| Reference | 
|---|
| Celli L, Gasparini P, Biino G, Zannini L, Cardano M. CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome. Cell Biosci. 2024;14:15 pubmed  publisher | 
| Eshchenko N, Sergeeva M, Zhuravlev E, Kudria K, Goncharova E, Komissarov A, et al . A Knockout of the IFITM3 Gene Increases the Sensitivity of WI-38 VA13 Cells to the Influenza A Virus. Int J Mol Sci. 2024;25: pubmed  publisher | 
| Rickman O, Guignard E, Chabanon T, Bertoldi G, Auberson M, Hummler E. Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport. Life Sci Alliance. 2024;7: pubmed  publisher | 
| Flinois A, M xe9 an I, Mutero Maeda A, Guillemot L, Citi S. Paracingulin recruits CAMSAP3 to tight junctions and regulates microtubule and polarized epithelial cell organization. J Cell Sci. 2024;137: pubmed  publisher | 
| King A, Reichl P, Metson J, Parker R, Munro D, Oliveira C, et al . Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice. bioRxiv. 2023;: pubmed  publisher | 
| Zhang C, Chang F, Miao H, Fu Y, Tong X, Feng Y, et al . Construction and application of a multifunctional CHO cell platform utilizing Cre/lox and Dre/rox site-specific recombination systems. Front Bioeng Biotechnol. 2023;11:1320841 pubmed  publisher | 
| Huth T, Dreher E, Lemke S, Fritzsche S, Sugiyanto R, Castven D, et al . Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer. Sci Adv. 2023;9:eadh1442 pubmed  publisher | 
| De Pace R, Maroofian R, Paimboeuf A, Zamani M, Zaki M, Sadeghian S, et al . Biallelic BORCS8 variants cause an infantile-onset neurodegenerative disorder with altered lysosome dynamics. Brain. 2023;: pubmed  publisher | 
| Lee J, Lee H, Lee H, Shin M, Shin M, Seo J, et al . ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells. Nat Commun. 2023;14:8463 pubmed  publisher | 
| Voon H, Hii L, Garvie A, Udugama M, Krug B, Russo C, et al . Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies. Genome Biol. 2023;24:284 pubmed  publisher | 
| Maltseva E, Vasil eva I, Moor N, Kim D, Dyrkheeva N, Kutuzov M, et al . Cas9 is mostly orthogonal to human systems of DNA break sensing and repair. PLoS ONE. 2023;18:e0294683 pubmed  publisher | 
| Edrei Y, Levy R, Kaye D, Marom A, Radlwimmer B, Hellman A. Methylation-directed regulatory networks determine enhancing and silencing of mutation disease driver genes and explain inter-patient expression variation. Genome Biol. 2023;24:264 pubmed  publisher | 
| Ruiz Pastor M, S xe1 nchez S xe1 ez X, Kutsyr O, Albertos Arranz H, S xe1 nchez Castillo C, Ortu xf1 o Lizar xe1 n I, et al . Prph2 knock-in mice recapitulate human central areolar choroidal dystrophy retinal degeneration and exhibit aberrant synaptic remodeling and microglial activation. Cell Death Dis. 2023;14:711 pubmed  publisher | 
| Khandwala C, Sarkar P, Schmidt H, Ma M, Kinnebrew M, Pusapati G, et al . Direct ionic stress sensing and mitigation by the transcription factor NFAT5. bioRxiv. 2023;: pubmed  publisher | 
| Firth W, Robb J, Stewart D, Pye K, Bamford R, Oguro Ando A, et al . Regulation of astrocyte metabolism by mitochondrial translocator protein 18kDa. bioRxiv. 2023;: pubmed  publisher | 
| Pathak T, Benson J, Johnson M, Xin P, Abdelnaby A, Walter V, et al . Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway. bioRxiv. 2023;: pubmed  publisher | 
| Dubaić M, Peskova L, Hampl M, Weissová K, Celiker C, Shylo N, et al . Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid. Life Sci Alliance. 2023;6: pubmed  publisher | 
| Yi K, Kong H, Zheng C, Zhuo C, Jin Y, Zhong Q, et al . A LIGHTFUL nanomedicine overcomes EGFR-mediated drug resistance for enhanced tyrosine-kinase-inhibitor-based hepatocellular carcinoma therapy. Biomaterials. 2023;302:122349 pubmed  publisher | 
| Xu J, Dai Y, Gao Y, Chai R, Lu C, Yu B, et al . RAD51D Secondary Mutation-Mediated Resistance to PARP-Inhibitor-Based Therapy in HGSOC. Int J Mol Sci. 2023;24: pubmed  publisher | 
| Lau M, Hu Z, Zhao X, Tan Y, Liu J, Huang H, et al . Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription. Nat Commun. 2023;14:6464 pubmed  publisher | 
| Li J, Krause G, Gui Q, Kaushik S, Róna G, Zhang Q, et al . A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion. Sci Adv. 2023;9:eadh1134 pubmed  publisher | 
| Idoko Akoh A, Goldhill D, Sheppard C, Bialy D, Quantrill J, Sukhova K, et al . Creating resistance to avian influenza infection through genome editing of the ANP32 gene family. Nat Commun. 2023;14:6136 pubmed  publisher | 
| Kim J, Diaz L, Miller M, Leadem B, Krivega I, Dean A. An enhancer RNA recruits MLL1 to regulate transcription of Myb. bioRxiv. 2023;: pubmed  publisher | 
| Ausejo Mauleon I, Labiano S, de la Nava D, Laspidea V, Zalacain M, Marrod xe1 n L, et al . TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory. Cancer Cell. 2023;41:1911-1926.e8 pubmed  publisher | 
| Huang X, Yao J, Liu L, Chen J, Mei L, Huangfu J, et al . S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy. Mol Cell. 2023;83:3485-3501.e11 pubmed  publisher | 
| Clancy A, Rusilowicz Jones E, Wallace I, Swatek K, Urb xe9 S, Clague M. ISGylation-independent protection of cell growth by USP18 following interferon stimulation. Biochem J. 2023;480:1571-1581 pubmed  publisher | 
| Ying P, Chen C, Lu Z, Chen S, Zhang M, Cai Y, et al . Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk. Nat Commun. 2023;14:5958 pubmed  publisher | 
| Ra E, Kim M, Lee G. Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson's disease pathology. STAR Protoc. 2023;4:102609 pubmed  publisher | 
| Jo A, Deniz S, Xu J, Duvoisin R, DeVries S, Zhu Y. A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina. Nat Commun. 2023;14:5937 pubmed  publisher | 
| O Neill M, Yang T, Laudeman J, Calandranis M, Solus J, Roden D, et al . ParSE-seq: A Calibrated Multiplexed Assay to Facilitate the Clinical Classification of Putative Splice-altering Variants. medRxiv. 2023;: pubmed  publisher | 
| Oh M, Jang S, Lee J, Kim J, Jung Y, Kim J, et al . The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism. Nat Commun. 2023;14:5728 pubmed  publisher | 
| Ang H, Sutiman N, Deng X, Liu A, Cerda Smith C, Hutchinson H, et al . Cooperative regulation of coupled oncoprotein synthesis and stability in triple-negative breast cancer by EGFR and CDK12/13. Proc Natl Acad Sci U S A. 2023;120:e2221448120 pubmed  publisher | 
| Gonz xe1 lez Romero E, Mart xed nez Valiente C, Garc xed a Garc xed a G, Rosal Vela A, Mill xe1 n J, Sanz M, et al . PCR-Based Strategy for Introducing CRISPR/Cas9 Machinery into Hematopoietic Cell Lines. Cancers (Basel). 2023;15: pubmed  publisher | 
| Recoules L, Tanguy Le Gac N, Moutahir F, Bystricky K, Lavigne A. Recruitment of the Histone Variant MacroH2A1 to the Pericentric Region Occurs upon Chromatin Relaxation and Is Responsible for Major Satellite Transcriptional Regulation. Cells. 2023;12: pubmed  publisher | 
| Ei Z, Mutirangura A, Arunmanee W, Chanvorachote P. The Role of Box A of HMGB1 in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-aging Therapy. In Vivo. 2023;37:2006-2017 pubmed  publisher | 
| Verboom L, Anderson C, Jans M, Petta I, Blancke G, Martens A, et al . OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection. Cell Death Dis. 2023;14:534 pubmed  publisher | 
| Han S, Lee M, Shin Y, Giovanni R, Chakrabarty R, Herrerias M, et al . Mitochondrial integrated stress response controls lung epithelial cell fate. Nature. 2023;620:890-897 pubmed  publisher | 
| Hoffmann T, H xf6 rmann A, Corcokovic M, Zmajkovic J, Hinterndorfer M, Salkanovic J, et al . Precision RNAi using synthetic shRNAmir target sites. elife. 2023;12: pubmed  publisher | 
| Singh P, Ali S, Kumar S, Mohanty A. CRISPR-Cas9 based knockout of S100A8 in mammary epithelial cells enhances cell proliferation and triggers oncogenic transformation via the PI3K-Akt pathway: Insights from a deep proteomic analysis. J Proteomics. 2023;288:104981 pubmed  publisher | 
| Park S, Kulkarni A, Konopka G. FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells. PLoS Biol. 2023;21:e3001852 pubmed  publisher | 
| Ploeg E, Britsch I, van Wijngaarden A, Ke X, Hendriks M, Samplonius D, et al . A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer. Cancers (Basel). 2023;15: pubmed  publisher | 
| Rodencal J, Kim N, Li V, He A, Lange M, He J, et al . A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2. bioRxiv. 2023;: pubmed  publisher | 
| Lin C, Chang T, Wang Y, Guo L, Gao Y, Bikorimana E, et al . Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer. Res Sq. 2023;: pubmed  publisher | 
| Kelly R, Parmar G, Bayat L, Maitland M, Lajoie G, Edgell D, et al . Noncanonical functions of Ku may underlie essentiality in human cells. Sci Rep. 2023;13:12162 pubmed  publisher | 
| Serrano Benítez A, Wells S, Drummond Clarke L, Russo L, Thomas J, Leal G, et al . Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity. EMBO J. 2023;:e113190 pubmed  publisher | 
| Gupta N, Yakhou L, Albert J, Azogui A, Ferry L, Kirsh O, et al . A genome-wide screen reveals new regulators of the 2-cell-like cell state. Nat Struct Mol Biol. 2023;: pubmed  publisher | 
| Zheng D, Mao Y, Gao Y, He F, Ma J. Daughter cell fate choice instructed preemptively by mother cells facing nutrient limitation. iScience. 2023;26:107198 pubmed  publisher | 
| Karnan S, Ota A, Murakami H, Rahman M, Wahiduzzaman M, Hasan M, et al . CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma. Cell Death Discov. 2023;9:257 pubmed  publisher | 
| Yamakawa T, Zhang G, Najjar L, Li C, Itakura K. The uncharacterized transcript KIAA0930 confers a cachexic phenotype on cancer cells. Oncotarget. 2023;14:723-737 pubmed  publisher | 
| Wang Z, Zhang N, Zhang M, Jiang Y, Ng A, Bridges E, et al . GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner. Cancer Res. 2023;: pubmed  publisher | 
| Nigam N, Bernard B, Sevilla S, Kim S, Dar M, Tsai D, et al . SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck. Cell Rep. 2023;42:112823 pubmed  publisher | 
| Shibata T, Sato R, Taoka M, Saitoh S, Komine M, Yamaguchi K, et al . TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. J Exp Med. 2023;220: pubmed  publisher | 
| Ohkawa Y, Kanto N, Nakano M, Fujinawa R, Kizuka Y, Johnson E, et al . Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model. J Biol Chem. 2023;:105052 pubmed  publisher | 
| Wa x17c y x144 ska M, Butera R, Requesens M, Plat A, Zarganes Tzitzikas T, Neochoritis C, et al . Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors. J Med Chem. 2023;66:9577-9591 pubmed  publisher | 
| Wang F, Cali Daylan A, Deng L, Yang J, Sharma J, Su C, et al . Heterogeneous Expression of PD-L1, B7x, B7-H3, and HHLA2 in Pulmonary Sarcomatoid Carcinoma and the Related Regulatory Signaling Pathways. Cancers (Basel). 2023;15: pubmed  publisher | 
| Dom xed nguez Zorita S, Romero Carrami xf1 ana I, Santacatterina F, Esparza Molt xf3 P, Sim xf3 C, del Arco A, et al . IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype. Cell Death Dis. 2023;14:413 pubmed  publisher | 
| Gracia Diaz C, Zhou Y, Yang Q, Maroofian R, Espana Bonilla P, Lee C, et al . Gain and loss of function variants in EZH1 disrupt neurogenesis and cause dominant and recessive neurodevelopmental disorders. Nat Commun. 2023;14:4109 pubmed  publisher | 
| Xu M, Chen J, Xu Y, Zhang J, Zhou Y, He J, et al . Generation of Centromere-Associated Protein-E CENP-E-/- Knockout Cell Lines using the CRISPR/Cas9 System. J Vis Exp. 2023;: pubmed  publisher | 
| Zhang W, Pan X, Xu Y, Guo H, Zheng M, Chen X, et al . Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA. Acta Pharm Sin B. 2023;13:2585-2600 pubmed  publisher | 
| Kado S, Bein K, Castañeda A, Pouraryan A, Garrity N, Ishihara Y, et al . Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer. Cells. 2023;12: pubmed  publisher | 
| Isozaki H, Sakhtemani R, Abbasi A, Nikpour N, Stanzione M, Oh S, et al . Therapy-induced APOBEC3A drives evolution of persistent cancer cells. Nature. 2023;: pubmed  publisher | 
| Yuan H, Ren Q, Du Y, Ma Y, Gu L, Zhou J, et al . LncRNA miR663AHG represses the development of colon cancer in a miR663a-dependent manner. Cell Death Discov. 2023;9:220 pubmed  publisher | 
| Canale F, Neumann J, von Renesse J, Loggi E, Pecoraro M, Vogel I, et al . Proteomics of immune cells from liver tumors reveals immunotherapy targets. Cell Genom. 2023;3:100331 pubmed  publisher | 
| Dave B, Chen X, McCready F, Charton C, Morley R, Tailor J, et al . Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis. Development. 2023;150: pubmed  publisher | 
| Corral Serrano J, Sladen P, Ottaviani D, Rezek O, Athanasiou D, Jovanovic K, et al . Eupatilin Improves Cilia Defects in Human CEP290 Ciliopathy Models. Cells. 2023;12: pubmed  publisher | 
| You G, Li W, Wang Y, Cao H, Li X, Gao L, et al . Reduced NR2F2 Expression in the Host Response to Infectious Bursal Disease Virus Infection Suppressed Viral Replication by Enhancing Type I Interferon Expression by Targeting SOCS5. J Virol. 2023;97:e0066423 pubmed  publisher | 
| Chornyi S, Costa C, IJlst L, Fransen M, Wanders R, van Roermund C, et al . Human peroxisomal NAD+/NADH homeostasis is regulated by two independent NAD(H) shuttle systems. Free Radic Biol Med. 2023;206:22-32 pubmed  publisher | 
| Dong F, Amlal H, Venkatakrishnan J, Zhang J, Fry M, Yuan Y, et al . The gene therapy for corneal pathology with novel nonsense cystinosis mouse lines created by CRISPR Gene Editing. Ocul Surf. 2023;29:432-443 pubmed  publisher | 
| Wojnacki J, Lujan A, Brouwers N, Aranda Vallejo C, Bigliani G, Rodriguez M, et al . Tetraspanin-8 sequesters syntaxin-2 to control biphasic release propensity of mucin granules. Nat Commun. 2023;14:3710 pubmed  publisher | 
| Minet N, Boschat A, Lane R, Laughton D, Beer P, Asnagli H, et al . Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation. Life Sci Alliance. 2023;6: pubmed  publisher | 
| Onda M, Ota A, Ito K, Ono T, Karnan S, Kato M, et al . Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma. Cancer Med. 2023;: pubmed  publisher | 
| Kim M, Ra E, Kweon S, Seo B, Ko H, Oh Y, et al . Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. Cell Stem Cell. 2023;30:973-986.e11 pubmed  publisher | 
| Loftus D, Bae B, Whilden C, Whipple A. Allelic chromatin structure primes imprinted expression of Kcnk9 during neurogenesis. bioRxiv. 2023;: pubmed  publisher | 
| Lopez Robles C, Scaramuzza S, Astorga Simón E, Ishida M, Williamson C, Ba xf1 os Mateos S, et al . Architecture of the ESCPE-1 membrane coat. Nat Struct Mol Biol. 2023;30:958-969 pubmed  publisher | 
| Trivedi P, Steele C, Au F, Alexandrov L, Cleveland D. Mitotic tethering enables inheritance of shattered micronuclear chromosomes. Nature. 2023;618:1049-1056 pubmed  publisher | 
| Berber M, Leng S, Wengi A, Winter D, Odermatt A, Beuschlein F, et al . Calcineurin regulates aldosterone production via dephosphorylation of NFATC4. JCI Insight. 2023;8: pubmed  publisher | 
| Ma F, Plazyo O, Billi A, Tsoi L, Xing X, Wasikowski R, et al . Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis. Nat Commun. 2023;14:3455 pubmed  publisher | 
| Zhou J, Sturtevant D, Love C, Kulkarni A, Biyani N, Kathad U, et al . LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair. Oncotarget. 2023;14:597-611 pubmed  publisher | 
| Owen L, Rainger J, Bengani H, Kilanowski F, Fitzpatrick D, Papanastasiou A. Characterization of an eye field-like state during optic vesicle organoid development. Development. 2023;: pubmed  publisher | 
| Kim S, Ong Q, Liao Y, Ding Z, Tan A, Lim L, et al . Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling. Int J Mol Sci. 2023;24: pubmed  publisher | 
| Vatandaslar H, Garzia A, Meyer C, Godbersen S, Brandt L, Griesbach E, et al . In vivo PAR-CLIP (viP-CLIP) of liver TIAL1 unveils targets regulating cholesterol synthesis and secretion. Nat Commun. 2023;14:3386 pubmed  publisher | 
| Nishi W, Wakamatsu E, Machiyama H, Matsushima R, Saito K, Yoshida Y, et al . Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters. Nat Commun. 2023;14:3157 pubmed  publisher | 
| Moriya K, Nakano T, Honda Y, Tsumura M, Ogishi M, Sonoda M, et al . Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity. J Exp Med. 2023;220: pubmed  publisher | 
| Haldrup J, Weiss S, Schmidt L, S xf8 rensen K. Investigation of enzalutamide, docetaxel, and cabazitaxel resistance in the castration resistant prostate cancer cell line C4 using genome-wide CRISPR/Cas9 screening. Sci Rep. 2023;13:9043 pubmed  publisher | 
| Yuan T, Tang H, Xu X, Shao J, Wu G, Cho Y, et al . Inflammation conditional genome editing mediated by the CRISPR-Cas9 system. iScience. 2023;26:106872 pubmed  publisher | 
| Pecori R, Ren W, Pirmoradian M, Wang X, Liu D, Berglund M, et al . ADAR1-mediated RNA editing promotes B cell lymphomagenesis. iScience. 2023;26:106864 pubmed  publisher | 
| Ala Nisula T, Sah Teli S, Ronkainen V, Dimova E, Koivunen P. Human phytanoyl-CoA dioxygenase domain-containing 1 (PHYHD1) is a putative oxygen sensor associated with RNA and carbohydrate metabolism. FEBS Lett. 2023;597:1651-1666 pubmed  publisher | 
| Fujii S, Ushioda R, Nagata K. Redox states in the endoplasmic reticulum directly regulate the activity of calcium channel, inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A. 2023;120:e2216857120 pubmed  publisher | 
| Wang Y, Guo Y, Song Y, Zou W, Zhang J, Yi Q, et al . A pan-cancer analysis of the expression and molecular mechanism of DHX9 in human cancers. Front Pharmacol. 2023;14:1153067 pubmed  publisher | 
| Maier C, Hartmann O, Prieto Garcia C, Al Shami K, Schlicker L, Vogel F, et al . USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer. Cell Death Differ. 2023;30:1710-1725 pubmed  publisher | 
| Healy M, McNally K, Butkovi x10d R, Chilton M, Kato K, Sacharz J, et al . Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Cell. 2023;186:2219-2237.e29 pubmed  publisher | 
| Tal A, Aguilera J, Bren I, Strauss C, Schlesinger S. Differential effect of histone H3.3 depletion on retroviral repression in embryonic stem cells. Clin Epigenetics. 2023;15:83 pubmed  publisher | 
| Ma Z, Zhang F, Liu A, Lin H, Liu C. Somatic-to-primordial germ cell-like transformation is critical in tumor initiation of mouse breast tumor 4T1 cells. Am J Cancer Res. 2023;13:1471-1485 pubmed | 
| Pu J, Lin L, Jiang H, Hu Z, Li H, Yan Z, et al . Parkin Maintains Robust Pacemaking in Human Induced Pluripotent Stem Cell-Derived A9 Dopaminergic Neurons. Mov Disord. 2023;38:1273-1281 pubmed  publisher | 
| Peker E, Weiss K, Song J, Zarges C, Gerlich S, Boehm V, et al . A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis. J Cell Biol. 2023;222: pubmed  publisher | 
| Donati G, Nicoli P, Verrecchia A, Vallelonga V, Croci O, Rodighiero S, et al . Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC-driven lymphoma. EMBO Mol Med. 2023;15:e16910 pubmed  publisher | 
| Shi Y, Liao Y, Liu Q, Ni Z, Zhang Z, Shi M, et al . BRD4-targeting PROTAC as a unique tool to study biomolecular condensates. Cell Discov. 2023;9:47 pubmed  publisher | 
| Lei X, Tian X, Wang H, Xu X, Li G, Liu W, et al . Noncoding SNP at rs1663689 represses ADGRG6 via interchromosomal interaction and reduces lung cancer progression. EMBO Rep. 2023;24:e56212 pubmed  publisher | 
| Conrad S, Mays J, Hearn C, Dunn J. Targeted Ablation of Exon 2 of the Avian Leukosis Virus-A (ALV-A) Receptor Gene in a Chicken Fibroblast Cell Line by CRISPR Abrogates ALV-A Infection. Avian Dis. 2023;67:102-107 pubmed  publisher | 
| Zhang J, Hu Z, Chung H, Tian Y, Lau K, Ser Z, et al . Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. Nat Commun. 2023;14:2439 pubmed  publisher | 
| Olivas T, Wu Y, Yu S, Luan L, Choi P, Guinn E, et al . ATG9 vesicles comprise the seed membrane of mammalian autophagosomes. J Cell Biol. 2023;222: pubmed  publisher | 
| Elcocks H, Brazel A, McCarron K, Kaulich M, Husnjak K, Mortiboys H, et al . FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels. EMBO J. 2023;42:e112799 pubmed  publisher | 
| Long T, Bhattacharyya T, Repele A, Naylor M, Nooti S, Krueger S, et al . The contributions of DNA accessibility and transcription factor occupancy to enhancer activity during cellular differentiation. bioRxiv. 2023;: pubmed  publisher | 
| Mudumbi K, Burns E, Schodt D, Petrova Z, Kiyatkin A, Kim L, et al . Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes. bioRxiv. 2023;: pubmed  publisher | 
| Gupta A, Li Y, Chen S, Papas B, Martin N, Morgan M. TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication. Commun Biol. 2023;6:438 pubmed  publisher | 
| Pawlak J, Hsu J, Xia H, Han P, Suh H, Grove T, et al . CMPK2 restricts Zika virus replication by inhibiting viral translation. PLoS Pathog. 2023;19:e1011286 pubmed  publisher | 
| Lee D, Choi C, Sanders D, Beckers L, Riback J, Brangwynne C, et al . Size distributions of intracellular condensates reflect competition between coalescence and nucleation. Nat Phys. 2023;19:586-596 pubmed  publisher | 
| Im J, Duic I, Yoshimura S, Onomoto K, Yoneyama M, Kato H, et al . Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I. Sci Rep. 2023;13:6318 pubmed  publisher | 
| Bi H, Tranell J, Harper D, Lin W, Li J, Hellstr xf6 m A, et al . A frame-shift mutation in COMTD1 is associated with impaired pheomelanin pigmentation in chicken. PLoS Genet. 2023;19:e1010724 pubmed  publisher | 
| Dinter J, Friedrich R, Yang H, Pilarsky C, Mangge H, P xf6 ttler M, et al . Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids. Materials (Basel). 2023;16: pubmed  publisher | 
| Bhatia V, Kamat N, Pariva T, Wu L, Tsao A, Sasaki K, et al . Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy. Nat Commun. 2023;14:2041 pubmed  publisher | 
| Xu L, Xiang Y, Hu J. Molecular basis of Climp63-mediated ER lumen spacing. J Cell Sci. 2023;136: pubmed  publisher | 
| Bogomiakova M, Sekretova E, Anufrieva K, Khabarova P, Kazakova A, Bobrovsky P, et al . iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors. Stem Cell Res Ther. 2023;14:77 pubmed  publisher | 
| Chen L, Shi K, Ditzel N, Qiu W, Figeac F, Nielsen L, et al . KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration. Nat Commun. 2023;14:2016 pubmed  publisher | 
| Garg V, Yang Y, Nowotschin S, Setty M, Kuo Y, Sharma R, et al . Single-cell analysis of bidirectional reprogramming between early embryonic states reveals mechanisms of differential lineage plasticities. bioRxiv. 2023;: pubmed  publisher | 
| Weigert R, Hetzel S, Bailly N, Haggerty C, Ilik I, Yung P, et al . Dynamic antagonism between key repressive pathways maintains the placental epigenome. Nat Cell Biol. 2023;25:579-591 pubmed  publisher | 
| Li S, Zhang R, Lavrijsen M, van den Bosch T, Peppelenbosch M, Smits R. Issues with RNF43 antibodies to reliably detect intracellular location. PLoS ONE. 2023;18:e0283894 pubmed  publisher | 
| D Augustin O, Gaudon V, Siberchicot C, Smith R, Chapuis C, Depagne J, et al . Identification of key residues of the DNA glycosylase OGG1 controlling efficient DNA sampling and recruitment to oxidized bases in living cells. Nucleic Acids Res. 2023;51:4942-4958 pubmed  publisher | 
| Dorard C, Madry C, Buhard O, Toifl S, Didusch S, Ratovomanana T, et al . RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status. Oncogene. 2023;42:1649-1660 pubmed  publisher | 
| Ruminski K, Celis Gutierrez J, Jarmuzynski N, Maturin E, Audebert S, Malissen M, et al . Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway. Front Immunol. 2023;14:1139123 pubmed  publisher | 
| Delaney J, La Spada A. Protocol for mapping double-stranded DNA break sites across the genome with translocation capture sequencing. STAR Protoc. 2023;4:102205 pubmed  publisher | 
| Chornyi S, Ofman R, Koster J, Waterham H. The origin of long-chain fatty acids required for de novo ether lipid/plasmalogen synthesis. J Lipid Res. 2023;64:100364 pubmed  publisher | 
| Sidhaye J, Trepte P, Sepke N, Novatchkova M, Schutzbier M, D xfc rnberger G, et al . Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids. elife. 2023;12: pubmed  publisher | 
| Perdig xe3 o P, Ollington B, Sai H, Leung A, Sacristán Reviriego A, van der Spuy J. Retinal Organoids from an AIPL1 CRISPR/Cas9 Knockout Cell Line Successfully Recapitulate the Molecular Features of LCA4 Disease. Int J Mol Sci. 2023;24: pubmed  publisher | 
| Dyrkheeva N, Malakhova A, Zakharenko A, Okorokova L, Shtokalo D, Pavlova S, et al . Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor. Int J Mol Sci. 2023;24: pubmed  publisher | 
| Bader S, W xfc rfel T, Jahner T, Nothdurfter C, Rupprecht R, Milenkovic V, et al . Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells. Cells. 2023;12: pubmed  publisher | 
| Nieddu V, Melocchi V, Battistini C, Franciosa G, Lupia M, Stellato C, et al . Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer. Cell Death Dis. 2023;14:220 pubmed  publisher | 
| Ngo A, Puschnik A. Genome-Scale Analysis of Cellular Restriction Factors That Inhibit Transgene Expression from Adeno-Associated Virus Vectors. J Virol. 2023;97:e0194822 pubmed  publisher | 
| Jeon W, Jung S, Lee C, Kim W, Kim H, Jang K, et al . Evaluation of Radiation Sensitivity Differences in Mouse Liver Tumor Organoids Using CRISPR/Cas9-Mediated Gene Mutation. Technol Cancer Res Treat. 2023;22:15330338231165125 pubmed  publisher | 
| Li R, Huang D, Zhao Y, Yuan Y, Sun X, Dai Z, et al . PR-DUB safeguards Polycomb repression through H2AK119ub1 restriction. Cell Prolif. 2023;:e13457 pubmed  publisher | 
| Meng X, Liu S, Deng T, Li D, You L, Hong H, et al . Loss of Histone Methyltransferase KMT2D Attenuates Angiogenesis in the Ischemic Heart by Inhibiting the Transcriptional Activation of VEGF-A. J Cardiovasc Transl Res. 2023;: pubmed  publisher | 
| Hu Y, Sun H, Sakurai M, Jones A, Liu L, Cheng T, et al . RNA Sensing and Innate Immunity Constitutes a Barrier for Interspecies Chimerism. bioRxiv. 2023;: pubmed  publisher | 
| Wei Y, Zhang E, Yu L, Ci B, Guo L, Sakurai M, et al . Dissecting embryonic and extra-embryonic lineage crosstalk with stem cell co-culture. bioRxiv. 2023;: pubmed  publisher | 
| Jaiswal A, Wang Z, Xudong Z, Ju Z. Unraveling the connection between calreticulin and myeloproliferative neoplasms via calcium signaling. Cell Biol Int. 2023;47:1229-1246 pubmed  publisher | 
| Heylen E, Verstraete P, Van Aerschot L, Geeraerts S, Venken T, Timcheva K, et al . Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer. Br J Cancer. 2023;128:1862-1878 pubmed  publisher | 
| Baughn M, Melamed Z, L xf3 pez Erauskin J, Beccari M, Ling K, Zuberi A, et al . Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies. Science. 2023;379:1140-1149 pubmed  publisher | 
