, Lafarga V, Rodríguez Corsino M, Megias D, et al. PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection. J Biol Chem. 2020;295:146-157 pubmed publisher
|
Di Giorgio E, Dalla E, Franforte E, Paluvai H, Minisini M, Trevisanut M, et al. Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells. Nucleic Acids Res. 2019;: pubmed publisher
|
Pu J, Dai S, Gao T, Hu J, Fang Y, Zheng R, et al. Nystagmus-related FRMD7 gene influences the maturation and complexities of neuronal processes in human neurons. Brain Behav. 2019;9:e01473 pubmed publisher
|
Li J, Ryan S, DeBoer E, Cook K, Fitzgerald S, Lachman H, et al. Mitochondrial deficits in human iPSC-derived neurons from patients with 22q11.2 deletion syndrome and schizophrenia. Transl Psychiatry. 2019;9:302 pubmed publisher
|
Alexander J, Findlay G, Kircher M, Shendure J. Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement. BMC Biol. 2019;17:90 pubmed publisher
|
Mózsik L, Büttel Z, Bovenberg R, Driessen A, Nygård Y. Synthetic control devices for gene regulation in Penicillium chrysogenum. Microb Cell Fact. 2019;18:203 pubmed publisher
|
Cao Y, Yuan L, Zhao Q, Yuan J, Miao C, Chang Y, et al. Hsp40 Protein DNAJB6 Interacts with Viral NS3 and Inhibits the Replication of the Japanese Encephalitis Virus. Int J Mol Sci. 2019;20: pubmed publisher
|
Laptev I, Shvetsova E, Levitskii S, Serebryakova M, Rubtsova M, Bogdanov A, et al. Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m5U formation in both tRNA and rRNA. RNA Biol. 2020;17:441-450 pubmed publisher
|
Huang Y, Mouttet B, Warnatz H, Risch T, Rietmann F, Frommelt F, et al. The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability. Cancer Cell. 2019;36:630-644.e9 pubmed publisher
|
Kampf L, Schneider R, Gerstner L, Thünauer R, Chen M, Helmstädter M, et al. TBC1D8B Mutations Implicate RAB11-Dependent Vesicular Trafficking in the Pathogenesis of Nephrotic Syndrome. J Am Soc Nephrol. 2019;30:2338-2353 pubmed publisher
|
Sale M, Minihane E, Monks N, Gilley R, Richards F, Schifferli K, et al. Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors. Nat Commun. 2019;10:5167 pubmed publisher
|
Póti A, Gyergyák H, Nemeth E, Rusz O, Tóth S, Kovácsházi C, et al. Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents. Genome Biol. 2019;20:240 pubmed publisher
|
Liebelt F, Schimmel J, Verlaan de Vries M, Klemann E, van Royen M, van der Weegen Y, et al. Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation. Nucleic Acids Res. 2019;: pubmed publisher
|
Garland W, Comet I, Wu M, Radzisheuskaya A, Rib L, Vitting Seerup K, et al. A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2. Cell Rep. 2019;29:1800-1811.e6 pubmed publisher
|
Weiterer S, Meier Soelch J, Georgomanolis T, Mizi A, Beyerlein A, Weiser H, et al. Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J. 2019;:e101533 pubmed publisher
|
Qin X, Wang H, Ma L, Shen J, Liu Q, Xue L. Knockout of the Placenta Specific 8 Gene Affects the Proliferation and Migration of Human Embryonic Kidney 293T Cell. Cell Biochem Biophys. 2019;: pubmed publisher
|
Valetdinova K, Ovechkina V, Zakian S. Methods for Correction of the Single-Nucleotide Substitution c.840C>T in Exon 7 of the SMN2 Gene. Biochemistry (Mosc). 2019;84:1074-1084 pubmed publisher
|
Wang Y, Li Y, Qiao J, Li N, Qiao S. AMPK α1 mediates the protective effect of adiponectin against insulin resistance in INS-1 pancreatic β cells. Cell Biochem Funct. 2019;37:625-632 pubmed publisher
|
Fischer B, Ly T, Schmidt V, Hendig D, Kuhn J, Knabbe C, et al. Xylosyltransferase-deficient human HEK293 cells show a strongly reduced proliferation capacity and viability. Biochem Biophys Res Commun. 2020;521:507-513 pubmed publisher
|
Escobar T, Oksuz O, Saldaña Meyer R, Descostes N, Bonasio R, Reinberg D. Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication. Cell. 2019;179:953-963.e11 pubmed publisher
|
Moore P, Qi J, Thamsen M, Ghosh R, Peng J, Gliedt M, et al. Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Res. 2019;79:6190-6203 pubmed publisher
|
Marbaix A, Chehade G, Noel G, Morsomme P, Vertommen D, Bommer G, et al. Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P). Biochem J. 2019;476:3033-3052 pubmed publisher
|
Schmidt H, Barreau A, Rohatgi R. Phase separation-deficient TDP43 remains functional in splicing. Nat Commun. 2019;10:4890 pubmed publisher
|
Du X, Zhou L, Aw Y, Mak H, Xu Y, Rae J, et al. ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets. J Cell Biol. 2020;219: pubmed publisher
|
Gehring T, Erdmann T, Rahm M, Graß C, Flatley A, O Neill T, et al. MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. Cell Rep. 2019;29:873-888.e10 pubmed publisher
|
Liu R, Olano L, Mirzakhanyan Y, Gershon P, Moss B. Vaccinia Virus Ankyrin-Repeat/F-Box Protein Targets Interferon-Induced IFITs for Proteasomal Degradation. Cell Rep. 2019;29:816-828.e6 pubmed publisher
|
Renz P, Imahorn E, Spoerri I, Aushev M, March O, Wariwoda H, et al. Arginine- but not alanine-rich carboxy-termini trigger nuclear translocation of mutant keratin 10 in ichthyosis with confetti. J Cell Mol Med. 2019;23:8442-8452 pubmed publisher
|
Ko P, Woodrow C, Dubreuil M, Martin B, Skouta R, Bassik M, et al. A ZDHHC5-GOLGA7 Protein Acyltransferase Complex Promotes Nonapoptotic Cell Death. Cell Chem Biol. 2019;26:1716-1724.e9 pubmed publisher
|
Qian X, Li X, Shi Z, Bai X, Xia Y, Zheng Y, et al. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Mol Cell. 2019;: pubmed publisher
|
Virion Z, Doly S, Saha K, Lambert M, Guillonneau F, Bied C, et al. Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili. Nat Commun. 2019;10:4752 pubmed publisher
|
Stubb A, Guzman C, Närvä E, Aaron J, Chew T, Saari M, et al. Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells. Nat Commun. 2019;10:4756 pubmed publisher
|
Freyre C, Rauher P, Ejsing C, Klemm R. MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Mol Cell. 2019;76:811-825.e14 pubmed publisher
|
LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai R, Kara H, et al. LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells. Sci Adv. 2019;5:eaay3068 pubmed publisher
|
Graham M, Kim J, Da J, Brosnan Cashman J, Rizzo A, Baena Del Valle J, et al. Functional Loss of ATRX and TERC Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer Cells. Mol Cancer Res. 2019;17:2480-2491 pubmed publisher
|
Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nat Commun. 2019;10:4624 pubmed publisher
|
Smith E, Somma D, Kerrigan D, McIntyre Z, Cole J, Liang K, et al. The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80. Nucleic Acids Res. 2019;47:11151-11163 pubmed publisher
|
Amoasii L, Li H, Zhang Y, Min Y, Sanchez Ortiz E, Shelton J, et al. In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse. Nat Commun. 2019;10:4537 pubmed publisher
|
Ha S, Cho W, DeKoter R, Kim S. The transcription factor PU.1 mediates enhancer-promoter looping that is required for IL-1β eRNA and mRNA transcription in mouse melanoma and macrophage cell lines. J Biol Chem. 2019;294:17487-17500 pubmed publisher
|
Lundby A, Franciosa G, Emdal K, Refsgaard J, Gnosa S, Bekker Jensen D, et al. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Cell. 2019;179:543-560.e26 pubmed publisher
|
Garcin E, Gon S, Sullivan M, Brunette G, Cian A, Concordet J, et al. Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells. PLoS Genet. 2019;15:e1008355 pubmed publisher
|
Jeong J, Jager A, Domizi P, Pavel Dinu M, Gojenola L, Iwasaki M, et al. High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells. Blood Adv. 2019;3:2825-2835 pubmed publisher
|
Li X, Li Q, Yu X, Li H, Huang G. Reverse of microtubule-directed chemotherapeutic drugs resistance induced by cancer-associated fibroblasts in breast cancer. Onco Targets Ther. 2019;12:7963-7973 pubmed publisher
|
Matre P, Mu X, Wu J, Danila D, Hall M, Kolonin M, et al. CRISPR/Cas9-Based Dystrophin Restoration Reveals a Novel Role for Dystrophin in Bioenergetics and Stress Resistance of Muscle Progenitors. Stem Cells. 2019;37:1615-1628 pubmed publisher
|
Acharya S, Mishra A, Paul D, Ansari A, Azhar M, Kumar M, et al. Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing. Proc Natl Acad Sci U S A. 2019;116:20959-20968 pubmed publisher
|
Dart D, Koushyar S, Lanning B, Jiang W. MiR-221 Is Specifically Elevated in PC3 Cells and its Deletion Reduces Adhesion, Motility and Growth. Anticancer Res. 2019;39:5311-5327 pubmed publisher
|
Sackmann V, Sinha M, Sackmann C, Civitelli L, Bergström J, Ansell Schultz A, et al. Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia. Front Mol Neurosci. 2019;12:200 pubmed publisher
|
Kashyap A, Fernandez Rodriguez L, Zhao Y, Monaco G, Trefny M, Yoshida N, et al. GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses. Cell Rep. 2019;28:3367-3380.e8 pubmed publisher
|
Li J, Han W, Wu K, Li Y, Liu Q, Lu W. A Conserved Tyrosine Residue in Slitrk3 Carboxyl-Terminus Is Critical for GABAergic Synapse Development. Front Mol Neurosci. 2019;12:213 pubmed publisher
|
Vagni P, Perlini L, Chenais N, Marchetti T, Parrini M, Contestabile A, et al. Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration. Front Neurosci. 2019;13:945 pubmed publisher
|
Adriaens C, Rambow F, Bervoets G, Silla T, Mito M, Chiba T, et al. The long noncoding RNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth. RNA. 2019;25:1681-1695 pubmed publisher
|
Fang S, Li J, Xiao Y, Lee M, Guo L, Han W, et al. Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development. Nat Commun. 2019;10:4297 pubmed publisher
|
Bernkopf D, Brückner M, Hadjihannas M, Behrens J. An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy. Nat Commun. 2019;10:4251 pubmed publisher
|
Ohneda K, Ohmori S, Yamamoto M. Mouse Tryptase Gene Expression is Coordinately Regulated by GATA1 and GATA2 in Bone Marrow-Derived Mast Cells. Int J Mol Sci. 2019;20: pubmed publisher
|
Du C, Hansen L, Singh S, Wang F, Sun R, Moure C, et al. A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis. Cell Rep. 2019;28:3199-3211.e5 pubmed publisher
|
Masamsetti V, Low R, Mak K, O Connor A, Riffkin C, Lamm N, et al. Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. Nat Commun. 2019;10:4224 pubmed publisher
|
Healy E, Mucha M, Glancy E, Fitzpatrick D, Conway E, Neikes H, et al. PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation. Mol Cell. 2019;76:437-452.e6 pubmed publisher
|
Vriend J, Peters J, Nieskens T, Škovroňová R, Blaimschein N, Schmidts M, et al. Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia. Biochim Biophys Acta Gen Subj. 2020;1864:129433 pubmed publisher
|
Ngo A, Shurtleff M, Popova K, Kulsuptrakul J, Weissman J, Puschnik A. The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins. elife. 2019;8: pubmed publisher
|
Hashwah H, Bertram K, Stirm K, Stelling A, Wu C, Kasser S, et al. The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma. EMBO Mol Med. 2019;11:e10576 pubmed publisher
|
Deshayes N, Arkan S, Hansen C. The Molecular Chaperone DNAJB6, but Not DNAJB1, Suppresses the Seeded Aggregation of Alpha-Synuclein in Cells. Int J Mol Sci. 2019;20: pubmed publisher
|
Williamson I, Kane L, Devenney P, Flyamer I, Anderson E, Kilanowski F, et al. Developmentally regulated Shh expression is robust to TAD perturbations. Development. 2019;146: pubmed publisher
|
Chang J, Yeh H, Park M, Erber L, Sun J, Cheng S, et al. mTOR-regulated U2af1 tandem exon splicing specifies transcriptome features for translational control. Nucleic Acids Res. 2019;47:10373-10387 pubmed publisher
|
Driscoll M, Welf E, Jamieson A, Dean K, Isogai T, Fiolka R, et al. Robust and automated detection of subcellular morphological motifs in 3D microscopy images. Nat Methods. 2019;16:1037-1044 pubmed publisher
|
Selvaraj S, Dhoke N, Kiley J, Mateos Aierdi A, Tungtur S, Mondragón González R, et al. Gene Correction of LGMD2A Patient-Specific iPSCs for the Development of Targeted Autologous Cell Therapy. Mol Ther. 2019;27:2147-2157 pubmed publisher
|
Burke J, Moon S, Matheny T, Parker R. RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs. Mol Cell. 2019;75:1203-1217.e5 pubmed publisher
|
Qian X, Li X, Shi Z, Xia Y, Cai Q, Xu D, et al. PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1. Mol Cell. 2019;76:516-527.e7 pubmed publisher
|
Sagi I, De Pinho J, Zuccaro M, Atzmon C, Golan Lev T, Yanuka O, et al. Distinct Imprinting Signatures and Biased Differentiation of Human Androgenetic and Parthenogenetic Embryonic Stem Cells. Cell Stem Cell. 2019;25:419-432.e9 pubmed publisher
|
van der Schoot J, Fennemann F, Valente M, Dölen Y, Hagemans I, Becker A, et al. Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering. Sci Adv. 2019;5:eaaw1822 pubmed publisher
|
Richard A, Vallin E, Romestaing C, Roussel D, Gandrillon O, Gonin Giraud S. Erythroid differentiation displays a peak of energy consumption concomitant with glycolytic metabolism rearrangements. PLoS ONE. 2019;14:e0221472 pubmed publisher
|
Sun H, Fan Z, Gingras A, López Ramírez M, Ginsberg M, Ley K. Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling. J Leukoc Biol. 2020;107:175-183 pubmed publisher
|
Sathyan K, McKenna B, Anderson W, Duarte F, Core L, Guertin M. An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion. Genes Dev. 2019;33:1441-1455 pubmed publisher
|
Kasitinon S, Eskiocak U, Martin M, Bezwada D, Khivansara V, Tasdogan A, et al. TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling. Cell Rep. 2019;28:2293-2305.e9 pubmed publisher
|
Stephan T, Roesch A, Riedel D, Jakobs S. Live-cell STED nanoscopy of mitochondrial cristae. Sci Rep. 2019;9:12419 pubmed publisher
|
Wallroth A, Koch P, Marat A, Krause E, Haucke V. Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1. Nat Cell Biol. 2019;21:1093-1101 pubmed publisher
|
Li S, Prasanna X, Salo V, Vattulainen I, Ikonen E. An efficient auxin-inducible degron system with low basal degradation in human cells. Nat Methods. 2019;16:866-869 pubmed publisher