| Aimola G, Wight D, Flamand L, Kaufer B. Excision of Integrated Human Herpesvirus 6A Genomes Using CRISPR/Cas9 Technology. Microbiol Spectr. 2023;11:e0076423 pubmed  publisher | 
| Lambuta R, Nanni L, Liu Y, Diaz Miyar J, Iyer A, Tavernari D, et al . Whole-genome doubling drives oncogenic loss of chromatin segregation. Nature. 2023;615:925-933 pubmed  publisher | 
| Killarney S, Washart R, Soderquist R, Hoj J, Lebhar J, Lin K, et al . Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis. Nat Commun. 2023;14:1399 pubmed  publisher | 
| Russo S, Scotto di Carlo F, Maurizi A, Fortunato G, Teti A, Licastro D, et al . A mutation in the ZNF687 gene that is responsible for the severe form of Paget's disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model. Bone Res. 2023;11:16 pubmed  publisher | 
| Silginer M, Papa E, Szab xf3 E, Vasella F, Pruschy M, Stroh C, et al . Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition. Acta Neuropathol Commun. 2023;11:41 pubmed  publisher | 
| Bonjoch L, Fernández Rozadilla C, Álvarez Barona M, Lopez Novo A, Herrera Pariente C, Amigo J, et al . BMPR2 as a Novel Predisposition Gene for Hereditary Colorectal Polyposis. Gastroenterology. 2023;165:162-172.e5 pubmed  publisher | 
| Szwarc M, Guarnieri A, Joshi M, Duc H, Laird M, Pandey A, et al . FAM193A is a positive regulator of p53 activity. Cell Rep. 2023;42:112230 pubmed  publisher | 
| Qiao Y, Sun Q, Chen X, He L, Wang D, Su R, et al . Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export. elife. 2023;12: pubmed  publisher | 
| Mao L, Su S, Li J, Yu S, Gong Y, Chen C, et al . Development of Engineered CAR T Cells Targeting Tumor-Associated Glycoforms of MUC1 for the Treatment of Intrahepatic Cholangiocarcinoma. J Immunother. 2023;46:89-95 pubmed  publisher | 
| Li B, Zhao H, Tu Z, Yang W, Han R, Wang L, et al . CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate. Cell Discov. 2023;9:27 pubmed  publisher | 
| Zhang J, Pan L, Zhang Q, Zhao Y, Wang W, Lin N, et al . MFN2 deficiency affects calcium homeostasis in lung adenocarcinoma cells via downregulation of UCP4. FEBS Open Bio. 2023;13:1107-1124 pubmed  publisher | 
| Huynh D, Hu J, Schneider J, Tsolova K, Soderblom E, Watson A, et al . O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations. bioRxiv. 2023;: pubmed  publisher | 
| Radford B, Zhao X, Glazer T, Eaton M, Blackwell D, Mohammad S, et al . Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease. Nat Commun. 2023;14:1174 pubmed  publisher | 
| Przanowski P, Przanowska R, Guertin M. ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation. Commun Biol. 2023;6:231 pubmed  publisher | 
| Norris M, Mendell J. Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein. Genes Dev. 2023;37:191-203 pubmed  publisher | 
| Adell M, Klockner T, H xf6 fler R, Wallner L, Schmid J, Markovic A, et al . Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies. Genes Dev. 2023;37:171-190 pubmed  publisher | 
| Poverennaya E, Pyatnitskiy M, Dolgalev G, Arzumanian V, Kiseleva O, Kurbatov I, et al . Exploiting Multi-Omics Profiling and Systems Biology to Investigate Functions of TOMM34. Biology (Basel). 2023;12: pubmed  publisher | 
| Bademosi A, Decet M, Kuenen S, Calatayud C, Swerts J, Gallego S, et al . EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation. Neuron. 2023;111:1402-1422.e13 pubmed  publisher | 
| Tanushi X, Pinna G, Vandamme M, Siberchicot C, D Augustin O, Di Guilmi A, et al . OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression. Front Cell Dev Biol. 2023;11:1124960 pubmed  publisher | 
| Chai A, Cui M, Chemello F, Li H, Chen K, Tan W, et al . Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice. Nat Med. 2023;29:401-411 pubmed  publisher | 
| Collignon E, Cho B, Fothergill Robinson J, Furlan G, Ross R, Limbach P, et al . m 6 A RNA methylation orchestrates transcriptional dormancy during developmental pausing. bioRxiv. 2023;: pubmed  publisher | 
| Chen A, Lee Y, Ruan H, Huang W, Fong S, Tian S, et al . Expanded Potential Stem Cells from Human Embryos Have an Open Chromatin Configuration with Enhanced Trophoblast Differentiation Ability. Adv Sci (Weinh). 2023;10:e2204797 pubmed  publisher | 
| Vallverd xfa Prats M, Carreras D, P xe9 rez G, Campuzano O, Brugada R, Alcalde M. Alterations in Calcium Handling Are a Common Feature in an Arrhythmogenic Cardiomyopathy Cell Model Triggered by Desmosome Genes Loss. Int J Mol Sci. 2023;24: pubmed  publisher | 
| Reyes Ballista J, Miazgowicz K, Acciani M, Jimenez A, Belloli R, Havranek K, et al . Chikungunya virus entry and infectivity is primarily facilitated through cell line dependent attachment factors in mammalian and mosquito cells. Front Cell Dev Biol. 2023;11:1085913 pubmed  publisher | 
| Rosspopoff O, Cazottes E, Huret C, Loda A, Collier A, Casanova M, et al . Species-specific regulation of XIST by the JPX/FTX orthologs. Nucleic Acids Res. 2023;51:2177-2194 pubmed  publisher | 
| Li Y, Lian D, Wang J, Zhao Y, Li Y, Liu G, et al . MDM2 antagonists promote CRISPR/Cas9-mediated precise genome editing in sheep primary cells. Mol Ther Nucleic Acids. 2023;31:309-323 pubmed  publisher | 
| Dema A, Charafeddine R, Rahgozar S, van Haren J, Wittmann T. Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant. elife. 2023;12: pubmed  publisher | 
| Du Y, Chang W, Gao L, Deng L, Ji W. Tex2 is required for lysosomal functions at TMEM55-dependent ER membrane contact sites. J Cell Biol. 2023;222: pubmed  publisher | 
| K xf6 ster K, Duque Escobar J, Fietkau A, Toledo R, Oetjen E. Increase of c-FOS promoter transcriptional activity by the dual leucine zipper kinase. Naunyn Schmiedebergs Arch Pharmacol. 2023;396:1223-1233 pubmed  publisher | 
| Yang J, Chen J, Liu Y, Chen K, Baraban J, Qiu Z. Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA. Neuron. 2023;111:1104-1117.e6 pubmed  publisher | 
| Bredeck G, Busch M, Rossi A, Stahlmecke B, Fomba K, Herrmann H, et al . Inhalable Saharan dust induces oxidative stress, NLRP3 inflammasome activation, and inflammatory cytokine release. Environ Int. 2023;172:107732 pubmed  publisher | 
| Tatsumi M, Kishi T, Ishida S, Kawana H, Uwamizu A, Ono Y, et al . Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels. PLoS ONE. 2023;18:e0280448 pubmed  publisher | 
| Toledano S, Sabag A, Ilan N, Liburkin Dan T, Kessler O, Neufeld G. Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells. Cell Death Dis. 2023;14:41 pubmed  publisher | 
| Storchova R, Palek M, Palkova N, Veverka P, Brom T, Hofr C, et al . Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres. Nucleic Acids Res. 2023;51:1154-1172 pubmed  publisher | 
| Edginton White B, Maytum A, Kellaway S, Goode D, Keane P, Pagnuco I, et al . A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification. Nat Commun. 2023;14:267 pubmed  publisher | 
| Zhou C, H xe4 neke T, Rohner E, Sohlm xe9 r J, Kameneva P, Artemov A, et al . STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development. Cardiovasc Res. 2023;119:1202-1217 pubmed  publisher | 
| Briukhovetska D, Suarez Gosalvez J, Voigt C, Markota A, Giannou A, Sch xfc bel M, et al . T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis. Immunity. 2023;56:143-161.e11 pubmed  publisher | 
| Tandon V, Moreno R, Allmeroth K, Quinn J, Wiley S, Nicely L, et al . Dual inhibition of HSF1 and DYRK2 impedes cancer progression. Biosci Rep. 2023;43: pubmed  publisher | 
| Irazoki A, Gordaliza Alaguero I, Frank E, Giakoumakis N, Seco J, Palac xed n M, et al . Disruption of mitochondrial dynamics triggers muscle inflammation through interorganellar contacts and mitochondrial DNA mislocation. Nat Commun. 2023;14:108 pubmed  publisher | 
| Ohkawa Y, Kitano M, Maeda K, Nakano M, Kanto N, Kizuka Y, et al . Core Fucosylation Is Required for the Secretion of and the Enzymatic Activity of SOD3 in Nonsmall-Cell Lung Cancer Cells. Antioxid Redox Signal. 2023;38:1201-1211 pubmed  publisher | 
| Zhao D, Yuan H, Fang Y, Gao J, Li H, Li M, et al . Histone Methyltransferase KMT2B Promotes Metastasis and Angiogenesis of Cervical Cancer by Upregulating EGF Expression. Int J Biol Sci. 2023;19:34-49 pubmed  publisher | 
| Bruno P, Timms R, Abdelfattah N, Leng Y, Lélis F, Wesemann D, et al . High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform. Nat Biotechnol. 2023;41:980-992 pubmed  publisher | 
| Serrano R, Feyen D, Bruyneel A, Hnatiuk A, Vu M, Amatya P, et al . A deep learning platform to assess drug proarrhythmia risk. Cell Stem Cell. 2023;30:86-95.e4 pubmed  publisher | 
| Ott J, Sehr J, Schmidt N, Schliebs W, Erdmann R. Comparison of human PEX knockout cell lines suggests a dual role of PEX1 in peroxisome biogenesis. Biol Chem. 2023;404:209-219 pubmed  publisher | 
| Kl xfc mper N, Ralser D, Ellinger J, Roghmann F, Albrecht J, Below E, et al . Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance. Clin Cancer Res. 2023;29:1496-1505 pubmed  publisher | 
| Demin D, Murashko M, Uvarova A, Stasevich E, Shyrokova E, Gorlachev G, et al . Adversary of DNA integrity: A long non-coding RNA stimulates driver oncogenic chromosomal rearrangement in human thyroid cells. Int J Cancer. 2023;152:1452-1462 pubmed  publisher | 
| Ngai H, Barragan G, Tian G, Balzeau J, Zhang C, Courtney A, et al . LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells. Cancer Immunol Res. 2023;11:171-183 pubmed  publisher | 
| Clava xed n L, Fern xe1 ndez Pisonero I, Movilla N, Lorenzo Mart xed n L, Nieto B, Abad A, et al . Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors. Oncogene. 2023;42:389-405 pubmed  publisher | 
| Ustiugova A, Ekaterina D, Nataliya M, Alexey D, Dmitry K, Marina A. CRISPR/Cas9 genome editing demonstrates functionality of the autoimmunity-associated SNP rs12946510. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166599 pubmed  publisher | 
| Czaplinska D, Ialchina R, Andersen H, Yao J, Stigliani A, Dannesboe J, et al . Crosstalk between tumor acidosis, p53 and extracellular matrix regulates pancreatic cancer aggressiveness. Int J Cancer. 2023;152:1210-1225 pubmed  publisher | 
| Ma Z, Bai J, Jiang C, Zhu H, Liu D, Pan M, et al . Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy. Autophagy. 2023;19:1512-1532 pubmed  publisher | 
| Vu Hong A, Bourg N, Sanatine P, Poupiot J, Charton K, Gicquel E, et al . Dlk1-Dio3 cluster miRNAs regulate mitochondrial functions in the dystrophic muscle in Duchenne muscular dystrophy. Life Sci Alliance. 2023;6: pubmed  publisher | 
| Hattori T, Maso L, Araki K, Koide A, Hayman J, Akkapeddi P, et al . Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy. Cancer Discov. 2023;13:132-145 pubmed  publisher | 
| Kim D, Weller B, Lin C, Sheykhkarimli D, Knapp J, Dugied G, et al . A proteome-scale map of the SARS-CoV-2-human contactome. Nat Biotechnol. 2023;41:140-149 pubmed  publisher | 
| Christians A, Kesdiren E, Hennies I, Hofmann A, Trowe M, Brand F, et al . Heterozygous variants in the DVL2 interaction region of DACT1 cause CAKUT and features of Townes-Brocks syndrome 2. Hum Genet. 2023;142:73-88 pubmed  publisher | 
| Prahl J, Pierce S, van der Schans E, Coetzee G, Tyson T. The Parkinson's disease variant rs356182 regulates neuronal differentiation independently from alpha-synuclein. Hum Mol Genet. 2023;32:1-14 pubmed  publisher | 
| Pecori R, Chill xf3 n I, Lo Giudice C, Arnold A, W xfc st S, Binder M, et al . ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts. Front Cell Dev Biol. 2022;10:1080626 pubmed  publisher | 
| Park J, Park G, Lee J, Park J, Kim S, Kim E, et al . ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth. Front Mol Biosci. 2022;9:1030725 pubmed  publisher | 
| Kol A, Fan X, Ważyńska M, van Duijnhoven S, Giesen D, Plat A, et al . Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration. J Immunother Cancer. 2022;10: pubmed  publisher | 
| Leung A, Yiu T, Liu L, Tam H, Gu S, Tu J, et al . Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells. Cell Biosci. 2022;12:212 pubmed  publisher | 
| Pu L, Xie L, Chen J, Sun H, Huang Z, Xu T, et al . Tracking the dynamics of female germ cell development during peri-hatch periods using a gene-edited chicken model. Poult Sci. 2022;102:102377 pubmed  publisher | 
| Jiang X, Isogai T, Chi J, Danuser G. Fine-grained, nonlinear registration of live cell movies reveals spatiotemporal organization of diffuse molecular processes. PLoS Comput Biol. 2022;18:e1009667 pubmed  publisher | 
| Wu Y, Kram H, Gempt J, Liesche Starnecker F, Wu W, Schlegel J. ALDH1-Mediated Autophagy Sensitizes Glioblastoma Cells to Ferroptosis. Cells. 2022;11: pubmed  publisher | 
| Ho B, Pang J, Chen Y, Loh Y, An O, Yang H, et al . Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases. Stem Cell Res Ther. 2022;13:529 pubmed  publisher | 
| Griess K, Rieck M, M xfc ller N, Karsai G, Hartwig S, Pelligra A, et al . Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nat Cell Biol. 2022;: pubmed  publisher | 
| Clarke M, Marsoner T, Adell M, Ravichandran M, Campbell C. Adaptation to high rates of chromosomal instability and aneuploidy through multiple pathways in budding yeast. EMBO J. 2022;:e111500 pubmed  publisher | 
| Pan Y, Han H, Hu H, Wang H, Song Y, Hao Y, et al . KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Cancer Cell. 2022;: pubmed  publisher | 
| Iwai M, Kajino T, Nakatochi M, Yanagisawa K, Hosono Y, Isomura H, et al . Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer. Oncogene. 2022;: pubmed  publisher | 
| Heller Trulli D, Liu H, Mukherjee S, Moore C. UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells. Mol Cell Biol. 2022;42:e0017422 pubmed  publisher | 
| Karpov D, Demidova N, Kulagin K, Shuvalova A, Kovalev M, Simonov R, et al . Complete and Prolonged Inhibition of Herpes Simplex Virus Type 1 Infection In Vitro by CRISPR/Cas9 and CRISPR/CasX Systems. Int J Mol Sci. 2022;23: pubmed  publisher | 
| Viegas J, Azad G, Lv Y, Fishman L, Paltiel T, Pattabiraman S, et al . RNA degradation eliminates developmental transcripts during murine embryonic stem cell differentiation via CAPRIN1-XRN2. Dev Cell. 2022;57:2731-2744.e5 pubmed  publisher | 
| Takahashi G, Kondo D, Maeda M, Morishita Y, Miyaoka Y. Genome editing is induced in a binary manner in single human cells. iScience. 2022;25:105619 pubmed  publisher | 
| Niu Y, Ferreira Azevedo C, Li X, Kamali E, Haagen Nielsen O, Storgaard S xf8 rensen C, et al . Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select. Nat Genet. 2022;54:1983-1993 pubmed  publisher | 
| Solaimuthu B, Lichtenstein M, Hayashi A, Khatib A, Plaschkes I, Nevo Y, et al . Depletion of Fumarate Hydratase, an Essential TCA Cycle Enzyme, Drives Proliferation in a Two-Step Model. Cancers (Basel). 2022;14: pubmed  publisher | 
| Nishiyama T, Zhang Y, Cui M, Li H, Sanchez Ortiz E, McAnally J, et al . Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy. Sci Transl Med. 2022;14:eade1633 pubmed  publisher | 
| Liu Y, Azizian N, Sullivan D, Li Y. mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resistant persisters. Nat Commun. 2022;13:7047 pubmed  publisher | 
| Di Paola S, Matarese M, Barretta M, Dathan N, Colanzi A, Corda D, et al . PARP10 Mediates Mono-ADP-Ribosylation of Aurora-A Regulating G2/M Transition of the Cell Cycle. Cancers (Basel). 2022;14: pubmed  publisher | 
| Geiller H, Harvey A, Jones R, Grimstead J, Cleal K, Hendrickson E, et al . ATRX modulates the escape from a telomere crisis. PLoS Genet. 2022;18:e1010485 pubmed  publisher | 
| Heijink A, Stok C, Porubský D, Manolika E, de Kanter J, Kok Y, et al . Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51. Nat Commun. 2022;13:6722 pubmed  publisher | 
| Hanzl A, Casement R, Imrichová H, Hughes S, Barone E, Testa A, et al . Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders. Nat Chem Biol. 2022;: pubmed  publisher | 
| Zimmerli D, Brambillasca C, Talens F, Bhin J, Linstra R, Romanens L, et al . MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling. Nat Commun. 2022;13:6579 pubmed  publisher | 
| Chen H, Ho Y, Mezzadra R, Adrover J, Smolkin R, Zhu C, et al . Senescence rewires microenvironment sensing to facilitate anti-tumor immunity. Cancer Discov. 2022;: pubmed  publisher | 
| Galiani S, Reglinski K, Carravilla P, Barbotin A, Urban x10d i x10d I, Ott J, et al . Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5. Biophys Rep (N Y). 2022;2:None pubmed  publisher | 
| Brooks R, Monzy J, Aaron B, Zhang X, Kossenkov A, Hayden J, et al . Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis. Cell Rep. 2022;41:111514 pubmed  publisher | 
| Hou G, Zhou T, Xu N, Yin Z, Zhu X, Zhang Y, et al . Integrative functional genomics identifies SLE causal genetic variant in the IRF5 risk locus. Arthritis Rheumatol. 2022;: pubmed  publisher | 
| Winkler R, Quaas M, Glasmacher S, Wolfrum U, Thalheim T, Galle J, et al . The Adhesion G-Protein-Coupled Receptor GPR115/ADGRF4 Regulates Epidermal Differentiation and Associates with Cytoskeletal KRT1. Cells. 2022;11: pubmed  publisher | 
| Kokate S, Ciuba K, Tran V, Kumari R, Tojkander S, Engel U, et al . Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments. Nat Commun. 2022;13:6032 pubmed  publisher | 
| Novakova Z, Milosevic M, Kutil Z, Ondrakova M, Havlinova B, Kaspárek P, et al . Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene. Sci Rep. 2022;12:17081 pubmed  publisher | 
| Zhang J, Wang B, Gao X, Peng C, Shan C, Johnson S, et al . RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy. Nat Commun. 2022;13:6007 pubmed  publisher | 
| Blomberg E, Silginer M, Roth P, Weller M. Programmed death ligand 1 gene silencing in murine glioma models reveals cell line-specific modulation of tumor growth in vivo. Neurooncol Adv. 2022;4:vdac148 pubmed  publisher | 
| Fern xe1 ndez Vizarra E, L xf3 pez Calcerrada S, Sierra Magro A, P xe9 rez P xe9 rez R, Formosa L, Hock D, et al . Two independent respiratory chains adapt OXPHOS performance to glycolytic switch. Cell Metab. 2022;34:1792-1808.e6 pubmed  publisher | 
| Ras xe9 V, Hayward R, Haughian J, Pullen N. Th17, Th22, and Myeloid-Derived Suppressor Cell Population Dynamics and Response to IL-6 in 4T1 Mammary Carcinoma. Int J Mol Sci. 2022;23: pubmed  publisher | 
| Hutter K, R xfc licke T, Szabó T, Andersen L, Villunger A, Herzog S. The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression. Front Immunol. 2022;13:967914 pubmed  publisher | 
| Zhao X, Wang P, Diedrich J, Smart B, Reyes N, Yoshimura S, et al . Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia. Nat Commun. 2022;13:5401 pubmed  publisher | 
| Glentis A, Blanch Mercader C, Balasubramaniam L, Saw T, D Alessandro J, Janel S, et al . The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces. Sci Adv. 2022;8:eabn5406 pubmed  publisher | 
| Van Royen T, Sedeyn K, Moschonas G, Toussaint W, Vuylsteke M, Van Haver D, et al . An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25. J Virol. 2022;96:e0129722 pubmed  publisher | 
| Kim Y, Potashnikova D, Gisina A, Kholodenko I, Kopylov A, Tikhonova O, et al . TRIM28 Is a Novel Regulator of CD133 Expression Associated with Cancer Stem Cell Phenotype. Int J Mol Sci. 2022;23: pubmed  publisher | 
| Damkham N, Lorthongpanich C, Klaihmon P, Lueangamornnara U, Kheolamai P, Trakarnsanga K, et al . YAP and TAZ play a crucial role in human erythrocyte maturation and enucleation. Stem Cell Res Ther. 2022;13:467 pubmed  publisher | 
| Bridges J, Safina C, Pirard B, Brown K, Filuta A, Panchanathan R, et al . Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism. elife. 2022;11: pubmed  publisher | 
| van Schendel R, Schimmel J, Tijsterman M. SIQ: easy quantitative measurement of mutation profiles in sequencing data. NAR Genom Bioinform. 2022;4:lqac063 pubmed  publisher | 
| Colicchia V, H xe4 ggblad M, Sirozh O, Porebski B, Balan M, Li X, et al . New regulators of the tetracycline-inducible gene expression system identified by chemical and genetic screens. FEBS Open Bio. 2022;12:1896-1908 pubmed  publisher | 
| Harlow C, Gandawijaya J, Bamford R, Martin E, Wood A, van der Most P, et al . Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies. Am J Hum Genet. 2022;109:1638-1652 pubmed  publisher | 
| Makaryan V, Kelley M, Fletcher B, Archibald I, Poulsen T, Dale D. Comparison of Gene Editing versus a Neutrophil Elastase Inhibitor as Potential Therapies for ELANE Neutropenia. J Cell Immunol. 2022;4:19-28 pubmed  publisher | 
| Shi M, McCracken K, Patel A, Zhang W, Ester L, Valerius M, et al . Human ureteric bud organoids recapitulate branching morphogenesis and differentiate into functional collecting duct cell types. Nat Biotechnol. 2022;: pubmed  publisher | 
| Zhdanova P, Lomzov A, Prokhorova D, Stepanov G, Chernonosov A, Koval V. Thermodynamic Swings: How Ideal Complex of Cas9-RNA/DNA Forms. Int J Mol Sci. 2022;23: pubmed  publisher | 
| Vanneste D, Staal J, Haegman M, Driege Y, Carels M, Van Nuffel E, et al . CARD14 Signalling Ensures Cell Survival and Cancer Associated Gene Expression in Prostate Cancer Cells. Biomedicines. 2022;10: pubmed  publisher | 
| Busch M, Bredeck G, Waag F, Rahimi K, Ramachandran H, Bessel T, et al . Assessing the NLRP3 Inflammasome Activating Potential of a Large Panel of Micro- and Nanoplastics in THP-1 Cells. Biomolecules. 2022;12: pubmed  publisher | 
| Ibarra I, Ratnu V, Gordillo L, Hwang I, Mariani L, Weinand K, et al . Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements. Mol Syst Biol. 2022;18:e10473 pubmed  publisher | 
| Liu H, Heller Trulli D, Moore C. Targeting the mRNA endonuclease CPSF73 inhibits breast cancer cell migration, invasion, and self-renewal. iScience. 2022;25:104804 pubmed  publisher | 
| De Angeli P, Reuter P, Hauser S, Sch xf6 ls L, Stingl K, Wissinger B, et al . Effective splicing restoration of a deep-intronic ABCA4 variant in cone photoreceptor precursor cells by CRISPR/SpCas9 approaches. Mol Ther Nucleic Acids. 2022;29:511-524 pubmed  publisher | 
| Cumin C, Huang Y, Rossdam C, Ruoff F, C xe9 spedes S, Liang C, et al . Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways. Cell Rep. 2022;40:111181 pubmed  publisher | 
| Khateb M, Perovanovic J, Ko K, Jiang K, Feng X, Acevedo Luna N, et al . Transcriptomics, regulatory syntax, and enhancer identification in mesoderm-induced ESCs at single-cell resolution. Cell Rep. 2022;40:111219 pubmed  publisher | 
| Groen K, van Nieuwkoop S, Lamers M, Fouchier R, van den Hoogen B. Evidence against the Human Metapneumovirus G, SH, and M2-2 Proteins as Bona Fide Interferon Antagonists. J Virol. 2022;96:e0072322 pubmed  publisher | 
| Blessing C, Apelt K, van den Heuvel D, González Leal C, Rother M, van der Woude M, et al . XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair. Nat Commun. 2022;13:4762 pubmed  publisher | 
| Gerardo Ram xed rez M, Keggenhoff F, Giam V, Becker D, Groth M, Hartmann N, et al . CD44 Contributes to the Regulation of MDR1 Protein and Doxorubicin Chemoresistance in Osteosarcoma. Int J Mol Sci. 2022;23: pubmed  publisher | 
| Lebeau B, Zhao K, Jangal M, Zhao T, Guerra M, Greenwood C, et al . Single base-pair resolution analysis of DNA binding motif with MoMotif reveals an oncogenic function of CTCF zinc-finger 1 mutation. Nucleic Acids Res. 2022;50:8441-8458 pubmed  publisher | 
| Solinger J, Rashid H, Spang A. FERARI and cargo adaptors coordinate cargo flow through sorting endosomes. Nat Commun. 2022;13:4620 pubmed  publisher | 
| Yousefi M, Lee W, Yan B, Cui L, Yong C, Yap X, et al . TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection. PLoS Pathog. 2022;18:e1010763 pubmed  publisher | 
| Wang J, Zhang Z, Jiang J, Tang L, Wang X, Wang Z, et al . KDM2A plays a dual role in regulating the expression of malignancy-related genes in esophageal squamous cell carcinoma. Biochem Biophys Res Commun. 2022;624:53-58 pubmed  publisher | 
| Pfromm J, Bonillo M, Dauletbekov D, Bucher K, Fischer M. Plasmid-mediated gene transfer of Cas9 induces vector-related but not SpCas9-related immune responses in human retinal pigment epithelial cells. Sci Rep. 2022;12:13202 pubmed  publisher | 
| Bolgi O, Silva Garcia M, Ross B, Pilla E, Kari V, Killisch M, et al . Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. EMBO Rep. 2022;23:e54136 pubmed  publisher | 
| Na Z, Dai X, Zheng S, Bryant C, Loh K, Su H, et al . Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID. Mol Cell. 2022;82:2900-2911.e7 pubmed  publisher | 
| Feng H, Lane K, Roumeliotis T, Jeggo P, Somaiah N, Choudhary J, et al . PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance. Genes Dev. 2022;36:790-806 pubmed  publisher | 
| Gómez Navarro N, Maldutyte J, Poljak K, Peak Chew S, Orme J, Bisnett B, et al . Selective inhibition of protein secretion by abrogating receptor-coat interactions during ER export. Proc Natl Acad Sci U S A. 2022;119:e2202080119 pubmed  publisher | 
| Moya J xf3 dar M, Coppiello G, Rodr xed guez Madoz J, Abizanda G, Barlab xe9 P, Vilas Zornoza A, et al . One-Step In Vitro Generation of ETV2-Null Pig Embryos. Animals (Basel). 2022;12: pubmed  publisher | 
| Mugarza E, Van Maldegem F, Boumelha J, Moore C, Rana S, Llorian Sopena M, et al . Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers. Sci Adv. 2022;8:eabm8780 pubmed  publisher | 
| Slusher A, Kim J, Ribick M, Pollens Voigt J, Bankhead A, Palmbos P, et al . Intronic Cis-Element DR8 in hTERT Is Bound by Splicing Factor SF3B4 and Regulates hTERT Splicing in Non-Small Cell Lung Cancer. Mol Cancer Res. 2022;20:1574-1588 pubmed  publisher | 
| Fu H, Wang T, Kong X, Yan K, Yang Y, Cao J, et al . A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells. Nat Commun. 2022;13:3984 pubmed  publisher | 
| Kim H, Moon S, Hong S, Won H, Kim J. DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300. Nucleic Acids Res. 2022;: pubmed  publisher | 
| Feng Z, Hom M, Bearrood T, Rosenthal Z, Fernandez D, Ondrus A, et al . Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. Nat Chem Biol. 2022;: pubmed  publisher | 
| Cheng J, Clayton J, Acemel R, Zheng Y, Taylor R, Kele x15f S, et al . Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer. Front Immunol. 2022;13:901747 pubmed  publisher | 
| Rinzema N, Sofiadis K, Tjalsma S, Verstegen M, Oz Y, Valdes Quezada C, et al . Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes. Nat Struct Mol Biol. 2022;29:563-574 pubmed  publisher | 
| Rahimi H, Zaboli K, Thekkiniath J, Mousavi S, Johari B, Hashemi M, et al . BSA-PEI Nanoparticle Mediated Efficient Delivery of CRISPR/Cas9 into MDA-MB-231 Cells. Mol Biotechnol. 2022;64:1376-1387 pubmed  publisher | 
| Hancock Cerutti W, Wu Z, Xu P, Yadavalli N, Leonzino M, Tharkeshwar A, et al . ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling. J Cell Biol. 2022;221: pubmed  publisher | 