|
Li X, Sun T, Wang X, Tang J, Liu Y. Restore natural fertility of Kitw/Kitwv mouse with nonobstructive azoospermia through gene editing on SSCs mediated by CRISPR-Cas9. Stem Cell Res Ther. 2019;10:271 pubmed publisher
|
Jameson N, Ma J, Benitez J, Izurieta A, Han J, Mendez R, et al. Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins. Mol Cancer Res. 2019;17:2208-2220 pubmed publisher
|
Kappel S, Stokłosa P, Hauert B, Ross Kaschitza D, Borgström A, Baur R, et al. TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells. Mol Oncol. 2019;13:2393-2405 pubmed publisher
|
Guo C, Wang M, Zhu Z, He S, Liu H, Liu X, et al. Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection. Front Immunol. 2019;10:1846 pubmed publisher
|
Kang J, Park J, Ko J, Kim Y. Regulation of gene expression by altered promoter methylation using a CRISPR/Cas9-mediated epigenetic editing system. Sci Rep. 2019;9:11960 pubmed publisher
|
Sherstyuk V, Davletshina G, Vyatkin Y, Shtokalo D, Vlasov V, Zakian S. A New MicroRNA Cluster Involved in the Reprogramming to a Pluripotent State. Acta Naturae. 2019;11:92-97 pubmed publisher
|
SEGEL M, Neumann B, Hill M, Weber I, Viscomi C, Zhao C, et al. Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature. 2019;573:130-134 pubmed publisher
|
El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, van Blerkom P, et al. A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell. 2019;178:1145-1158.e20 pubmed publisher
|
Ruicci K, Plantinga P, Pinto N, Khan M, Stecho W, Dhaliwal S, et al. Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition. Mol Oncol. 2019;13:2160-2177 pubmed publisher
|
Schmidt N, Domingues P, Golebiowski F, Patzina C, Tatham M, Hay R, et al. An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity. Proc Natl Acad Sci U S A. 2019;116:17399-17408 pubmed publisher
|
Sundaravinayagam D, Rahjouei A, Andreani M, Tupiņa D, Balasubramanian S, Saha T, et al. 53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function. Cell Rep. 2019;28:1389-1399.e6 pubmed publisher
|
Bittermann E, Abdelhamed Z, Liegel R, Menke C, Timms A, Beier D, et al. Differential requirements of tubulin genes in mammalian forebrain development. PLoS Genet. 2019;15:e1008243 pubmed publisher
|
Ooi Y, Majzoub K, Flynn R, Mata M, Diep J, Li J, et al. An RNA-centric dissection of host complexes controlling flavivirus infection. Nat Microbiol. 2019;4:2369-2382 pubmed publisher
|
Cichy A, Shah A, Dewan A, Kaye S, Bozza T. Genetic Depletion of Class I Odorant Receptors Impacts Perception of Carboxylic Acids. Curr Biol. 2019;29:2687-2697.e4 pubmed publisher
|
Walia R, Ho C, Lee C, Gilch S, Schatzl H. Gene-edited murine cell lines for propagation of chronic wasting disease prions. Sci Rep. 2019;9:11151 pubmed publisher
|
de Wispelaere M, Du G, Donovan K, Zhang T, Eleuteri N, Yuan J, et al. Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations. Nat Commun. 2019;10:3468 pubmed publisher
|
Saez I, Gerbracht J, Koyuncu S, Lee H, Horn M, Kroef V, et al. The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. FEBS Lett. 2019;: pubmed publisher
|
Elliott B, Ho H, Ranganathan S, Vangaveti S, Ilkayeva O, Abou Assi H, et al. Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo. Nat Commun. 2019;10:3401 pubmed publisher
|
Lu M, Wei W. Proximity labeling to detect RNA-protein interactions in live cells. FEBS Open Bio. 2019;9:1860-1868 pubmed publisher
|
Hollern D, Swiatnicki M, Rennhack J, Misek S, Matson B, McAuliff A, et al. E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration. Sci Rep. 2019;9:10718 pubmed publisher
|
Khoshnejad M, Brenner J, Parhiz H, Muzykantov V. CRISPR/Cas9-Mediated Genetic Engineering of Hybridomas for Creation of Antibodies that Allow for Site-Specific Conjugation. Methods Mol Biol. 2019;2033:81-93 pubmed publisher
|
Rennhack J, To B, Swiatnicki M, Dulak C, Ogrodzinski M, Zhang Y, et al. Integrated analyses of murine breast cancer models reveal critical parallels with human disease. Nat Commun. 2019;10:3261 pubmed publisher
|
Ullrich F, Blin S, Lazarow K, Daubitz T, von Kries J, Jentsch T. Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels. elife. 2019;8: pubmed publisher
|
Yang D, Liu X, Xu W, Gu Z, Yang C, Zhang L, et al. The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection. PLoS Pathog. 2019;15:e1007917 pubmed publisher
|
Fukumoto T, Fatkhutdinov N, Zundell J, Tcyganov E, Nacarelli T, Karakashev S, et al. HDAC6 Inhibition Synergizes with Anti-PD-L1 Therapy in ARID1A-Inactivated Ovarian Cancer. Cancer Res. 2019;79:5482-5489 pubmed publisher
|
Pham D, Bruelle C, Thi Do H, Pajanoja C, Jin C, Srinivasan V, et al. Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells. Cell Death Dis. 2019;10:537 pubmed publisher
|
Espinoza J, Zisi A, Kanellis D, Carreras Puigvert J, Henriksson M, Huhn D, et al. The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity. Cell Death Differ. 2019;: pubmed publisher
|
Fang M, Markmiller S, Vu A, Javaherian A, Dowdle W, Jolivet P, et al. Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. 2019;: pubmed publisher
|
Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy A, et al. Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. EMBO J. 2019;38:e100926 pubmed publisher
|
Lignitto L, LeBoeuf S, Homer H, Jiang S, Askenazi M, Karakousi T, et al. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. Cell. 2019;: pubmed publisher
|
Chen S, Sun S, Moonen D, Lee C, Lee A, Schaffer D, et al. CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection. Cell Rep. 2019;27:3780-3789.e4 pubmed publisher
|
Clancy J, Zhang Y, Sheehan C, D SOUZA SCHOREY C. An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles. Nat Cell Biol. 2019;: pubmed publisher
|
Přikryl D, Plachy J, Kucerova D, Koslová A, Reinisová M, Senigl F, et al. The novel avian leukosis virus subgroup K shares its cellular chicken receptor with subgroup A. J Virol. 2019;: pubmed publisher
|
Travers T, Kanagy W, Mansbach R, Jhamba E, Cleyrat C, Goldstein B, et al. Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ. Mol Biol Cell. 2019;:mbcE18110722 pubmed publisher
|
Gothe H, Bouwman B, Gusmao E, Piccinno R, Petrosino G, Sayols S, et al. Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations. Mol Cell. 2019;: pubmed publisher
|
Salo V, Li S, Vihinen H, Hölttä Vuori M, Szkalisity A, Horvath P, et al. Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact. Dev Cell. 2019;: pubmed publisher
|
Moir Meyer G, Cheong P, Olijnik A, Brown J, Knight S, King A, et al. Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors. Methods Protoc. 2018;1: pubmed publisher
|
Kwon P, Kim H, Kim S, Kang B, Yi H, Ku H, et al. The poly(C) motif in the proximal promoter region of D-box binding protein (Dbp) drives its high-amplitude oscillation. Mol Cell Biol. 2019;: pubmed publisher
|
Zeitz M, Calhoun P, James C, Taetzsch T, George K, Robel S, et al. Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging. Cell Rep. 2019;27:2737-2747.e5 pubmed publisher
|
Artegiani B, van Voorthuijsen L, Lindeboom R, Seinstra D, Heo I, Tapia P, et al. Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids. Cell Stem Cell. 2019;: pubmed publisher
|
Krug B, De Jay N, Harutyunyan A, Deshmukh S, Marchione D, Guilhamon P, et al. Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas. Cancer Cell. 2019;35:782-797.e8 pubmed publisher
|
Alateeq S, Ovchinnikov D, Tracey T, Whitworth D, Al Rubaish A, Al Ali A, et al. Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns. APL Bioeng. 2018;2:046103 pubmed publisher
|
Mohan A, Dean K, Isogai T, Kasitinon S, Murali V, Roudot P, et al. Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. Dev Cell. 2019;49:444-460.e9 pubmed publisher
|
Mitchell D, Menon A, Garner A. Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. Cell Chem Biol. 2019;: pubmed publisher
|
McNamara D, Dovey C, Hale A, Quarato G, Grace C, Guibao C, et al. Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites. Cell Chem Biol. 2019;26:863-877.e7 pubmed publisher
|
Chino H, Hatta T, Natsume T, Mizushima N. Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Mol Cell. 2019;74:909-921.e6 pubmed publisher
|
Alapati D, Zacharias W, Hartman H, Rossidis A, Stratigis J, Ahn N, et al. In utero gene editing for monogenic lung disease. Sci Transl Med. 2019;11: pubmed publisher
|
Hoffmann M, Aschenbrenner S, Grosse S, Rapti K, Domenger C, Fakhiri J, et al. Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins. Nucleic Acids Res. 2019;: pubmed publisher
|
Princely Abudu Y, Pankiv S, Mathai B, Håkon Lystad A, Bindesbøll C, Brenne H, et al. NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Dev Cell. 2019;49:509-525.e12 pubmed publisher
|
Martens G, Ladowski J, Estrada J, Wang Z, Reyes L, Easlick J, et al. HLA Class I-sensitized Renal Transplant Patients Have Antibody Binding to SLA Class I Epitopes. Transplantation. 2019;103:1620-1629 pubmed publisher
|
Lee S, Mayr C. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. Mol Cell. 2019;: pubmed publisher
|
Ferguson F, Doctor Z, Ficarro S, Browne C, Marto J, Johnson J, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019;26:804-817.e12 pubmed publisher
|
Roake C, Chen L, Chakravarthy A, Ferrell J, Raffa G, Artandi S. Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease. Mol Cell. 2019;74:688-700.e3 pubmed publisher
|
Bottermann M, Foss S, Caddy S, Clift D, van Tienen L, Vaysburd M, et al. Complement C4 Prevents Viral Infection through Capsid Inactivation. Cell Host Microbe. 2019;25:617-629.e7 pubmed publisher
|
Turco E, Witt M, Abert C, Bock Bierbaum T, Su M, Trapannone R, et al. FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Mol Cell. 2019;74:330-346.e11 pubmed publisher
|
Bäck S, Necarsulmer J, Whitaker L, Coke L, Koivula P, Heathward E, et al. Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Neuron. 2019;102:105-119.e8 pubmed publisher
|
Bajc Česnik A, Darovic S, Prpar Mihevc S, Stalekar M, Malnar M, Motaln H, et al. Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies. J Cell Sci. 2019;132: pubmed publisher
|
Habich M, Salscheider S, Murschall L, Hoehne M, Fischer M, Schorn F, et al. Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay. Cell Rep. 2019;26:759-774.e5 pubmed publisher
|
Liu L, Wang T, Wang M, Tong Q, Sun Y, Pu J, et al. Recombinant turkey herpesvirus expressing H9 hemagglutinin providing protection against H9N2 avian influenza. Virology. 2019;529:7-15 pubmed publisher
|
Asai R, Tsuchiya H, Amisaki M, Makimoto K, Takenaga A, Sakabe T, et al. CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line. Cancer Med. 2019;8:773-782 pubmed publisher
|
Zhu Q, Fang L, Heuberger J, Kranz A, Schipper J, Scheckenbach K, et al. The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Cell Rep. 2019;26:415-428.e5 pubmed publisher
|
Martyn G, Wienert B, Kurita R, Nakamura Y, Quinlan K, Crossley M. A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site. Blood. 2019;133:852-856 pubmed publisher
|
Atakpa P, van Marrewijk L, Apta Smith M, Chakraborty S, Taylor C. GPN does not release lysosomal Ca2+ but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C. J Cell Sci. 2019;132: pubmed publisher
|
Jayachandran R, Gumienny A, Bolinger B, Ruehl S, Lang M, Fucile G, et al. Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity. Immunity. 2019;50:152-165.e8 pubmed publisher
|
Abernathy E, Mateo R, Majzoub K, van Buuren N, Bird S, Carette J, et al. Differential and convergent utilization of autophagy components by positive-strand RNA viruses. PLoS Biol. 2019;17:e2006926 pubmed publisher
|
Xu W, Liang D, Wang Q, Shen J, Liu Q, Peng Y. Knockdown of KDM2A inhibits proliferation associated with TGF-β expression in HEK293T cell. Mol Cell Biochem. 2019;456:95-104 pubmed publisher
|
Verschuren E, Hoenderop J, Peters D, Arjona F, Bindels R. Tubular flow activates magnesium transport in the distal convoluted tubule. FASEB J. 2019;33:5034-5044 pubmed publisher
|
Jeong Y, Simoneschi D, Keegan S, Melville D, Adler N, Saraf A, et al. The ULK1-FBXW5-SEC23B nexus controls autophagy. elife. 2018;7: pubmed publisher
|
Chou A, Aslanian A, Sun H, Hunter T. An internal ribosome entry site in the coding region of tyrosyl-DNA phosphodiesterase 2 drives alternative translation start. J Biol Chem. 2019;294:2665-2677 pubmed publisher
|
Lu X, Zhang D, Shoji H, Duan C, Zhang G, Isaji T, et al. Deficiency of α1,6-fucosyltransferase promotes neuroinflammation by increasing the sensitivity of glial cells to inflammatory mediators. Biochim Biophys Acta Gen Subj. 2018;1863:598-608 pubmed publisher
|
Chumley P, Zhou J, Mrug S, Chacko B, Parant J, Challa A, et al. Truncating PKHD1 and PKD2 mutations alter energy metabolism. Am J Physiol Renal Physiol. 2019;316:F414-F425 pubmed publisher
|
Claude Taupin A, Fonderflick L, Gauthier T, Mansi L, Pallandre J, Borg C, et al. ATG9A Is Overexpressed in Triple Negative Breast Cancer and Its In Vitro Extinction Leads to the Inhibition of Pro-Cancer Phenotypes. Cells. 2018;7: pubmed publisher
|
Kallimasioti Pazi E, Thelakkad Chathoth K, Taylor G, Meynert A, Ballinger T, Kelder M, et al. Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair. PLoS Biol. 2018;16:e2005595 pubmed publisher
|
Mentink R, Rella L, Radaszkiewicz T, Gybel T, Betist M, Bryja V, et al. The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism. PLoS Genet. 2018;14:e1007840 pubmed publisher
|
Gao Z, Herrera Carrillo E, Berkhout B. A Single H1 Promoter Can Drive Both Guide RNA and Endonuclease Expression in the CRISPR-Cas9 System. Mol Ther Nucleic Acids. 2018;14:32-40 pubmed publisher
|
Yamaguchi H, Hopf F, Li S, de Lecea L. In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness. Nat Commun. 2018;9:5211 pubmed publisher
|