| Nguyen T, Ramachandran H, Martins S, Krutmann J, Rossi A. Identification of genome edited cells using CRISPRnano. Nucleic Acids Res. 2022;: pubmed  publisher | 
| Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, et al . Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022;24:954-967 pubmed  publisher | 
| Sousa D, Gaspar R, Ferreira C, Baltazar F, Rodrigues L, Silva B. In Vitro CRISPR/Cas9 Transfection and Gene-Editing Mediated by Multivalent Cationic Liposome-DNA Complexes. Pharmaceutics. 2022;14: pubmed  publisher | 
| Gangopadhyay A, Devi S, Tenguria S, Carrière J, Nguyen H, Jäger E, et al . NLRP3 licenses NLRP11 for inflammasome activation in human macrophages. Nat Immunol. 2022;23:892-903 pubmed  publisher | 
| Kim Y, Nomakuchi T, Papaleonidopoulou F, Yang L, Zhang Q, Krainer A. Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy. Nat Commun. 2022;13:2978 pubmed  publisher | 
| Zhu D, Han F, Sun L, Agnihotri S, Hu Y, Bueler H. Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial Fission. Front Oncol. 2022;12:893396 pubmed  publisher | 
| Schlo xdf hauer J, Cavak N, Zemella A, Thoring L, Kubick S. Cell Engineering and Cultivation of Chinese Hamster Ovary Cells for the Development of Orthogonal Eukaryotic Cell-free Translation Systems. Front Mol Biosci. 2022;9:832379 pubmed  publisher | 
| Gao Q, Wang S, Li F, Lian J, Cheng S, Yue D, et al . High Mobility Group Protein B1 Decreases Surface Localization of PD-1 to Augment T-cell Activation. Cancer Immunol Res. 2022;10:844-855 pubmed  publisher | 
| Duclaux Loras R, Lebreton C, Berthelet J, Charbit Henrion F, Nicolle O, Revenu de Courtils C, et al . UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking. J Clin Invest. 2022;132: pubmed  publisher | 
| Fernandez R, Gardner Z, Slovik K, Liberti D, Estep K, Yang W, et al . GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells. elife. 2022;11: pubmed  publisher | 
| Reticker Flynn N, Zhang W, Belk J, Basto P, Escalante N, Pilarowski G, et al . Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Cell. 2022;185:1924-1942.e23 pubmed  publisher | 
| Liu J, Knopp K, Rackaityte E, Wang C, Laurie M, Sunshine S, et al . Genome-Wide Knockout Screen Identifies Human Sialomucin CD164 as an Essential Entry Factor for Lymphocytic Choriomeningitis Virus. MBio. 2022;13:e0020522 pubmed  publisher | 
| Kappel S, Ross Kaschitza D, Hauert B, Rother K, Peinelt C. p53 alters intracellular Ca2+ signaling through regulation of TRPM4. Cell Calcium. 2022;104:102591 pubmed  publisher | 
| Hanna M, Suen P, Wu Y, Reinisch K, De Camilli P. SHIP164 is a chorein motif lipid transfer protein that controls endosome-Golgi membrane traffic. J Cell Biol. 2022;221: pubmed  publisher | 
| Mockly S, Houbron É, Seitz H. A rationalized definition of general tumor suppressor microRNAs excludes miR-34a. Nucleic Acids Res. 2022;: pubmed  publisher | 
| Zakharova V, Magnitov M, Del Maestro L, Ulianov S, Glentis A, Uyanik B, et al . SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties. Nucleic Acids Res. 2022;: pubmed  publisher | 
| Zhang X, Jiang Y, Wang Q, An W, Zhang X, Xu M, et al . Atypical U3 snoRNA Suppresses the Process of Pterygium Through Modulating 18S Ribosomal RNA Synthesis. Invest Ophthalmol Vis Sci. 2022;63:17 pubmed  publisher | 
| Wu L, Shukla V, Yadavalli A, Dinesh R, Xu D, Rao A, et al . HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation. Genes Dev. 2022;36:433-450 pubmed  publisher | 
| Llimos G, Gardeux V, Koch U, Kribelbauer J, Hafner A, Alpern D, et al . A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation. Nat Commun. 2022;13:2042 pubmed  publisher | 
| Daoud M, Broxtermann P, Schorn F, Werthenbach J, Seeger J, Schiffmann L, et al . XIAP promotes melanoma growth by inducing tumour neutrophil infiltration. EMBO Rep. 2022;23:e53608 pubmed  publisher | 
| Rylee J, Nin Velez A, Mahato S, Helms K, Wade M, Zentner G, et al . Generating and testing the efficacy of transgenic Cas9 in Tribolium castaneum. Insect Mol Biol. 2022;31:543-550 pubmed  publisher | 
| Pokusaeva V, Diez A, Espinar L, Pérez A, Filion G. Strand asymmetry influences mismatch resolution during a single-strand annealing. Genome Biol. 2022;23:93 pubmed  publisher | 
| Bordeira Carriço R, Teixeira J, Duque M, Galhardo M, Ribeiro D, Acemel R, et al . Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers. Nat Commun. 2022;13:1945 pubmed  publisher | 
| Pladevall Morera D, Castejón Griñán M, Aguilera P, Gaardahl K, Ingham A, Brosnan Cashman J, et al . ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors. Cancers (Basel). 2022;14: pubmed  publisher | 
| V xe1 squez Limeta A, Lukasik K, Kong D, Sullenberger C, Luvsanjav D, Sahabandu N, et al . CPAP insufficiency leads to incomplete centrioles that duplicate but fragment. J Cell Biol. 2022;221: pubmed  publisher | 
| Mishra T, Bhardwaj V, Ahuja N, Gadgil P, Ramdas P, Shukla S, et al . Improved loss-of-function CRISPR-Cas9 genome editing in human cells concomitant with inhibition of TGF-β signaling. Mol Ther Nucleic Acids. 2022;28:202-218 pubmed  publisher | 
| Rubio Ramos A, Bernabé Rubio M, Labat de Hoz L, Casares Arias J, Kremer L, Correas I, et al . MALL, a membrane-tetra-spanning proteolipid overexpressed in cancer, is present in membraneless nuclear biomolecular condensates. Cell Mol Life Sci. 2022;79:236 pubmed  publisher | 
| Zhou T, Zhu X, Ye Z, Wang Y, Yao C, Xu N, et al . Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery. Nat Commun. 2022;13:1855 pubmed  publisher | 
| Liu Z, Wu A, Wu Z, Wang T, Pan Y, Li B, et al . TOX4 facilitates promoter-proximal pausing and C-terminal domain dephosphorylation of RNA polymerase II in human cells. Commun Biol. 2022;5:300 pubmed  publisher | 
| Di Minin G, Holzner M, Grison A, Dumeau C, Chan W, Monfort A, et al . TMED2 binding restricts SMO to the ER and Golgi compartments. PLoS Biol. 2022;20:e3001596 pubmed  publisher | 
| Adpaikar A, Zhang S, Kim H, Kim K, Moon S, Lee J, et al . Fine-tuning of epithelial taste bud organoid to promote functional recapitulation of taste reactivity. Cell Mol Life Sci. 2022;79:211 pubmed  publisher | 
| Angelopoulou A, Papaspyropoulos A, Papantonis A, Gorgoulis V. CRISPR-Cas9-mediated induction of large chromosomal inversions in human bronchial epithelial cells. STAR Protoc. 2022;3:101257 pubmed  publisher | 
| Miki S, Koga T, McKinney A, Parisian A, Tadokoro T, Vadla R, et al . TERT promoter C228T mutation in neural progenitors confers growth advantage following telomere shortening in vivo. Neuro Oncol. 2022;: pubmed  publisher | 
| Maharaj A, Guran T, Buonocore F, Achermann J, Metherell L, Prasad R, et al . Insights From Long-term Follow-up of a Girl With Adrenal Insufficiency and Sphingosine-1-Phosphate Lyase Deficiency. J Endocr Soc. 2022;6:bvac020 pubmed  publisher | 
| Guo X, Zhao Y, Kim J, Dean A. Hemogen/BRG1 cooperativity modulates promoter and enhancer activation during erythropoiesis. Blood. 2022;139:3532-3545 pubmed  publisher | 
| Fung T, Chakrabarti R, Kollasser J, Rottner K, Stradal T, Kage F, et al . Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria. Curr Biol. 2022;32:1577-1592.e8 pubmed  publisher | 
| Aouida M, Aljogol D, Ali R, Ramotar D. A simple protocol to isolate a single human cell PRDX1 knockout generated by CRISPR-Cas9 system. STAR Protoc. 2022;3:101216 pubmed  publisher | 
| Li C, Ogawa H, Ng S, Chen X, Kishimoto E, Sakabe K, et al . Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency. JHEP Rep. 2022;4:100446 pubmed  publisher | 
| Zamberlan M, Boeckx A, Muller F, Vinelli F, Ek O, Vianello C, et al . Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth. J Exp Clin Cancer Res. 2022;41:95 pubmed  publisher | 
| Stormo A, Shavarebi F, FitzGibbon M, Earley E, Ahrendt H, Lum L, et al . The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. J Cell Biol. 2022;221: pubmed  publisher | 
| Arnold P, Jackson B, Paras K, Brunner J, Hart M, Newsom O, et al . A non-canonical tricarboxylic acid cycle underlies cellular identity. Nature. 2022;603:477-481 pubmed  publisher | 
| Lee D, Apelt K, Lee S, Chan H, Luijsterburg M, Leung J, et al . ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination. Nucleic Acids Res. 2022;50:3922-3943 pubmed  publisher | 
| Ishihara S, Sato T, Fujikado N, Miyazaki H, Yoshimoto T, Yamamoto H, et al . Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling. Commun Biol. 2022;5:206 pubmed  publisher | 
| Cujba A, Alvarez Fallas M, Pedraza Arevalo S, Laddach A, Shepherd M, Hattersley A, et al . An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function. Cell Rep. 2022;38:110425 pubmed  publisher | 
| D Annibale O, Koppes E, Sethuraman M, Bloom K, Mohsen A, Vockley J. Characterization of exonic variants of uncertain significance in very long-chain acyl-CoA dehydrogenase identified through newborn screening. J Inherit Metab Dis. 2022;45:529-540 pubmed  publisher | 
| Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, et al . Low-dose metformin targets the lysosomal AMPK pathway through PEN2. Nature. 2022;603:159-165 pubmed  publisher | 
| Nataraj N, Noronha A, Lee J, Ghosh S, Mohan Raju H, Sekar A, et al . Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. Cell Rep. 2022;38:110418 pubmed  publisher | 
| Sivakumar S, Qi S, Cheng N, Sathe A, Kanchwala M, Kumar A, et al . TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling. Cell Rep. 2022;38:110395 pubmed  publisher | 
| Kim H, Jang S, Lee Y. The m6A(m)-independent role of FTO in regulating WNT signaling pathways. Life Sci Alliance. 2022;5: pubmed  publisher | 
| Sreenivasan L, Li L, Leclair P, Lim C. Targeting the gp130/STAT3 Axis Attenuates Tumor Microenvironment Mediated Chemoresistance in Group 3 Medulloblastoma Cells. Cells. 2022;11: pubmed  publisher | 
| Umansky C, Morellato A, Rieckher M, Scheidegger M, Martinefski M, Fernández G, et al . Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity. Nat Commun. 2022;13:745 pubmed  publisher | 
| Pan Y, Shao M, Li P, Xu C, Nie J, Zhang K, et al . Polyaminoglycoside-mediated cell reprogramming system for the treatment of diabetes mellitus. J Control Release. 2022;343:420-433 pubmed  publisher | 
| Meinhardt A, Munkhbaatar E, Höckendorf U, Dietzen M, Dechant M, Anton M, et al . The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner. Oncogene. 2022;41:1376-1382 pubmed  publisher | 
| Rodríguez Caparrós A, Álvarez Santiago J, López Castellanos L, Ruiz Rodríguez C, Valle Pastor M, López Ros J, et al . Differently Regulated Gene-Specific Activity of Enhancers Located at the Boundary of Subtopologically Associated Domains: TCRα Enhancer. J Immunol. 2022;208:910-928 pubmed  publisher | 
| Riesenberg S, Helmbrecht N, Kanis P, Maricic T, Paabo S. Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage. Nat Commun. 2022;13:489 pubmed  publisher | 
| Siqueira E, Obiols Guardia A, Jorge Torres O, Oliveira Mateos C, Soler M, Ramesh Kumar D, et al . Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome. Mol Ther Nucleic Acids. 2022;27:621-644 pubmed  publisher | 
| Uceda Castro R, van Asperen J, Vennin C, Sluijs J, van Bodegraven E, Margarido A, et al . GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence. Sci Rep. 2022;12:424 pubmed  publisher | 
| Ajore R, Niroula A, Pertesi M, Cafaro C, Thodberg M, Went M, et al . Functional dissection of inherited non-coding variation influencing multiple myeloma risk. Nat Commun. 2022;13:151 pubmed  publisher | 
| Cacho Navas C, Reglero Real N, Colás Algora N, Barroso S, de Rivas G, Stamatakis K, et al . Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells. Cell Mol Life Sci. 2022;79:61 pubmed  publisher | 
| Vogeley C, Sondermann N, Woeste S, Momin A, Gilardino V, Hartung F, et al . Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response. Environ Int. 2022;158:106989 pubmed  publisher | 
| Wang Z, Lv J, Yu P, Qu Y, Zhou Y, Zhou L, et al . SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterol-increased endosomal pH of alveolar macrophages. Cell Mol Immunol. 2022;: pubmed  publisher | 
| Ishikawa M, Osaki M, Uno N, Ohira T, Kugoh H, Okada F. MTA1, a metastasis‑associated protein, in endothelial cells is an essential molecule for angiogenesis. Mol Med Rep. 2022;25: pubmed  publisher | 
| Wu F, Xu L, Tu Y, Cheung O, Szeto L, Mok M, et al . Sirtuin 7 super-enhancer drives epigenomic reprogramming in hepatocarcinogenesis. Cancer Lett. 2022;525:115-130 pubmed  publisher | 
| Millarte V, Schlienger S, Kälin S, Spiess M. Rabaptin5 targets autophagy to damaged endosomes and Salmonella vacuoles via FIP200 and ATG16L1. EMBO Rep. 2022;23:e53429 pubmed  publisher | 
| Leon F, Seshacharyulu P, Nimmakayala R, Chugh S, Karmakar S, Nallasamy P, et al . Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and metastasis in pancreatic cancer. Oncogene. 2022;41:57-71 pubmed  publisher | 
| Yin Y, Yan F, Zhou R, Li M, Ma J, Liu Z, et al . Single-domain antibody screening by isPLA-seq. Life Sci Alliance. 2022;5: pubmed  publisher | 
| Huhn D, Marti Rodrigo P, Mouron S, Hansel C, Tschapalda K, Porebski B, et al . Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells. Mol Oncol. 2022;16:148-165 pubmed  publisher | 
| Naakka E, Barros Filho M, Adnan Awad S, Al Samadi A, Marchi F, Kuasne H, et al . miR-22 and miR-205 Drive Tumor Aggressiveness of Mucoepidermoid Carcinomas of Salivary Glands. Front Oncol. 2021;11:786150 pubmed  publisher | 
| López Muneta L, Linares J, Casis O, Martínez Ibáñez L, González Miqueo A, Bezunartea J, et al . Generation of NKX2.5GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts. Front Cell Dev Biol. 2021;9:797927 pubmed  publisher | 
| Tsortouktzidis D, Tröscher A, Schulz H, Opitz T, Schoch S, Becker A, et al . A Versatile Clustered Regularly Interspaced Palindromic Repeats Toolbox to Study Neurological CaV3.2 Channelopathies by Promoter-Mediated Transcription Control. Front Mol Neurosci. 2021;14:667143 pubmed  publisher | 
| Deng C, Hu F, Zhao Z, Zhou Y, Liu Y, Zhang T, et al . The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance. Front Cell Dev Biol. 2021;9:797005 pubmed  publisher | 
| Shafaattalab S, Li A, Gunawan M, Kim B, Jayousi F, Maaref Y, et al . Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant I79N. Front Cell Dev Biol. 2021;9:787581 pubmed  publisher | 
| Kaku H, Ludlow A, Gutknecht M, Rothstein T. Fas Apoptosis Inhibitory Molecule Blocks and Dissolves Pathological Amyloid-β Species. Front Mol Neurosci. 2021;14:750578 pubmed  publisher | 
| Lange K, Best S, Tsiropoulou S, Berry I, Johnson C, Blacque O. Interpreting ciliopathy-associated missense variants of uncertain significance (VUS) in Caenorhabditis elegans. Hum Mol Genet. 2021;: pubmed  publisher | 
| Koslová A, Trefil P, Mucksová J, Krchlíková V, Plachy J, Krijt J, et al . Knock-Out of Retrovirus Receptor Gene Tva in the Chicken Confers Resistance to Avian Leukosis Virus Subgroups A and K and Affects Cobalamin (Vitamin B12)-Dependent Level of Methylmalonic Acid. Viruses. 2021;13: pubmed  publisher | 
| Guha J, Chari R. Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells. Vaccines (Basel). 2021;9: pubmed  publisher | 
| Kaiser F, Morawski M, Krohn K, Rayes N, Hsiao C, Quaas M, et al . Adhesion GPCR GPR56 Expression Profiling in Human Tissues. Cells. 2021;10: pubmed  publisher | 
| Hirayama H, Tachida Y, Seino J, Suzuki T. A method for assaying peptide: N-glycanase/N-Glycanase 1 activities in crude extracts using an N-glycosylated cyclopeptide. Glycobiology. 2021;: pubmed  publisher | 
| Sun X, Bai J, Xu J, Xi X, Gu M, Zhu C, et al . Multiple DSB Resection Activities Redundantly Promote Alternative End Joining-Mediated Class Switch Recombination. Front Cell Dev Biol. 2021;9:767624 pubmed  publisher | 
| Rovelet Lecrux A, Feuillette S, Miguel L, Schramm C, Pernet S, Quenez O, et al . Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease. Acta Neuropathol Commun. 2021;9:196 pubmed  publisher | 
| Ma K, Fokkens M, van Laar T, Verbeek D. Systematic analysis of PINK1 variants of unknown significance shows intact mitophagy function for most variants. NPJ Parkinsons Dis. 2021;7:113 pubmed  publisher | 
| Poetz F, Corbo J, Levdansky Y, Spiegelhalter A, Lindner D, Magg V, et al . RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation. Nat Commun. 2021;12:7175 pubmed  publisher | 
| Griffiths S, Schwab R, El Omari K, Bishop B, Iverson E, Malinauskas T, et al . Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun. 2021;12:7171 pubmed  publisher | 
| Jacobs Catane L, Moshel O, Smith Y, Davidson B, Reich R. Splice-Variant Knock-Out of TGFβ Receptors Perturbates the Proteome of Ovarian Carcinoma Cells. Int J Mol Sci. 2021;22: pubmed  publisher | 
| Miyake M, Zhang J, Yasue A, Hisanaga S, Tsugawa K, Sakaue H, et al . Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity. iScience. 2021;24:103448 pubmed  publisher | 
| Magdy T, Jouni M, Kuo H, Weddle C, Lyra Leite D, Fonoudi H, et al . Identification of Drug Transporter Genomic Variants and Inhibitors that Protect Against Doxorubicin-Induced Cardiotoxicity. Circulation. 2021;: pubmed  publisher | 
| Jiang H, Alahmad A, Fu S, Fu X, Liu Z, Han X, et al . Identification and characterization of novel MPC1 gene variants causing mitochondrial pyruvate carrier deficiency. J Inherit Metab Dis. 2021;: pubmed  publisher | 
| Mauthe M, Dinesh Kumar N, Verlhac P, van de Beek N, Reggiori F. HSBP1 Is a Novel Interactor of FIP200 and ATG13 That Promotes Autophagy Initiation and Picornavirus Replication. Front Cell Infect Microbiol. 2021;11:745640 pubmed  publisher | 
| Kim E, Liu P, Zhang S, Donahue K, Wang Y, Schehr J, et al . BAF155 methylation drives metastasis by hijacking super-enhancers and subverting anti-tumor immunity. Nucleic Acids Res. 2021;49:12211-12233 pubmed  publisher | 
| Reisman B, Guo H, Ramsey H, Wright M, Reinfeld B, Ferrell P, et al . Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase. Nat Chem Biol. 2021;: pubmed  publisher | 
| Robert Finestra T, Tan B, Mira Bontenbal H, Timmers E, Gontan C, Merzouk S, et al . SPEN is required for Xist upregulation during initiation of X chromosome inactivation. Nat Commun. 2021;12:7000 pubmed  publisher | 
| Donnelly L, Hogan T, Lenahan S, Nandagopal G, Eaton J, Lebeau M, et al . Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers. Carcinogenesis. 2021;42:1428-1438 pubmed  publisher | 
| Adhikari B, Narain A, Wolf E. Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells. STAR Protoc. 2021;2:100949 pubmed  publisher | 
| Podinovskaia M, Prescianotto Baschong C, Buser D, Spang A. A novel live-cell imaging assay reveals regulation of endosome maturation. elife. 2021;10: pubmed  publisher | 
| Feng Y, Li C, Stewart J, Barbulescu P, Desivo N, Alvarez Quilón A, et al . FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature. 2021;600:324-328 pubmed  publisher | 
| Kim D, Lee J, Lee E, Jang H, Han S, Kim H, et al . O-GlcNAcylation of Sox2 at threonine 258 regulates the self-renewal and early cell fate of embryonic stem cells. Exp Mol Med. 2021;53:1759-1768 pubmed  publisher | 
| King R, Lin Z, Balbin Cuesta G, Myers G, Friedman A, Zhu G, et al . SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II. Sci Adv. 2021;7:eabj5293 pubmed  publisher | 
| Adamowicz M, Hailstone R, Demin A, Komulainen E, Hanzlikova H, Brazina J, et al . XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair. Nat Cell Biol. 2021;23:1287-1298 pubmed  publisher | 
| Dara M, Razban V, Mazloomrezaei M, Ranjbar M, Nourigorji M, Dianatpour M. Dystrophin gene editing by CRISPR/Cas9 system in human skeletal muscle cell line (HSkMC). Iran J Basic Med Sci. 2021;24:1153-1158 pubmed  publisher | 
| Mailler E, Guardia C, Bai X, Jarnik M, Williamson C, Li Y, et al . The autophagy protein ATG9A enables lipid mobilization from lipid droplets. Nat Commun. 2021;12:6750 pubmed  publisher | 
| Song Y, Hou G, Diep J, Ooi Y, Akopyants N, Beverley S, et al . Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation. Nucleic Acids Res. 2021;49:12706-12715 pubmed  publisher | 
| Lyu P, Hoang T, Santiago C, Thomas E, Timms A, Appel H, et al . Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina. Cell Rep. 2021;37:109994 pubmed  publisher | 
| Lee H, Lee J, Park N, Dubey S, Kim T, Ruan K, et al . Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS. Nat Neurosci. 2021;24:1673-1685 pubmed  publisher | 
| Earley A, Burbulla L, Krainc D, Awatramani R. Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons. Sci Rep. 2021;11:22257 pubmed  publisher | 
| Gorrell L, Omari S, Makareeva E, Leikin S. Noncanonical ER-Golgi trafficking and autophagy of endogenous procollagen in osteoblasts. Cell Mol Life Sci. 2021;78:8283-8300 pubmed  publisher | 
| Schink K, Tan K, Spangenberg H, Martorana D, Sneeggen M, Stévenin V, et al . The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes. Nat Commun. 2021;12:6577 pubmed  publisher | 
| Smith J, Banerjee R, Waly R, Urbano A, Gimenez G, Day R, et al . Locus-Specific DNA Methylation Editing in Melanoma Cell Lines Using a CRISPR-Based System. Cancers (Basel). 2021;13: pubmed  publisher | 
| Dyrkheeva N, Filimonov A, Luzina O, Orlova K, Chernyshova I, Kornienko T, et al . New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1. Int J Mol Sci. 2021;22: pubmed  publisher | 
| Han S, Lee H, Lee A, Kim S, Jung I, Koh G, et al . CHD4 Conceals Aberrant CTCF-Binding Sites at TAD Interiors by Regulating Chromatin Accessibility in Mouse Embryonic Stem Cells. Mol Cells. 2021;44:805-829 pubmed  publisher | 
| Rahman M, Hyodo T, Hasan M, Mihara Y, Karnan S, Ota A, et al . Flow cytometry-based quantification of targeted knock-in events in human cell lines using a GPI-anchor biosynthesis gene PIGP. Biosci Rep. 2021;41: pubmed  publisher | 
| Mirzaei R, Gordon A, Zemp F, Kumar M, Sarkar S, Luchman H, et al . PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway. Sci Adv. 2021;7:eabh2148 pubmed  publisher | 
| Mózsik L, Pohl C, Meyer V, Bovenberg R, Nygård Y, Driessen A. Modular Synthetic Biology Toolkit for Filamentous Fungi. ACS Synth Biol. 2021;10:2850-2861 pubmed  publisher | 
| Kim J, Jeon Y, Lim S, Ryu J, Lee J, Chang I, et al . Akt-mediated Ephexin1-Ras interaction promotes oncogenic Ras signaling and colorectal and lung cancer cell proliferation. Cell Death Dis. 2021;12:1013 pubmed  publisher | 
| Aronson B, Scourzic L, Shah V, Swanzey E, Kloetgen A, Polyzos A, et al . A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus. Dev Cell. 2021;56:3052-3065.e5 pubmed  publisher | 
| Xu F, Wang N, Li G, Tian D, Shi X. ANGPTL8/Betatrophin Improves Glucose Tolerance in Older Mice and Metabolomic Analysis Reveals Its Role in Insulin Resistance in HepG2 Cells. Diabetes Metab Syndr Obes. 2021;14:4209-4221 pubmed  publisher | 
| Radaszkiewicz T, Nosková M, Gömöryová K, Vondálová Blanárová O, Radaszkiewicz K, Pícková M, et al . RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy. elife. 2021;10: pubmed  publisher | 
| Liniger M, Gerber M, Renzullo S, García Nicolás O, Ruggli N. TNF-Mediated Inhibition of Classical Swine Fever Virus Replication Is IRF1-, NF-κB- and JAK/STAT Signaling-Dependent. Viruses. 2021;13: pubmed  publisher | 
| Tamura N, Sakai S, Martorell L, Colome R, Mizuike A, Goto A, et al . Intellectual-disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution. J Biol Chem. 2021;297:101338 pubmed  publisher | 
| Schuster J, de Guidi C, Fatima A, Sobol M, Dahl N. Syndromic RNA polymerase II insufficiency: Generation of a human induced pluripotent stem cell line (UUIGPi002A-5) with a heterozygous disruption of POLR2A. Stem Cell Res. 2021;57:102577 pubmed  publisher | 
| Romano E, Trionfini P, Giampietro R, Benigni A, Tomasoni S. Generation of a homozygous CIITA knockout iPS cell line using the CRISPR-Cas9 system. Stem Cell Res. 2021;57:102580 pubmed  publisher | 
| Duan S, Moro L, Qu R, Simoneschi D, Cho H, Jiang S, et al . Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis. Cell Rep. 2021;37:109870 pubmed  publisher | 
| Li Z, Liu W, Fu J, Cheng S, Xu Y, Wang Z, et al . Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11. Nature. 2021;599:290-295 pubmed  publisher | 
| Averina O, Permyakov O, Grigorieva O, Starshin A, Mazur A, Prokhortchouk E, et al . Comparative Analysis of Genome Editors Efficiency on a Model of Mice Zygotes Microinjection. Int J Mol Sci. 2021;22: pubmed  publisher | 
| Donati G, Ravà M, Filipuzzi M, Nicoli P, Cassina L, Verrecchia A, et al . Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma. Mol Oncol. 2021;: pubmed  publisher | 
| Karvelis T, Druteika G, Bigelyte G, Budre K, Zedaveinyte R, Silanskas A, et al . Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease. Nature. 2021;599:692-696 pubmed  publisher | 
| Sluysmans S, Méan I, Xiao T, Boukhatemi A, Ferreira F, Jond L, et al . PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis. Mol Biol Cell. 2021;32:ar34 pubmed  publisher | 
| Bai W, Zhu G, Xu J, Chen P, Meng F, Xue H, et al . The 3'-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching. Cell Rep. 2021;36:109756 pubmed  publisher | 
| Liang R, Yung M, He F, Jiao P, Chan K, Ngan H, et al . The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment. Cancers (Basel). 2021;13: pubmed  publisher | 
| Spek C, Aberson H, Butler J, de Vos A, Duitman J. CEBPD Potentiates the Macrophage Inflammatory Response but CEBPD Knock-Out Macrophages Fail to Identify CEBPD-Dependent Pro-Inflammatory Transcriptional Programs. Cells. 2021;10: pubmed  publisher | 
| Biber G, Ben Shmuel A, Noy E, Joseph N, Puthenveetil A, Reiss N, et al . Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies. Nat Commun. 2021;12:5581 pubmed  publisher | 
| Kohela A, van Kampen S, Moens T, Wehrens M, Molenaar B, Boogerd C, et al . Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy. Sci Transl Med. 2021;13:eabf2750 pubmed  publisher | 
| Smith L, Ladner J, Hodara V, Parodi L, Harris R, Callery J, et al . Multiplexed Simian Immunodeficiency Virus-Specific Paired RNA-Guided Cas9 Nickases Inactivate Proviral DNA. J Virol. 2021;95:e0088221 pubmed  publisher | 
| D Annibale O, Koppes E, Alodaib A, Kochersperger C, Karunanidhi A, Mohsen A, et al . Characterization of variants of uncertain significance in isovaleryl-CoA dehydrogenase identified through newborn screening: An approach for faster analysis. Mol Genet Metab. 2021;134:29-36 pubmed  publisher | 
| Kim D, Kulishova L, Torgasheva N, Melentyev V, Dianov G, Medvedev S, et al . Mild phenotype of knockouts of the major apurinic/apyrimidinic endonuclease APEX1 in a non-cancer human cell line. PLoS ONE. 2021;16:e0257473 pubmed  publisher | 
| Soblechero Martin P, Albiasu Arteta E, Anton Martinez A, de la Puente Ovejero L, Garcia Jimenez I, González Iglesias G, et al . Duchenne muscular dystrophy cell culture models created by CRISPR/Cas9 gene editing and their application in drug screening. Sci Rep. 2021;11:18188 pubmed  publisher | 
| Temocin O, Regele D, Sathianathan M, Überbacher C, Hartl M, Edenhofer F, et al . Generation of an hiPSC-1 knock-in line expressing TY1-tagged MNX1-protein together with mScarlet. Stem Cell Res. 2021;56:102522 pubmed  publisher | 
| Tromans Coia C, Sanchi A, Moeller G, Timinszky G, Lopes M, Ahel I. TARG1 protects against toxic DNA ADP-ribosylation. Nucleic Acids Res. 2021;49:10477-10492 pubmed  publisher | 
| Yue X, Qian Y, Zhu L, Gim B, Bao M, Jia J, et al . ACBD3 modulates KDEL receptor interaction with PKA for its trafficking via tubulovesicular carrier. BMC Biol. 2021;19:194 pubmed  publisher | 
| Šikrová D, Cadar V, Ariyurek Y, Laros J, Balog J, van der Maarel S. Adenine base editing of the DUX4 polyadenylation signal for targeted genetic therapy in facioscapulohumeral muscular dystrophy. Mol Ther Nucleic Acids. 2021;25:342-354 pubmed  publisher | 
| Santiago F, Li Y, Khachigian L. Serine 26 in Early Growth Response-1 Is Critical for Endothelial Proliferation, Migration, and Network Formation. J Am Heart Assoc. 2021;10:e020521 pubmed  publisher | 
| Redman Rivera L, Shaver T, Jin H, Marshall C, Schafer J, Sheng Q, et al . Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes. Nat Commun. 2021;12:5184 pubmed  publisher | 
| Lai X, Liu J, Zou Z, Wang Y, Wang Y, Liu X, et al . SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells. Cell Death Dis. 2021;12:814 pubmed  publisher | 
| Mariani L, Guo X, Menezes N, Drozd A, Çakal S, Wang Q, et al . A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm. Nat Commun. 2021;12:5136 pubmed  publisher | 
| Pierre M, Djemai M, Poulin H, Chahine M. NaV1.5 knockout in iPSCs: a novel approach to study NaV1.5 variants in a human cardiomyocyte environment. Sci Rep. 2021;11:17168 pubmed  publisher | 
| Guardia C, Jain A, Mattera R, Friefeld A, Li Y, Bonifacino J. RUSC2 and WDR47 oppositely regulate kinesin-1-dependent distribution of ATG9A to the cell periphery. Mol Biol Cell. 2021;32:ar25 pubmed  publisher | 
| Morrow C, Porter T, Moore D. Fluorescent tagging of endogenous proteins with CRISPR/Cas9 in primary mouse neural stem cells. STAR Protoc. 2021;2:100744 pubmed  publisher | 
| Li P, Li S, Gao S, Dong D. CRISPR/Cas9-mediated gene editing on Sox2ot promoter leads to its truncated expression and does not influence neural tube closure and embryonic development in mice. Biochem Biophys Res Commun. 2021;573:107-111 pubmed  publisher | 
| Li X, Chen M, Liu B, Lu P, Lv X, Zhao X, et al . Transcriptional silencing of fetal hemoglobin expression by NonO. Nucleic Acids Res. 2021;49:9711-9723 pubmed  publisher | 
| Geurts M, de Poel E, Pleguezuelos Manzano C, Oka R, Carrillo L, Andersson Rolf A, et al . Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids. Life Sci Alliance. 2021;4: pubmed  publisher | 
| Stanton C, Findlay A, Drake C, Mustafa M, Gautier P, McKie L, et al . A Mouse Model of Brittle Cornea Syndrome caused by mutation in Zfp469. Dis Model Mech. 2021;: pubmed  publisher | 
| Cui Z, Dabas H, Leonard B, Shiah J, Grandis J, Johnson D. Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction. Cell Death Dis. 2021;12:775 pubmed  publisher | 
| Ramakrishnan A, Chen L, Burby P, Cadigan K. Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif. Nucleic Acids Res. 2021;: pubmed  publisher | 
| Dyrkheeva N, Filimonov A, Luzina O, Zakharenko A, Ilina E, Malakhova A, et al . New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. Biomolecules. 2021;11: pubmed  publisher | 
| Hellwig C, Delgado M, Skoko J, Dyck L, Hanna C, Wentges A, et al . Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol. Cell Death Differ. 2021;: pubmed  publisher | 
| Ring S, Cupovic J, Onder L, Lütge M, Perez Shibayama C, Gil Cruz C, et al . Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nat Commun. 2021;12:4734 pubmed  publisher | 
| Nuebel E, Morgan J, Fogarty S, Winter J, Lettlova S, Berg J, et al . The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder. EMBO Rep. 2021;:e51991 pubmed  publisher | 
| Anderson C, Medina C, Barron B, Karvelyte L, Aaes T, Lambertz I, et al . Microbes exploit death-induced nutrient release by gut epithelial cells. Nature. 2021;596:262-267 pubmed  publisher | 
| Gao C, Wu P, Yu L, Liu L, Liu H, Tan X, et al . The application of CRISPR/Cas9 system in cervical carcinogenesis. Cancer Gene Ther. 2021;: pubmed  publisher | 
| Liu R, Li J, Shao J, Lee J, Qiu X, Xiao Y, et al . Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair. Cell Metab. 2021;: pubmed  publisher | 
| Gautheron J, Morisseau C, Chung W, Zammouri J, Auclair M, Baujat G, et al . EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. elife. 2021;10: pubmed  publisher | 
| Cui J, Duizer C, Bouwman L, van Rooijen K, Voogdt C, van Putten J, et al . The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells. PLoS Pathog. 2021;17:e1009787 pubmed  publisher | 
| Willms A, Schupp H, Poelker M, Adawy A, Debus J, Hartwig T, et al . TRAIL-receptor 2-a novel negative regulator of p53. Cell Death Dis. 2021;12:757 pubmed  publisher | 
| Becker J, Clifford G, Bonnet C, Groth A, Wilson M, Chapman J. BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination. Nature. 2021;: pubmed  publisher | 
| Saric A, Freeman S, Williamson C, Jarnik M, Guardia C, Fernandopulle M, et al . SNX19 restricts endolysosome motility through contacts with the endoplasmic reticulum. Nat Commun. 2021;12:4552 pubmed  publisher | 
| Brandt M, Kim Hellmuth S, Ziosi M, Gokden A, Wolman A, Lam N, et al . An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?. PLoS Genet. 2021;17:e1009684 pubmed  publisher | 
| Escrevente C, Falcão A, Hall M, Lopes da Silva M, Antas P, Mesquita M, et al . Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction. Invest Ophthalmol Vis Sci. 2021;62:39 pubmed  publisher | 
| Hattersley K, Carosi J, Hein L, Bensalem J, Sargeant T. PICALM regulates cathepsin D processing and lysosomal function. Biochem Biophys Res Commun. 2021;570:103-109 pubmed  publisher | 
| Anzai T, Hara H, Chanthra N, Sadahiro T, Ieda M, Hanazono Y, et al . Generation of Efficient Knock-in Mouse and Human Pluripotent Stem Cells Using CRISPR-Cas9. Methods Mol Biol. 2021;2320:247-259 pubmed  publisher | 
| Neguembor M, Martin L, Castells Garcia A, Gomez Garcia P, Vicario C, Carnevali D, et al . Transcription-mediated supercoiling regulates genome folding and loop formation. Mol Cell. 2021;81:3065-3081.e12 pubmed  publisher | 
| McAndrews K, Xiao F, Chronopoulos A, LeBleu V, Kugeratski F, Kalluri R. Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer. Life Sci Alliance. 2021;4: pubmed  publisher | 
| Stefanovic B, Stefanovic L, Manojlovic Z. Imaging of type I procollagen biosynthesis in cells reveals biogenesis in highly organized bodies; Collagenosomes. Matrix Biol Plus. 2021;12:100076 pubmed  publisher | 
| Bianchi G, Czarnecki P, Ho M, Roccaro A, Sacco A, Kawano Y, et al . ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment. Blood Cancer Discov. 2021;2:338-353 pubmed  publisher | 
| Yu J, LeRoy G, Bready D, Frenster J, Saldaña Meyer R, Jin Y, et al . The H3K36me2 writer-reader dependency in H3K27M-DIPG. Sci Adv. 2021;7: pubmed  publisher | 
| Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kucukkose C, et al . Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery. Nat Commun. 2021;12:4284 pubmed  publisher | 
| Duan Z, Baughn L, Wang X, Zhang Y, Gupta V, MacCarthy T, et al . Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes. Proc Natl Acad Sci U S A. 2021;118: pubmed  publisher | 
| Cassioli C, Onnis A, Finetti F, Capitani N, Brunetti J, Compeer E, et al . The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly. J Cell Sci. 2021;: pubmed  publisher | 
| Wang W, Lu G, Liu H, Xiong Z, Leung H, Cao R, et al . Pten Regulates Cardiomyocyte Differentiation by Modulating Non-CG Methylation via Dnmt3. Adv Sci (Weinh). 2021;:e2100849 pubmed  publisher | 
| Kumar D, Rains A, Herranz Pérez V, Lu Q, Shi X, Swaney D, et al . A ciliopathy complex builds distal appendages to initiate ciliogenesis. J Cell Biol. 2021;220: pubmed  publisher | 
| Bogomiakova M, Sekretova E, Eremeev A, Shuvalova L, Bobrovsky P, Zerkalenkova E, et al . Derivation of induced pluripotent stem cells line (RCPCMi007-A-1) with inactivation of the beta-2-microglobulin gene by CRISPR/Cas9 genome editing. Stem Cell Res. 2021;55:102451 pubmed  publisher | 
| Ruiz E, Lan L, Diefenbacher M, Riising E, Da Costa C, Chakraborty A, et al . JunD, not c-Jun, is the AP-1 transcription factor required for Ras-induced lung cancer. JCI Insight. 2021;6: pubmed  publisher | 
| Serifi I, Besta S, Karetsou Z, Giardoglou P, Beis D, Niewiadomski P, et al . Targeting of SET/I2PP2A oncoprotein inhibits Gli1 transcription revealing a new modulator of Hedgehog signaling. Sci Rep. 2021;11:13940 pubmed  publisher | 
| Chu X, Jaeger M, Beumer J, Bakker O, Aguirre Gamboa R, Oosting M, et al . Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease. Genome Biol. 2021;22:198 pubmed  publisher | 
| Barile M, Imaz Rosshandler I, Inzani I, Ghazanfar S, Nichols J, Marioni J, et al . Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation. Genome Biol. 2021;22:197 pubmed  publisher | 
| Berthelsen M, Riedel M, Cai H, Skaarup S, Alstrup A, Dagnæs Hansen F, et al . The CRISPR/Cas9 Minipig-A Transgenic Minipig to Produce Specific Mutations in Designated Tissues. Cancers (Basel). 2021;13: pubmed  publisher | 
| Bownes L, Williams A, Marayati R, Quinn C, Hutchins S, Stewart J, et al . Serine-Threonine Kinase Receptor-Associated Protein (STRAP) Knockout Decreases the Malignant Phenotype in Neuroblastoma Cell Lines. Cancers (Basel). 2021;13: pubmed  publisher | 
| Kuzuoğlu Öztürk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang G, et al . Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Cell Rep. 2021;35:109321 pubmed  publisher | 
| Conway E, Rossi F, Fernandez Perez D, Ponzo E, Ferrari K, Zanotti M, et al . BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation. Mol Cell. 2021;: pubmed  publisher | 
| Park S, Bennett Baker P, Ahmed S, Arlt M, Ljungman M, Glover T, et al . Locus-specific transcription silencing at the FHIT gene suppresses replication stress-induced copy number variant formation and associated replication delay. Nucleic Acids Res. 2021;49:7507-7524 pubmed  publisher | 
| Zhou J, Gelot C, Pantelidou C, Li A, Yücel H, Davis R, et al . A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. Nat Cancer. 2021;2:598-610 pubmed  publisher | 
| Zhang H, Zhang Y, Williams R, Smyth H. Development of PEGylated chitosan/CRISPR-Cas9 dry powders for pulmonary delivery via thin-film freeze-drying. Int J Pharm. 2021;605:120831 pubmed  publisher | 
| Perez García V, Lea G, Lopez Jimenez P, Okkenhaug H, Burton G, Moffett A, et al . BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion. elife. 2021;10: pubmed  publisher | 
| Szanto A, Aguilar R, Kesner B, Blum R, Wang D, Cifuentes Rojas C, et al . A disproportionate impact of G9a methyltransferase deficiency on the X chromosome. Genes Dev. 2021;35:1035-1054 pubmed  publisher | 
| Jamalpoor A, van Gelder C, Yousef Yengej F, Zaal E, Berlingerio S, Veys K, et al . Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis. EMBO Mol Med. 2021;13:e13067 pubmed  publisher | 
| Li P, Walsh J, Lopez K, Isidan A, Zhang W, Chen A, et al . Genetic engineering of porcine endothelial cell lines for evaluation of human-to-pig xenoreactive immune responses. Sci Rep. 2021;11:13131 pubmed  publisher | 
| Leung E, Patel J, Hollywood J, Zafar A, Tomek P, Barker D, et al . Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. Oncol Ther. 2021;: pubmed  publisher | 
| Corvaisier M, Zhou J, Malycheva D, Cornella N, Chioureas D, Gustafsson N, et al . The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells. Commun Biol. 2021;4:767 pubmed  publisher | 
| Chen D, Gregory A, Li X, Wei J, Burton C, Gibson G, et al . RIP3-dependent necroptosis contributes to the pathogenesis of chronic obstructive pulmonary disease. JCI Insight. 2021;6: pubmed  publisher | 
| Martens Y, Xu S, Tait R, Li G, Zhao X, Lu W, et al . Generation and validation of APOE knockout human iPSC-derived cerebral organoids. STAR Protoc. 2021;2:100571 pubmed  publisher | 
| Nieto Torres J, Shanahan S, Chassefeyre R, Chaiamarit T, Zaretski S, Landeras Bueno S, et al . LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Curr Biol. 2021;31:3440-3449.e7 pubmed  publisher | 
| Liu Y, Du M, Lin H. Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization. J Cell Mol Med. 2021;25:7690-7708 pubmed  publisher | 
| Shah A, Ratkowski M, Rosa A, Feinstein P, Bozza T. Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers. Nat Commun. 2021;12:3797 pubmed  publisher | 
| Kaufman M, Goodson N, Park K, Schwanke M, Office E, Schneider S, et al . Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity. Development. 2021;148: pubmed  publisher | 
| Xu S, Wu X, Wang P, Cao S, Peng B, Xu X. ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability. iScience. 2021;24:102534 pubmed  publisher | 
| Gažová I, Lefèvre L, Bush S, Rojo R, Hume D, Lengeling A, et al . CRISPR-Cas9 Editing of Human Histone Deubiquitinase Gene USP16 in Human Monocytic Leukemia Cell Line THP-1. Front Cell Dev Biol. 2021;9:679544 pubmed  publisher | 
| González Acosta D, Blanco Romero E, Ubieto Capella P, Mutreja K, Míguez S, Llanos S, et al . PrimPol-mediated repriming facilitates replication traverse of DNA interstrand crosslinks. EMBO J. 2021;40:e106355 pubmed  publisher | 
| Ma K, Fokkens M, Reggiori F, Mari M, Verbeek D. Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy. Transl Neurodegener. 2021;10:19 pubmed  publisher | 
| Mercer T, Ohashi Y, Boeing S, Jefferies H, De Tito S, Flynn H, et al . Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy. EMBO J. 2021;40:e105985 pubmed  publisher | 
| Bansal A, Pandey M, Barham W, Liu X, Harrington S, Lucien F, et al . Non-invasive immunoPET imaging of PD-L1 using anti-PD-L1-B11 in breast cancer and melanoma tumor model. Nucl Med Biol. 2021;100-101:4-11 pubmed  publisher | 
| Kimura H, Sada R, Takada N, Harada A, Doki Y, Eguchi H, et al . The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers. Oncogene. 2021;40:4486-4502 pubmed  publisher | 
| Dahlet T, Truss M, Frede U, Al Adhami H, Bardet A, Dumas M, et al . E2F6 initiates stable epigenetic silencing of germline genes during embryonic development. Nat Commun. 2021;12:3582 pubmed  publisher | 
| Weems J, Slaughter B, Unruh J, Weaver K, Miller B, Delventhal K, et al . A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription. J Biol Chem. 2021;297:100862 pubmed  publisher | 
| Tan K, Nähse V, Campsteijn C, Brech A, Schink K, Stenmark H. JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes. J Cell Sci. 2021;134: pubmed  publisher | 
| Xiong F, Wang R, Lee J, Li S, Chen S, Liao Z, et al . RNA m6A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability. Cell Res. 2021;31:861-885 pubmed  publisher | 
| van der Weegen Y, de Lint K, van den Heuvel D, Nakazawa Y, Mevissen T, van Schie J, et al . ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation. Nat Cell Biol. 2021;23:595-607 pubmed  publisher | 
| Xu J, Xu K, Jung S, Conte A, Lieberman J, Muecksch F, et al . Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants. Nature. 2021;595:278-282 pubmed  publisher | 
| Yao J, Wang Y, Cao C, Song R, Bi D, Zhang H, et al . CRISPR/Cas9-mediated correction of MITF homozygous point mutation in a Waardenburg syndrome 2A pig model. Mol Ther Nucleic Acids. 2021;24:986-999 pubmed  publisher | 
| Gisina A, NOVIKOVA S, Kim Y, Sidorov D, Bykasov S, Volchenko N, et al . CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells. Cancer Biomark. 2021;: pubmed  publisher | 
| Varone A, Amoruso C, Monti M, Patheja M, Greco A, Auletta L, et al . The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function. Cell Commun Signal. 2021;19:64 pubmed  publisher | 
| Wei C, Luo Q, Wang B, Long Y, Zhang M, Shan W, et al . Generation of a FTO gene knockout human embryonic stem cell line using CRISPR/Cas9 editing. Stem Cell Res. 2021;53:102362 pubmed  publisher | 
| Kato H, Maezawa Y, Ouchi Y, Takayama N, Sone M, Sone K, et al . Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome. Stem Cell Res. 2021;53:102360 pubmed  publisher | 
| Yamamoto Y, Chino H, Tsukamoto S, Ode K, Ueda H, Mizushima N. NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA. Nat Commun. 2021;12:3292 pubmed  publisher | 
| Liu R, Lee J, Li J, Yu R, Tan L, Xia Y, et al . Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. Mol Cell. 2021;81:2722-2735.e9 pubmed  publisher | 
| Ryu H, Jung Y, Lee N, Seo J, Kim S, Lee K, et al . HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation. Int J Mol Sci. 2021;22: pubmed  publisher | 
| Liedtke V, Schröder C, Roggenbuck D, Weiss R, Stohwasser R, Schierack P, et al . LEDGF/p75 Is Required for an Efficient DNA Damage Response. Int J Mol Sci. 2021;22: pubmed  publisher | 
| Ord T, Ord D, Kaikkonen M, Ord T. Pharmacological or TRIB3-Mediated Suppression of ATF4 Transcriptional Activity Promotes Hepatoma Cell Resistance to Proteasome Inhibitor Bortezomib. Cancers (Basel). 2021;13: pubmed  publisher | 
| Rook M, Miaro M, Couch T, Kneisley D, Musgaard M, MacLean D. Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1. J Gen Physiol. 2021;153: pubmed  publisher | 
| Zhao Q, Kong Y, Kittredge A, Li Y, Shen Y, Zhang Y, et al . Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations. elife. 2021;10: pubmed  publisher | 
| Torres Fernandez L, Emich J, Port Y, Mitschka S, Wöste M, Schneider S, et al . TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility. Front Cell Dev Biol. 2021;9:658966 pubmed  publisher | 
| Xuan Y, Sheng Y, Zhang D, Zhang K, Zhang Z, Ping Y, et al . Targeting CD276 by CAR-T cells induces regression of esophagus squamous cell carcinoma in xenograft mouse models. Transl Oncol. 2021;14:101138 pubmed  publisher | 
| Karnan S, Hanamura I, Ota A, Takasugi S, Nakamura A, Takahashi M, et al . CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia. Cell Death Discov. 2021;7:121 pubmed  publisher | 
| Li L, Galichon P, Xiao X, Figueroa Ramirez A, Tamayo D, Lee J, et al . Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. EMBO Rep. 2021;22:e51169 pubmed  publisher | 
| Muller I, Moroni A, Shlyueva D, Sahadevan S, Schoof E, Radzisheuskaya A, et al . MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells. Nat Commun. 2021;12:3034 pubmed  publisher | 
| Junyent S, Reeves J, Szczerkowski J, Garcin C, Trieu T, Wilson M, et al . Wnt- and glutamate-receptors orchestrate stem cell dynamics and asymmetric cell division. elife. 2021;10: pubmed  publisher | 
| Mosig R, Castaneda A, Deslauriers J, Frazier L, He K, Maghzian N, et al . Natural antisense transcript of Period2, Per2AS, regulates the amplitude of the mouse circadian clock. Genes Dev. 2021;35:899-913 pubmed  publisher | 
| Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, et al . High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts. EMBO Mol Med. 2021;13:e13579 pubmed  publisher | 
| Servetto A, Kollipara R, Formisano L, Lin C, Lee K, Sudhan D, et al . Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer. Clin Cancer Res. 2021;27:4379-4396 pubmed  publisher | 
| Ostojic J, Yoon Y, Sonntag T, Nguyen B, Vaughan J, Shokhirev M, et al . Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways. Cell Rep. 2021;35:109136 pubmed  publisher | 
| Rasmussen K, Helin K. ChIP-Sequencing of TET Proteins. Methods Mol Biol. 2021;2272:251-262 pubmed  publisher | 
| Cuello F, Knaust A, Saleem U, Loos M, Raabe J, Mosqueira D, et al . Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation. EMBO Mol Med. 2021;13:e13074 pubmed  publisher | 
| Weinberg D, Rosenbaum P, Chen X, Barrows D, Horth C, Marunde M, et al . Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands. Nat Genet. 2021;53:794-800 pubmed  publisher | 
| Wan Y, Anastasakis D, Rodriguez J, Palangat M, Gudla P, Zaki G, et al . Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and stochastic splice site selection. Cell. 2021;184:2878-2895.e20 pubmed  publisher | 
| Lee M, Shorthouse D, Mahen R, Hall B, Venkitaraman A. Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance. Nucleic Acids Res. 2021;49:5588-5604 pubmed  publisher | 
| Mylonas C, Lee C, Auld A, Cisse I, Boyer L. A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation. Nat Struct Mol Biol. 2021;28:435-442 pubmed  publisher | 
| Akbaba H, Erel Akbaba G, Senturk S. Special Focus Issue Part II: Recruitment of solid lipid nanoparticles for the delivery of CRISPR/Cas9: primary evaluation of anticancer gene editing. Nanomedicine (Lond). 2021;16:963-978 pubmed  publisher | 
| Zhang R, He H, Yuan B, Wu Z, Wang X, Du Y, et al . An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development. Neurosci Bull. 2021;37:1091-1106 pubmed  publisher | 
| Venkatesan S, Angelova M, Puttick C, Zhai H, Caswell D, Lu W, et al . Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution. Cancer Discov. 2021;: pubmed  publisher | 
| Morello G, Cancila V, La Rosa M, Germano G, Lecis D, Amodio V, et al . T Cells Expressing Receptor Recombination/Revision Machinery Are Detected in the Tumor Microenvironment and Expanded in Genomically Over-unstable Models. Cancer Immunol Res. 2021;9:825-837 pubmed  publisher | 
| Simoes Eugénio M, Faurez F, Kara Ali G, Lagarrigue M, Uhart P, Bonnet M, et al . TRIM21, a New Component of the TRAIL-Induced Endogenous Necrosome Complex. Front Mol Biosci. 2021;8:645134 pubmed  publisher | 
| Noort R, Christopher G, Esseltine J. Pannexin 1 Influences Lineage Specification of Human iPSCs. Front Cell Dev Biol. 2021;9:659397 pubmed  publisher | 
| Woodley C, Romer A, Wang J, Guarnaccia A, Elion D, Maxwell J, et al . Multiple interactions of the oncoprotein transcription factor MYC with the SWI/SNF chromatin remodeler. Oncogene. 2021;40:3593-3609 pubmed  publisher | 
| Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella J, et al . Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia. Nat Commun. 2021;12:2482 pubmed  publisher | 
| Chemello F, Chai A, Li H, Rodriguez Caycedo C, Sanchez Ortiz E, Atmanli A, et al . Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing. Sci Adv. 2021;7: pubmed  publisher | 
| Li Y, Wang Y, Du X, Zhang T, Mak H, Hancock S, et al . TMEM41B and VMP1 are scramblases and regulate the distribution of cholesterol and phosphatidylserine. J Cell Biol. 2021;220: pubmed  publisher | 
| Shi X, Wen Z, Wang Y, Liu Y, Shi K, Jiu Y. Feedback-Driven Mechanisms Between Phosphorylated Caveolin-1 and Contractile Actin Assemblies Instruct Persistent Cell Migration. Front Cell Dev Biol. 2021;9:665919 pubmed  publisher | 
| Dahou H, Minati M, Jacquemin P, Assi M. Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells. Antioxidants (Basel). 2021;10: pubmed  publisher | 
| Nagaraj S, Want A, Laskowska Kaszub K, Fesiuk A, Vaz S, Logarinho E, et al . Candidate Alzheimer's Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression. Int J Mol Sci. 2021;22: pubmed  publisher | 
| Grochowska M, Carreras Mascaro A, Boumeester V, Natale D, Breedveld G, Geut H, et al . LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and dementia with Lewy bodies. Acta Neuropathol. 2021;142:117-137 pubmed  publisher | 
| Lin Y, Liang Y, Wang H, Tung L, Forster M, Subramani P, et al . Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1. Front Immunol. 2021;12:626418 pubmed  publisher | 
| Thrun A, Garzia A, Kigoshi Tansho Y, Patil P, Umbaugh C, Dallinger T, et al . Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing. Mol Cell. 2021;81:2112-2122.e7 pubmed  publisher | 
| Dannenmann B, Klimiankou M, Oswald B, Solovyeva A, Mardan J, Nasri M, et al . iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia. Cell Stem Cell. 2021;28:906-922.e6 pubmed  publisher | 
| Barger C, Chee L, Albahrani M, Munoz Trujillo C, Boghean L, Branick C, et al . Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer. elife. 2021;10: pubmed  publisher | 
| Formosa L, Reljic B, Sharpe A, Hock D, Muellner Wong L, Stroud D, et al . Optic atrophy-associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I. Proc Natl Acad Sci U S A. 2021;118: pubmed  publisher | 
| Rivera O, Mallory M, Quesnel Vallieres M, Chatrikhi R, Schultz D, Carroll M, et al . Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2021;118: pubmed  publisher | 
| Low H, Wong Z, Wu B, Kong L, Png C, Cho Y, et al . DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death. Nat Commun. 2021;12:2284 pubmed  publisher | 
| Simoneschi D, Róna G, Zhou N, Jeong Y, Jiang S, Milletti G, et al . CRL4AMBRA1 is a master regulator of D-type cyclins. Nature. 2021;592:789-793 pubmed  publisher | 
| Wang M, Liu J, Tu Y, Zhao Z, Qu J, Chen K, et al . RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to downregulation of ERK signaling. J Biol Chem. 2021;296:100109 pubmed  publisher | 
| Fayad R, Rojas M, Partisani M, Finetti P, Dib S, Abélanet S, et al . EFA6B regulates a stop signal for collective invasion in breast cancer. Nat Commun. 2021;12:2198 pubmed  publisher | 
| Lester E, Ooi F, Bakkar N, Ayers J, Woerman A, Wheeler J, et al . Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. 2021;109:1675-1691.e9 pubmed  publisher | 
| Mehta G, Angus S, Khella C, Tong K, Khanna P, Dixon S, et al . SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2. NPJ Breast Cancer. 2021;7:40 pubmed  publisher | 
| Tran D, Kesavan R, Rion H, Soflaee M, Solmonson A, Bezwada D, et al . Mitochondrial NADP+ is essential for proline biosynthesis during cell growth. Nat Metab. 2021;3:571-585 pubmed  publisher | 
| Gu Z, Liu Y, Zhang Y, Cao H, Lyu J, Wang X, et al . Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia. Nat Genet. 2021;53:672-682 pubmed  publisher | 
| Aoto K, Kato M, Akita T, Nakashima M, Mutoh H, Akasaka N, et al . ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice. Nat Commun. 2021;12:2107 pubmed  publisher | 
| Day K, Kago G, Wang L, Richter J, Hayden C, Lafer E, et al . Liquid-like protein interactions catalyse assembly of endocytic vesicles. Nat Cell Biol. 2021;23:366-376 pubmed  publisher | 
| Ho K, Luo H, Zhu W, Tang Y. Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress. Sci Rep. 2021;11:7502 pubmed  publisher | 