Varela Eirin M, Varela Vazquez A, Guitián Caamaño A, Paíno C, Mato V, Largo R, et al. Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis. Cell Death Dis. 2018;9:1166 pubmed publisher
|
Close V, Close W, Kugler S, Reichenzeller M, Yosifov D, Bloehdorn J, et al. FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL. Blood. 2019;133:830-839 pubmed publisher
|
Bialk P, Wang Y, Banas K, Kmiec E. Functional Gene Knockout of NRF2 Increases Chemosensitivity of Human Lung Cancer A549 Cells In Vitro and in a Xenograft Mouse Model. Mol Ther Oncolytics. 2018;11:75-89 pubmed publisher
|
Sluch V, Chamling X, Wenger C, Duan Y, Rice D, Zack D. Highly efficient scarless knock-in of reporter genes into human and mouse pluripotent stem cells via transient antibiotic selection. PLoS ONE. 2018;13:e0201683 pubmed publisher
|
Liu X, Liu H, Wang M, Li R, Zeng J, Mo D, et al. Disruption of the ZBED6 binding site in intron 3 of IGF2 by CRISPR/Cas9 leads to enhanced muscle development in Liang Guang Small Spotted pigs. Transgenic Res. 2019;28:141-150 pubmed publisher
|
Heyn P, Logan C, Fluteau A, Challis R, Auchynnikava T, Martin C, et al. Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions. Nat Genet. 2019;51:96-105 pubmed publisher
|
Krueger K, Catanese L, Sciesielski L, Kirschner K, Scholz H. Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression. Biochim Biophys Acta Gene Regul Mech. 2018;1862:71-83 pubmed publisher
|
Cheng W, Chen L, Ho H, Lin H, Sheu M. Stearyl polyethylenimine complexed with plasmids as the core of human serum albumin nanoparticles noncovalently bound to CRISPR/Cas9 plasmids or siRNA for disrupting or silencing PD-L1 expression for immunotherapy. Int J Nanomedicine. 2018;13:7079-7094 pubmed publisher
|
Gonzalez P, O Prey J, Cardaci S, Barthet V, Sakamaki J, Beaumatin F, et al. Mannose impairs tumour growth and enhances chemotherapy. Nature. 2018;563:719-723 pubmed publisher
|
Churko J, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, et al. Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis. Nat Commun. 2018;9:4906 pubmed publisher
|
Nieminen T, Scott T, Lin F, Chen Z, Yla Herttuala S, Morris K. Long Non-Coding RNA Modulation of VEGF-A during Hypoxia. Noncoding RNA. 2018;4: pubmed publisher
|
Shah J, Rouaud F, Guerrera D, Vasileva E, Popov L, Kelley W, et al. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. Cell Rep. 2018;25:2132-2147.e7 pubmed publisher
|
Maeda A, Nishino T, Matsunaga R, Yokoyama A, Suga H, Yagi T, et al. Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling. Biochim Biophys Acta Mol Cell Res. 2019;1866:285-295 pubmed publisher
|
Davis J, Vadlamudi S, Roman T, Zeynalzadeh M, Iyengar A, Mohlke K. Enhancer deletion and allelic effects define a regulatory molecular mechanism at the VLDLR cholesterol GWAS locus. Hum Mol Genet. 2019;28:888-895 pubmed publisher
|
Miller D, Bloxham R, Jiang M, Gori I, Saunders R, Das D, et al. The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery. Cell Rep. 2018;25:1841-1855.e5 pubmed publisher
|
Chen S, Luperchio T, Wong X, Doan E, Byrd A, Roy Choudhury K, et al. A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus. Cell Rep. 2018;25:1729-1740.e6 pubmed publisher
|
Wu W, Chen T. Ribonucleoproteins Mediated Efficient In Vivo Gene Editing in Skin Stem Cells. Methods Mol Biol. 2019;1879:75-86 pubmed publisher
|
Wahiduzzaman M, Karnan S, Ota A, Hanamura I, Murakami H, Inoko A, et al. Establishment and characterization of CRISPR/Cas9-mediated NF2-/- human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma. Cancer Sci. 2019;110:180-193 pubmed publisher
|
Stafford J, Lee C, Voigt P, Descostes N, Saldaña Meyer R, Yu J, et al. Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma. Sci Adv. 2018;4:eaau5935 pubmed publisher
|
Koslová A, Kucerova D, Reinisová M, Geryk J, Trefil P, Hejnar J. Genetic Resistance to Avian Leukosis Viruses Induced by CRISPR/Cas9 Editing of Specific Receptor Genes in Chicken Cells. Viruses. 2018;10: pubmed publisher
|
Wei Y, Toth J, Blanco G, Bobkov A, Petroski M. Adapted ATPase domain communication overcomes the cytotoxicity of p97 inhibitors. J Biol Chem. 2018;293:20169-20180 pubmed publisher
|
Bubeck F, Hoffmann M, Harteveld Z, Aschenbrenner S, Bietz A, Waldhauer M, et al. Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9. Nat Methods. 2018;15:924-927 pubmed publisher
|
Nakamura T, Nakajima K, Ohnishi T, Yoshikawa T, Nakanishi M, Takumi T, et al. Quantitative evaluation of incomplete preweaning lethality in mice by using the CRISPR/Cas9 system. Sci Rep. 2018;8:16025 pubmed publisher
|
Liegel R, Finnerty E, Blizzard L, Distasio A, Hufnagel R, Saal H, et al. Using human sequencing to guide craniofacial research. Genesis. 2019;57:e23259 pubmed publisher
|
Young L, Hartig N, Boned Del Río I, Sari S, Ringham Terry B, Wainwright J, et al. SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis. Proc Natl Acad Sci U S A. 2018;115:E10576-E10585 pubmed publisher
|
Mendoza Topaz C, Nelson G, Howard G, Hafner S, Rademacher P, Frick M, et al. Cells respond to deletion of CAV1 by increasing synthesis of extracellular matrix. PLoS ONE. 2018;13:e0205306 pubmed publisher
|
Ying Z, Pan C, Shao T, Liu L, Li L, Guo D, et al. Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury. Mol Cell. 2018;72:457-468.e5 pubmed publisher
|
Park J, Lee H, Han N, Kwak S, Lee H, Kim J, et al. Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization. Nucleic Acids Res. 2018;46:11759-11775 pubmed publisher
|
Mahpour A, Scruggs B, Smiraglia D, Ouchi T, Gelman I. A methyl-sensitive element induces bidirectional transcription in TATA-less CpG island-associated promoters. PLoS ONE. 2018;13:e0205608 pubmed publisher
|
Krischuns T, Günl F, Henschel L, Binder M, Willemsen J, Schloer S, et al. Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Front Immunol. 2018;9:2229 pubmed publisher
|
Janssen A, Katrukha E, van Straaten W, Verlhac P, Reggiori F, Kapitein L. Probing aggrephagy using chemically-induced protein aggregates. Nat Commun. 2018;9:4245 pubmed publisher
|
Zhang G, Isaji T, Xu Z, Lu X, Fukuda T, Gu J. N-acetylglucosaminyltransferase-I as a novel regulator of epithelial-mesenchymal transition. FASEB J. 2018;:fj201801478R pubmed publisher
|
Wu S, Fatkhutdinov N, Fukumoto T, Bitler B, Park P, Kossenkov A, et al. SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells. Nat Commun. 2018;9:4116 pubmed publisher
|
Delgado Benito V, Rosen D, Wang Q, Gazumyan A, Pai J, Oliveira T, et al. The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination. Mol Cell. 2018;72:636-649.e8 pubmed publisher
|
Van Treuren T, Vishwanatha J. CRISPR deletion of MIEN1 in breast cancer cells. PLoS ONE. 2018;13:e0204976 pubmed publisher
|
Yamamoto M, Ben Shlomo A, Kameda H, Fukuoka H, Deng N, Ding Y, et al. Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function. JCI Insight. 2018;3: pubmed publisher
|
Schlauderer F, Seeholzer T, Desfosses A, Gehring T, Strauss M, Hopfner K, et al. Molecular architecture and regulation of BCL10-MALT1 filaments. Nat Commun. 2018;9:4041 pubmed publisher
|
Lahaye X, Gentili M, Silvin A, Conrad C, Picard L, Jouve M, et al. NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation. Cell. 2018;175:488-501.e22 pubmed publisher
|
Fan Y, Li M, Luo Y, Chen Q, Wang L, Zhang H, et al. Cationic lipid-assisted nanoparticles for delivery of mRNA cancer vaccine. Biomater Sci. 2018;6:3009-3018 pubmed publisher
|
Stefanoska K, Bertz J, Volkerling A, van der Hoven J, Ittner L, Ittner A. Neuronal MAP kinase p38? inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour. Sci Rep. 2018;8:14296 pubmed publisher
|
Zielke S, Meyer N, Mari M, Abou El Ardat K, Reggiori F, van Wijk S, et al. Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Cell Death Dis. 2018;9:994 pubmed publisher
|
Fort L, Batista J, Thomason P, Spence H, Whitelaw J, Tweedy L, et al. Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nat Cell Biol. 2018;20:1159-1171 pubmed publisher
|
Parola C, Mason D, Zingg A, Neumeier D, Reddy S. Genome Engineering of Hybridomas to Generate Stable Cell Lines for Antibody Expression. Methods Mol Biol. 2018;1850:79-111 pubmed publisher
|
Hayashi Y, Nemoto Sasaki Y, Matsumoto N, Hama K, Tanikawa T, Oka S, et al. Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels. J Biol Chem. 2018;293:17505-17522 pubmed publisher
|
Zhu D, Shen H, Tan S, Hu Z, Wang L, Yu L, et al. Nanoparticles Based on Poly (β-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy. Mol Ther. 2018;26:2443-2455 pubmed publisher
|
Dunn Fletcher C, Muglia L, Pavlicev M, Wolf G, Sun M, Hu Y, et al. Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length. PLoS Biol. 2018;16:e2006337 pubmed publisher
|
Monfort A, Di Minin G, Wutz A. Screening for Factors Involved in X Chromosome Inactivation Using Haploid ESCs. Methods Mol Biol. 2018;1861:1-18 pubmed publisher
|
Thompson K, Mai N, Oláhová M, Scialò F, Formosa L, Stroud D, et al. OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. EMBO Mol Med. 2018;10: pubmed publisher
|
Han Y, Bedarida T, Ding Y, Somba B, Lu Q, Wang Q, et al. β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4. Mol Cell. 2018;71:1064-1078.e5 pubmed publisher
|
Bin Moon S, Lee J, Kang J, Lee N, Ha D, Kim D, et al. Highly efficient genome editing by CRISPR-Cpf1 using CRISPR RNA with a uridinylate-rich 3'-overhang. Nat Commun. 2018;9:3651 pubmed publisher
|
Issuree P, Day K, Au C, Raviram R, Zappile P, Skok J, et al. Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development. Nat Commun. 2018;9:3594 pubmed publisher
|
Delcourt V, Brunelle M, Roy A, Jacques J, Salzet M, Fournier I, et al. The Protein Coded by a Short Open Reading Frame, Not by the Annotated Coding Sequence, Is the Main Gene Product of the Dual-Coding Gene MIEF1. Mol Cell Proteomics. 2018;17:2402-2411 pubmed publisher
|
Chen S, Jang G, Hüttenhain R, Gordon D, Du D, Newton B, et al. CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018;37: pubmed publisher
|
Zdralević M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, et al. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. J Biol Chem. 2018;293:15947-15961 pubmed publisher
|
Lei K, Sun R, Chen L, Diplas B, Moure C, Wang W, et al. Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells. Sci Rep. 2018;8:12507 pubmed publisher
|
Brown N, Paluch A, Nashu M, Komurov K, Waltz S. Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation. Neoplasia. 2018;20:917-929 pubmed publisher
|
Sun Z, Chadwick B. Loss of SETDB1 decompacts the inactive X chromosome in part through reactivation of an enhancer in the IL1RAPL1 gene. Epigenetics Chromatin. 2018;11:45 pubmed publisher
|
Diao Y, Rahman M, Vyatkin Y, Azatyan A, St Laurent G, Kapranov P, et al. Identification of novel GLI1 target genes and regulatory circuits in human cancer cells. Mol Oncol. 2018;12:1718-1734 pubmed publisher
|
Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, et al. Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation. J Cell Biol. 2018;217:3817-3828 pubmed publisher
|
Prinz E, Aviram S, Aronheim A. WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis. Mol Biol Cell. 2018;29:2470-2480 pubmed publisher
|
Huang X, Wu B, Nguyen D, Liu Y, Marani M, Hench J, et al. CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10. Hum Mol Genet. 2018;27:3881-3900 pubmed publisher
|
Ludlow A, Wong M, Robin J, Batten K, Yuan L, Lai T, et al. NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer. Nat Commun. 2018;9:3112 pubmed publisher
|
Yang D, Zheng X, Chen S, Wang Z, Xu W, Tan J, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish. Nat Commun. 2018;9:3052 pubmed publisher
|
Leung J, Emery L, Miller K. CRISPR/Cas9 Gene Editing of Human Histone H2A Variant H2AX and MacroH2A. Methods Mol Biol. 2018;1832:255-269 pubmed publisher
|
Fuentes D, Swigut T, Wysocka J. Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation. elife. 2018;7: pubmed publisher
|
de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed publisher
|
Amador Cañizares Y, Panigrahi M, Huys A, Kunden R, Adams H, Schinold M, et al. miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5' UTR RNA to stabilize and promote viral RNA accumulation. Nucleic Acids Res. 2018;46:9776-9792 pubmed publisher
|
Ghezraoui H, Oliveira C, Becker J, Bilham K, Moralli D, Anzilotti C, et al. 53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ. Nature. 2018;560:122-127 pubmed publisher
|
Hynes A, Rousseau G, Agudelo D, Goulet A, Amigues B, Loehr J, et al. Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins. Nat Commun. 2018;9:2919 pubmed publisher
|
Kondo Y, Fu J, Wang H, Hoover C, McDaniel J, Steet R, et al. Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking. JCI Insight. 2018;3: pubmed publisher
|
Freimer J, Hu T, Blelloch R. Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells. elife. 2018;7: pubmed publisher
|
Yoo T, Choi J, Conway W, Yu C, Pappu R, Needleman D. Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments. elife. 2018;7: pubmed publisher
|
Espitia Jaimes C, Fish R, Neerman Arbez M. Local chromatin interactions contribute to expression of the fibrinogen gene cluster. J Thromb Haemost. 2018;16:2070-2082 pubmed publisher
|
Dewan A, Cichy A, Zhang J, Miguel K, Feinstein P, Rinberg D, et al. Single olfactory receptors set odor detection thresholds. Nat Commun. 2018;9:2887 pubmed publisher
|
Rysenkova K, Semina E, Karagyaur M, Shmakova A, Dyikanov D, Vasiluev P, et al. CRISPR/Cas9 nickase mediated targeting of urokinase receptor gene inhibits neuroblastoma cell proliferation. Oncotarget. 2018;9:29414-29430 pubmed publisher
|
Przepiorski A, Sander V, TRAN T, Hollywood J, Sorrenson B, Shih J, et al. A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells. Stem Cell Reports. 2018;11:470-484 pubmed publisher
|
Darnell A, Subramaniam A, O Shea E. Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells. Mol Cell. 2018;71:229-243.e11 pubmed publisher
|
Chen K, Stroup E, Budhipramono A, Rakheja D, Nichols Vinueza D, Xu L, et al. Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1. Genes Dev. 2018;32:996-1007 pubmed publisher
|
Sarkar M, Hile G, Tsoi L, Xing X, Liu J, Liang Y, et al. Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa. Ann Rheum Dis. 2018;77:1653-1664 pubmed publisher
|
Bydlinski N, Maresch D, Schmieder V, Klanert G, Strasser R, Borth N. The contributions of individual galactosyltransferases to protein specific N-glycan processing in Chinese Hamster Ovary cells. J Biotechnol. 2018;282:101-110 pubmed publisher
|
Chen A, Liu A, Krishnakumar R, Freimer J, DeVeale B, Blelloch R. GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency. Cell Stem Cell. 2018;23:226-238.e4 pubmed publisher
|
Wienert B, Shin J, Zelin E, Pestal K, Corn J. In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway. PLoS Biol. 2018;16:e2005840 pubmed publisher
|
Lemmens B, Hegarat N, Akopyan K, Sala Gaston J, Bartek J, Hochegger H, et al. DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation. Mol Cell. 2018;71:117-128.e3 pubmed publisher
|
Loureiro M, Zorzetto Fernandes A, Radoshitzky S, Chi X, Dallari S, Marooki N, et al. DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection. PLoS Pathog. 2018;14:e1007125 pubmed publisher
|
Fukui R, Yamamoto C, Matsumoto F, Onji M, Shibata T, Murakami Y, et al. Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA. Front Immunol. 2018;9:1491 pubmed publisher
|
Baradaran R, Wang C, Siliciano A, LONG S. Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters. Nature. 2018;559:580-584 pubmed publisher
|
Cárdenas A, Villalba A, de Juan Romero C, Picó E, Kyrousi C, Tzika A, et al. Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Cell. 2018;174:590-606.e21 pubmed publisher
|
Seeley J, Baker R, Mohamed G, Bruns T, Hayden M, Deshmukh S, et al. Induction of innate immune memory via microRNA targeting of chromatin remodelling factors. Nature. 2018;559:114-119 pubmed publisher
|
Liu B, Yang H, Pilarsky C, Weber G. The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3β in Pancreatic Cancer. Int J Mol Sci. 2018;19: pubmed publisher
|
Wahiduzzaman M, Ota A, Karnan S, Hanamura I, Mizuno S, Kanasugi J, et al. Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo. Cancer Lett. 2018;433:117-130 pubmed publisher
|
Meyer N, Zielke S, Michaelis J, Linder B, Warnsmann V, Rakel S, et al. AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy. 2018;14:1693-1709 pubmed publisher
|
Oksuz O, Narendra V, Lee C, Descostes N, LeRoy G, Raviram R, et al. Capturing the Onset of PRC2-Mediated Repressive Domain Formation. Mol Cell. 2018;70:1149-1162.e5 pubmed publisher
|
Zhao C, Dong C, Frah M, Deng Y, Marie C, Zhang F, et al. Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Dev Cell. 2018;45:753-768.e8 pubmed publisher
|
Liu Q, Thoms J, Nunez A, Huang Y, Knezevic K, Packham D, et al. Disruption of a -35 kb Enhancer Impairs CTCF Binding and MLH1 Expression in Colorectal Cells. Clin Cancer Res. 2018;24:4602-4611 pubmed publisher
|
Zhang S, He Y, Sen B, Chen X, Xie Y, Keasling J, et al. Alleviation of reactive oxygen species enhances PUFA accumulation in Schizochytrium sp. through regulating genes involved in lipid metabolism. Metab Eng Commun. 2018;6:39-48 pubmed publisher
|
Marcassa E, Kallinos A, Jardine J, Rusilowicz Jones E, Martinez A, Kuehl S, et al. Dual role of USP30 in controlling basal pexophagy and mitophagy. EMBO Rep. 2018;19: pubmed publisher
|
Yasunaga K, Ito T, Miki M, Ueda K, Fujiyama T, Tachibana Y, et al. Using CRISPR/Cas9 to Knock out Amylase in Acinar Cells Decreases Pancreatitis-Induced Autophagy. Biomed Res Int. 2018;2018:8719397 pubmed publisher
|
Almeida Souza L, Frank R, García Nafría J, Colussi A, Gunawardana N, Johnson C, et al. A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits. Cell. 2018;174:325-337.e14 pubmed publisher
|
Luo J, Lu L, Gu Y, Huang R, Gui L, Li S, et al. Speed genome editing by transient CRISPR/Cas9 targeting and large DNA fragment deletion. J Biotechnol. 2018;281:11-20 pubmed publisher
|
Dovey C, Diep J, Clarke B, Hale A, McNamara D, Guo H, et al. MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol Cell. 2018;70:936-948.e7 pubmed publisher
|
Inamori K, Ito H, Tamura Y, Nitta T, Yang X, Nihei W, et al. Deficient ganglioside synthesis restores responsiveness to leptin and melanocortin signaling in obese KKAy mice. J Lipid Res. 2018;59:1472-1481 pubmed publisher
|
Højland Knudsen C, Ásgrímsdóttir E, Rahimi K, Gill K, Frandsen S, Hvolbøl Buchholdt S, et al. A Modified Monomeric Red Fluorescent Protein Reporter for Assessing CRISPR Activity. Front Cell Dev Biol. 2018;6:54 pubmed publisher
|
Lin Y, Seo J, Gao F, Feldman H, Wen H, Penney J, et al. APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. 2018;98:1141-1154.e7 pubmed publisher
|
György B, Lööv C, Zaborowski M, Takeda S, Kleinstiver B, Commins C, et al. CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Mol Ther Nucleic Acids. 2018;11:429-440 pubmed publisher
|
Fiddes I, Lodewijk G, Mooring M, Bosworth C, Ewing A, Mantalas G, et al. Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis. Cell. 2018;173:1356-1369.e22 pubmed publisher
|
Fiedler E, Bhutkar A, Lawler E, Besada R, Hemann M. In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL. Blood Adv. 2018;2:1229-1242 pubmed publisher
|
Eisenhut P, Klanert G, Weinguny M, Baier L, Jadhav V, Ivansson D, et al. A CRISPR/Cas9 based engineering strategy for overexpression of multiple genes in Chinese hamster ovary cells. Metab Eng. 2018;48:72-81 pubmed publisher
|
Kanatsu K, Hori Y, Ebinuma I, Chiu Y, Tomita T. Retrograde transport of ?-secretase from endosomes to the trans-Golgi network regulates A?42 production. J Neurochem. 2018;: pubmed publisher
|
Kobayashi K, Sudaka Y, Takashino A, Imura A, Fujii K, Koike S. Amino Acid Variation at VP1-145 of Enterovirus 71 Determines Attachment Receptor Usage and Neurovirulence in Human Scavenger Receptor B2 Transgenic Mice. J Virol. 2018;92: pubmed publisher
|
Weissmann S, Cloos P, Sidoli S, Jensen O, Pollard S, Helin K. The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation. Cancer Res. 2018;78:4114-4125 pubmed publisher
|
Lambrus B, Moyer T, Holland A. Applying the auxin-inducible degradation system for rapid protein depletion in mammalian cells. Methods Cell Biol. 2018;144:107-135 pubmed publisher
|
Marx N, Grünwald Gruber C, Bydlinski N, Dhiman H, Ngoc Nguyen L, Klanert G, et al. CRISPR-Based Targeted Epigenetic Editing Enables Gene Expression Modulation of the Silenced Beta-Galactoside Alpha-2,6-Sialyltransferase 1 in CHO Cells. Biotechnol J. 2018;13:e1700217 pubmed publisher
|
Diplas B, He X, Brosnan Cashman J, Liu H, Chen L, Wang Z, et al. The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. Nat Commun. 2018;9:2087 pubmed publisher
|
Chen H, Li C, Zhou Z, Liang H. Fast-Evolving Human-Specific Neural Enhancers Are Associated with Aging-Related Diseases. Cell Syst. 2018;6:604-611.e4 pubmed publisher
|
Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N. Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J Cell Biol. 2018;217:2633-2645 pubmed publisher
|
Dedoni S, CAMPBELL L, Harvey B, Avdoshina V, Mocchetti I. The orphan G-protein-coupled receptor 75 signaling is activated by the chemokine CCL5. J Neurochem. 2018;146:526-539 pubmed publisher
|
Kumar S, Morrison J, Dingli D, Poeschla E. HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products. J Virol. 2018;92: pubmed publisher
|
Arshad N, Cresswell P. Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I. J Biol Chem. 2018;293:9555-9569 pubmed publisher
|
Lork M, Kreike M, Staal J, Beyaert R. Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKK?/TBK1 as a Case Study. Front Cell Dev Biol. 2018;6:40 pubmed publisher
|
Haabeth O, Fauskanger M, Manzke M, Lundin K, Corthay A, Bogen B, et al. CD4+ T-cell-Mediated Rejection of MHC Class II-Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs. Cancer Res. 2018;78:4573-4585 pubmed publisher
|
Yu Z, Surface L, Park C, Horlbeck M, Wyant G, Abu Remaileh M, et al. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. elife. 2018;7: pubmed publisher
|
Parry A, Hoare M, Bihary D, Hänsel Hertsch R, Smith S, Tomimatsu K, et al. NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat Commun. 2018;9:1840 pubmed publisher
|
Du Y, Zhao Y, Li C, Zheng Q, Tian J, Li Z, et al. Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes. J Exp Med. 2018;215:1665-1677 pubmed publisher
|
Chang J, Zhang W, Yeh H, Park M, Yao C, Shi Y, et al. An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response. Nucleic Acids Res. 2018;46:5996-6008 pubmed publisher
|
Tröder S, Ebert L, Butt L, Assenmacher S, Schermer B, Zevnik B. An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes. PLoS ONE. 2018;13:e0196891 pubmed publisher
|
Peters Hall J, Coquelin M, Torres M, LaRanger R, Alabi B, Sho S, et al. Long-term culture and cloning of primary human bronchial basal cells that maintain multipotent differentiation capacity and CFTR channel function. Am J Physiol Lung Cell Mol Physiol. 2018;315:L313-L327 pubmed publisher
|
Guy J, Alexander Howden B, Fitzpatrick L, Desousa D, Koerner M, Selfridge J, et al. A mutation-led search for novel functional domains in MeCP2. Hum Mol Genet. 2018;27:2531-2545 pubmed publisher
|
Hegge B, Sjøttem E, Mikkola I. Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress. BMC Cancer. 2018;18:496 pubmed publisher
|
Yu J, Zhou J, Xu F, Bai W, Zhang W. High expression of Aurora-B is correlated with poor prognosis and drug resistance in non-small cell lung cancer. Int J Biol Markers. 2018;33:215-221 pubmed publisher
|
Nguyen Q, Nicoll R. The GABAA Receptor β Subunit Is Required for Inhibitory Transmission. Neuron. 2018;98:718-725.e3 pubmed publisher
|
Balestrieri C, Alfarano G, Milan M, Tosi V, Prosperini E, Nicoli P, et al. Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity. Cell. 2018;173:1150-1164.e14 pubmed publisher
|
Peng X, Xu X, Wang Y, Hawke D, Yu S, Han L, et al. A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer. Cancer Cell. 2018;33:817-828.e7 pubmed publisher
|
Seong H, Manoharan R, Ha H. Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity. Cell Death Dis. 2018;9:471 pubmed publisher
|
Mercado Matos J, Janusis J, Zhu S, Chen S, Shaw L. Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2. Mol Cell Biol. 2018;38: pubmed publisher
|
Wang W, Zheng W, Hu F, He X, Wu D, Zhang W, et al. Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9. ACS Synth Biol. 2018;7:1259-1268 pubmed publisher
|
Lin G, Zhang K, Peng R, Han Y, Xie J, Li J. Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR-Associated Endonuclease Cas9-Mediated Homology-Independent Integration for Generating Quality Control Materials for Clinical Molecular Genetic Testing. J Mol Diagn. 2018;20:373-380 pubmed publisher
|
Takahashi C, Miyatake K, Kusakabe M, Nishida E. The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture. J Biol Chem. 2018;293:8342-8361 pubmed publisher
|
Lee K, Chatterjee P, Choi E, Sung M, Oh J, Won H, et al. Selection on the regulation of sympathetic nervous activity in humans and chimpanzees. PLoS Genet. 2018;14:e1007311 pubmed publisher
|
Zhu S, Ward B, Yu J, Matthew Onabanjo A, Janusis J, Hsieh C, et al. IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. JCI Insight. 2018;3: pubmed publisher
|
He X, Kläsener K, Iype J, Becker M, Maity P, Cavallari M, et al. Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells. EMBO J. 2018;37: pubmed publisher
|
Finley L, Vardhana S, Carey B, Alonso Curbelo D, Koche R, Chen Y, et al. Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity. Nat Cell Biol. 2018;20:565-574 pubmed publisher
|
Ding S, Diep J, Feng N, Ren L, Li B, Ooi Y, et al. STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. Nat Commun. 2018;9:1485 pubmed publisher
|
Yu X, Zhang Y, Ma X, Pertsemlidis A. miR-195 potentiates the efficacy of microtubule-targeting agents in non-small cell lung cancer. Cancer Lett. 2018;427:85-93 pubmed publisher
|
Moutal A, Sun L, Yang X, Li W, Cai S, Luo S, et al. CRMP2-Neurofibromin Interface Drives NF1-related Pain. Neuroscience. 2018;381:79-90 pubmed publisher
|
Mahen R. Stable centrosomal roots disentangle to allow interphase centriole independence. PLoS Biol. 2018;16:e2003998 pubmed publisher
|
Sanli I, Lalevée S, Cammisa M, Perrin A, Rage F, Lleres D, et al. Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis. Cell Rep. 2018;23:337-348 pubmed publisher
|
Anderson D, Kaplan D, Bell K, Koutsis K, Haynes J, Mills R, et al. NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. Nat Commun. 2018;9:1373 pubmed publisher
|
Liu B, Yang H, Taher L, Denz A, Grutzmann R, Pilarsky C, et al. Identification of Prognostic Biomarkers by Combined mRNA and miRNA Expression Microarray Analysis in Pancreatic Cancer. Transl Oncol. 2018;11:700-714 pubmed publisher
|
Lecuyer H, Virion Z, Barnier J, Matczak S, Bourdoulous S, Bianchini E, et al. An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. PLoS Pathog. 2018;14:e1006981 pubmed publisher
|
Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, et al. A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Mol Cell. 2018;70:408-421.e8 pubmed publisher
|
Chen W, Chen M, Xu Y, Chen X, Zhou P, Zhao X, et al. Long non-coding RNA THOR promotes human osteosarcoma cell growth in vitro and in vivo. Biochem Biophys Res Commun. 2018;499:913-919 pubmed publisher
|
Chen H, Li C, Peng X, Zhou Z, Weinstein J, Liang H. A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples. Cell. 2018;173:386-399.e12 pubmed publisher
|
Martyn G, Wienert B, Yang L, Shah M, Norton L, Burdach J, et al. Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding. Nat Genet. 2018;50:498-503 pubmed publisher