| Wang W, Liu P, Lavrijsen M, Li S, Zhang R, Li S, et al . Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines. Sci Rep. 2021;11:7470 pubmed  publisher | 
| Meira W, Daher B, Parks S, Cormerais Y, Durivault J, Tambutte E, et al . A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCTKO Pancreatic Ductal Adenocarcinoma Cells. Cancers (Basel). 2021;13: pubmed  publisher | 
| Pellanda P, Dalsass M, Filipuzzi M, Loffreda A, Verrecchia A, Castillo Cano V, et al . Integrated requirement of non-specific and sequence-specific DNA binding in Myc-driven transcription. EMBO J. 2021;40:e105464 pubmed  publisher | 
| Cho E, Lou H, Kuruvilla L, Calderwood D, Turk B. PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK. Cell Rep. 2021;34:108928 pubmed  publisher | 
| Gowrishankar S, Lyons L, Rafiq N, Roczniak Ferguson A, De Camilli P, Ferguson S. Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons. Mol Biol Cell. 2021;32:1094-1103 pubmed  publisher | 
| Nguyen T, Padman B, Zellner S, Khuu G, Uoselis L, Lam W, et al . ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system. Mol Cell. 2021;81:2013-2030.e9 pubmed  publisher | 
| Ahmed R, Sarwar S, Hu J, Cardin V, Qiu L, Zapata G, et al . Transgenic mice with an R342X mutation in Phf6 display clinical features of Börjeson-Forssman-Lehmann Syndrome. Hum Mol Genet. 2021;30:575-594 pubmed  publisher | 
| Okawa F, Hama Y, Zhang S, Morishita H, Yamamoto H, Levine T, et al . Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1. J Cell Sci. 2021;134: pubmed  publisher | 
| Macrae T, Ramalho Santos M. The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development. Nat Commun. 2021;12:1865 pubmed  publisher | 
| Benito Kwiecinski S, Giandomenico S, Sutcliffe M, Riis E, Freire Pritchett P, Kelava I, et al . An early cell shape transition drives evolutionary expansion of the human forebrain. Cell. 2021;184:2084-2102.e19 pubmed  publisher | 
| Vogel C, Lazennec G, Kado S, Dahlem C, He Y, Castañeda A, et al . Targeting the Aryl Hydrocarbon Receptor Signaling Pathway in Breast Cancer Development. Front Immunol. 2021;12:625346 pubmed  publisher | 
| Burckhardt C, Minna J, Danuser G. SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt. Dev Cell. 2021;56:1164-1181.e12 pubmed  publisher | 
| Villa E, Sahu U, O Hara B, Ali E, Helmin K, Asara J, et al . mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. Mol Cell. 2021;81:2076-2093.e9 pubmed  publisher | 
| Westervelt N, Yoest A, Sayed S, Von Zimmerman M, Kaps K, Chadwick B. Deletion of the XIST promoter from the human inactive X chromosome compromises polycomb heterochromatin maintenance. Chromosoma. 2021;: pubmed  publisher | 
| Owa M, DYNLACHT B. A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division. Commun Biol. 2021;4:358 pubmed  publisher | 
| Kulsuptrakul J, Wang R, Meyers N, Ott M, Puschnik A. A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection. Cell Rep. 2021;34:108859 pubmed  publisher | 
| Zhang X, Wang X, Yuan Z, Radford S, Liu C, Libutti S, et al . Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis. Cell Rep. 2021;34:108830 pubmed  publisher | 
| Fernandez Vizarra E, López Calcerrada S, Formosa L, Pérez Pérez R, Ding S, Fearnley I, et al . SILAC-based complexome profiling dissects the structural organization of the human respiratory supercomplexes in SCAFIKO cells. Biochim Biophys Acta Bioenerg. 2021;1862:148414 pubmed  publisher | 
| Fan H, Lee K, Chen Y, Lin L, Yang T, Lin S, et al . Wdhd1 is essential for early mouse embryogenesis. Biochim Biophys Acta Mol Cell Res. 2021;1868:119011 pubmed  publisher | 
| Baxley R, Leung W, Schmit M, Matson J, Yin L, Oram M, et al . Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening. Nat Commun. 2021;12:1626 pubmed  publisher | 
| Sanchez Vazquez R, Martinez P, Blasco M. AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. PLoS Genet. 2021;17:e1009410 pubmed  publisher | 
| Bartoschek M, Ugur E, Nguyen T, Rodschinka G, Wierer M, Lang K, et al . Identification of permissive amber suppression sites for efficient non-canonical amino acid incorporation in mammalian cells. Nucleic Acids Res. 2021;49:e62 pubmed  publisher | 
| Dorrington M, Bradfield C, Lack J, Lin B, Liang J, Starr T, et al . Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol. PLoS Pathog. 2021;17:e1009395 pubmed  publisher | 
| Du R, Sullivan D, Azizian N, Liu Y, Li Y. Inhibition of ERAD synergizes with FTS to eradicate pancreatic cancer cells. BMC Cancer. 2021;21:237 pubmed  publisher | 
| Zhang X, SABIO E, Krishna C, Ma X, Wang J, Jiang H, et al . Qa-1b Modulates Resistance to Anti-PD-1 Immune Checkpoint Blockade in Tumors with Defects in Antigen Processing. Mol Cancer Res. 2021;19:1076-1084 pubmed  publisher | 
| Song H, Yang Y, Chien Y, Lai W, Lin Y, Chou S, et al . Reversal of the Inflammatory Responses in Fabry Patient iPSC-Derived Cardiovascular Endothelial Cells by CRISPR/Cas9-Corrected Mutation. Int J Mol Sci. 2021;22: pubmed  publisher | 
| Di Stazio M, Foschi N, Athanasakis E, Gasparini P, d Adamo A. Systematic analysis of factors that improve homologous direct repair (HDR) efficiency in CRISPR/Cas9 technique. PLoS ONE. 2021;16:e0247603 pubmed  publisher | 
| Azami Y, Tsuyama N, Abe Y, Sugai Takahashi M, Kudo K, Ota A, et al . Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells. Sci Rep. 2021;11:5216 pubmed  publisher | 
| Emrich S, Yoast R, Xin P, Arige V, Wagner L, Hempel N, et al . Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling. Cell Rep. 2021;34:108760 pubmed  publisher | 
| Berthelsen M, Leknes S, Riedel M, Pedersen M, Joseph J, Hager H, et al . Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9. Cancers (Basel). 2021;13: pubmed  publisher | 
| Zhu S, Ding W, Chen Y, Wang W, Xu R, Liu C, et al . High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells. Genomics Proteomics Bioinformatics. 2021;: pubmed  publisher | 
| Alambeladi S, Hosseiny S, Jafarinia M, Dianatpour M. Use of dual-transfection for programmed death cell protein 1 disruption mediated by CRISPR-Cas9 in human peripheral blood mononuclear cells. Iran J Basic Med Sci. 2021;24:44-50 pubmed  publisher | 
| Nair Gill E, Bonora M, Zhong X, Liu A, Miranda A, Stewart N, et al . Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence and lymphoproliferative diseases. EMBO J. 2021;40:e104888 pubmed  publisher | 
| Tigano M, Vargas D, Tremblay Belzile S, Fu Y, Sfeir A. Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance. Nature. 2021;591:477-481 pubmed  publisher | 
| Milewski D, Shukla S, Gryder B, Pradhan A, Donovan J, Sudha P, et al . FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma. Oncogene. 2021;40:2182-2199 pubmed  publisher | 
| Bloemberg D, Sosa Miranda C, Nguyen T, Weeratna R, McComb S. Self-Cutting and Integrating CRISPR Plasmids Enable Targeted Genomic Integration of Genetic Payloads for Rapid Cell Engineering. CRISPR J. 2021;4:104-119 pubmed  publisher | 
| Krall A, Mullen P, Surjono F, Momcilovic M, Schmid E, Halbrook C, et al . Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metab. 2021;33:1013-1026.e6 pubmed  publisher | 
| Augereau A, Mariotti M, Pousse M, Filipponi D, Libert F, Beck B, et al . Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen. Sci Adv. 2021;7: pubmed  publisher | 
| Omarjee O, Mathieu A, Quiniou G, Moreews M, Ainouze M, Frachette C, et al . LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages. J Exp Med. 2021;218: pubmed  publisher | 
| Naetar N, Georgiou K, Knapp C, Bronshtein I, Zier E, Fichtinger P, et al . LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior. elife. 2021;10: pubmed  publisher | 
| Liu Q, Chen X, Novak M, Zhang S, Hu W. Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs. elife. 2021;10: pubmed  publisher | 
| Li M, Soder R, Abhyankar S, Abdelhakim H, Braun M, Trinidad C, et al . WJMSC-derived small extracellular vesicle enhance T cell suppression through PD-L1. J Extracell Vesicles. 2021;10:e12067 pubmed  publisher | 
| Sinha A, Fan V, Ramakrishnan A, Engelhardt N, KENNELL J, Cadigan K. Repression of Wnt/β-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2. Sci Adv. 2021;7: pubmed  publisher | 
| Perrin Cocon L, Vidalain P, Jacquemin C, Aublin Gex A, Olmstead K, Panthu B, et al . A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity. Commun Biol. 2021;4:217 pubmed  publisher | 
| Mann N, Mzoughi S, Schneider R, Kühl S, Schanze D, Klämbt V, et al . Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome. J Am Soc Nephrol. 2021;32:580-596 pubmed  publisher | 
| Srivastava S, Sahu U, Zhou Y, Hogan A, Sathyan K, Bodner J, et al . NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia. Sci Adv. 2021;7: pubmed  publisher | 
| Maglitto A, Mariani S, de Pater E, Rodríguez Seoane C, Vink C, Piao X, et al . Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation. Blood Adv. 2021;5:829-842 pubmed  publisher | 
| Girbig M, Misiaszek A, Vorländer M, Lafita A, Grötsch H, Baudin F, et al . Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Nat Struct Mol Biol. 2021;28:210-219 pubmed  publisher | 
| Hakala M, Wioland H, Tolonen M, Kotila T, Jégou A, Romet Lemonne G, et al . Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks. Nat Cell Biol. 2021;23:147-159 pubmed  publisher | 
| Brandel A, Aigal S, Lagies S, Schlimpert M, Meléndez A, Xu M, et al . The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa. Cell Mol Life Sci. 2021;78:3637-3656 pubmed  publisher | 
| Fan X, Masamsetti V, Sun J, Engholm Keller K, Osteil P, Studdert J, et al . TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. elife. 2021;10: pubmed  publisher | 
| Kim T, Piao J, Koo S, Kriks S, Chung S, Betel D, et al . Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell Stem Cell. 2021;28:343-355.e5 pubmed  publisher | 
| Geusz R, Wang A, Chiou J, Lancman J, Wetton N, Kefalopoulou S, et al . Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. elife. 2021;10: pubmed  publisher | 
| Dolskiy A, Bodnev S, Nazarenko A, Smirnova A, Pyankova O, Matveeva A, et al . Deletion of BST2 Cytoplasmic and Transmembrane N-Terminal Domains Results in SARS-CoV, SARS-CoV-2, and Influenza Virus Production Suppression in a Vero Cell Line. Front Mol Biosci. 2020;7:616798 pubmed  publisher | 
| Zhu S, Chen W, Wang J, Qi L, Pan H, Feng Z, et al . SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing. Theranostics. 2021;11:3359-3375 pubmed  publisher | 
| Alonso Curbelo D, Ho Y, Burdziak C, Mååg J, Morris J, Chandwani R, et al . A gene-environment-induced epigenetic program initiates tumorigenesis. Nature. 2021;: pubmed  publisher | 
| Simpson C, Tokito M, Uppala R, Sarkar M, Gudjonsson J, Holzbaur E. NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation. Cell Rep. 2021;34:108689 pubmed  publisher | 
| Mueller A, Piper M, Goodspeed A, Bhuvane S, Williams J, Bhatia S, et al . Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer. Cancer Res. 2021;81:3255-3269 pubmed  publisher | 
| Masalmeh R, Taglini F, Rubio Ramon C, Musialik K, Higham J, Davidson Smith H, et al . De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands. Nat Commun. 2021;12:694 pubmed  publisher | 
| Kamali E, Rahbarizadeh F, Hojati Z, Frodin M. CRISPR/Cas9-mediated knockout of clinically relevant alloantigenes in human primary T cells. BMC Biotechnol. 2021;21:9 pubmed  publisher | 
| Ortiz Cordero C, Magli A, Dhoke N, Kuebler T, Selvaraj S, Oliveira N, et al . NAD+ enhances ribitol and ribose rescue of α-dystroglycan functional glycosylation in human FKRP-mutant myotubes. elife. 2021;10: pubmed  publisher | 
| Zheng C, Hu Y, Sakurai M, Pinzon Arteaga C, Li J, Wei Y, et al . Cell Competition Constitutes a Barrier for Interspecies Chimerism. Nature. 2021;: pubmed  publisher | 
| Suzuki T, Katada E, Mizuoka Y, Takagi S, Kazuki Y, Oshimura M, et al . A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing. Nucleic Acids Res. 2021;: pubmed  publisher | 
| Alizada A, Khyzha N, Wang L, Antounians L, Chen X, Khor M, et al . Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals. Nat Commun. 2021;12:567 pubmed  publisher | 
| Papa G, Mallery D, Albecka A, Welch L, Cattin Ortolá J, Lupták J, et al . Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion. PLoS Pathog. 2021;17:e1009246 pubmed  publisher | 
| Kressler C, Gasparoni G, Nordstrom K, Hamo D, Salhab A, Dimitropoulos C, et al . Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype. Front Immunol. 2020;11:609891 pubmed  publisher | 
| Zhang Y, Sun Y, Zhang Y, Miao Q, Wang Q, Yang B, et al . Nuclear factor Y participates in alcoholic liver disease by activating SREBP1 expression in mice. Biochem Biophys Res Commun. 2021;541:90-94 pubmed  publisher | 
| Unsicker C, Cristian F, von Hahn M, Eckstein V, Rappold G, Berkel S. SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differentiation in SH-SY5Y cells. Sci Rep. 2021;11:2128 pubmed  publisher | 
| Harris E, Zimmerman D, Warga E, Bamezai A, Elmer J. Nonviral gene delivery to T cells with Lipofectamine LTX. Biotechnol Bioeng. 2021;118:1693-1706 pubmed  publisher | 
| Han Y, Zhang J, Lee J, Mason J, Karginova O, Yoshimatsu T, et al . The BRCA1 Pseudogene Negatively Regulates Anti-Tumor Responses through Inhibition of Innate Immune Defense Mechanisms. Cancer Res. 2021;: pubmed  publisher | 
| Liu S, Liao Y, Chen B, Chen Y, Yu Z, Wei H, et al . Critical role of Syk-dependent STAT1 activation in innate antiviral immunity. Cell Rep. 2021;34:108627 pubmed  publisher | 
| Hao M, Yeo S, Turner K, Harold A, Yang Y, Zhang X, et al . Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles. Dev Cell. 2021;56:341-355.e5 pubmed  publisher | 
| Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, et al . Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death. Autophagy. 2021;:1-20 pubmed  publisher | 
| Challagulla A, Jenkins K, O Neil T, Shi S, Morris K, Wise T, et al . In Vivo Inhibition of Marek's Disease Virus in Transgenic Chickens Expressing Cas9 and gRNA against ICP4. Microorganisms. 2021;9: pubmed  publisher | 
| Mohamud Y, Xue Y, Liu H, Ng C, Bahreyni A, Jan E, et al . The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy. Biochem Biophys Res Commun. 2021;540:75-82 pubmed  publisher | 
| Roliński M, Montaldo N, Aksu M, Fordyce Martin S, Brambilla A, Kunath N, et al . Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation. Nucleic Acids Res. 2021;: pubmed  publisher | 
| Ji Z, Li Y, Liu S, Sharrocks A. The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation. Nucleic Acids Res. 2021;49:1345-1363 pubmed  publisher | 
| Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, et al . Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells. Nat Protoc. 2021;16:919-936 pubmed  publisher | 
| Tsyklauri O, Niederlova V, Forsythe E, Prasai A, Drobek A, Kaspárek P, et al . Bardet-Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance. EMBO Rep. 2021;22:e50785 pubmed  publisher | 
| Harland L, Simon C, Senft A, Costello I, Greder L, Imaz Rosshandler I, et al . The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors. Nat Cell Biol. 2021;23:61-74 pubmed  publisher | 
| Jung H, Lee K, Choi J. Comprehensive characterisation of intronic mis-splicing mutations in human cancers. Oncogene. 2021;40:1347-1361 pubmed  publisher | 
| Hou G, Harley I, Lu X, Zhou T, Xu N, Yao C, et al . SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression. Nat Commun. 2021;12:135 pubmed  publisher | 
| Gori I, George R, Purkiss A, Strohbuecker S, Randall R, Ogrodowicz R, et al . Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization. elife. 2021;10: pubmed  publisher | 
| Berg J, Perfler B, Hatzl S, Mayer M, Wurm S, Uhl B, et al . Micro-RNA-125a mediates the effects of hypomethylating agents in chronic myelomonocytic leukemia. Clin Epigenetics. 2021;13:1 pubmed  publisher | 
| Wu J, Zhao K, Du Z, Chen Y, Zhang F, Jiang W, et al . Systemic effect of FHL1 on neuromuscular junction and myotube formation via insulin-like growth factor and myostatin signaling pathways. Biochem Biophys Res Commun. 2021;537:125-131 pubmed  publisher | 
| Ho R, Workman M, Mathkar P, Wu K, Kim K, O Rourke J, et al . Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures. Cell Syst. 2021;12:159-175.e9 pubmed  publisher | 
| Alberts A, Klingberg A, Hoffmeister L, Wessig A, Brand K, Pich A, et al . Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures. Front Immunol. 2020;11:596103 pubmed  publisher | 
| Jia X, Burugula B, Chen V, Lemons R, Jayakody S, Maksutova M, et al . Massively parallel functional testing of MSH2 missense variants conferring Lynch syndrome risk. Am J Hum Genet. 2021;108:163-175 pubmed  publisher | 
| Cui H, Kapur M, Diedrich J, Iii J, Ackerman S, Schimmel P. Regulation of ex-translational activities is the primary function of the multi-tRNA synthetase complex. Nucleic Acids Res. 2020;: pubmed  publisher | 
| Guan J, Lu C, Jin Q, Lu H, Chen X, Tian L, et al . MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway. Cancer Cell. 2021;39:109-121.e5 pubmed  publisher | 
| Wang R, Simoneau C, Kulsuptrakul J, Bouhaddou M, Travisano K, Hayashi J, et al . Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses. Cell. 2021;184:106-119.e14 pubmed  publisher | 
| Hewitt G, Borel V, Segura Bayona S, Takaki T, Ruis P, Bellelli R, et al . Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD. Mol Cell. 2020;: pubmed  publisher | 
| Lin S, Wu H, Yeh L, Yang C, Kao S, Chang K. Activation of the miR-371/372/373 miRNA Cluster Enhances Oncogenicity and Drug Resistance in Oral Carcinoma Cells. Int J Mol Sci. 2020;21: pubmed  publisher | 
| Gally F, Sasse S, Kurche J, Gruca M, Cardwell J, Okamoto T, et al . The MUC5B-associated variant rs35705950 resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling. JCI Insight. 2021;6: pubmed  publisher | 
| Apelt K, White S, Kim H, Yeo J, Kragten A, Wondergem A, et al . ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients. J Exp Med. 2021;218: pubmed  publisher | 
| Guibentif C, Griffiths J, Imaz Rosshandler I, Ghazanfar S, Nichols J, Wilson V, et al . Diverse Routes toward Early Somites in the Mouse Embryo. Dev Cell. 2021;56:141-153.e6 pubmed  publisher | 
| Sun X, Hou W, Liu X, Chai J, Guo H, Yu J. Targeting REV7 effectively reverses 5-FU and oxaliplatin resistance in colorectal cancer. Cancer Cell Int. 2020;20:580 pubmed  publisher | 
| Huang T, Fang L, He R, Weng H, Chen X, Ye Q, et al . Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels. Aging (Albany NY). 2020;13:77-88 pubmed  publisher | 
| Suzuki R, Murata M, Manguso N, Watanabe T, Mouakkad Montoya L, Igari F, et al . The fragility of a structurally diverse duplication block triggers recurrent genomic amplification. Nucleic Acids Res. 2021;49:244-256 pubmed  publisher | 
| Inderbitzin A, Kok Y, Jörimann L, Kelley A, Neumann K, Heinzer D, et al . HIV-1 promoter is gradually silenced when integrated into BACH2 in Jurkat T-cells. Peerj. 2020;8:e10321 pubmed  publisher | 
| Sreenivasan L, Wang H, Yap S, Leclair P, Tam A, Lim C. Autocrine IL-6/STAT3 signaling aids development of acquired drug resistance in Group 3 medulloblastoma. Cell Death Dis. 2020;11:1035 pubmed  publisher | 
| Ucuncu E, Rajamani K, Wilson M, Medina Cano D, Altin N, David P, et al . MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia. Nat Commun. 2020;11:6087 pubmed  publisher | 
| Ho H, Bigliardi P, Stelmashenko O, Ramasamy S, Postlethwaite M, Bigliardi Qi M. Functionally expressed bitter taste receptor TAS2R14 in human epidermal keratinocytes serves as a chemosensory receptor. Exp Dermatol. 2021;30:216-225 pubmed  publisher | 
| Canals Hernaez D, Hughes M, Dean P, Bergqvist P, Samudio I, Blixt O, et al . PODO447: a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin. J Immunother Cancer. 2020;8: pubmed  publisher | 
| Mulholland C, Nishiyama A, Ryan J, Nakamura R, Yiğit M, Glück I, et al . Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nat Commun. 2020;11:5972 pubmed  publisher | 
| Keren Kaplan T, Bonifacino J. ARL8 Relieves SKIP Autoinhibition to Enable Coupling of Lysosomes to Kinesin-1. Curr Biol. 2021;31:540-554.e5 pubmed  publisher | 
| Harutyunyan A, Chen H, Lu T, Horth C, Nikbakht H, Krug B, et al . H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation. Cell Rep. 2020;33:108390 pubmed  publisher | 
| Ma H, Jeppesen J, Jaenisch R. Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction. Cell Rep Med. 2020;1:100097 pubmed  publisher | 
| Knyazeva A, Khudiakov A, Vaz R, Muravyev A, Sukhareva K, Sejersen T, et al . FLNC Expression Level Influences the Activity of TEAD-YAP/TAZ Signaling. Genes (Basel). 2020;11: pubmed  publisher | 
| Chua X, Aballo T, Elnemer W, Tran M, Salomon A. Quantitative Interactomics of Lck-TurboID in Living Human T Cells Unveils T Cell Receptor Stimulation-Induced Proximal Lck Interactors. J Proteome Res. 2021;20:715-726 pubmed  publisher | 
| Han J, LaVigne C, Jones B, Zhang H, Gillett F, Mendell J. A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming. Science. 2020;370: pubmed  publisher | 
| Buffet A, Zhang J, Rebel H, Corssmit E, Jansen J, Hensen E, et al . Germline DLST Variants Promote Epigenetic Modifications in Pheochromocytoma-Paraganglioma. J Clin Endocrinol Metab. 2021;106:459-471 pubmed  publisher | 
| Pattabiraman S, Azad G, Amen T, Brielle S, Park J, Sze S, et al . Vimentin protects differentiating stem cells from stress. Sci Rep. 2020;10:19525 pubmed  publisher | 
| Nemeth J, Schundner A, Quast K, Winkelmann V, Frick M. A Novel Fibroblast Reporter Cell Line for in vitro Studies of Pulmonary Fibrosis. Front Physiol. 2020;11:567675 pubmed  publisher | 
| Kong H, Reczek C, McElroy G, Steinert E, Wang T, Sabatini D, et al . Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species. Sci Adv. 2020;6: pubmed  publisher | 
| Fan H, Lu J, Guo Y, Li D, Zhang Z, Tsai Y, et al . BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nat Genet. 2020;52:1384-1396 pubmed  publisher | 
| Wang X, Hayes J, Xu X, Gao X, Mehta D, Lilja H, et al . Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing. Gene. 2021;768:145265 pubmed  publisher | 
| Sakamoto H, Yamasaki T, Sumiyoshi T, Takeda M, Shibasaki N, Utsunomiya N, et al . Functional and genomic characterization of patient-derived xenograft model to study the adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma. Cancer Med. 2021;10:119-134 pubmed  publisher | 
| Nath A, Oak A, Chen K, Li I, Splichal R, Portis J, et al . Palmitate-Induced IRE1-XBP1-ZEB Signaling Represses Desmoplakin Expression and Promotes Cancer Cell Migration. Mol Cancer Res. 2021;19:240-248 pubmed  publisher | 
| Sreevalsan S, Döring M, Paszkowski Rogacz M, Brux M, Blanck C, Meyer M, et al . MLLT6 maintains PD-L1 expression and mediates tumor immune resistance. EMBO Rep. 2020;:e50155 pubmed  publisher | 
| Møller T, Pedersen M, van Senten J, Seiersen S, Mathiesen J, Bouvier M, et al . Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells. Sci Rep. 2020;10:17395 pubmed  publisher | 
| Sarangi P, Clairmont C, Galli L, Moreau L, D Andrea A. p31comet promotes homologous recombination by inactivating REV7 through the TRIP13 ATPase. Proc Natl Acad Sci U S A. 2020;117:26795-26803 pubmed  publisher | 
| Shi X, Fan C, Jiu Y. Unidirectional Regulation of Vimentin Intermediate Filaments to Caveolin-1. Int J Mol Sci. 2020;21: pubmed  publisher | 
| Fedele C, Li S, Teng K, Foster C, Peng D, Ran H, et al . SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling. J Exp Med. 2021;218: pubmed  publisher | 
| Shinozawa T, Kimura M, Cai Y, Saiki N, Yoneyama Y, Ouchi R, et al . High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids. Gastroenterology. 2021;160:831-846.e10 pubmed  publisher | 
| Kwon S, Jang H, Shen S, Baek S, Kim K, Yang J, et al . ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8. Nucleic Acids Res. 2020;48:11097-11112 pubmed  publisher | 
| Liu B, Liu Z, Chen S, Ki M, Erickson C, Reis Filho J, et al . Mutant SF3B1 promotes AKT- and NF-κB-driven mammary tumorigenesis. J Clin Invest. 2021;131: pubmed  publisher | 
| Kok Y, Guerrero Llobet S, Schoonen P, Everts M, Bhattacharya A, Fehrmann R, et al . Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors. Oncogenesis. 2020;9:88 pubmed  publisher | 
| Brinck Andersen N, Jørgensen S, Skipper K, Larsen S, Heinz J, Thomsen M, et al . Essential role of autophagy in restricting poliovirus infection revealed by identification of an ATG7 defect in a poliomyelitis patient. Autophagy. 2020;:1-16 pubmed  publisher | 
| Guo L, Cui C, Wang J, Yuan J, Yang Q, Zhang P, et al . PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth. Nat Commun. 2020;11:4913 pubmed  publisher | 
| Tishchenko A, Azorín D, Vidal Brime L, Muñoz M, Arenas P, Pearce C, et al . Cx43 and Associated Cell Signaling Pathways Regulate Tunneling Nanotubes in Breast Cancer Cells. Cancers (Basel). 2020;12: pubmed  publisher | 
| Zhang H, Zhang Y, Zhou X, Wright S, Hyle J, Zhao L, et al . Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen. elife. 2020;9: pubmed  publisher | 
| Quagliano A, Gopalakrishnapillai A, Kolb E, Barwe S. CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia. Blood Adv. 2020;4:4393-4405 pubmed  publisher | 
| Levitas A, Muhammad E, Zhang Y, Perea Gil I, Serrano R, Diaz N, et al . A Novel Recessive Mutation in SPEG Causes Early Onset Dilated Cardiomyopathy. PLoS Genet. 2020;16:e1009000 pubmed  publisher | 
| Fox S, Myers J, Davidson C, Getman M, Kingsley P, Frankiewicz N, et al . Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function. Nat Commun. 2020;11:4544 pubmed  publisher | 
| Chen F, Zhang W, Xie D, Gao T, Dong Z, Lu X. Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters. Nucleic Acids Res. 2020;48:10211-10225 pubmed  publisher | 
| Galdos F, Darsha A, Paige S, Wu S. Purification of Pluripotent Stem Cell-Derived Cardiomyocytes Using CRISPR/Cas9-Mediated Integration of Fluorescent Reporters. Methods Mol Biol. 2021;2158:223-240 pubmed  publisher | 
| Shi H, Tao T, Abraham B, Durbin A, Zimmerman M, Kadoch C, et al . ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression. Sci Adv. 2020;6:eaaz3440 pubmed  publisher | 
| Lee M, Yun S, Lee B, Jeong E, Yoon G, Kim K, et al . Association of TIM-3 expression with glucose metabolism in Jurkat T cells. BMC Immunol. 2020;21:48 pubmed  publisher | 
| Lv L, Chen P, Cao L, Li Y, Zeng Z, Cui Y, et al . Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. elife. 2020;9: pubmed  publisher | 
| Staal J, Driege Y, Haegman M, Kreike M, Iliaki S, Vanneste D, et al . Defining the combinatorial space of PKC::CARD-CC signal transduction nodes. FEBS J. 2021;288:1630-1647 pubmed  publisher | 