|
Bazzani L, Donnini S, Giachetti A, Christofori G, Ziche M. PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells. Oncotarget. 2018;9:14939-14958 pubmed publisher
|
Rosselli Murai L, Yates J, Yoshida S, Bourg J, Ho K, White M, et al. Loss of PTEN promotes formation of signaling-capable clathrin-coated pits. J Cell Sci. 2018;131: pubmed publisher
|
Nerys Junior A, Braga Dias L, Pezzuto P, Cotta de Almeida V, Tanuri A. Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene. Genet Mol Biol. 2018;41:167-179 pubmed publisher
|
Zhang L, Li J, Zhang P, Gao Z, Zhao Y, Qiao X, et al. PI4KII? regulates insulin secretion and glucose homeostasis via a PKD-dependent pathway. Biophys Rep. 2018;4:25-38 pubmed publisher
|
Sarin S, ZUNIGA SANCHEZ E, Kurmangaliyev Y, Cousins H, Patel M, Hernandez J, et al. Role for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In Vivo Somatic CRISPR Mutagenesis. Neuron. 2018;98:109-126.e8 pubmed publisher
|
Hertzog J, Dias Júnior A, Rigby R, Donald C, Mayer A, Sezgin E, et al. Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling. Eur J Immunol. 2018;48:1120-1136 pubmed publisher
|
Qiang L, Wang J, Zhang Y, Ge P, Chai Q, Li B, et al. Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. Cell Mol Immunol. 2018;: pubmed publisher
|
Cheng L, Tang Y, Chen X, Zhao L, Liu S, Ma Y, et al. Deletion of MBD2 inhibits proliferation of chronic myeloid leukaemia blast phase cells. Cancer Biol Ther. 2018;19:676-686 pubmed publisher
|
Barbier J, Chen X, Sanchez G, Cai M, Helsmoortel M, Higuchi T, et al. An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression. Cell Res. 2018;28:556-571 pubmed publisher
|
Mazel Sanchez B, Boal Carvalho I, Silva F, Dijkman R, Schmolke M. H5N1 Influenza A Virus PB1-F2 Relieves HAX-1-Mediated Restriction of Avian Virus Polymerase PA in Human Lung Cells. J Virol. 2018;92: pubmed publisher
|
Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth C, et al. Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. J Biol Chem. 2018;293:7408-7422 pubmed publisher
|
Amaya Ramirez C, Hubbe P, Mandel N, Béthune J. 4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2. Nucleic Acids Res. 2018;46:5792-5808 pubmed publisher
|
Kanwal M, Ding X, Song X, Zhou G, Cao Y. MUC16 overexpression induced by gene mutations promotes lung cancer cell growth and invasion. Oncotarget. 2018;9:12226-12239 pubmed publisher
|
Perez García V, Fineberg E, Wilson R, Murray A, Mazzeo C, Tudor C, et al. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018;555:463-468 pubmed publisher
|
Takaku M, Grimm S, Roberts J, Chrysovergis K, Bennett B, Myers P, et al. GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network. Nat Commun. 2018;9:1059 pubmed publisher
|
Pines A, Dijk M, Makowski M, Meulenbroek E, Vrouwe M, van der Weegen Y, et al. TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A. Nat Commun. 2018;9:1040 pubmed publisher
|
Zhang Y, Guan Q, Liu Y, Zhang Y, Chen Y, Chen J, et al. Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice. J Biol Chem. 2018;293:7894-7904 pubmed publisher
|
Horn M, Kroef V, Allmeroth K, Schüller N, Miethe S, Peifer M, et al. Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells. Oncotarget. 2018;9:9838-9851 pubmed publisher
|
Huang J, Li K, Cai W, Liu X, Zhang Y, Orkin S, et al. Dissecting super-enhancer hierarchy based on chromatin interactions. Nat Commun. 2018;9:943 pubmed publisher
|
Caprara G, Prosperini E, Piccolo V, Sigismondo G, Melacarne A, Cuomo A, et al. PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN-Inducible Proteins. J Immunol. 2018;200:2439-2454 pubmed publisher
|
Gao Z, Herrera Carrillo E, Berkhout B. Delineation of the Exact Transcription Termination Signal for Type 3 Polymerase III. Mol Ther Nucleic Acids. 2018;10:36-44 pubmed publisher
|
Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, et al. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018;20:285-295 pubmed publisher
|
McArthur K, Whitehead L, Heddleston J, Li L, Padman B, Oorschot V, et al. BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science. 2018;359: pubmed publisher
|
Macheret M, Halazonetis T. Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress. Nature. 2018;555:112-116 pubmed publisher
|
Delorme Axford E, Abernathy E, Lennemann N, Bernard A, Ariosa A, Coyne C, et al. The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy. Autophagy. 2018;14:898-912 pubmed publisher
|
Kornete M, Marone R, Jeker L. Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells. J Immunol. 2018;200:2489-2501 pubmed publisher
|
Li R, Cauchy P, Ramamoorthy S, Boller S, Chavez L, Grosschedl R. Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming. Genes Dev. 2018;32:96-111 pubmed publisher
|
Bernkopf D, Jalal K, Brückner M, Knaup K, Gentzel M, Schambony A, et al. Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling. J Cell Biol. 2018;217:1383-1394 pubmed publisher
|
Kuliyev E, Gingras S, Guy C, Howell S, Vogel P, Pelletier S. Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. J Neurosci. 2018;38:2615-2630 pubmed publisher
|
Swindell W, Beamer M, Sarkar M, Loftus S, Fullmer J, Xing X, et al. RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature. Front Immunol. 2018;9:80 pubmed publisher
|
Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T. The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression. Mol Cell. 2018;69:622-635.e6 pubmed publisher
|
Ebner P, Poetsch I, Deszcz L, Hoffmann T, Zuber J, Ikeda F. The IAP family member BRUCE regulates autophagosome-lysosome fusion. Nat Commun. 2018;9:599 pubmed publisher
|
Arnhold V, Schmelz K, Proba J, Winkler A, W nschel J, Toedling J, et al. Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma. Oncotarget. 2018;9:2304-2319 pubmed publisher
|
Yu X, Zhang Y, Cavazos D, Ma X, Zhao Z, Du L, et al. miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer. Cell Death Dis. 2018;9:193 pubmed publisher
|
Jafarnejad S, Chapat C, Matta Camacho E, Gelbart I, Hesketh G, Arguello M, et al. Translational control of ERK signaling through miRNA/4EHP-directed silencing. elife. 2018;7: pubmed publisher
|
Long C, Li H, Tiburcy M, Rodriguez Caycedo C, Kyrychenko V, Zhou H, et al. Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Sci Adv. 2018;4:eaap9004 pubmed publisher
|
Shen Y, Zhang J, Yu T, Qi C. Generation of PTEN knockout bone marrow mesenchymal stem cell lines by CRISPR/Cas9-mediated genome editing. Cytotechnology. 2018;70:783-791 pubmed publisher
|
Jia S, Zhang R, Lin G, Peng R, Gao P, Han Y, et al. A novel cell line generated using the CRISPR/Cas9 technology as universal quality control material for KRAS G12V mutation testing. J Clin Lab Anal. 2018;32:e22391 pubmed publisher
|
van Haren J, Charafeddine R, Ettinger A, Wang H, Hahn K, Wittmann T. Local control of intracellular microtubule dynamics by EB1 photodissociation. Nat Cell Biol. 2018;20:252-261 pubmed publisher
|
Khoshnejad M, Brenner J, Motley W, Parhiz H, Greineder C, Villa C, et al. Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9. Sci Rep. 2018;8:1760 pubmed publisher
|
Markmiller S, Soltanieh S, Server K, Mak R, Jin W, Fang M, et al. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018;172:590-604.e13 pubmed publisher
|
Calo E, Gu B, Bowen M, Aryan F, Zalc A, Liang J, et al. Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature. 2018;554:112-117 pubmed publisher
|
de Groot R, Lüthi J, Lindsay H, Holtackers R, Pelkmans L. Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens. Mol Syst Biol. 2018;14:e8064 pubmed publisher
|
Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, et al. Lack of beta-arrestin signaling in the absence of active G proteins. Nat Commun. 2018;9:341 pubmed publisher
|
Cao S, Zhou K, Zhang Z, Luger K, Straight A. Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell. Mol Biol Cell. 2018;29:751-762 pubmed publisher
|
Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, et al. Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Nat Commun. 2018;9:242 pubmed publisher
|
Cormerais Y, Massard P, Vucetic M, Giuliano S, Tambutte E, Durivault J, et al. The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). J Biol Chem. 2018;293:2877-2887 pubmed publisher
|
Fernández Barrera J, Bernabé Rubio M, Casares Arias J, Rangel L, Fernández Martín L, Correas I, et al. The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression. J Cell Biol. 2018;217:929-944 pubmed publisher
|
Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh J, et al. The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. EMBO J. 2018;37: pubmed publisher
|
Steyer B, Bu Q, Cory E, Jiang K, Duong S, Sinha D, et al. Scarless Genome Editing of Human Pluripotent Stem Cells via Transient Puromycin Selection. Stem Cell Reports. 2018;10:642-654 pubmed publisher
|
Anding A, Wang C, Chang T, Sliter D, Powers C, Hofmann K, et al. Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Curr Biol. 2018;28:287-295.e6 pubmed publisher
|
Wu W, Schecker J, Würstle S, Schneider F, Schönfelder M, Schlegel J. Aldehyde dehydrogenase 1A3 (ALDH1A3) is regulated by autophagy in human glioblastoma cells. Cancer Lett. 2018;417:112-123 pubmed publisher
|
Cleyrat C, Girard R, Choi E, Jeziorski E, Lavabre Bertrand T, Hermouet S, et al. Gene editing rescue of a novel MPL mutant associated with congenital amegakaryocytic thrombocytopenia. Blood Adv. 2017;1:1815-1826 pubmed publisher
|
Ji Y, Huang Z, Yang X, Wang X, Zhao L, Wang P, et al. The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat Med. 2018;24:213-223 pubmed publisher
|
Pusapati G, Kong J, Patel B, Krishnan A, Sagner A, Kinnebrew M, et al. CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Dev Cell. 2018;44:113-129.e8 pubmed publisher
|
Flores Pérez A, Elizondo G. Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chem Biol Interact. 2018;281:98-105 pubmed publisher
|
Corsinotti A, Wong F, Tatar T, Szczerbinska I, Halbritter F, Colby D, et al. Distinct SoxB1 networks are required for naïve and primed pluripotency. elife. 2017;6: pubmed publisher
|
Kim J, Sturgill D, Sebastian R, Khurana S, Tran A, Edwards G, et al. Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. Mol Cell. 2018;69:36-47.e7 pubmed publisher
|
Gao Y, Lee C, Song J, Li S, Cui Y, Liu Y, et al. Digenic mutations on SCAP and AGXT2 predispose to premature myocardial infarction. Oncotarget. 2017;8:100141-100149 pubmed publisher
|
Hosono Y, Niknafs Y, Prensner J, Iyer M, Dhanasekaran S, Mehra R, et al. Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Cell. 2017;171:1559-1572.e20 pubmed publisher
|
Zhu T, Yong X, Xia D, Widagdo J, Anggono V. Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein. J Mol Biol. 2018;430:363-371 pubmed publisher
|
Wang J, Hanada K, Gareri C, Rockman H. Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling. J Cell Biochem. 2018;119:3586-3597 pubmed publisher
|
Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, et al. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Cell. 2018;172:373-386.e10 pubmed publisher
|
Tucker N, McLellan M, Hu D, Ye J, Parsons V, Mills R, et al. Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy. Circ Cardiovasc Genet. 2017;10: pubmed publisher
|
Adikusuma F, Pfitzner C, Thomas P. Versatile single-step-assembly CRISPR/Cas9 vectors for dual gRNA expression. PLoS ONE. 2017;12:e0187236 pubmed publisher
|
Xin Q, Kong S, Yan J, Qiu J, He B, Zhou C, et al. Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation. J Clin Invest. 2018;128:175-189 pubmed publisher
|
Taketani Y, Kitamoto K, Sakisaka T, Kimakura M, Toyono T, Yamagami S, et al. Repair of the TGFBI gene in human corneal keratocytes derived from a granular corneal dystrophy patient via CRISPR/Cas9-induced homology-directed repair. Sci Rep. 2017;7:16713 pubmed publisher
|
Wang Y, Yin B, Li D, Wang G, Han X, Sun X. GSDME mediates caspase-3-dependent pyroptosis in gastric cancer. Biochem Biophys Res Commun. 2018;495:1418-1425 pubmed publisher
|
Gurbuz F, Desai S, Diao F, Turkkahraman D, Wranitz F, Wood Trageser M, et al. Novel inactivating mutations of the DCAF17 gene in American and Turkish families cause male infertility and female subfertility in the mouse model. Clin Genet. 2018;93:853-859 pubmed publisher
|
Wang J, Hanada K, Staus D, Makara M, Dahal G, Chen Q, et al. Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. Nat Commun. 2017;8:1706 pubmed publisher
|
de Padua M, Delodi G, Vucetic M, Durivault J, Vial V, Bayer P, et al. Disrupting glucose-6-phosphate isomerase fully suppresses the "Warburg effect" and activates OXPHOS with minimal impact on tumor growth except in hypoxia. Oncotarget. 2017;8:87623-87637 pubmed publisher
|
Johnson A, Petrov A, Fuchs G, Majzoub K, Grosely R, Choi J, et al. Fluorescently-tagged human eIF3 for single-molecule spectroscopy. Nucleic Acids Res. 2018;46:e8 pubmed publisher
|
Mircetic J, Dietrich A, Paszkowski Rogacz M, Krause M, Buchholz F. Development of a genetic sensor that eliminates p53 deficient cells. Nat Commun. 2017;8:1463 pubmed publisher
|
Yuan C, Hu Y. A Transgenic Core Facility's Experience in Genome Editing Revolution. Adv Exp Med Biol. 2017;1016:75-90 pubmed publisher
|
Huang H, Dobrovolsky D, Paulk J, Yang G, Weisberg E, Doctor Z, et al. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Cell Chem Biol. 2018;25:88-99.e6 pubmed publisher
|
Lee J, Jefcoate C. Monitoring of Dual CRISPR/Cas9-Mediated Steroidogenic Acute Regulatory Protein Gene Deletion and Cholesterol Accumulation Using High-Resolution Fluorescence In Situ Hybridization in a Single Cell. Front Endocrinol (Lausanne). 2017;8:289 pubmed publisher
|
Tamura N, Nishimura T, Sakamaki Y, Koyama Honda I, Yamamoto H, Mizushima N. Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets. FEBS Lett. 2017;591:3819-3830 pubmed publisher
|
Thomson B, Souma T, Tompson S, Onay T, Kizhatil K, Siggs O, et al. Angiopoietin-1 is required for Schlemm's canal development in mice and humans. J Clin Invest. 2017;127:4421-4436 pubmed publisher
|
Frejno M, Zenezini Chiozzi R, Wilhelm M, Koch H, Zheng R, Klaeger S, et al. Pharmacoproteomic characterisation of human colon and rectal cancer. Mol Syst Biol. 2017;13:951 pubmed publisher
|
De Tomasi L, David P, Humbert C, Silbermann F, Arrondel C, Tores F, et al. Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice. Am J Hum Genet. 2017;101:803-814 pubmed publisher
|
Berrens R, Andrews S, Spensberger D, Santos F, Dean W, Gould P, et al. An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells. Cell Stem Cell. 2017;21:694-703.e7 pubmed publisher
|
Wyler E, Menegatti J, Franke V, Kocks C, Boltengagen A, Hennig T, et al. Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection. Genome Biol. 2017;18:209 pubmed publisher
|
Jordi M, Marty J, Mordasini V, Lünemann A, McComb S, Bernasconi M, et al. IRAK4 is essential for TLR9-induced suppression of Epstein-Barr virus BZLF1 transcription in Akata Burkitt's lymphoma cells. PLoS ONE. 2017;12:e0186614 pubmed publisher
|
Yu Y, Scheel T, Luna J, Chung H, Nishiuchi E, Scull M, et al. miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence. PLoS Pathog. 2017;13:e1006694 pubmed publisher
|
Schimmel J, Kool H, van Schendel R, Tijsterman M. Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells. EMBO J. 2017;36:3634-3649 pubmed publisher
|
Yik J, Crossley M, Quinlan K. Genome Editing of Erythroid Cell Culture Model Systems. Methods Mol Biol. 2018;1698:245-257 pubmed publisher
|
Duchêne B, Iyombe Engembe J, Rousseau J, Tremblay J, Ouellet D. From gRNA Identification to the Restoration of Dystrophin Expression: A Dystrophin Gene Correction Strategy for Duchenne Muscular Dystrophy Mutations Using the CRISPR-Induced Deletion Method. Methods Mol Biol. 2018;1687:267-283 pubmed publisher
|
Thompson E, Yeo J, Lee E, Kan Y, Raghunandan M, Wiek C, et al. FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response. Nucleic Acids Res. 2017;45:11837-11857 pubmed publisher
|
Goyal A, Fiskin E, Gutschner T, Polycarpou Schwarz M, Groß M, Neugebauer J, et al. A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression. Nucleic Acids Res. 2017;45:12496-12508 pubmed publisher
|
Malek M, Kielkowska A, Chessa T, Anderson K, Barneda D, Pir P, et al. PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Mol Cell. 2017;68:566-580.e10 pubmed publisher
|
Lehtimäki J, Fenix A, Kotila T, Balistreri G, Paavolainen L, Varjosalo M, et al. UNC-45a promotes myosin folding and stress fiber assembly. J Cell Biol. 2017;216:4053-4072 pubmed publisher
|
Lindström L, Alvarado Kristensson M. Characterization of gamma-tubulin filaments in mammalian cells. Biochim Biophys Acta Mol Cell Res. 2018;1865:158-171 pubmed publisher
|
Vonderstein K, Nilsson E, Hubel P, Nygård Skalman L, Upadhyay A, Pasto J, et al. Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles. J Virol. 2018;92: pubmed publisher
|
Walters D, Arendt B, Tschumper R, Wu X, Jelinek D. Characterization and use of the novel human multiple myeloma cell line MC-B11/14 to study biological consequences of CRISPR-mediated loss of immunoglobulin A heavy chain. Exp Hematol. 2018;57:42-49.e1 pubmed publisher
|
Wang H, Li S, Chao T, Wang X, Shi L, Zhang L, et al. A point mutation in the extracellular domain of CD4 completely abolishes CD4 T cell development in C57BL/6 mouse. Mol Immunol. 2017;92:12-20 pubmed publisher
|
Chen Y, Spitzer S, Agathou S, Karadottir R, Smith A. Gene Editing in Rat Embryonic Stem Cells to Produce In Vitro Models and In Vivo Reporters. Stem Cell Reports. 2017;9:1262-1274 pubmed publisher
|
Gressel S, Schwalb B, Decker T, Qin W, Leonhardt H, Eick D, et al. CDK9-dependent RNA polymerase II pausing controls transcription initiation. elife. 2017;6: pubmed publisher
|
Pu J, Keren Kaplan T, Bonifacino J. A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability. J Cell Biol. 2017;216:4183-4197 pubmed publisher
|
Abulaiti X, Zhang H, Wang A, Li N, Li Y, Wang C, et al. Phosphorylation of Threonine343 Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency. Stem Cell Reports. 2017;9:1630-1641 pubmed publisher
|
ter Huurne M, Chappell J, Dalton S, Stunnenberg H. Distinct Cell-Cycle Control in Two Different States of Mouse Pluripotency. Cell Stem Cell. 2017;21:449-455.e4 pubmed publisher
|
Maddox J, Khorsandi N, Gleason E. TRPC5 is required for the NO-dependent increase in dendritic Ca2+ and GABA release from chick retinal amacrine cells. J Neurophysiol. 2018;119:262-273 pubmed publisher
|
Schmieder V, Bydlinski N, Strasser R, Baumann M, Kildegaard H, Jadhav V, et al. Enhanced Genome Editing Tools For Multi-Gene Deletion Knock-Out Approaches Using Paired CRISPR sgRNAs in CHO Cells. Biotechnol J. 2018;13:e1700211 pubmed publisher
|
Tucker N, Dolmatova E, Lin H, Cooper R, Ye J, Hucker W, et al. Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential. Circ Cardiovasc Genet. 2017;10: pubmed publisher
|
Yau E, Kummetha I, Lichinchi G, Tang R, Zhang Y, Rana T. Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Cancer Res. 2017;77:6330-6339 pubmed publisher
|
Yeow I, Howard G, Chadwick J, Mendoza Topaz C, Hansen C, Nichols B, et al. EHD Proteins Cooperate to Generate Caveolar Clusters and to Maintain Caveolae during Repeated Mechanical Stress. Curr Biol. 2017;27:2951-2962.e5 pubmed publisher
|
Yang R, Chen L, Hansen L, Carpenter A, Moure C, Liu H, et al. Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation. Cancer Res. 2017;77:6097-6108 pubmed publisher
|
Ruiz Torres S, Benight N, Karns R, Lower E, Guan J, Waltz S. HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical ?-catenin signaling. Oncotarget. 2017;8:58918-58933 pubmed publisher
|
Mroczek S, Chlebowska J, Kulinski T, Gewartowska O, Gruchota J, Cysewski D, et al. The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. Nat Commun. 2017;8:619 pubmed publisher
|
Kyrychenko V, Kyrychenko S, Tiburcy M, Shelton J, Long C, Schneider J, et al. Functional correction of dystrophin actin binding domain mutations by genome editing. JCI Insight. 2017;2: pubmed publisher
|
Chung C, Wang Q, Yang S, Ponce S, Kirsch B, Zhang H, et al. Combinatorial genome and protein engineering yields monoclonal antibodies with hypergalactosylation from CHO cells. Biotechnol Bioeng. 2017;114:2848-2856 pubmed publisher
|
Moreno Fortuny A, Bragg L, Cossu G, Roostalu U. MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation. Biol Open. 2017;6:1592-1601 pubmed publisher
|
Zweemer A, French C, Mesfin J, Gordonov S, Meyer A, Lauffenburger D. Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells. Mol Cancer Res. 2017;15:1656-1666 pubmed publisher
|
Riffelmacher T, Clarke A, Richter F, Stranks A, Pandey S, Danielli S, et al. Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation. Immunity. 2017;47:466-480.e5 pubmed publisher
|
Blumer T, Coto Llerena M, Duong F, Heim M. SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)-induced gene expression in vivo. J Biol Chem. 2017;292:17928-17938 pubmed publisher
|
Burman J, Pickles S, Wang C, Sekine S, Vargas J, Zhang Z, et al. Mitochondrial fission facilitates the selective mitophagy of protein aggregates. J Cell Biol. 2017;216:3231-3247 pubmed publisher
|
Kang M, Li Y, Zhao Y, He S, Shi J. miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer. Clin Transl Oncol. 2018;20:457-466 pubmed publisher
|
Mettananda S, Fisher C, Hay D, Badat M, Quek L, Clark K, et al. Editing an ?-globin enhancer in primary human hematopoietic stem cells as a treatment for ?-thalassemia. Nat Commun. 2017;8:424 pubmed publisher
|
Schwartz S, Cleyrat C, Olah M, Relich P, Phillips G, Hlavacek W, et al. Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics. Mol Biol Cell. 2017;28:3397-3414 pubmed publisher
|
Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, et al. Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. J Biol Chem. 2017;292:17703-17717 pubmed publisher
|
Liu X, Zhang Y, Chen Y, Li M, Zhou F, Li K, et al. In Situ Capture of Chromatin Interactions by Biotinylated dCas9. Cell. 2017;170:1028-1043.e19 pubmed publisher
|
Reboud E, Bouillot S, Patot S, Béganton B, Attree I, Huber P. Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation. PLoS Pathog. 2017;13:e1006579 pubmed publisher
|
Aprile F, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C. The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Sci Rep. 2017;7:9039 pubmed publisher
|
Hashwah H, Schmid C, Kasser S, Bertram K, Stelling A, Manz M, et al. Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth. Proc Natl Acad Sci U S A. 2017;114:9701-9706 pubmed publisher
|
Jia R, Guardia C, Pu J, Chen Y, Bonifacino J. BORC coordinates encounter and fusion of lysosomes with autophagosomes. Autophagy. 2017;13:1648-1663 pubmed publisher
|
Moutal A, Yang X, Li W, Gilbraith K, Luo S, Cai S, et al. CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Pain. 2017;158:2301-2319 pubmed publisher
|
Zwart N, Andringa D, de Leeuw W, Kojima H, Iida M, Houtman C, et al. Improved androgen specificity of AR-EcoScreen by CRISPR based glucocorticoid receptor knockout. Toxicol In Vitro. 2017;45:1-9 pubmed publisher
|
Postler T, Pantry S, Desrosiers R, Ghosh S. Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection. Virology. 2017;511:30-39 pubmed publisher
|
Miotti S, Gulino A, Ferri R, Parenza M, Chronowska A, Lecis D, et al. Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities. FASEB J. 2017;31:5356-5370 pubmed publisher
|
Shao Y, Taniguchi K, Townshend R, Miki T, Gumucio D, Fu J. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017;8:208 pubmed publisher
|
Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, et al. Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells. Sci Rep. 2017;7:7411 pubmed publisher
|
Chakraborty D, Benham V, Bullard B, Kearney T, Hsia H, Gibbon D, et al. Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer. Oncogene. 2017;36:6668-6679 pubmed publisher
|
Khan M, Salomaa S, Jacquemet G, Butt U, Miihkinen M, Deguchi T, et al. The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex. J Cell Sci. 2017;130:3094-3107 pubmed publisher
|
Stewart S, Menzies S, Popa S, Savinykh N, Petrunkina Harrison A, Lehner P, et al. A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface. J Cell Sci. 2017;130:3234-3247 pubmed publisher
|
Schwerd T, Twigg S, Aschenbrenner D, Manrique S, Miller K, Taylor I, et al. A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis. J Exp Med. 2017;214:2547-2562 pubmed publisher
|
Lumb J, Li Q, Popov L, Ding S, Keith M, Merrill B, et al. DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes. Cell Rep. 2017;20:819-831 pubmed publisher
|
Luna J, Barajas J, Teng K, Sun H, Moore M, Rice C, et al. Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. Mol Cell. 2017;67:400-410.e7 pubmed publisher
|
Maina P, Shao P, Jia X, Liu Q, Umesalma S, Marin M, et al. Histone demethylase PHF8 regulates hypoxia signaling through HIF1? and H3K4me3. Biochim Biophys Acta Gene Regul Mech. 2017;1860:1002-1012 pubmed publisher
|
Zhang C, Hawley S, Zong Y, Li M, Wang Z, Gray A, et al. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. 2017;548:112-116 pubmed publisher
|
Liu J, Zhao Y, Li W, Hou Y, Li T, Zhao Z, et al. Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. Proc Natl Acad Sci U S A. 2017;: pubmed publisher
|
Kohli P, Höhne M, Jüngst C, Bertsch S, Ebert L, Schauss A, et al. The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia. EMBO Rep. 2017;18:1521-1535 pubmed publisher
|
Nabet B, Qiu Y, Shabason J, Wu T, Yoon T, Kim B, et al. Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer. Cell. 2017;170:352-366.e13 pubmed publisher
|
Balatti V, Nigita G, Veneziano D, Drusco A, Stein G, Messier T, et al. tsRNA signatures in cancer. Proc Natl Acad Sci U S A. 2017;114:8071-8076 pubmed publisher
|
Lei Y, Zhang X, Su J, Jeong M, Gundry M, Huang Y, et al. Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nat Commun. 2017;8:16026 pubmed publisher
|
Niemz J, Kliche S, Pils M, Morrison E, Manns A, Freund C, et al. The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells. Eur J Microbiol Immunol (Bp). 2017;7:112-126 pubmed publisher
|
Flack J, Mieszczanek J, Novcic N, Bienz M. Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Mol Cell. 2017;67:181-193.e5 pubmed publisher
|
Zelensky A, Schimmel J, Kool H, Kanaar R, Tijsterman M. Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA. Nat Commun. 2017;8:66 pubmed publisher
|
Roman T, Cannon M, Vadlamudi S, Buchkovich M, Wolford B, Welch R, et al. A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus. Diabetes. 2017;66:2521-2530 pubmed publisher
|
Bharaj P, Atkins C, Luthra P, Giraldo M, Dawes B, Miorin L, et al. The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication. J Virol. 2017;91: pubmed publisher
|
Tang C, Shan L, Wang W, Lu G, Tare R, Lee K. Generation of a Bag1 homozygous knockout mouse embryonic stem cell line using CRISPR/Cas9. Stem Cell Res. 2017;21:29-31 pubmed publisher
|
Castaño J, Bueno C, Jiménez Delgado S, Roca Ho H, Fraga M, Fernandez A, et al. Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the "safe harbor" AAVS1 locus. Stem Cell Res. 2017;21:137-140 pubmed publisher
|
Biering S, Choi J, Halstrom R, Brown H, Beatty W, Lee S, et al. Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. Cell Host Microbe. 2017;22:74-85.e7 pubmed publisher
|
Hamey J, Wienert B, Quinlan K, Wilkins M. METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout. Mol Cell Proteomics. 2017;16:2229-2242 pubmed publisher
|
Wienert B, Martyn G, Kurita R, Nakamura Y, Quinlan K, Crossley M. KLF1 drives the expression of fetal hemoglobin in British HPFH. Blood. 2017;130:803-807 pubmed publisher
|