| Nur Patria Y, Stenta T, Lilianty J, Rowley L, Stanley E, Elefanty A, et al . CRISPR/Cas9 gene editing of a SOX9 reporter human iPSC line to produce two TRPV4 patient heterozygous missense mutant iPSC lines, MCRIi001-A-3 (TRPV4 p.F273L) and MCRIi001-A-4 (TRPV4 p.P799L). Stem Cell Res. 2020;48:101942 pubmed  publisher | 
| Sato T, Ishihara S, Marui R, Takagi J, Katagiri K. Dissection of α4β7 integrin regulation by Rap1 using novel conformation-specific monoclonal anti-β7 antibodies. Sci Rep. 2020;10:13221 pubmed  publisher | 
| Prasai A, Schmidt Cernohorska M, Ruppova K, Niederlova V, Andelova M, Dráber P, et al . The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cells. J Biol Chem. 2020;295:14279-14290 pubmed  publisher | 
| Blayney J, Foster E, Jagielowicz M, Kreuzer M, Morotti M, Reglinski K, et al . Unexpectedly High Levels of Inverted Re-Insertions Using Paired sgRNAs for Genomic Deletions. Methods Protoc. 2020;3: pubmed  publisher | 
| Diem K, Fauler M, Fois G, Hellmann A, Winokurow N, Schumacher S, et al . Mechanical stretch activates piezo1 in caveolae of alveolar type I cells to trigger ATP release and paracrine stimulation of surfactant secretion from alveolar type II cells. FASEB J. 2020;34:12785-12804 pubmed  publisher | 
| Zhang K, Chooi W, Liu S, Chin J, Murray A, Nizetic D, et al . Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering. Biomaterials. 2020;256:120225 pubmed  publisher | 
| Lerner T, Kluesner M, Tasakis R, Moriarity B, Papavasiliou F, Pecori R. C-to-U RNA Editing: From Computational Detection to Experimental Validation. Methods Mol Biol. 2021;2181:51-67 pubmed  publisher | 
| Feyen D, McKeithan W, Bruyneel A, Spiering S, Hörmann L, Ulmer B, et al . Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. Cell Rep. 2020;32:107925 pubmed  publisher | 
| Butt L, Unnersjö Jess D, Höhne M, EDWARDS A, Binz Lotter J, Reilly D, et al . A molecular mechanism explaining albuminuria in kidney disease. Nat Metab. 2020;2:461-474 pubmed  publisher | 
| Jiménez Gutiérrez G, Mondragón González R, Soto Ponce L, Gómez Monsiváis W, García Aguirre I, Pacheco Rivera R, et al . Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability. Int J Mol Sci. 2020;21: pubmed  publisher | 
| Qi Y, Liu J, Chao J, Greer P, Li S. PTEN dephosphorylates Abi1 to promote epithelial morphogenesis. J Cell Biol. 2020;219: pubmed  publisher | 
| Löber J, Hitzing C, Münchhalfen M, Engels N. Vav family proteins constitute disparate branching points for distinct BCR signaling pathways. Eur J Immunol. 2020;: pubmed  publisher | 
| Bandaru S, Tsuji M, Shimizu Y, Usami K, Lee S, Takei N, et al . Structure-based design of gRNA for Cas13. Sci Rep. 2020;10:11610 pubmed  publisher | 
| Yin Q, Jian Y, Xu M, Huang X, Wang N, Liu Z, et al . CDK4/6 regulate lysosome biogenesis through TFEB/TFE3. J Cell Biol. 2020;219: pubmed  publisher | 
| Morrison E, Wegner T, Zucchetti A, Alvaro Benito M, Zheng A, Kliche S, et al . Dynamic palmitoylation events following T-cell receptor signaling. Commun Biol. 2020;3:368 pubmed  publisher | 
| Shrestha A, Bruckmueller H, Kildalsen H, Kaur G, Gaestel M, Wetting H, et al . Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38MAPK-MK2 axis and affects NF-κB-mediated transcription. Sci Rep. 2020;10:11388 pubmed  publisher | 
| Brannvoll A, Xue X, Kwon Y, Kompocholi S, Simonsen A, Viswalingam K, et al . The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells. Cell Rep. 2020;32:107849 pubmed  publisher | 
| Inde Z, Forcina G, Denton K, Dixon S. Kinetic Heterogeneity of Cancer Cell Fractional Killing. Cell Rep. 2020;32:107845 pubmed  publisher | 
| Ikeda M, Taniguchi Ikeda M, Kato T, Shinkai Y, Tanaka S, Hagiwara H, et al . Unexpected Mutations by CRISPR-Cas9 CTG Repeat Excision in Myotonic Dystrophy and Use of CRISPR Interference as an Alternative Approach. Mol Ther Methods Clin Dev. 2020;18:131-144 pubmed  publisher | 
| Rusilowicz Jones E, Jardine J, Kallinos A, Pinto Fernandez A, Guenther F, Giurrandino M, et al . USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation. Life Sci Alliance. 2020;3: pubmed  publisher | 
| Osei Amponsa V, Sridharan V, Tandon M, Evans C, Klarmann K, Cheng K, et al . Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity. Mol Cell Biol. 2020;: pubmed  publisher | 
| Busse D, Habgood Coote D, Clare S, Brandt C, Bassano I, Kaforou M, et al . Interferon-induced Protein-44 and Interferon-induced Protein 44-like restrict replication of Respiratory Syncytial Virus. J Virol. 2020;: pubmed  publisher | 
| Yan P, Patel H, Sharma S, Corben A, Wang T, Panchal P, et al . Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone. Cell Rep. 2020;31:107840 pubmed  publisher | 
| Goldspink D, Lu V, Miedzybrodzka E, Smith C, Foreman R, Billing L, et al . Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture. Cell Rep. 2020;31:107833 pubmed  publisher | 
| Krishn S, Salem I, Quaglia F, Naranjo N, Agarwal E, Liu Q, et al . The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis. J Extracell Vesicles. 2020;9:1763594 pubmed  publisher | 
| Zhou T, Damsky W, Weizman O, McGeary M, Hartmann K, Rosen C, et al . IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy. Nature. 2020;583:609-614 pubmed  publisher | 
| Lin Y, Nakatochi M, Hosono Y, Ito H, Kamatani Y, Inoko A, et al . Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer. Nat Commun. 2020;11:3175 pubmed  publisher | 
| Vergara Mendoza M, Gomez Quiroz L, Miranda Labra R, Fuentes Romero L, Romero Rodríguez D, González Ruiz J, et al . Regulation of Cas9 by viral proteins Tat and Rev for HIV-1 inactivation. Antiviral Res. 2020;180:104856 pubmed  publisher | 
| Murai N, Mitalipova M, Jaenisch R. Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell-derived microglia-like cells. Eur J Neurosci. 2020;: pubmed  publisher | 
| Laptev I, Shvetsova E, Levitskii S, Serebryakova M, Rubtsova M, Zgoda V, et al . METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue. Nucleic Acids Res. 2020;: pubmed  publisher | 
| Tian Y, Liu Q, Yu S, Chu Q, Chen Y, Wu K, et al . NRF2-Driven KEAP1 Transcription in Human Lung Cancer. Mol Cancer Res. 2020;: pubmed  publisher | 
| Stephan T, Brüser C, Deckers M, Steyer A, Balzarotti F, Barbot M, et al . MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation. EMBO J. 2020;39:e104105 pubmed  publisher | 
| Schilling M, Bridgeman A, Gray N, Hertzog J, Hublitz P, Kohl A, et al . RIG-I Plays a Dominant Role in the Induction of Transcriptional Changes in Zika Virus-Infected Cells, which Protect from Virus-Induced Cell Death. Cells. 2020;9: pubmed  publisher | 
| Younis S, Naboulsi R, Wang X, Cao X, Larsson M, Sargsyan E, et al . The importance of the ZBED6-IGF2 axis for metabolic regulation in mouse myoblast cells. FASEB J. 2020;: pubmed  publisher | 
| Gao C, Song Q, Zhang M, Li J, Miao Y, Li Z, et al . Generation, ex vivo expansion and safety of engineered PD1-knockout primary T cells from cynomolgus macaques. Mol Immunol. 2020;124:100-108 pubmed  publisher | 
| Shvets E, Mendoza Topaz C. Tagging and Deleting of Endogenous Caveolar Components Using CRISPR/Cas9 Technology. Methods Mol Biol. 2020;2169:149-166 pubmed  publisher | 
| Liu J, Zuo Z, Sastalla I, Liu C, Jang J, Sekine Y, et al . Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors. Cell Host Microbe. 2020;: pubmed  publisher | 
| Knights A, Vohralik E, Houweling P, Stout E, Norton L, Alexopoulos S, et al . Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3). Nat Commun. 2020;11:2922 pubmed  publisher | 
| Dirac Svejstrup A, Walker J, Faull P, Encheva V, Akimov V, Puglia M, et al . DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1. Mol Cell. 2020;79:332-341.e7 pubmed  publisher | 
| Cenni V, Squarzoni S, Loi M, Mattioli E, Lattanzi G, Capanni C. Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization. Cells. 2020;9: pubmed  publisher | 
| Charlton J, Jung E, Mattei A, Bailly N, Liao J, Martin E, et al . TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers. Nat Genet. 2020;: pubmed  publisher | 
| Zhang F, Liu R, Liu C, Zhang H, Lu Y. Nanos3, a cancer-germline gene, promotes cell proliferation, migration, chemoresistance, and invasion of human glioblastoma. Cancer Cell Int. 2020;20:197 pubmed  publisher | 
| Cassinari K, Rovelet Lecrux A, Tury S, Quenez O, Richard A, Charbonnier C, et al . Haploinsufficiency of the Primary Familial Brain Calcification Gene SLC20A2 Mediated by Disruption of a Regulatory Element. Mov Disord. 2020;: pubmed  publisher | 
| Kuhny M, Forbes L, Çakan E, Vega Loza A, Kostiuk V, Dinesh R, et al . Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID. J Clin Invest. 2020;: pubmed  publisher | 
| Pinch B, Doctor Z, Nabet B, Browne C, Seo H, Mohardt M, et al . Identification of a potent and selective covalent Pin1 inhibitor. Nat Chem Biol. 2020;: pubmed  publisher | 
| Zhang X, Zhu B, Chen L, Xie L, Yu W, Wang Y, et al . Dual base editor catalyzes both cytosine and adenine base conversions in human cells. Nat Biotechnol. 2020;38:856-860 pubmed  publisher | 
| Xiong L, Zhao K, Cao Y, Guo H, Pan J, Yang X, et al . Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency. PLoS Biol. 2020;18:e3000731 pubmed  publisher | 
| Malankhanova T, Sorokin M, Medvedev S, Zakian S, Malakhova A. Introducing an Expanded Trinucleotide Repeat Tract into the Human Genome for Huntington's Disease Modeling In Vitro. Curr Protoc Hum Genet. 2020;106:e100 pubmed  publisher | 
| Dang L, Glanowska K, Iffland Ii P, Barnes A, Baybis M, Liu Y, et al . Multimodal Analysis of STRADA Function in Brain Development. Front Cell Neurosci. 2020;14:122 pubmed  publisher | 
| Lilianty J, Nur Patria Y, Stanley E, Elefanty A, Bateman J, Lamande S. Generation of a heterozygous COL2A1 (p.R989C) spondyloepiphyseal dysplasia congenita mutation iPSC line, MCRIi001-B, using CRISPR/Cas9 gene editing. Stem Cell Res. 2020;45:101843 pubmed  publisher | 
| Montico B, Colizzi F, Giurato G, Rizzo A, Salvati A, Baboci L, et al . Loss of Spry1 reduces growth of BRAFV600-mutant cutaneous melanoma and improves response to targeted therapy. Cell Death Dis. 2020;11:392 pubmed  publisher | 
| Stöhr D, Schmid J, Beigl T, Mack A, Maichl D, Cao K, et al . Stress-induced TRAILR2 expression overcomes TRAIL resistance in cancer cell spheroids. Cell Death Differ. 2020;: pubmed  publisher | 
| Dubey R, van Kerkhof P, Jordens I, Malinauskas T, Pusapati G, McKenna J, et al . R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling. elife. 2020;9: pubmed  publisher | 
| Singhal J, Chikara S, Horne D, Awasthi S, Salgia R, Singhal S. Targeting RLIP with CRISPR/Cas9 controls tumor growth. Carcinogenesis. 2020;: pubmed  publisher | 
| Rodríguez González C, Lin S, Arkan S, Hansen C. Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation. Sci Rep. 2020;10:8130 pubmed  publisher | 
| Yu H, Ding J, Zhu H, Jing Y, Zhou H, Tian H, et al . LOXL1 confers antiapoptosis and promotes gliomagenesis through stabilizing BAG2. Cell Death Differ. 2020;: pubmed  publisher | 
| Wrona D, Pastukhov O, Pritchard R, Raimondi F, Tchinda J, Jinek M, et al . CRISPR-Directed Therapeutic Correction at the NCF1 Locus Is Challenged by Frequent Incidence of Chromosomal Deletions. Mol Ther Methods Clin Dev. 2020;17:936-943 pubmed  publisher | 
| Nielsen C, Zhang T, Barisic M, Kalitsis P, Hudson D. Topoisomerase IIα is essential for maintenance of mitotic chromosome structure. Proc Natl Acad Sci U S A. 2020;117:12131-12142 pubmed  publisher | 
| Chen T, Zhang W, Huang B, Chen X, Huang C. UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway. Cells. 2020;9: pubmed  publisher | 
| Collins M, Stransky L, Forgac M. AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells. J Biol Chem. 2020;295:9433-9444 pubmed  publisher | 
| Zurli V, Montecchi T, Heilig R, Poschke I, Volkmar M, Wimmer G, et al . Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells. Sci Signal. 2020;13: pubmed  publisher | 
| Halder L, Jo E, Hasan M, Ferreira Gomes M, Krüger T, Westermann M, et al . Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles. Nat Commun. 2020;11:2331 pubmed  publisher | 
| Agosto M, Wensel T. LRRTM4 is a member of the transsynaptic complex between rod photoreceptors and bipolar cells. J Comp Neurol. 2020;: pubmed  publisher | 
| Pinzon Arteaga C, Snyder M, Lazzarotto C, Moreno N, Juras R, Raudsepp T, et al . Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9. Sci Rep. 2020;10:7411 pubmed  publisher | 
| Liu C, Huang C, Chen H, Lu H, Hsieh P, Lee J. Generation of a gene corrected human isogenic IBMS-iPSC-014-C from polycystic-kidney-disease induced pluripotent stem cell line using CRISPR/Cas9. Stem Cell Res. 2020;45:101784 pubmed  publisher | 
| Liu Q, Li A, Wang L, He W, Zhao L, Wu C, et al . Stomatin-like Protein 2 Promotes Tumor Cell Survival by Activating the JAK2-STAT3-PIM1 Pathway, Suggesting a Novel Therapy in CRC. Mol Ther Oncolytics. 2020;17:169-179 pubmed  publisher | 
| Liu Y, Huang X, Nguyen D, Shammas M, Wu B, Dombi E, et al . Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations. Hum Mol Genet. 2020;29:1547-1567 pubmed  publisher | 
| Yang F, Sun S, Wang C, Haas M, Yeo S, Guan J. Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation. Br J Cancer. 2020;122:1791-1802 pubmed  publisher | 
| Waaler J, Mygland L, Tveita A, Strand M, Solberg N, Olsen P, et al . Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Commun Biol. 2020;3:196 pubmed  publisher | 
| Jin H, Lee B, Luo Y, Choi Y, Choi E, Jin H, et al . FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku. Nat Commun. 2020;11:2010 pubmed  publisher | 
| Grosch M, Ittermann S, Rusha E, Greisle T, Ori C, Truong D, et al . Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation. BMC Biol. 2020;18:42 pubmed  publisher | 
| Tu J, Wan C, Zhang F, Cao L, Law P, Tian Y, et al . Genetic correction of Werner syndrome gene reveals impaired pro-angiogenic function and HGF insufficiency in mesenchymal stem cells. Aging Cell. 2020;19:e13116 pubmed  publisher | 
| Lee E, Yu J, Paek A, Lee S, Jang H, Cho S, et al . Targeting TJP1 attenuates cell-cell aggregation and modulates chemosensitivity against doxorubicin in leiomyosarcoma. J Mol Med (Berl). 2020;98:761-773 pubmed  publisher | 
| Hock D, Reljic B, Ang C, Muellner Wong L, Mountford H, Compton A, et al . HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV. Mol Cell Proteomics. 2020;19:1145-1160 pubmed  publisher | 
| Morita K, He S, Nowak R, Wang J, Zimmerman M, Fu C, et al . Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2. Cell. 2020;181:702-715.e20 pubmed  publisher | 
| Lee Y, Lee E, Choi B, Jang H, Myung J, You H. The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability. Mol Cells. 2020;43:459-468 pubmed  publisher | 
| Stojic L, Lun A, Mascalchi P, Ernst C, Redmond A, Mangei J, et al . A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division. Nat Commun. 2020;11:1851 pubmed  publisher | 
| Vyhlídalová B, Krasulová K, Pecinkova P, Marcalíková A, Vrzal R, Zemankova L, et al . Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization. Int J Mol Sci. 2020;21: pubmed  publisher | 
| Deng X, Iwagawa T, Fukushima M, Watanabe S. Characterization of human-induced pluripotent stem cells carrying homozygous RB1 gene deletion. Genes Cells. 2020;25:510-517 pubmed  publisher | 
| Yao S, Ye J, Yin M, Yu R. DMAMCL exerts antitumor effects on hepatocellular carcinoma both in vitro and in vivo. Cancer Lett. 2020;483:87-97 pubmed  publisher | 
| Grosshans H, Fischer T, Steinle J, Brill A, Ehrlich B. Neuronal Calcium Sensor 1 is up-regulated in response to stress to promote cell survival and motility in cancer cells. Mol Oncol. 2020;14:1134-1151 pubmed  publisher | 
| Witte A, Rohlfing A, Dannenmann B, Dicenta V, Nasri M, Kolb K, et al . The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4. Cardiovasc Res. 2020;: pubmed  publisher | 
| Vanderboor C, Thibeault P, Nixon K, Gros R, Kramer J, Ramachandran R. Proteinase-Activated Receptor 4 Activation Triggers Cell Membrane Blebbing through RhoA and β-Arrestin. Mol Pharmacol. 2020;97:365-376 pubmed  publisher | 
| Wang Z, Xu C, Diplas B, Moure C, Chen C, Chen L, et al . Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib. Mol Cancer Res. 2020;18:968-980 pubmed  publisher | 
| Knights A, Yang L, Shah M, Norton L, Green G, Stout E, et al . Krüppel-like factor 3 (KLF3) suppresses NF-κB-driven inflammation in mice. J Biol Chem. 2020;295:6080-6091 pubmed  publisher | 
| Viol L, Hata S, Pastor Peidro A, Neuner A, Murke F, Wuchter P, et al . Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis. J Cell Biol. 2020;219: pubmed  publisher | 
| Fatima A, Schuster J, Akram T, Sobol M, Hoeber J, Dahl N. Generation of a human Neurochondrin deficient iPSC line KICRi002-A-3 using CRISPR/Cas9. Stem Cell Res. 2020;44:101758 pubmed  publisher | 
| Hollywood J, Przepiorski A, D Souza R, Sreebhavan S, Wolvetang E, Harrison P, et al . Use of Human Induced Pluripotent Stem Cells and Kidney Organoids To Develop a Cysteamine/mTOR Inhibition Combination Therapy for Cystinosis. J Am Soc Nephrol. 2020;31:962-982 pubmed  publisher | 
| Yu L, Wang L, Yi H, Wu X. LRP6-CRISPR prevents activation of hepatic stellate cells and liver fibrogenesis in rats. Am J Transl Res. 2020;12:397-408 pubmed | 
| Pirouzfar M, Amiri F, Dianatpour M, Takhshid M. CRISPR/Cas9-mediated knockout of MLL5 enhances apoptotic effect of cisplatin in HeLa cells in vitro. EXCLI J. 2020;19:170-182 pubmed  publisher | 
| Li K, Zhang Y, Liu X, Liu Y, Gu Z, Cao H, et al . Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies. Cancer Discov. 2020;10:724-745 pubmed  publisher | 
| Xu Y, Fulciniti M, Samur M, Ho M, Deng S, Liu L, et al . YWHAE/14-3-3ε expression impacts the protein load, contributing to proteasome inhibitor sensitivity in multiple myeloma. Blood. 2020;136:468-479 pubmed  publisher | 
| Renema P, Hardy K, Housley N, Dunbar G, Annamdevula N, Britain A, et al . cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection. Am J Physiol Lung Cell Mol Physiol. 2020;318:L1074-L1083 pubmed  publisher | 
| Fan X, Waardenberg A, Demuth M, Osteil P, Sun J, Loebel D, et al . TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation. Mol Cell Biol. 2020;40: pubmed  publisher | 
| Kanasugi J, Hanamura I, Ota A, Karnan S, Lam V, Mizuno S, et al . Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells. Cancer Sci. 2020;111:1663-1675 pubmed  publisher | 
| Kaku H, Rothstein T. FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With Accumulation of Stress-Induced Protein Aggregates. Front Mol Biosci. 2020;7:32 pubmed  publisher | 
| Yang P, Wang Y, Tang W, Sun W, Ma Y, Lin S, et al . Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice. Sci Rep. 2020;10:4701 pubmed  publisher | 
| Koyama S, Tsuchiya H, Amisaki M, Sakaguchi H, Honjo S, Fujiwara Y, et al . NEAT1 is Required for the Expression of the Liver Cancer Stem Cell Marker CD44. Int J Mol Sci. 2020;21: pubmed  publisher | 
| Brenner E, Schörg B, Ahmetlić F, Wieder T, Hilke F, Simon N, et al . Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours. Nat Commun. 2020;11:1335 pubmed  publisher | 
| Dubois M, Meller A, Samandi S, Brunelle M, Frion J, Brunet M, et al . UBB pseudogene 4 encodes functional ubiquitin variants. Nat Commun. 2020;11:1306 pubmed  publisher | 
| Martin E, Minet N, Boschat A, Sanquer S, Sobrino S, Lenoir C, et al . Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation. JCI Insight. 2020;5: pubmed  publisher | 
| Sun C, Liu M, Chang J, Yang D, Zhao B, Wang H, et al . Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region. J Virol. 2020;94: pubmed  publisher | 
| Liang J, Lingeman E, Luong T, Ahmed S, Muhar M, Nguyen T, et al . A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation. Cell. 2020;180:1160-1177.e20 pubmed  publisher | 
| Verschuren E, Rigalli J, Castenmiller C, Rohrbach M, Bindels R, Peters D, et al . Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease. FASEB J. 2020;34:6382-6398 pubmed  publisher | 
| Buel G, Chen X, Chari R, O Neill M, Ebelle D, Jenkins C, et al . Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10. Nat Commun. 2020;11:1291 pubmed  publisher | 
| Pu J, Gao T, Zheng R, Fang Y, Ruan Y, Jin C, et al . Parkin mutation decreases neurite complexity and maturation in neurons derived from human fibroblasts. Brain Res Bull. 2020;159:9-15 pubmed  publisher | 
| Apelt K, Zoutendijk I, Gout D, Wondergem A, van den Heuvel D, Luijsterburg M. Human HMGN1 and HMGN2 are not required for transcription-coupled DNA repair. Sci Rep. 2020;10:4332 pubmed  publisher | 
| Cao J, Chen X, Jiang L, Lu B, Yuan M, Zhu D, et al . DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase. Nat Commun. 2020;11:1251 pubmed  publisher | 
| Zheng Z, Anurag M, Lei J, Cao J, Singh P, Peng J, et al . Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer. Cancer Cell. 2020;37:387-402.e7 pubmed  publisher | 
| He B, Yang N, Man C, Ng N, Cher C, Leung H, et al . Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia. EMBO Mol Med. 2020;12:e10895 pubmed  publisher | 
| Fatima A, Schuster J, Akram T, González C, Sobol M, Hoeber J, et al . Incontinentia pigmenti: Generation of an IKBKG deficient human iPSC line (KICRi002-A-1) on a 46,XY background using CRISPR/Cas9. Stem Cell Res. 2020;44:101739 pubmed  publisher | 
| Sato H, Schoenfeld A, Siau E, Lu Y, Tai H, Suzawa K, et al . MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by ROS1 Fusions. Clin Cancer Res. 2020;26:2932-2945 pubmed  publisher | 
| Cao Y, Wang X, Tang L, Li Y, Song X, Liu X, et al . Engrailed-2 promotes a malignant phenotype of esophageal squamous cell carcinoma through upregulating the expression of pro-oncogenic genes. Peerj. 2020;8:e8662 pubmed  publisher | 
| Gao X, Jin Z, Tan X, Zhang C, Zou C, Zhang W, et al . Hyperbranched poly(β-amino ester) based polyplex nanopaticles for delivery of CRISPR/Cas9 system and treatment of HPV infection associated cervical cancer. J Control Release. 2020;321:654-668 pubmed  publisher | 
| Morrow C, Porter T, Xu N, Arndt Z, Ako Asare K, Heo H, et al . Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit. Cell Stem Cell. 2020;26:558-568.e9 pubmed  publisher | 
| Smolina N, Khudiakov A, Knyazeva A, Zlotina A, Sukhareva K, Kondratov K, et al . Desmin mutations result in mitochondrial dysfunction regardless of their aggregation properties. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165745 pubmed  publisher | 
| Takahashi H, Ranjan A, Chen S, Suzuki H, Shibata M, Hirose T, et al . The role of Mediator and Little Elongation Complex in transcription termination. Nat Commun. 2020;11:1063 pubmed  publisher | 
| Dimchev G, Amiri B, Humphries A, Schaks M, Dimchev V, Stradal T, et al . Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation. J Cell Sci. 2020;133: pubmed  publisher | 
| Wu W, Wu Y, Mayer K, von Rosenstiel C, Schecker J, Baur S, et al . Lipid Peroxidation Plays an Important Role in Chemotherapeutic Effects of Temozolomide and the Development of Therapy Resistance in Human Glioblastoma. Transl Oncol. 2020;13:100748 pubmed  publisher | 
| Sawahata M, Mori D, Arioka Y, Kubo H, Kushima I, Kitagawa K, et al . Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia. Psychiatry Clin Neurosci. 2020;74:318-327 pubmed  publisher | 
| Jin J, Xu Y, Huo L, Ma L, Scott A, Pizzi M, et al . An improved strategy for CRISPR/Cas9 gene knockout and subsequent wildtype and mutant gene rescue. PLoS ONE. 2020;15:e0228910 pubmed  publisher | 
| Park J, Burckhardt C, Lazcano R, Solis L, Isogai T, Li L, et al . Mechanical regulation of glycolysis via cytoskeleton architecture. Nature. 2020;578:621-626 pubmed  publisher | 
| Wang W, Lu G, Su X, Tang C, Li H, Xiong Z, et al . Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells. Cell Death Dis. 2020;11:107 pubmed  publisher | 
| Pimenova A, Goate A. Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations. Neurobiol Dis. 2020;138:104785 pubmed  publisher | 
| Xu X, Xin S, Mao H, Zhang H, Chen L, Li L, et al . SHOX CNE9/10 Knockout in U2OS Osteosarcoma Cells and Its Effects on Cell Growth and Apoptosis. Med Sci Monit. 2020;26:e921233 pubmed  publisher | 
| Ruegenberg S, Horn M, Pichlo C, Allmeroth K, Baumann U, Denzel M. Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis. Nat Commun. 2020;11:687 pubmed  publisher | 
| Nguyen C, Sawangarun W, Mandasari M, Morita K, Harada H, Kayamori K, et al . AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression. PLoS ONE. 2020;15:e0222689 pubmed  publisher | 
| Li Y, Zhang M, Wang X, Liu W, Wang H, Yang Y. Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice. Nat Commun. 2020;11:581 pubmed  publisher | 
| Ballabio C, Anderle M, Gianesello M, Lago C, Miele E, Cardano M, et al . Modeling medulloblastoma in vivo and with human cerebellar organoids. Nat Commun. 2020;11:583 pubmed  publisher | 
| Momoi Y, Nishikimi A, Du G, Kataoka T, Katagiri K. Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration. Biochem Biophys Res Commun. 2020;524:325-331 pubmed  publisher | 
| Koga T, Chaim I, Benitez J, Markmiller S, Parisian A, Hevner R, et al . Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nat Commun. 2020;11:550 pubmed  publisher | 
| Komatsu T, Shimizu T, Kanoh M, Miyakawa T, Satta Y, Yasukochi Y, et al . Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion. Immunogenetics. 2020;72:143-153 pubmed  publisher | 
| Koslová A, Trefil P, Mucksová J, Reinisová M, Plachy J, Kalina J, et al . Precise CRISPR/Cas9 editing of the NHE1 gene renders chickens resistant to the J subgroup of avian leukosis virus. Proc Natl Acad Sci U S A. 2020;117:2108-2112 pubmed  publisher | 
| Montaño A, Ordóñez J, Alonso Pérez V, Hernández Sánchez J, Santos S, Gonzalez T, et al . ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia. Cells. 2020;9: pubmed  publisher | 
| Deng W, Bates J, Wei H, Bartoschek M, Conradt B, Leonhardt H. Tunable light and drug induced depletion of target proteins. Nat Commun. 2020;11:304 pubmed  publisher | 
| Dubey R, Stivala C, Nguyen H, Goo Y, Paul A, Carette J, et al . Lipid droplets can promote drug accumulation and activation. Nat Chem Biol. 2020;16:206-213 pubmed  publisher | 
| Li R, Zeng W, Ma M, Wei Z, Liu H, Liu X, et al . Precise editing of myostatin signal peptide by CRISPR/Cas9 increases the muscle mass of Liang Guang Small Spotted pigs. Transgenic Res. 2020;29:149-163 pubmed  publisher | 
| Mithal A, Capilla A, Heinze D, Berical A, Villacorta Martin C, Vedaie M, et al . Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nat Commun. 2020;11:215 pubmed  publisher | 