Hindriksen S, Bramer A, Truong M, Vromans M, Post J, Verlaan Klink I, et al. Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. PLoS ONE. 2017;12:e0179514 pubmed publisher
|
Ng H, Jennings S, Wang J, Molina P, Nelson S, Wang G. Non-canonical Glucocorticoid Receptor Transactivation of gilz by Alcohol Suppresses Cell Inflammatory Response. Front Immunol. 2017;8:661 pubmed publisher
|
Dagg R, Pickett H, Neumann A, Napier C, Henson J, Teber E, et al. Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres. Cell Rep. 2017;19:2544-2556 pubmed publisher
|
Bloh K, Bialk P, Gopalakrishnapillai A, Kolb E, Kmiec E. CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome. Mol Ther Nucleic Acids. 2017;7:288-298 pubmed publisher
|
Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, et al. PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017;546:554-558 pubmed publisher
|
Liu Q, Miller L, Blecha F, Sang Y. Reduction of infection by inhibiting mTOR pathway is associated with reversed repression of type I interferon by porcine reproductive and respiratory syndrome virus. J Gen Virol. 2017;98:1316-1328 pubmed publisher
|
Gao Z, Harwig A, Berkhout B, Herrera Carrillo E. Mutation of nucleotides around the +1 position of type 3 polymerase III promoters: The effect on transcriptional activity and start site usage. Transcription. 2017;8:275-287 pubmed publisher
|
Vigueira P, McCommis K, Hodges W, Schweitzer G, Cole S, Oonthonpan L, et al. The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol. 2017;102:985-999 pubmed publisher
|
Rodvold J, Chiu K, Hiramatsu N, Nussbacher J, Galimberti V, Mahadevan N, et al. Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal. 2017;10: pubmed publisher
|
Feng Y, Zhang Q, Fu M, Zhang Z, Wei M, Zhou J, et al. Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer. Oncol Rep. 2017;38:109-119 pubmed publisher
|
Gingras S, Kuliyev E, Pelletier S. SCYL1 does not regulate REST expression and turnover. PLoS ONE. 2017;12:e0178680 pubmed publisher
|
Quinn M, Goh Q, Kurosaka M, Gamage D, Petrany M, Prasad V, et al. Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development. Nat Commun. 2017;8:15665 pubmed publisher
|
Yost S, de Wolf B, Hanks S, Zachariou A, Marcozzi C, Clarke M, et al. Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation. Nat Genet. 2017;49:1148-1151 pubmed publisher
|
Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee J, et al. Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell. 2017;66:684-697.e9 pubmed publisher
|
Tang S, Wang X, Li W, Yang X, Li Z, Liu W, et al. Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella. Am J Hum Genet. 2017;100:854-864 pubmed publisher
|
Butler J, Santos R, Martens G, Ladowski J, Wang Z, Li P, et al. Efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombination. J Surg Res. 2017;212:238-245 pubmed publisher
|
Louis Sam Titus A, Yusuff T, Cassar M, Thomas E, Kretzschmar D, D Mello S. Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease. J Neurosci. 2017;37:6575-6587 pubmed publisher
|
Gomes Silva D, Srinivasan M, Sharma S, Lee C, Wagner D, Davis T, et al. CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies. Blood. 2017;130:285-296 pubmed publisher
|
Fish J, Cantu Gutierrez M, Dang L, Khyzha N, Chen Z, Veitch S, et al. Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development. 2017;144:2428-2444 pubmed publisher
|
Vanoli F, Jasin M. Generation of chromosomal translocations that lead to conditional fusion protein expression using CRISPR-Cas9 and homology-directed repair. Methods. 2017;121-122:138-145 pubmed publisher
|
Krivega I, Dean A. LDB1-mediated enhancer looping can be established independent of mediator and cohesin. Nucleic Acids Res. 2017;45:8255-8268 pubmed publisher
|
Liu Y, Conlon D, Bi X, Slovik K, Shi J, Edelstein H, et al. Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress. Cell Rep. 2017;19:1456-1466 pubmed publisher
|
Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, et al. MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Mol Cell. 2017;66:698-710.e5 pubmed publisher
|
Bednash J, Weathington N, Londino J, Rojas M, Gulick D, Fort R, et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun. 2017;8:15203 pubmed publisher
|
Tammela T, Sanchez Rivera F, Cetinbas N, Wu K, Joshi N, Helenius K, et al. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Nature. 2017;545:355-359 pubmed publisher
|
Sandweiss A, McIntosh M, Moutal A, Davidson Knapp R, Hu J, Giri A, et al. Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential. Mol Psychiatry. 2018;23:1745-1755 pubmed publisher
|
Narni Mancinelli E, Gauthier L, Baratin M, Guia S, Fenis A, Deghmane A, et al. Complement factor P is a ligand for the natural killer cell-activating receptor NKp46. Sci Immunol. 2017;2: pubmed publisher
|
Higashioka K, Koizumi N, Sakurai H, Sotozono C, Sato T. Myogenic Differentiation from MYOGENIN-Mutated Human iPS Cells by CRISPR/Cas9. Stem Cells Int. 2017;2017:9210494 pubmed publisher
|
Chen N, Uddin B, Hardt R, Ding W, Panic M, Lucibello I, et al. Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm. Proc Natl Acad Sci U S A. 2017;114:5201-5206 pubmed publisher
|
Galaz Montoya M, Wright S, Rodriguez G, Lichtarge O, Wensel T. ?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem. 2017;292:9967-9974 pubmed publisher
|
Zhang Y, Long C, Li H, McAnally J, Baskin K, Shelton J, et al. CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice. Sci Adv. 2017;3:e1602814 pubmed publisher
|
Diamantopoulou Z, White G, Fadlullah M, Dreger M, Pickering K, Maltas J, et al. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell. 2017;31:621-634.e6 pubmed publisher
|
Bazzani L, Donnini S, Finetti F, Christofori G, Ziche M. PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells. Oncotarget. 2017;8:31270-31287 pubmed publisher
|
Yao C, Liu Y, Lee I, Wang Y, Wu P. A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis. PLoS Biol. 2017;15:e2000931 pubmed publisher
|
Kelton W, Waindok A, Pesch T, Pogson M, Ford K, Parola C, et al. Reprogramming MHC specificity by CRISPR-Cas9-assisted cassette exchange. Sci Rep. 2017;7:45775 pubmed publisher
|
Dallari S, Macal M, Loureiro M, Jo Y, Swanson L, Hesser C, et al. Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses. Nat Commun. 2017;8:14830 pubmed publisher
|
Matreyek K, Stephany J, Fowler D. A platform for functional assessment of large variant libraries in mammalian cells. Nucleic Acids Res. 2017;45:e102 pubmed publisher
|
Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, et al. FMNL formins boost lamellipodial force generation. Nat Commun. 2017;8:14832 pubmed publisher
|
Vanoli F, Tomishima M, Feng W, Lamribet K, Babin L, Brunet E, et al. CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells. Proc Natl Acad Sci U S A. 2017;114:3696-3701 pubmed publisher
|
Xu J, Songyang Z, Liu D, Kim H. Analysis of Average Telomere Length in Human Telomeric Protein Knockout Cells Generated by CRISPR/Cas9. Methods Mol Biol. 2017;1587:15-28 pubmed publisher
|
Donato V, Bonora M, Simoneschi D, Sartini D, Kudo Y, Saraf A, et al. The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol. 2017;19:341-351 pubmed publisher
|
Gu J, Li T, Zhao L, Liang X, Fu X, Wang J, et al. Identification of Significant Pathways Induced by PAX5 Haploinsufficiency Based on Protein-Protein Interaction Networks and Cluster Analysis in Raji Cell Line. Biomed Res Int. 2017;2017:5326370 pubmed publisher
|
Shathasivam P, Kollara A, Spybey T, Park S, Clarke B, Ringuette M, et al. VEPH1 expression decreases vascularisation in ovarian cancer xenografts and inhibits VEGFA and IL8 expression through inhibition of AKT activation. Br J Cancer. 2017;116:1065-1076 pubmed publisher
|
Das K, Eisel D, Lenkl C, Goyal A, Diederichs S, Dickes E, et al. Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system. PLoS ONE. 2017;12:e0174077 pubmed publisher
|
Jacquin E, Leclerc Mercier S, Judon C, Blanchard E, Fraitag S, Florey O. Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation. Autophagy. 2017;13:854-867 pubmed publisher
|
Page S, Hamersky G, Gallo R, Rannals M, Calcaterra N, Campbell M, et al. The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner. Mol Psychiatry. 2018;23:304-315 pubmed publisher
|
Cui J, Chew S, Shi Y, Gong Z, Shen H. CRISPR system for genome engineering: the application for autophagy study. BMB Rep. 2017;50:247-256 pubmed
|
Wrona D, Siler U, Reichenbach J. CRISPR/Cas9-generated p47phox-deficient cell line for Chronic Granulomatous Disease gene therapy vector development. Sci Rep. 2017;7:44187 pubmed publisher
|
Stallaert W, Van der Westhuizen E, Schönegge A, Plouffe B, Hogue M, Lukashova V, et al. Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells. Mol Pharmacol. 2017;91:533-544 pubmed publisher
|
Yamasaki T, Hoyos Ramirez E, Martenson J, Morimoto Tomita M, Tomita S. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Neuron. 2017;93:1138-1152.e6 pubmed publisher
|
Mittal K, Choi D, Ogden A, Donthamsetty S, Melton B, Gupta M, et al. Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells. Sci Rep. 2017;7:43984 pubmed publisher
|
Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
|
Schimmack G, Schorpp K, Kutzner K, Gehring T, Brenke J, Hadian K, et al. YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB. elife. 2017;6: pubmed publisher
|
Drané P, Brault M, Cui G, Meghani K, Chaubey S, Detappe A, et al. TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature. 2017;543:211-216 pubmed publisher
|
Luijsterburg M, Typas D, Caron M, Wiegant W, van den Heuvel D, Boonen R, et al. A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation. elife. 2017;6: pubmed publisher
|
Cahill T, Thomsen A, Tarrasch J, Plouffe B, Nguyen A, Yang F, et al. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proc Natl Acad Sci U S A. 2017;114:2562-2567 pubmed publisher
|
Williamson L, Saponaro M, Boeing S, East P, Mitter R, Kantidakis T, et al. UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene. Cell. 2017;168:843-855.e13 pubmed publisher
|
Seong H, Manoharan R, Ha H. Zinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-β/p53 signaling pathways. Sci Rep. 2017;7:42502 pubmed publisher
|
Dietsch F, Donzeau M, Cordonnier A, Weiss E, Chatton B, Vigneron M. A fast method for analyzing essential protein mutants in human cells. Biotechniques. 2017;62:80-82 pubmed publisher
|
Lau H, Tang J, Casey P, Wang M. Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms. Oncogene. 2017;36:3934-3942 pubmed publisher
|
Spraggon L, Martelotto L, Hmeljak J, Hitchman T, Wang J, Wang L, et al. Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair. J Pathol. 2017;242:102-112 pubmed publisher
|
Goyal A, Myacheva K, Groß M, Klingenberg M, Duran Arqué B, Diederichs S. Challenges of CRISPR/Cas9 applications for long non-coding RNA genes. Nucleic Acids Res. 2017;45:e12 pubmed publisher
|
Andretta E, Cartón García F, Martinez Barriocanal A, de Marcondes P, Jiménez Flores L, Macaya I, et al. Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer. Sci Rep. 2017;7:41576 pubmed publisher
|
Nounamo B, Li Y, O Byrne P, Kearney A, Khan A, Liu J. An interaction domain in human SAMD9 is essential for myxoma virus host-range determinant M062 antagonism of host anti-viral function. Virology. 2017;503:94-102 pubmed publisher
|
Gao Y, Wu H, Wang Y, Liu X, Chen L, Li Q, et al. Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biol. 2017;18:13 pubmed publisher
|
Wu W, Lu Z, Li F, Wang W, Qian N, Duan J, et al. Efficient in vivo gene editing using ribonucleoproteins in skin stem cells of recessive dystrophic epidermolysis bullosa mouse model. Proc Natl Acad Sci U S A. 2017;114:1660-1665 pubmed publisher
|
Hummel B, Hansen E, Yoveva A, Aprile Garcia F, Hussong R, Sawarkar R. The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses. Nat Struct Mol Biol. 2017;24:234-242 pubmed publisher
|
Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett E. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Mol Cell. 2017;65:751-760.e4 pubmed publisher
|
Yi X, Tao Y, Lin X, Dai Y, Yang T, Yue X, et al. Histone methyltransferase Setd2 is critical for the proliferation and differentiation of myoblasts. Biochim Biophys Acta Mol Cell Res. 2017;1864:697-707 pubmed publisher
|
Hong S, Yada R, Choi K, Carpentier A, Liang T, Merling R, et al. Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers. Mol Ther. 2017;25:44-53 pubmed publisher
|
Phillips A, Millet A, Tigano M, Dubois S, Crimmins H, Babin L, et al. Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion. Mol Cell. 2017;65:527-538.e6 pubmed publisher
|
Min J, Wright W, Shay J. Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Nucleic Acids Res. 2017;45:2615-2628 pubmed publisher
|
Parks S, Cormerais Y, Durivault J, Pouyssegur J. Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells. Oncotarget. 2017;8:10225-10237 pubmed publisher
|
Rivera Torres N, Banas K, Bialk P, Bloh K, Kmiec E. Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides. PLoS ONE. 2017;12:e0169350 pubmed publisher
|
Crefcoeur R, Zgheib O, Halazonetis T. A Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System. PLoS ONE. 2017;12:e0169126 pubmed publisher
|
Mahajan A, Youssef L, Cleyrat C, Grattan R, Lucero S, Mattison C, et al. Allergen Valency, Dose, and FcεRI Occupancy Set Thresholds for Secretory Responses to Pen a 1 and Motivate Design of Hypoallergens. J Immunol. 2017;198:1034-1046 pubmed publisher
|
Kim E, Hurtz C, Koehrer S, Wang Z, Balasubramanian S, Chang B, et al. Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK. Blood. 2017;129:1155-1165 pubmed publisher
|
Ouellet D, Cherif K, Rousseau J, Tremblay J. Deletion of the GAA repeats from the human frataxin gene using the CRISPR-Cas9 system in YG8R-derived cells and mouse models of Friedreich ataxia. Gene Ther. 2017;24:265-274 pubmed publisher