| Omi J, Watanabe Takahashi M, Igai K, Shimizu E, Tseng C, Miyasaka T, et al . The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection. Nat Commun. 2020;11:162 pubmed  publisher | 
| Prieto Bermejo R, Romo González M, Pérez Fernández A, García Tuñón I, Sanchez Martin M, Hernández Hernández A. Cyba-deficient mice display an increase in hematopoietic stem cells and an overproduction of immunoglobulins. Haematologica. 2020;: pubmed  publisher | 
| Clairmont C, Sarangi P, Ponnienselvan K, Galli L, Csete I, Moreau L, et al . TRIP13 regulates DNA repair pathway choice through REV7 conformational change. Nat Cell Biol. 2020;22:87-96 pubmed  publisher | 
| Qi F, Isaji T, Duan C, Yang J, Wang Y, Fukuda T, et al . ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins. FASEB J. 2020;34:881-897 pubmed  publisher | 
| Peters Hall J, Min J, Tedone E, Sho S, Siteni S, Mender I, et al . Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings. FASEB J. 2020;34:386-398 pubmed  publisher | 
| Okuyama Y, Nagashima H, Ushio Fukai M, Croft M, Ishii N, So T. IQGAP1 restrains T-cell cosignaling mediated by OX40. FASEB J. 2020;34:540-554 pubmed  publisher | 
| Duan C, Fukuda T, Isaji T, Qi F, Yang J, Wang Y, et al . Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system. FASEB J. 2020;34:3239-3252 pubmed  publisher | 
| Abe H, Alavattam K, Hu Y, Pang Q, Andreassen P, Hegde R, et al . The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Curr Biol. 2019;: pubmed  publisher | 
| Moskal N, Riccio V, Bashkurov M, Taddese R, Datti A, Lewis P, et al . ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway. Nat Commun. 2020;11:88 pubmed  publisher | 
| Wang H, Zhu N, Ye X, Wang L, Wang B, Shan W, et al . PTPN21-CDSlong isoform inhibits the response of acute lymphoblastic leukemia cells to NK-mediated lysis via the KIR/HLA-I axis. J Cell Biochem. 2020;121:3298-3312 pubmed  publisher | 
| Burke J, Lester E, Tauber D, Parker R. RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules. J Biol Chem. 2020;295:1426-1438 pubmed  publisher | 
| Thibeault P, LeSarge J, Arends D, Fernandes M, Chidiac P, Stathopulos P, et al . Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4). J Biol Chem. 2020;295:2520-2540 pubmed  publisher | 
| Brydon E, Bronstein R, Buskin A, Lako M, Pierce E, Fernandez Godino R. AAV-Mediated Gene Augmentation Therapy Restores Critical Functions in Mutant PRPF31+/- iPSC-Derived RPE Cells. Mol Ther Methods Clin Dev. 2019;15:392-402 pubmed  publisher | 
| Nur Patria Y, Lilianty J, Elefanty A, Stanley E, Labonne T, Bateman J, et al . Generation of a SOX9-tdTomato reporter human iPSC line, MCRIi001-A-2, using CRISPR/Cas9 editing. Stem Cell Res. 2019;42:101689 pubmed  publisher | 
| Tamburri S, Lavarone E, Fernandez Perez D, Conway E, Zanotti M, Manganaro D, et al . Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression. Mol Cell. 2019;: pubmed  publisher | 
| Bode K, Bujupi F, Link C, Hein T, Zimmermann S, Peiris D, et al . Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2. Cell Rep. 2019;29:4435-4446.e9 pubmed  publisher | 
| Peng Y, Yang T, Tang X, Chen F, Wang S. Construction of an Inducible CRISPR/Cas9 System for CXCR4 Gene and Demonstration of its Effects on MKN-45 Cells. Cell Biochem Biophys. 2019;: pubmed  publisher | 
| Park E, Scott P, Clutario K, Cassidy K, Zhan K, Gerber S, et al . WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication. J Cell Biol. 2020;219: pubmed  publisher | 
| Ulloa Navas M, García Tárraga P, Garcia Verdugo J, Herranz Pérez V. Immunogold Labeling to Detect Streptococcus pyogenes Cas9 in Cell Culture and Tissues by Electron Microscopy. CRISPR J. 2019;2:395-405 pubmed  publisher | 
| Senigl F, Maman Y, Dinesh R, Alinikula J, Seth R, Pecnova L, et al . Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. Cell Rep. 2019;29:3902-3915.e8 pubmed  publisher | 
| Matsumoto R, Suga H, Aoi T, Bando H, Fukuoka H, Iguchi G, et al . Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells. J Clin Invest. 2019;: pubmed  publisher | 
| Wu C, Cho S, Huang H, Lu C, Russ J, Cruz L, et al . MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation. Sci Adv. 2019;5:eaaw1715 pubmed  publisher | 
| Valderrama J, Kulkarni S, Nizet V, Bier E. A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. Nat Commun. 2019;10:5726 pubmed  publisher | 
| García Tuñón I, Vuelta E, Lozano L, Herrero M, Mendez L, Palomero Hernandez J, et al . Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology. Mol Biol Rep. 2020;47:1381-1391 pubmed  publisher | 
| Xie L, Sun J, Mo L, Xu T, Shahzad Q, Chen D, et al . HMEJ-mediated efficient site-specific gene integration in chicken cells. J Biol Eng. 2019;13:90 pubmed  publisher | 
| Uezu A, Hisey E, Kobayashi Y, Gao Y, Bradshaw T, Devlin P, et al . Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice. elife. 2019;8: pubmed  publisher | 
| Liao K, Chuo V, Fagg W, Bradrick S, Pompon J, Garcia Blanco M. The RNA binding protein Quaking represses host interferon response by downregulating MAVS. RNA Biol. 2019;:1-15 pubmed  publisher | 
| Casanova M, Moscatelli M, Chauvière L, Huret C, Samson J, Liyakat Ali T, et al . A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Nat Commun. 2019;10:5652 pubmed  publisher | 
| Moyer C, Ivanovich J, Gillespie J, Doberstein R, Radke M, Richardson M, et al . Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer. Cancer Res. 2020;80:857-867 pubmed  publisher | 
| Abe H, Satoh J, Shirasaka Y, Kogure A, Kato H, Ito S, et al . Priming Phosphorylation of TANK-Binding Kinase 1 by IκB Kinase β Is Essential in Toll-Like Receptor 3/4 Signaling. Mol Cell Biol. 2020;40: pubmed  publisher | 
| Yang J, Isaji T, Zhang G, Qi F, Duan C, Fukuda T, et al . EpCAM associates with integrin and regulates cell adhesion in cancer cells. Biochem Biophys Res Commun. 2020;522:903-909 pubmed  publisher | 
| Ysselstein D, Nguyen M, Young T, Severino A, Schwake M, Merchant K, et al . LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. Nat Commun. 2019;10:5570 pubmed  publisher | 
| Czech Sioli M, Siebels S, Radau S, Zahedi R, Schmidt C, Dobner T, et al . The Ubiquitin-Specific Protease Usp7, a Novel Merkel Cell Polyomavirus Large T-Antigen Interaction Partner, Modulates Viral DNA Replication. J Virol. 2020;94: pubmed  publisher | 
| Liu P, Zhao L, Loos F, Marty C, Xie W, Martins I, et al . Immunosuppression by Mutated Calreticulin Released from Malignant Cells. Mol Cell. 2019;: pubmed  publisher | 
| Montaldo N, Bordin D, Brambilla A, Rösinger M, Fordyce Martin S, Bjørås K, et al . Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression. Nat Commun. 2019;10:5460 pubmed  publisher | 
| Warmerdam D, Alonso de Vega I, Wiegant W, van den Broek B, Rother M, Wolthuis R, et al . PHF6 promotes non-homologous end joining and G2 checkpoint recovery. EMBO Rep. 2019;:e48460 pubmed  publisher | 
| Filippova J, Matveeva A, Zhuravlev E, Balakhonova E, Prokhorova D, Malanin S, et al . Are Small Nucleolar RNAs "CRISPRable"? A Report on Box C/D Small Nucleolar RNA Editing in Human Cells. Front Pharmacol. 2019;10:1246 pubmed  publisher | 
| Huang C, Wang H, Wang M, Hsu M, Wu Y, Jiang Y, et al . Kisspeptin-Activated Autophagy Independently Suppresses Non-Glucose-Stimulated Insulin Secretion from Pancreatic β-Cells. Sci Rep. 2019;9:17451 pubmed  publisher | 
| Hochberg Laufer H, Neufeld N, Brody Y, Nadav Eliyahu S, Ben Yishay R, Shav Tal Y. Availability of splicing factors in the nucleoplasm can regulate the release of mRNA from the gene after transcription. PLoS Genet. 2019;15:e1008459 pubmed  publisher | 
| Chappidi N, Nascakova Z, Boleslavska B, Zellweger R, Isik E, Andrs M, et al . Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops. Mol Cell. 2019;: pubmed  publisher | 
| Morales C, Ruiz Torres M, Rodriguez Acebes S, Lafarga V, Rodríguez Corsino M, Megias D, et al . PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection. J Biol Chem. 2020;295:146-157 pubmed  publisher | 
| Di Giorgio E, Dalla E, Franforte E, Paluvai H, Minisini M, Trevisanut M, et al . Different class IIa HDACs repressive complexes regulate specific epigenetic responses related to cell survival in leiomyosarcoma cells. Nucleic Acids Res. 2019;: pubmed  publisher | 
| Pu J, Dai S, Gao T, Hu J, Fang Y, Zheng R, et al . Nystagmus-related FRMD7 gene influences the maturation and complexities of neuronal processes in human neurons. Brain Behav. 2019;9:e01473 pubmed  publisher | 
| Li J, Ryan S, DeBoer E, Cook K, Fitzgerald S, Lachman H, et al . Mitochondrial deficits in human iPSC-derived neurons from patients with 22q11.2 deletion syndrome and schizophrenia. Transl Psychiatry. 2019;9:302 pubmed  publisher | 
| Alexander J, Findlay G, Kircher M, Shendure J. Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement. BMC Biol. 2019;17:90 pubmed  publisher | 
| Mózsik L, Büttel Z, Bovenberg R, Driessen A, Nygård Y. Synthetic control devices for gene regulation in Penicillium chrysogenum. Microb Cell Fact. 2019;18:203 pubmed  publisher | 
| Cao Y, Yuan L, Zhao Q, Yuan J, Miao C, Chang Y, et al . Hsp40 Protein DNAJB6 Interacts with Viral NS3 and Inhibits the Replication of the Japanese Encephalitis Virus. Int J Mol Sci. 2019;20: pubmed  publisher | 
| Laptev I, Shvetsova E, Levitskii S, Serebryakova M, Rubtsova M, Bogdanov A, et al . Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m5U formation in both tRNA and rRNA. RNA Biol. 2020;17:441-450 pubmed  publisher | 
| Huang Y, Mouttet B, Warnatz H, Risch T, Rietmann F, Frommelt F, et al . The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability. Cancer Cell. 2019;36:630-644.e9 pubmed  publisher | 
| Kampf L, Schneider R, Gerstner L, Thünauer R, Chen M, Helmstädter M, et al . TBC1D8B Mutations Implicate RAB11-Dependent Vesicular Trafficking in the Pathogenesis of Nephrotic Syndrome. J Am Soc Nephrol. 2019;30:2338-2353 pubmed  publisher | 
| Sale M, Minihane E, Monks N, Gilley R, Richards F, Schifferli K, et al . Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors. Nat Commun. 2019;10:5167 pubmed  publisher | 
| Póti A, Gyergyák H, Nemeth E, Rusz O, Tóth S, Kovácsházi C, et al . Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents. Genome Biol. 2019;20:240 pubmed  publisher | 
| Liebelt F, Schimmel J, Verlaan de Vries M, Klemann E, van Royen M, van der Weegen Y, et al . Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation. Nucleic Acids Res. 2019;: pubmed  publisher | 
| Garland W, Comet I, Wu M, Radzisheuskaya A, Rib L, Vitting Seerup K, et al . A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2. Cell Rep. 2019;29:1800-1811.e6 pubmed  publisher | 
| Weiterer S, Meier Soelch J, Georgomanolis T, Mizi A, Beyerlein A, Weiser H, et al . Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J. 2019;:e101533 pubmed  publisher | 
| Qin X, Wang H, Ma L, Shen J, Liu Q, Xue L. Knockout of the Placenta Specific 8 Gene Affects the Proliferation and Migration of Human Embryonic Kidney 293T Cell. Cell Biochem Biophys. 2019;: pubmed  publisher | 
| Valetdinova K, Ovechkina V, Zakian S. Methods for Correction of the Single-Nucleotide Substitution c.840C>T in Exon 7 of the SMN2 Gene. Biochemistry (Mosc). 2019;84:1074-1084 pubmed  publisher | 
| Wang Y, Li Y, Qiao J, Li N, Qiao S. AMPK α1 mediates the protective effect of adiponectin against insulin resistance in INS-1 pancreatic β cells. Cell Biochem Funct. 2019;37:625-632 pubmed  publisher | 
| Fischer B, Ly T, Schmidt V, Hendig D, Kuhn J, Knabbe C, et al . Xylosyltransferase-deficient human HEK293 cells show a strongly reduced proliferation capacity and viability. Biochem Biophys Res Commun. 2020;521:507-513 pubmed  publisher | 
| Escobar T, Oksuz O, Saldaña Meyer R, Descostes N, Bonasio R, Reinberg D. Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication. Cell. 2019;179:953-963.e11 pubmed  publisher | 
| Moore P, Qi J, Thamsen M, Ghosh R, Peng J, Gliedt M, et al . Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Res. 2019;79:6190-6203 pubmed  publisher | 
| Marbaix A, Chehade G, Noel G, Morsomme P, Vertommen D, Bommer G, et al . Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P). Biochem J. 2019;476:3033-3052 pubmed  publisher | 
| Schmidt H, Barreau A, Rohatgi R. Phase separation-deficient TDP43 remains functional in splicing. Nat Commun. 2019;10:4890 pubmed  publisher | 
| Du X, Zhou L, Aw Y, Mak H, Xu Y, Rae J, et al . ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets. J Cell Biol. 2020;219: pubmed  publisher | 
| Gehring T, Erdmann T, Rahm M, Graß C, Flatley A, O Neill T, et al . MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. Cell Rep. 2019;29:873-888.e10 pubmed  publisher | 
| Liu R, Olano L, Mirzakhanyan Y, Gershon P, Moss B. Vaccinia Virus Ankyrin-Repeat/F-Box Protein Targets Interferon-Induced IFITs for Proteasomal Degradation. Cell Rep. 2019;29:816-828.e6 pubmed  publisher | 
| Renz P, Imahorn E, Spoerri I, Aushev M, March O, Wariwoda H, et al . Arginine- but not alanine-rich carboxy-termini trigger nuclear translocation of mutant keratin 10 in ichthyosis with confetti. J Cell Mol Med. 2019;23:8442-8452 pubmed  publisher | 
| Ko P, Woodrow C, Dubreuil M, Martin B, Skouta R, Bassik M, et al . A ZDHHC5-GOLGA7 Protein Acyltransferase Complex Promotes Nonapoptotic Cell Death. Cell Chem Biol. 2019;26:1716-1724.e9 pubmed  publisher | 
| Qian X, Li X, Shi Z, Bai X, Xia Y, Zheng Y, et al . KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Mol Cell. 2019;: pubmed  publisher | 
| Virion Z, Doly S, Saha K, Lambert M, Guillonneau F, Bied C, et al . Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili. Nat Commun. 2019;10:4752 pubmed  publisher | 
| Stubb A, Guzman C, Närvä E, Aaron J, Chew T, Saari M, et al . Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells. Nat Commun. 2019;10:4756 pubmed  publisher | 
| Freyre C, Rauher P, Ejsing C, Klemm R. MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Mol Cell. 2019;76:811-825.e14 pubmed  publisher | 
| LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai R, Kara H, et al . LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells. Sci Adv. 2019;5:eaay3068 pubmed  publisher | 
| Graham M, Kim J, Da J, Brosnan Cashman J, Rizzo A, Baena Del Valle J, et al . Functional Loss of ATRX and TERC Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer Cells. Mol Cancer Res. 2019;17:2480-2491 pubmed  publisher | 
| Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nat Commun. 2019;10:4624 pubmed  publisher | 
| Smith E, Somma D, Kerrigan D, McIntyre Z, Cole J, Liang K, et al . The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80. Nucleic Acids Res. 2019;47:11151-11163 pubmed  publisher | 
| Amoasii L, Li H, Zhang Y, Min Y, Sanchez Ortiz E, Shelton J, et al . In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse. Nat Commun. 2019;10:4537 pubmed  publisher | 
| Ha S, Cho W, DeKoter R, Kim S. The transcription factor PU.1 mediates enhancer-promoter looping that is required for IL-1β eRNA and mRNA transcription in mouse melanoma and macrophage cell lines. J Biol Chem. 2019;294:17487-17500 pubmed  publisher | 
| Lundby A, Franciosa G, Emdal K, Refsgaard J, Gnosa S, Bekker Jensen D, et al . Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Cell. 2019;179:543-560.e26 pubmed  publisher | 
| Garcin E, Gon S, Sullivan M, Brunette G, Cian A, Concordet J, et al . Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells. PLoS Genet. 2019;15:e1008355 pubmed  publisher | 
| Jeong J, Jager A, Domizi P, Pavel Dinu M, Gojenola L, Iwasaki M, et al . High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells. Blood Adv. 2019;3:2825-2835 pubmed  publisher | 
| Li X, Li Q, Yu X, Li H, Huang G. Reverse of microtubule-directed chemotherapeutic drugs resistance induced by cancer-associated fibroblasts in breast cancer. Onco Targets Ther. 2019;12:7963-7973 pubmed  publisher | 
| Matre P, Mu X, Wu J, Danila D, Hall M, Kolonin M, et al . CRISPR/Cas9-Based Dystrophin Restoration Reveals a Novel Role for Dystrophin in Bioenergetics and Stress Resistance of Muscle Progenitors. Stem Cells. 2019;37:1615-1628 pubmed  publisher | 
| Acharya S, Mishra A, Paul D, Ansari A, Azhar M, Kumar M, et al . Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing. Proc Natl Acad Sci U S A. 2019;116:20959-20968 pubmed  publisher | 
| Dart D, Koushyar S, Lanning B, Jiang W. MiR-221 Is Specifically Elevated in PC3 Cells and its Deletion Reduces Adhesion, Motility and Growth. Anticancer Res. 2019;39:5311-5327 pubmed  publisher | 
| Sackmann V, Sinha M, Sackmann C, Civitelli L, Bergström J, Ansell Schultz A, et al . Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia. Front Mol Neurosci. 2019;12:200 pubmed  publisher | 
| Kashyap A, Fernandez Rodriguez L, Zhao Y, Monaco G, Trefny M, Yoshida N, et al . GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses. Cell Rep. 2019;28:3367-3380.e8 pubmed  publisher | 
| Li J, Han W, Wu K, Li Y, Liu Q, Lu W. A Conserved Tyrosine Residue in Slitrk3 Carboxyl-Terminus Is Critical for GABAergic Synapse Development. Front Mol Neurosci. 2019;12:213 pubmed  publisher | 
| Vagni P, Perlini L, Chenais N, Marchetti T, Parrini M, Contestabile A, et al . Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration. Front Neurosci. 2019;13:945 pubmed  publisher | 
| Adriaens C, Rambow F, Bervoets G, Silla T, Mito M, Chiba T, et al . The long noncoding RNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth. RNA. 2019;25:1681-1695 pubmed  publisher | 
| Fang S, Li J, Xiao Y, Lee M, Guo L, Han W, et al . Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development. Nat Commun. 2019;10:4297 pubmed  publisher | 
| Bernkopf D, Brückner M, Hadjihannas M, Behrens J. An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy. Nat Commun. 2019;10:4251 pubmed  publisher | 
| Ohneda K, Ohmori S, Yamamoto M. Mouse Tryptase Gene Expression is Coordinately Regulated by GATA1 and GATA2 in Bone Marrow-Derived Mast Cells. Int J Mol Sci. 2019;20: pubmed  publisher | 
| Du C, Hansen L, Singh S, Wang F, Sun R, Moure C, et al . A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis. Cell Rep. 2019;28:3199-3211.e5 pubmed  publisher | 
| Masamsetti V, Low R, Mak K, O Connor A, Riffkin C, Lamm N, et al . Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. Nat Commun. 2019;10:4224 pubmed  publisher | 
| Healy E, Mucha M, Glancy E, Fitzpatrick D, Conway E, Neikes H, et al . PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation. Mol Cell. 2019;76:437-452.e6 pubmed  publisher | 
| Vriend J, Peters J, Nieskens T, Škovroňová R, Blaimschein N, Schmidts M, et al . Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia. Biochim Biophys Acta Gen Subj. 2020;1864:129433 pubmed  publisher | 
| Ngo A, Shurtleff M, Popova K, Kulsuptrakul J, Weissman J, Puschnik A. The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins. elife. 2019;8: pubmed  publisher | 
| Hashwah H, Bertram K, Stirm K, Stelling A, Wu C, Kasser S, et al . The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma. EMBO Mol Med. 2019;11:e10576 pubmed  publisher | 
| Deshayes N, Arkan S, Hansen C. The Molecular Chaperone DNAJB6, but Not DNAJB1, Suppresses the Seeded Aggregation of Alpha-Synuclein in Cells. Int J Mol Sci. 2019;20: pubmed  publisher | 
| Williamson I, Kane L, Devenney P, Flyamer I, Anderson E, Kilanowski F, et al . Developmentally regulated Shh expression is robust to TAD perturbations. Development. 2019;146: pubmed  publisher | 
| Chang J, Yeh H, Park M, Erber L, Sun J, Cheng S, et al . mTOR-regulated U2af1 tandem exon splicing specifies transcriptome features for translational control. Nucleic Acids Res. 2019;47:10373-10387 pubmed  publisher | 
| Driscoll M, Welf E, Jamieson A, Dean K, Isogai T, Fiolka R, et al . Robust and automated detection of subcellular morphological motifs in 3D microscopy images. Nat Methods. 2019;16:1037-1044 pubmed  publisher | 
| Selvaraj S, Dhoke N, Kiley J, Mateos Aierdi A, Tungtur S, Mondragón González R, et al . Gene Correction of LGMD2A Patient-Specific iPSCs for the Development of Targeted Autologous Cell Therapy. Mol Ther. 2019;27:2147-2157 pubmed  publisher | 
| Burke J, Moon S, Matheny T, Parker R. RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs. Mol Cell. 2019;75:1203-1217.e5 pubmed  publisher | 
| Qian X, Li X, Shi Z, Xia Y, Cai Q, Xu D, et al . PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1. Mol Cell. 2019;76:516-527.e7 pubmed  publisher | 
| Sagi I, De Pinho J, Zuccaro M, Atzmon C, Golan Lev T, Yanuka O, et al . Distinct Imprinting Signatures and Biased Differentiation of Human Androgenetic and Parthenogenetic Embryonic Stem Cells. Cell Stem Cell. 2019;25:419-432.e9 pubmed  publisher | 
| van der Schoot J, Fennemann F, Valente M, Dölen Y, Hagemans I, Becker A, et al . Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering. Sci Adv. 2019;5:eaaw1822 pubmed  publisher | 
| Richard A, Vallin E, Romestaing C, Roussel D, Gandrillon O, Gonin Giraud S. Erythroid differentiation displays a peak of energy consumption concomitant with glycolytic metabolism rearrangements. PLoS ONE. 2019;14:e0221472 pubmed  publisher | 
| Sun H, Fan Z, Gingras A, López Ramírez M, Ginsberg M, Ley K. Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling. J Leukoc Biol. 2020;107:175-183 pubmed  publisher | 
| Sathyan K, McKenna B, Anderson W, Duarte F, Core L, Guertin M. An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion. Genes Dev. 2019;33:1441-1455 pubmed  publisher | 
| Kasitinon S, Eskiocak U, Martin M, Bezwada D, Khivansara V, Tasdogan A, et al . TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling. Cell Rep. 2019;28:2293-2305.e9 pubmed  publisher | 
| Stephan T, Roesch A, Riedel D, Jakobs S. Live-cell STED nanoscopy of mitochondrial cristae. Sci Rep. 2019;9:12419 pubmed  publisher | 
| Wallroth A, Koch P, Marat A, Krause E, Haucke V. Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1. Nat Cell Biol. 2019;21:1093-1101 pubmed  publisher | 
| Li S, Prasanna X, Salo V, Vattulainen I, Ikonen E. An efficient auxin-inducible degron system with low basal degradation in human cells. Nat Methods. 2019;16:866-869 pubmed  publisher | 
| Li X, Sun T, Wang X, Tang J, Liu Y. Restore natural fertility of Kitw/Kitwv mouse with nonobstructive azoospermia through gene editing on SSCs mediated by CRISPR-Cas9. Stem Cell Res Ther. 2019;10:271 pubmed  publisher | 
| Jameson N, Ma J, Benitez J, Izurieta A, Han J, Mendez R, et al . Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins. Mol Cancer Res. 2019;17:2208-2220 pubmed  publisher | 
| Kappel S, Stokłosa P, Hauert B, Ross Kaschitza D, Borgström A, Baur R, et al . TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells. Mol Oncol. 2019;13:2393-2405 pubmed  publisher | 
| Guo C, Wang M, Zhu Z, He S, Liu H, Liu X, et al . Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection. Front Immunol. 2019;10:1846 pubmed  publisher | 
| Kang J, Park J, Ko J, Kim Y. Regulation of gene expression by altered promoter methylation using a CRISPR/Cas9-mediated epigenetic editing system. Sci Rep. 2019;9:11960 pubmed  publisher | 
| Sherstyuk V, Davletshina G, Vyatkin Y, Shtokalo D, Vlasov V, Zakian S. A New MicroRNA Cluster Involved in the Reprogramming to a Pluripotent State. Acta Naturae. 2019;11:92-97 pubmed  publisher | 
| SEGEL M, Neumann B, Hill M, Weber I, Viscomi C, Zhao C, et al . Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature. 2019;573:130-134 pubmed  publisher | 
| El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, van Blerkom P, et al . A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell. 2019;178:1145-1158.e20 pubmed  publisher | 
| Ruicci K, Plantinga P, Pinto N, Khan M, Stecho W, Dhaliwal S, et al . Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition. Mol Oncol. 2019;13:2160-2177 pubmed  publisher | 
| Schmidt N, Domingues P, Golebiowski F, Patzina C, Tatham M, Hay R, et al . An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity. Proc Natl Acad Sci U S A. 2019;116:17399-17408 pubmed  publisher | 
| Sundaravinayagam D, Rahjouei A, Andreani M, Tupiņa D, Balasubramanian S, Saha T, et al . 53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function. Cell Rep. 2019;28:1389-1399.e6 pubmed  publisher | 
| Bittermann E, Abdelhamed Z, Liegel R, Menke C, Timms A, Beier D, et al . Differential requirements of tubulin genes in mammalian forebrain development. PLoS Genet. 2019;15:e1008243 pubmed  publisher | 
| Ooi Y, Majzoub K, Flynn R, Mata M, Diep J, Li J, et al . An RNA-centric dissection of host complexes controlling flavivirus infection. Nat Microbiol. 2019;4:2369-2382 pubmed  publisher | 
| Cichy A, Shah A, Dewan A, Kaye S, Bozza T. Genetic Depletion of Class I Odorant Receptors Impacts Perception of Carboxylic Acids. Curr Biol. 2019;29:2687-2697.e4 pubmed  publisher | 
| Walia R, Ho C, Lee C, Gilch S, Schatzl H. Gene-edited murine cell lines for propagation of chronic wasting disease prions. Sci Rep. 2019;9:11151 pubmed  publisher | 
| de Wispelaere M, Du G, Donovan K, Zhang T, Eleuteri N, Yuan J, et al . Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations. Nat Commun. 2019;10:3468 pubmed  publisher | 
| Saez I, Gerbracht J, Koyuncu S, Lee H, Horn M, Kroef V, et al . The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells. FEBS Lett. 2019;: pubmed  publisher | 
| Elliott B, Ho H, Ranganathan S, Vangaveti S, Ilkayeva O, Abou Assi H, et al . Modification of messenger RNA by 2'-O-methylation regulates gene expression in vivo. Nat Commun. 2019;10:3401 pubmed  publisher | 
| Lu M, Wei W. Proximity labeling to detect RNA-protein interactions in live cells. FEBS Open Bio. 2019;9:1860-1868 pubmed  publisher | 
| Hollern D, Swiatnicki M, Rennhack J, Misek S, Matson B, McAuliff A, et al . E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration. Sci Rep. 2019;9:10718 pubmed  publisher | 
| Khoshnejad M, Brenner J, Parhiz H, Muzykantov V. CRISPR/Cas9-Mediated Genetic Engineering of Hybridomas for Creation of Antibodies that Allow for Site-Specific Conjugation. Methods Mol Biol. 2019;2033:81-93 pubmed  publisher | 
| Rennhack J, To B, Swiatnicki M, Dulak C, Ogrodzinski M, Zhang Y, et al . Integrated analyses of murine breast cancer models reveal critical parallels with human disease. Nat Commun. 2019;10:3261 pubmed  publisher | 
| Ullrich F, Blin S, Lazarow K, Daubitz T, von Kries J, Jentsch T. Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels. elife. 2019;8: pubmed  publisher | 
| Yang D, Liu X, Xu W, Gu Z, Yang C, Zhang L, et al . The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection. PLoS Pathog. 2019;15:e1007917 pubmed  publisher | 