|
Peters E, Schirris T, van Asbeck A, Gerretsen J, Eymael J, Ashikov A, et al. Effects of a human recombinant alkaline phosphatase during impaired mitochondrial function in human renal proximal tubule epithelial cells. Eur J Pharmacol. 2017;796:149-157 pubmed publisher
|
Van Nostrand E, Gelboin Burkhart C, Wang R, Pratt G, Blue S, Yeo G. CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins. Methods. 2017;118-119:50-59 pubmed publisher
|
Bonneau B, Ando H, Kawaai K, Hirose M, Takahashi Iwanaga H, Mikoshiba K. IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact. elife. 2016;5: pubmed publisher
|
Allen S, Chen Y, Madden J, Fournier C, Altemus M, Hiziroglu A, et al. Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling. Sci Rep. 2016;6:39190 pubmed publisher
|
Dibley M, Ryan M, Stroud D. A novel isoform of the human mitochondrial complex I subunit NDUFV3. FEBS Lett. 2017;591:109-117 pubmed publisher
|
Shah R, Cholewa Waclaw J, Davies F, Paton K, Chaligne R, Heard E, et al. Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders. Wellcome Open Res. 2016;1:13 pubmed publisher
|
Chung C, Wang Q, Yang S, Yin B, Zhang H, Betenbaugh M. Integrated Genome and Protein Editing Swaps ?-2,6 Sialylation for ?-2,3 Sialic Acid on Recombinant Antibodies from CHO. Biotechnol J. 2017;12: pubmed publisher
|
Couturier A, Fleury H, Patenaude A, Bentley V, Rodrigue A, Coulombe Y, et al. Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. Nucleic Acids Res. 2016;44:10879-10897 pubmed
|
Termglinchan V, Seeger T, Chen C, Wu J, Karakikes I. Efficient Genome Editing in Induced Pluripotent Stem Cells with Engineered Nucleases In Vitro. Methods Mol Biol. 2017;1521:55-68 pubmed
|
Li T, Liu D, Lei X, Jiang Q. Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway. Biochem Biophys Res Commun. 2017;482:1037-1041 pubmed publisher
|
Ye J, Tucker N, Weng L, Clauss S, Lubitz S, Ellinor P. A Functional Variant Associated with Atrial Fibrillation Regulates PITX2c Expression through TFAP2a. Am J Hum Genet. 2016;99:1281-1291 pubmed publisher
|
Nguyen T, Padman B, Usher J, Oorschot V, Ramm G, Lazarou M. Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation. J Cell Biol. 2016;215:857-874 pubmed
|
Johnson G, Li J, Beaver L, Dashwood W, Sun D, Rajendran P, et al. A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells. Mol Nutr Food Res. 2017;61: pubmed publisher
|
Köferle A, Worf K, Breunig C, Baumann V, Herrero J, Wiesbeck M, et al. CORALINA: a universal method for the generation of gRNA libraries for CRISPR-based screening. BMC Genomics. 2016;17:917 pubmed
|
Sekine Y, Zyryanova A, Crespillo Casado A, Amin Wetzel N, Harding H, Ron D. Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells. PLoS ONE. 2016;11:e0166278 pubmed publisher
|
Chande A, Cuccurullo E, Rosa A, Ziglio S, Carpenter S, Pizzato M. S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3. Proc Natl Acad Sci U S A. 2016;113:13197-13202 pubmed
|
Verver D, Zheng Y, Speijer D, Hoebe R, Dekker H, Repping S, et al. Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress. Int J Mol Sci. 2016;17: pubmed
|
Wein M, Liang Y, Göransson O, Sundberg T, Wang J, Williams E, et al. SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2016;7:13176 pubmed publisher
|
Gammons M, Rutherford T, Steinhart Z, Angers S, Bienz M. Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay. J Cell Sci. 2016;129:3892-3902 pubmed
|
Sellou H, Lebeaupin T, Chapuis C, Smith R, Hegele A, Singh H, et al. The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage. Mol Biol Cell. 2016;27:3791-3799 pubmed
|
Hore T, von Meyenn F, Ravichandran M, Bachman M, Ficz G, Oxley D, et al. Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms. Proc Natl Acad Sci U S A. 2016;113:12202-12207 pubmed
|
Tadi S, Tellier Lebegue C, Nemoz C, Drevet P, Audebert S, Roy S, et al. PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF. Cell Rep. 2016;17:541-555 pubmed publisher
|
Stoyanova T, Riedinger M, Lin S, Faltermeier C, Smith B, Zhang K, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016;113:E6457-E6466 pubmed
|
Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd M, Kimura T, et al. TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Dev Cell. 2016;39:13-27 pubmed publisher
|
Vijai J, Topka S, Villano D, Ravichandran V, Maxwell K, Maria A, et al. A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer. Cancer Discov. 2016;6:1267-1275 pubmed
|
Kim E, Page P, Dellefave Castillo L, McNally E, Wyatt E. Direct reprogramming of urine-derived cells with inducible MyoD for modeling human muscle disease. Skelet Muscle. 2016;6:32 pubmed publisher
|
Gabriel C, Gross F, Karl M, Stephanowitz H, Hennig A, Weber M, et al. Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. J Biol Chem. 2016;291:24172-24187 pubmed
|
Tveita A, Fauskanger M, Bogen B, Haabeth O. Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display. Oncotarget. 2016;7:67175-67182 pubmed publisher
|
Stroud D, Surgenor E, Formosa L, Reljic B, Frazier A, Dibley M, et al. Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature. 2016;538:123-126 pubmed publisher
|
Bialk P, Sansbury B, Rivera Torres N, Bloh K, Man D, Kmiec E. Analyses of point mutation repair and allelic heterogeneity generated by CRISPR/Cas9 and single-stranded DNA oligonucleotides. Sci Rep. 2016;6:32681 pubmed publisher
|
Murray D, Jahnel M, Lauer J, Avellaneda M, Brouilly N, Cezanne A, et al. An endosomal tether undergoes an entropic collapse to bring vesicles together. Nature. 2016;537:107-111 pubmed publisher
|
Nguyen T, Park W, Park B, Kim C, Oh Y, Kim J, et al. PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. Proc Natl Acad Sci U S A. 2016;113:10091-6 pubmed publisher
|
Santos D, Kiskinis E, Eggan K, Merkle F. Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2016;38:5B.6.1-5B.6.60 pubmed publisher
|
Pogson M, Parola C, Kelton W, Heuberger P, Reddy S. Immunogenomic engineering of a plug-and-(dis)play hybridoma platform. Nat Commun. 2016;7:12535 pubmed publisher
|
Montero J, Lopez de Silanes I, Grana O, Blasco M. Telomeric RNAs are essential to maintain telomeres. Nat Commun. 2016;7:12534 pubmed publisher
|
Kotzin J, Spencer S, McCright S, Kumar D, Collet M, Mowel W, et al. The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature. 2016;537:239-243 pubmed publisher
|
Traxler E, Yao Y, Wang Y, Woodard K, Kurita R, Nakamura Y, et al. A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition. Nat Med. 2016;22:987-90 pubmed publisher
|
Khanom R, Nguyen C, Kayamori K, Zhao X, Morita K, Miki Y, et al. Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. PLoS ONE. 2016;11:e0161163 pubmed publisher
|
Dubey R, Lebensohn A, Bahrami Nejad Z, Marceau C, Champion M, Gevaert O, et al. Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1. Cancer Res. 2016;76:5810-5821 pubmed
|
Bluteau D, Masliah Planchon J, Clairmont C, Rousseau A, Ceccaldi R, Dubois d Enghien C, et al. Biallelic inactivation of REV7 is associated with Fanconi anemia. J Clin Invest. 2016;126:3580-4 pubmed publisher
|
Shy B, MacDougall M, Clarke R, Merrill B. Co-incident insertion enables high efficiency genome engineering in mouse embryonic stem cells. Nucleic Acids Res. 2016;44:7997-8010 pubmed publisher
|
Robijns J, Molenberghs F, Sieprath T, Corne T, Verschuuren M, De Vos W. In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells. Sci Rep. 2016;6:30325 pubmed publisher
|
Lambrus B, Daggubati V, Uetake Y, Scott P, Clutario K, Sluder G, et al. A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis. J Cell Biol. 2016;214:143-53 pubmed publisher
|
Jin H, Jung S, DebRoy A, Davuluri R. Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer. Oncotarget. 2016;7:54616-54626 pubmed publisher
|
Du J, Leung A, Trac C, Lee M, Parks B, Lusis A, et al. Chromatin variation associated with liver metabolism is mediated by transposable elements. Epigenetics Chromatin. 2016;9:28 pubmed publisher
|
Mahil S, Twelves S, Farkas K, Setta Kaffetzi N, Burden A, Gach J, et al. AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production. J Invest Dermatol. 2016;136:2251-2259 pubmed publisher
|
Schokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed publisher
|
Murphy M, Chatterjee S, Jain S, KATARI M, DasGupta R. TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3. Sci Rep. 2016;6:28299 pubmed publisher
|
Cheng M, Jin X, Mu L, Wang F, Li W, Zhong X, et al. Combination of the clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 technique with the piggybac transposon system for mouse in utero electroporation to study cortical development. J Neurosci Res. 2016;94:814-24 pubmed publisher
|
Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, et al. Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers. Nature. 2016;534:402-6 pubmed publisher
|
Tao G, Kahr P, Morikawa Y, Zhang M, Rahmani M, Heallen T, et al. Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature. 2016;534:119-23 pubmed publisher
|
Bell C, Amaral P, Kalsbeek A, Magor G, Gillinder K, Tangermann P, et al. The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation. Sci Rep. 2016;6:26657 pubmed publisher
|
Ho S, Zhang W, Tan N, Khatoo M, Suter M, Tripathi S, et al. The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells. Immunity. 2016;44:1177-89 pubmed publisher
|
Guo X, Chen P, Hou X, Xu W, Wang D, Wang T, et al. The recombined cccDNA produced using minicircle technology mimicked HBV genome in structure and function closely. Sci Rep. 2016;6:25552 pubmed publisher
|
Murray A, Sienerth A, Hemberger M. Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation. Sci Rep. 2016;6:25112 pubmed publisher
|
Castaño J, Herrero A, Bursen A, Gonzalez F, Marschalek R, Gutierrez N, et al. Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair. Oncotarget. 2016;7:30440-52 pubmed publisher
|
Wang Y, Li Y, Guo C, Lu Q, Wang W, Jia Z, et al. ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells. Nucleic Acids Res. 2016;44:6741-55 pubmed publisher
|
Gerl M, Bittl V, Kirchner S, Sachsenheimer T, Brunner H, Lüchtenborg C, et al. Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions. PLoS ONE. 2016;11:e0153009 pubmed publisher
|
Huang Y, Askew E, Knudson C, Knudson W. CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention. Matrix Biol. 2016;56:74-94 pubmed publisher
|
Roehm P, Shekarabi M, Wollebo H, Bellizzi A, He L, Salkind J, et al. Inhibition of HSV-1 Replication by Gene Editing Strategy. Sci Rep. 2016;6:23146 pubmed publisher
|
Guerrera D, Shah J, Vasileva E, Sluysmans S, Méan I, Jond L, et al. PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins. J Biol Chem. 2016;291:11016-29 pubmed publisher
|
Nelles D, Fang M, O Connell M, Xu J, Markmiller S, Doudna J, et al. Programmable RNA Tracking in Live Cells with CRISPR/Cas9. Cell. 2016;165:488-96 pubmed publisher
|
Young N, Kamireddy A, Van Nostrand J, Eichner L, Shokhirev M, Dayn Y, et al. AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 2016;30:535-52 pubmed publisher
|
Mavuluri J, Beesetti S, Surabhi R, Kremerskothen J, Venkatraman G, Rayala S. Phosphorylation-Dependent Regulation of the DNA Damage Response of Adaptor Protein KIBRA in Cancer Cells. Mol Cell Biol. 2016;36:1354-65 pubmed publisher
|
Nöske K, Stark H, Nevaril L, Berning M, Langbein L, Goyal A, et al. Mitotic Diversity in Homeostatic Human Interfollicular Epidermis. Int J Mol Sci. 2016;17: pubmed publisher
|
Pillay S, Meyer N, Puschnik A, Davulcu O, Diep J, Ishikawa Y, et al. An essential receptor for adeno-associated virus infection. Nature. 2016;530:108-12 pubmed publisher
|
Iyombe Engembe J, Ouellet D, Barbeau X, Rousseau J, Chapdelaine P, Lagüe P, et al. Efficient Restoration of the Dystrophin Gene Reading Frame and Protein Structure in DMD Myoblasts Using the CinDel Method. Mol Ther Nucleic Acids. 2016;5:e283 pubmed publisher
|
Hou S, Isaji T, Hang Q, Im S, Fukuda T, Gu J. Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells. Sci Rep. 2016;6:18430 pubmed publisher
|
Carroll K, Makarewich C, McAnally J, Anderson D, Zentilin L, Liu N, et al. A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9. Proc Natl Acad Sci U S A. 2016;113:338-43 pubmed publisher
|
Wang J, Xiao Y, Hsu C, Martinez Traverso I, Zhang M, Bai Y, et al. Yap and Taz play a crucial role in neural crest-derived craniofacial development. Development. 2016;143:504-15 pubmed publisher
|
Wojtal D, Kemaladewi D, Malam Z, Abdullah S, Wong T, Hyatt E, et al. Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders. Am J Hum Genet. 2016;98:90-101 pubmed publisher
|
Lukacs V, Mathur J, Mao R, Bayrak Toydemir P, Procter M, Cahalan S, et al. Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia. Nat Commun. 2015;6:8329 pubmed publisher
|
Hobbs R, DePianto D, Jacob J, Han M, Chung B, Batazzi A, et al. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015;47:933-8 pubmed publisher
|
Whiting J, Nygren P, Tunquist B, Langeberg L, Seternes O, Scott J. Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220. J Biol Chem. 2015;290:19445-57 pubmed publisher
|
Bialk P, Rivera Torres N, Strouse B, Kmiec E. Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems. PLoS ONE. 2015;10:e0129308 pubmed publisher
|
Krentz N, Nian C, Lynn F. TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm. PLoS ONE. 2014;9:e114275 pubmed publisher
|
Findlay G, Boyle E, Hause R, Klein J, Shendure J. Saturation editing of genomic regions by multiplex homology-directed repair. Nature. 2014;513:120-3 pubmed publisher
|
Goubau D, Schlee M, Deddouche S, Pruijssers A, Zillinger T, Goldeck M, et al. Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Nature. 2014;514:372-375 pubmed publisher
|
Ran F, Hsu P, Wright J, Agarwala V, Scott D, Zhang F. Genome engineering using the CRISPR-Cas9 system. Nat Protoc. 2013;8:2281-2308 pubmed publisher
|