| Fukumoto T, Fatkhutdinov N, Zundell J, Tcyganov E, Nacarelli T, Karakashev S, et al . HDAC6 Inhibition Synergizes with Anti-PD-L1 Therapy in ARID1A-Inactivated Ovarian Cancer. Cancer Res. 2019;79:5482-5489 pubmed  publisher | 
| Pham D, Bruelle C, Thi Do H, Pajanoja C, Jin C, Srinivasan V, et al . Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells. Cell Death Dis. 2019;10:537 pubmed  publisher | 
| Espinoza J, Zisi A, Kanellis D, Carreras Puigvert J, Henriksson M, Huhn D, et al . The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity. Cell Death Differ. 2019;: pubmed  publisher | 
| Fang M, Markmiller S, Vu A, Javaherian A, Dowdle W, Jolivet P, et al . Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. 2019;: pubmed  publisher | 
| Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy A, et al . Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. EMBO J. 2019;38:e100926 pubmed  publisher | 
| Lignitto L, LeBoeuf S, Homer H, Jiang S, Askenazi M, Karakousi T, et al . Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. Cell. 2019;: pubmed  publisher | 
| Chen S, Sun S, Moonen D, Lee C, Lee A, Schaffer D, et al . CRISPR-READI: Efficient Generation of Knockin Mice by CRISPR RNP Electroporation and AAV Donor Infection. Cell Rep. 2019;27:3780-3789.e4 pubmed  publisher | 
| Clancy J, Zhang Y, Sheehan C, D SOUZA SCHOREY C. An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles. Nat Cell Biol. 2019;: pubmed  publisher | 
| Přikryl D, Plachy J, Kucerova D, Koslová A, Reinisová M, Senigl F, et al . The novel avian leukosis virus subgroup K shares its cellular chicken receptor with subgroup A. J Virol. 2019;: pubmed  publisher | 
| Travers T, Kanagy W, Mansbach R, Jhamba E, Cleyrat C, Goldstein B, et al . Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ. Mol Biol Cell. 2019;:mbcE18110722 pubmed  publisher | 
| Gothe H, Bouwman B, Gusmao E, Piccinno R, Petrosino G, Sayols S, et al . Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations. Mol Cell. 2019;: pubmed  publisher | 
| Salo V, Li S, Vihinen H, Hölttä Vuori M, Szkalisity A, Horvath P, et al . Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact. Dev Cell. 2019;: pubmed  publisher | 
| Moir Meyer G, Cheong P, Olijnik A, Brown J, Knight S, King A, et al . Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors. Methods Protoc. 2018;1: pubmed  publisher | 
| Kwon P, Kim H, Kim S, Kang B, Yi H, Ku H, et al . The poly(C) motif in the proximal promoter region of D-box binding protein (Dbp) drives its high-amplitude oscillation. Mol Cell Biol. 2019;: pubmed  publisher | 
| Zeitz M, Calhoun P, James C, Taetzsch T, George K, Robel S, et al . Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging. Cell Rep. 2019;27:2737-2747.e5 pubmed  publisher | 
| Artegiani B, van Voorthuijsen L, Lindeboom R, Seinstra D, Heo I, Tapia P, et al . Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids. Cell Stem Cell. 2019;: pubmed  publisher | 
| Krug B, De Jay N, Harutyunyan A, Deshmukh S, Marchione D, Guilhamon P, et al . Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas. Cancer Cell. 2019;35:782-797.e8 pubmed  publisher | 
| Alateeq S, Ovchinnikov D, Tracey T, Whitworth D, Al Rubaish A, Al Ali A, et al . Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns. APL Bioeng. 2018;2:046103 pubmed  publisher | 
| Mohan A, Dean K, Isogai T, Kasitinon S, Murali V, Roudot P, et al . Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. Dev Cell. 2019;49:444-460.e9 pubmed  publisher | 
| Mitchell D, Menon A, Garner A. Chemoproteomic Profiling Uncovers CDK4-Mediated Phosphorylation of the Translational Suppressor 4E-BP1. Cell Chem Biol. 2019;: pubmed  publisher | 
| McNamara D, Dovey C, Hale A, Quarato G, Grace C, Guibao C, et al . Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites. Cell Chem Biol. 2019;26:863-877.e7 pubmed  publisher | 
| Chino H, Hatta T, Natsume T, Mizushima N. Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Mol Cell. 2019;74:909-921.e6 pubmed  publisher | 
| Alapati D, Zacharias W, Hartman H, Rossidis A, Stratigis J, Ahn N, et al . In utero gene editing for monogenic lung disease. Sci Transl Med. 2019;11: pubmed  publisher | 
| Hoffmann M, Aschenbrenner S, Grosse S, Rapti K, Domenger C, Fakhiri J, et al . Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins. Nucleic Acids Res. 2019;: pubmed  publisher | 
| Princely Abudu Y, Pankiv S, Mathai B, Håkon Lystad A, Bindesbøll C, Brenne H, et al . NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Dev Cell. 2019;49:509-525.e12 pubmed  publisher | 
| Martens G, Ladowski J, Estrada J, Wang Z, Reyes L, Easlick J, et al . HLA Class I-sensitized Renal Transplant Patients Have Antibody Binding to SLA Class I Epitopes. Transplantation. 2019;103:1620-1629 pubmed  publisher | 
| Lee S, Mayr C. Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. Mol Cell. 2019;: pubmed  publisher | 
| Ferguson F, Doctor Z, Ficarro S, Browne C, Marto J, Johnson J, et al . Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019;26:804-817.e12 pubmed  publisher | 
| Roake C, Chen L, Chakravarthy A, Ferrell J, Raffa G, Artandi S. Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease. Mol Cell. 2019;74:688-700.e3 pubmed  publisher | 
| Bottermann M, Foss S, Caddy S, Clift D, van Tienen L, Vaysburd M, et al . Complement C4 Prevents Viral Infection through Capsid Inactivation. Cell Host Microbe. 2019;25:617-629.e7 pubmed  publisher | 
| Turco E, Witt M, Abert C, Bock Bierbaum T, Su M, Trapannone R, et al . FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates. Mol Cell. 2019;74:330-346.e11 pubmed  publisher | 
| Bäck S, Necarsulmer J, Whitaker L, Coke L, Koivula P, Heathward E, et al . Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Neuron. 2019;102:105-119.e8 pubmed  publisher | 
| Bajc Česnik A, Darovic S, Prpar Mihevc S, Stalekar M, Malnar M, Motaln H, et al . Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies. J Cell Sci. 2019;132: pubmed  publisher | 
| Habich M, Salscheider S, Murschall L, Hoehne M, Fischer M, Schorn F, et al . Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay. Cell Rep. 2019;26:759-774.e5 pubmed  publisher | 
| Liu L, Wang T, Wang M, Tong Q, Sun Y, Pu J, et al . Recombinant turkey herpesvirus expressing H9 hemagglutinin providing protection against H9N2 avian influenza. Virology. 2019;529:7-15 pubmed  publisher | 
| Asai R, Tsuchiya H, Amisaki M, Makimoto K, Takenaga A, Sakabe T, et al . CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line. Cancer Med. 2019;8:773-782 pubmed  publisher | 
| Zhu Q, Fang L, Heuberger J, Kranz A, Schipper J, Scheckenbach K, et al . The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Cell Rep. 2019;26:415-428.e5 pubmed  publisher | 
| Martyn G, Wienert B, Kurita R, Nakamura Y, Quinlan K, Crossley M. A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site. Blood. 2019;133:852-856 pubmed  publisher | 
| Atakpa P, van Marrewijk L, Apta Smith M, Chakraborty S, Taylor C. GPN does not release lysosomal Ca2+ but evokes Ca2+ release from the ER by increasing the cytosolic pH independently of cathepsin C. J Cell Sci. 2019;132: pubmed  publisher | 
| Jayachandran R, Gumienny A, Bolinger B, Ruehl S, Lang M, Fucile G, et al . Disruption of Coronin 1 Signaling in T Cells Promotes Allograft Tolerance while Maintaining Anti-Pathogen Immunity. Immunity. 2019;50:152-165.e8 pubmed  publisher | 
| Abernathy E, Mateo R, Majzoub K, van Buuren N, Bird S, Carette J, et al . Differential and convergent utilization of autophagy components by positive-strand RNA viruses. PLoS Biol. 2019;17:e2006926 pubmed  publisher | 
| Xu W, Liang D, Wang Q, Shen J, Liu Q, Peng Y. Knockdown of KDM2A inhibits proliferation associated with TGF-β expression in HEK293T cell. Mol Cell Biochem. 2019;456:95-104 pubmed  publisher | 
| Verschuren E, Hoenderop J, Peters D, Arjona F, Bindels R. Tubular flow activates magnesium transport in the distal convoluted tubule. FASEB J. 2019;33:5034-5044 pubmed  publisher | 
| Jeong Y, Simoneschi D, Keegan S, Melville D, Adler N, Saraf A, et al . The ULK1-FBXW5-SEC23B nexus controls autophagy. elife. 2018;7: pubmed  publisher | 
| Chou A, Aslanian A, Sun H, Hunter T. An internal ribosome entry site in the coding region of tyrosyl-DNA phosphodiesterase 2 drives alternative translation start. J Biol Chem. 2019;294:2665-2677 pubmed  publisher | 
| Lu X, Zhang D, Shoji H, Duan C, Zhang G, Isaji T, et al . Deficiency of α1,6-fucosyltransferase promotes neuroinflammation by increasing the sensitivity of glial cells to inflammatory mediators. Biochim Biophys Acta Gen Subj. 2018;1863:598-608 pubmed  publisher | 
| Chumley P, Zhou J, Mrug S, Chacko B, Parant J, Challa A, et al . Truncating PKHD1 and PKD2 mutations alter energy metabolism. Am J Physiol Renal Physiol. 2019;316:F414-F425 pubmed  publisher | 
| Claude Taupin A, Fonderflick L, Gauthier T, Mansi L, Pallandre J, Borg C, et al . ATG9A Is Overexpressed in Triple Negative Breast Cancer and Its In Vitro Extinction Leads to the Inhibition of Pro-Cancer Phenotypes. Cells. 2018;7: pubmed  publisher | 
| Kallimasioti Pazi E, Thelakkad Chathoth K, Taylor G, Meynert A, Ballinger T, Kelder M, et al . Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair. PLoS Biol. 2018;16:e2005595 pubmed  publisher | 
| Mentink R, Rella L, Radaszkiewicz T, Gybel T, Betist M, Bryja V, et al . The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism. PLoS Genet. 2018;14:e1007840 pubmed  publisher | 
| Gao Z, Herrera Carrillo E, Berkhout B. A Single H1 Promoter Can Drive Both Guide RNA and Endonuclease Expression in the CRISPR-Cas9 System. Mol Ther Nucleic Acids. 2018;14:32-40 pubmed  publisher | 
| Yamaguchi H, Hopf F, Li S, de Lecea L. In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness. Nat Commun. 2018;9:5211 pubmed  publisher | 
| Varela Eirin M, Varela Vazquez A, Guitián Caamaño A, Paíno C, Mato V, Largo R, et al . Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis. Cell Death Dis. 2018;9:1166 pubmed  publisher | 
| Close V, Close W, Kugler S, Reichenzeller M, Yosifov D, Bloehdorn J, et al . FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL. Blood. 2019;133:830-839 pubmed  publisher | 
| Bialk P, Wang Y, Banas K, Kmiec E. Functional Gene Knockout of NRF2 Increases Chemosensitivity of Human Lung Cancer A549 Cells In Vitro and in a Xenograft Mouse Model. Mol Ther Oncolytics. 2018;11:75-89 pubmed  publisher | 
| Sluch V, Chamling X, Wenger C, Duan Y, Rice D, Zack D. Highly efficient scarless knock-in of reporter genes into human and mouse pluripotent stem cells via transient antibiotic selection. PLoS ONE. 2018;13:e0201683 pubmed  publisher | 
| Liu X, Liu H, Wang M, Li R, Zeng J, Mo D, et al . Disruption of the ZBED6 binding site in intron 3 of IGF2 by CRISPR/Cas9 leads to enhanced muscle development in Liang Guang Small Spotted pigs. Transgenic Res. 2019;28:141-150 pubmed  publisher | 
| Heyn P, Logan C, Fluteau A, Challis R, Auchynnikava T, Martin C, et al . Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions. Nat Genet. 2019;51:96-105 pubmed  publisher | 
| Krueger K, Catanese L, Sciesielski L, Kirschner K, Scholz H. Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression. Biochim Biophys Acta Gene Regul Mech. 2018;1862:71-83 pubmed  publisher | 
| Cheng W, Chen L, Ho H, Lin H, Sheu M. Stearyl polyethylenimine complexed with plasmids as the core of human serum albumin nanoparticles noncovalently bound to CRISPR/Cas9 plasmids or siRNA for disrupting or silencing PD-L1 expression for immunotherapy. Int J Nanomedicine. 2018;13:7079-7094 pubmed  publisher | 
| Gonzalez P, O Prey J, Cardaci S, Barthet V, Sakamaki J, Beaumatin F, et al . Mannose impairs tumour growth and enhances chemotherapy. Nature. 2018;563:719-723 pubmed  publisher | 
| Churko J, Garg P, Treutlein B, Venkatasubramanian M, Wu H, Lee J, et al . Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis. Nat Commun. 2018;9:4906 pubmed  publisher | 
| Nieminen T, Scott T, Lin F, Chen Z, Yla Herttuala S, Morris K. Long Non-Coding RNA Modulation of VEGF-A during Hypoxia. Noncoding RNA. 2018;4: pubmed  publisher | 
| Shah J, Rouaud F, Guerrera D, Vasileva E, Popov L, Kelley W, et al . A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. Cell Rep. 2018;25:2132-2147.e7 pubmed  publisher | 
| Maeda A, Nishino T, Matsunaga R, Yokoyama A, Suga H, Yagi T, et al . Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling. Biochim Biophys Acta Mol Cell Res. 2019;1866:285-295 pubmed  publisher | 
| Davis J, Vadlamudi S, Roman T, Zeynalzadeh M, Iyengar A, Mohlke K. Enhancer deletion and allelic effects define a regulatory molecular mechanism at the VLDLR cholesterol GWAS locus. Hum Mol Genet. 2019;28:888-895 pubmed  publisher | 
| Miller D, Bloxham R, Jiang M, Gori I, Saunders R, Das D, et al . The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery. Cell Rep. 2018;25:1841-1855.e5 pubmed  publisher | 
| Chen S, Luperchio T, Wong X, Doan E, Byrd A, Roy Choudhury K, et al . A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus. Cell Rep. 2018;25:1729-1740.e6 pubmed  publisher | 
| Wu W, Chen T. Ribonucleoproteins Mediated Efficient In Vivo Gene Editing in Skin Stem Cells. Methods Mol Biol. 2019;1879:75-86 pubmed  publisher | 
| Wahiduzzaman M, Karnan S, Ota A, Hanamura I, Murakami H, Inoko A, et al . Establishment and characterization of CRISPR/Cas9-mediated NF2-/- human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma. Cancer Sci. 2019;110:180-193 pubmed  publisher | 
| Stafford J, Lee C, Voigt P, Descostes N, Saldaña Meyer R, Yu J, et al . Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma. Sci Adv. 2018;4:eaau5935 pubmed  publisher | 
| Koslová A, Kucerova D, Reinisová M, Geryk J, Trefil P, Hejnar J. Genetic Resistance to Avian Leukosis Viruses Induced by CRISPR/Cas9 Editing of Specific Receptor Genes in Chicken Cells. Viruses. 2018;10: pubmed  publisher | 
| Wei Y, Toth J, Blanco G, Bobkov A, Petroski M. Adapted ATPase domain communication overcomes the cytotoxicity of p97 inhibitors. J Biol Chem. 2018;293:20169-20180 pubmed  publisher | 
| Bubeck F, Hoffmann M, Harteveld Z, Aschenbrenner S, Bietz A, Waldhauer M, et al . Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9. Nat Methods. 2018;15:924-927 pubmed  publisher | 
| Nakamura T, Nakajima K, Ohnishi T, Yoshikawa T, Nakanishi M, Takumi T, et al . Quantitative evaluation of incomplete preweaning lethality in mice by using the CRISPR/Cas9 system. Sci Rep. 2018;8:16025 pubmed  publisher | 
| Liegel R, Finnerty E, Blizzard L, Distasio A, Hufnagel R, Saal H, et al . Using human sequencing to guide craniofacial research. Genesis. 2019;57:e23259 pubmed  publisher | 
| Young L, Hartig N, Boned Del Río I, Sari S, Ringham Terry B, Wainwright J, et al . SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis. Proc Natl Acad Sci U S A. 2018;115:E10576-E10585 pubmed  publisher | 
| Mendoza Topaz C, Nelson G, Howard G, Hafner S, Rademacher P, Frick M, et al . Cells respond to deletion of CAV1 by increasing synthesis of extracellular matrix. PLoS ONE. 2018;13:e0205306 pubmed  publisher | 
| Ying Z, Pan C, Shao T, Liu L, Li L, Guo D, et al . Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury. Mol Cell. 2018;72:457-468.e5 pubmed  publisher | 
| Park J, Lee H, Han N, Kwak S, Lee H, Kim J, et al . Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization. Nucleic Acids Res. 2018;46:11759-11775 pubmed  publisher | 
| Mahpour A, Scruggs B, Smiraglia D, Ouchi T, Gelman I. A methyl-sensitive element induces bidirectional transcription in TATA-less CpG island-associated promoters. PLoS ONE. 2018;13:e0205608 pubmed  publisher | 
| Krischuns T, Günl F, Henschel L, Binder M, Willemsen J, Schloer S, et al . Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells. Front Immunol. 2018;9:2229 pubmed  publisher | 
| Janssen A, Katrukha E, van Straaten W, Verlhac P, Reggiori F, Kapitein L. Probing aggrephagy using chemically-induced protein aggregates. Nat Commun. 2018;9:4245 pubmed  publisher | 
| Zhang G, Isaji T, Xu Z, Lu X, Fukuda T, Gu J. N-acetylglucosaminyltransferase-I as a novel regulator of epithelial-mesenchymal transition. FASEB J. 2018;:fj201801478R pubmed  publisher | 
| Wu S, Fatkhutdinov N, Fukumoto T, Bitler B, Park P, Kossenkov A, et al . SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells. Nat Commun. 2018;9:4116 pubmed  publisher | 
| Delgado Benito V, Rosen D, Wang Q, Gazumyan A, Pai J, Oliveira T, et al . The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination. Mol Cell. 2018;72:636-649.e8 pubmed  publisher | 
| Van Treuren T, Vishwanatha J. CRISPR deletion of MIEN1 in breast cancer cells. PLoS ONE. 2018;13:e0204976 pubmed  publisher | 
| Yamamoto M, Ben Shlomo A, Kameda H, Fukuoka H, Deng N, Ding Y, et al . Somatostatin receptor subtype 5 modifies hypothalamic-pituitary-adrenal axis stress function. JCI Insight. 2018;3: pubmed  publisher | 
| Schlauderer F, Seeholzer T, Desfosses A, Gehring T, Strauss M, Hopfner K, et al . Molecular architecture and regulation of BCL10-MALT1 filaments. Nat Commun. 2018;9:4041 pubmed  publisher | 
| Lahaye X, Gentili M, Silvin A, Conrad C, Picard L, Jouve M, et al . NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation. Cell. 2018;175:488-501.e22 pubmed  publisher | 
| Fan Y, Li M, Luo Y, Chen Q, Wang L, Zhang H, et al . Cationic lipid-assisted nanoparticles for delivery of mRNA cancer vaccine. Biomater Sci. 2018;6:3009-3018 pubmed  publisher | 
| Stefanoska K, Bertz J, Volkerling A, van der Hoven J, Ittner L, Ittner A. Neuronal MAP kinase p38? inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour. Sci Rep. 2018;8:14296 pubmed  publisher | 
| Zielke S, Meyer N, Mari M, Abou El Ardat K, Reggiori F, van Wijk S, et al . Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Cell Death Dis. 2018;9:994 pubmed  publisher | 
| Fort L, Batista J, Thomason P, Spence H, Whitelaw J, Tweedy L, et al . Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nat Cell Biol. 2018;20:1159-1171 pubmed  publisher | 
| Parola C, Mason D, Zingg A, Neumeier D, Reddy S. Genome Engineering of Hybridomas to Generate Stable Cell Lines for Antibody Expression. Methods Mol Biol. 2018;1850:79-111 pubmed  publisher | 
| Hayashi Y, Nemoto Sasaki Y, Matsumoto N, Hama K, Tanikawa T, Oka S, et al . Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels. J Biol Chem. 2018;293:17505-17522 pubmed  publisher | 
| Zhu D, Shen H, Tan S, Hu Z, Wang L, Yu L, et al . Nanoparticles Based on Poly (β-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy. Mol Ther. 2018;26:2443-2455 pubmed  publisher | 
| Dunn Fletcher C, Muglia L, Pavlicev M, Wolf G, Sun M, Hu Y, et al . Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length. PLoS Biol. 2018;16:e2006337 pubmed  publisher | 
| Monfort A, Di Minin G, Wutz A. Screening for Factors Involved in X Chromosome Inactivation Using Haploid ESCs. Methods Mol Biol. 2018;1861:1-18 pubmed  publisher | 
| Thompson K, Mai N, Oláhová M, Scialò F, Formosa L, Stroud D, et al . OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. EMBO Mol Med. 2018;10: pubmed  publisher | 
| Han Y, Bedarida T, Ding Y, Somba B, Lu Q, Wang Q, et al . β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4. Mol Cell. 2018;71:1064-1078.e5 pubmed  publisher | 
| Bin Moon S, Lee J, Kang J, Lee N, Ha D, Kim D, et al . Highly efficient genome editing by CRISPR-Cpf1 using CRISPR RNA with a uridinylate-rich 3'-overhang. Nat Commun. 2018;9:3651 pubmed  publisher | 
| Issuree P, Day K, Au C, Raviram R, Zappile P, Skok J, et al . Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development. Nat Commun. 2018;9:3594 pubmed  publisher | 
| Delcourt V, Brunelle M, Roy A, Jacques J, Salzet M, Fournier I, et al . The Protein Coded by a Short Open Reading Frame, Not by the Annotated Coding Sequence, Is the Main Gene Product of the Dual-Coding Gene MIEF1. Mol Cell Proteomics. 2018;17:2402-2411 pubmed  publisher | 
| Chen S, Jang G, Hüttenhain R, Gordon D, Du D, Newton B, et al . CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018;37: pubmed  publisher | 
| Zdralević M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, et al . Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. J Biol Chem. 2018;293:15947-15961 pubmed  publisher | 
| Lei K, Sun R, Chen L, Diplas B, Moure C, Wang W, et al . Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells. Sci Rep. 2018;8:12507 pubmed  publisher | 
| Brown N, Paluch A, Nashu M, Komurov K, Waltz S. Tumor Cell Autonomous RON Receptor Expression Promotes Prostate Cancer Growth Under Conditions of Androgen Deprivation. Neoplasia. 2018;20:917-929 pubmed  publisher | 
| Sun Z, Chadwick B. Loss of SETDB1 decompacts the inactive X chromosome in part through reactivation of an enhancer in the IL1RAPL1 gene. Epigenetics Chromatin. 2018;11:45 pubmed  publisher | 
| Diao Y, Rahman M, Vyatkin Y, Azatyan A, St Laurent G, Kapranov P, et al . Identification of novel GLI1 target genes and regulatory circuits in human cancer cells. Mol Oncol. 2018;12:1718-1734 pubmed  publisher | 
| Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, et al . Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation. J Cell Biol. 2018;217:3817-3828 pubmed  publisher | 
| Prinz E, Aviram S, Aronheim A. WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis. Mol Biol Cell. 2018;29:2470-2480 pubmed  publisher | 
| Huang X, Wu B, Nguyen D, Liu Y, Marani M, Hench J, et al . CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10. Hum Mol Genet. 2018;27:3881-3900 pubmed  publisher | 
| Ludlow A, Wong M, Robin J, Batten K, Yuan L, Lai T, et al . NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer. Nat Commun. 2018;9:3112 pubmed  publisher | 
| Yang D, Zheng X, Chen S, Wang Z, Xu W, Tan J, et al . Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish. Nat Commun. 2018;9:3052 pubmed  publisher | 
| Leung J, Emery L, Miller K. CRISPR/Cas9 Gene Editing of Human Histone H2A Variant H2AX and MacroH2A. Methods Mol Biol. 2018;1832:255-269 pubmed  publisher | 
| Fuentes D, Swigut T, Wysocka J. Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation. elife. 2018;7: pubmed  publisher | 
| de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed  publisher | 
| Amador Cañizares Y, Panigrahi M, Huys A, Kunden R, Adams H, Schinold M, et al . miR-122, small RNA annealing and sequence mutations alter the predicted structure of the Hepatitis C virus 5' UTR RNA to stabilize and promote viral RNA accumulation. Nucleic Acids Res. 2018;46:9776-9792 pubmed  publisher | 
| Ghezraoui H, Oliveira C, Becker J, Bilham K, Moralli D, Anzilotti C, et al . 53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ. Nature. 2018;560:122-127 pubmed  publisher | 
| Hynes A, Rousseau G, Agudelo D, Goulet A, Amigues B, Loehr J, et al . Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins. Nat Commun. 2018;9:2919 pubmed  publisher | 
| Kondo Y, Fu J, Wang H, Hoover C, McDaniel J, Steet R, et al . Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking. JCI Insight. 2018;3: pubmed  publisher | 
| Freimer J, Hu T, Blelloch R. Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells. elife. 2018;7: pubmed  publisher | 
| Yoo T, Choi J, Conway W, Yu C, Pappu R, Needleman D. Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments. elife. 2018;7: pubmed  publisher | 
| Espitia Jaimes C, Fish R, Neerman Arbez M. Local chromatin interactions contribute to expression of the fibrinogen gene cluster. J Thromb Haemost. 2018;16:2070-2082 pubmed  publisher | 
| Dewan A, Cichy A, Zhang J, Miguel K, Feinstein P, Rinberg D, et al . Single olfactory receptors set odor detection thresholds. Nat Commun. 2018;9:2887 pubmed  publisher | 
| Rysenkova K, Semina E, Karagyaur M, Shmakova A, Dyikanov D, Vasiluev P, et al . CRISPR/Cas9 nickase mediated targeting of urokinase receptor gene inhibits neuroblastoma cell proliferation. Oncotarget. 2018;9:29414-29430 pubmed  publisher | 
| Przepiorski A, Sander V, TRAN T, Hollywood J, Sorrenson B, Shih J, et al . A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells. Stem Cell Reports. 2018;11:470-484 pubmed  publisher | 
| Darnell A, Subramaniam A, O Shea E. Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells. Mol Cell. 2018;71:229-243.e11 pubmed  publisher | 
| Chen K, Stroup E, Budhipramono A, Rakheja D, Nichols Vinueza D, Xu L, et al . Mutations in microRNA processing genes in Wilms tumors derepress the IGF2 regulator PLAG1. Genes Dev. 2018;32:996-1007 pubmed  publisher | 
| Sarkar M, Hile G, Tsoi L, Xing X, Liu J, Liang Y, et al . Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa. Ann Rheum Dis. 2018;77:1653-1664 pubmed  publisher | 
| Bydlinski N, Maresch D, Schmieder V, Klanert G, Strasser R, Borth N. The contributions of individual galactosyltransferases to protein specific N-glycan processing in Chinese Hamster Ovary cells. J Biotechnol. 2018;282:101-110 pubmed  publisher | 
| Chen A, Liu A, Krishnakumar R, Freimer J, DeVeale B, Blelloch R. GRHL2-Dependent Enhancer Switching Maintains a Pluripotent Stem Cell Transcriptional Subnetwork after Exit from Naive Pluripotency. Cell Stem Cell. 2018;23:226-238.e4 pubmed  publisher | 
| Wienert B, Shin J, Zelin E, Pestal K, Corn J. In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway. PLoS Biol. 2018;16:e2005840 pubmed  publisher | 
| Lemmens B, Hegarat N, Akopyan K, Sala Gaston J, Bartek J, Hochegger H, et al . DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation. Mol Cell. 2018;71:117-128.e3 pubmed  publisher | 
| Loureiro M, Zorzetto Fernandes A, Radoshitzky S, Chi X, Dallari S, Marooki N, et al . DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection. PLoS Pathog. 2018;14:e1007125 pubmed  publisher | 
| Fukui R, Yamamoto C, Matsumoto F, Onji M, Shibata T, Murakami Y, et al . Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA. Front Immunol. 2018;9:1491 pubmed  publisher | 
| Baradaran R, Wang C, Siliciano A, LONG S. Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters. Nature. 2018;559:580-584 pubmed  publisher | 
| Cárdenas A, Villalba A, de Juan Romero C, Picó E, Kyrousi C, Tzika A, et al . Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Cell. 2018;174:590-606.e21 pubmed  publisher | 
| Seeley J, Baker R, Mohamed G, Bruns T, Hayden M, Deshmukh S, et al . Induction of innate immune memory via microRNA targeting of chromatin remodelling factors. Nature. 2018;559:114-119 pubmed  publisher | 
| Liu B, Yang H, Pilarsky C, Weber G. The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3β in Pancreatic Cancer. Int J Mol Sci. 2018;19: pubmed  publisher | 
| Wahiduzzaman M, Ota A, Karnan S, Hanamura I, Mizuno S, Kanasugi J, et al . Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo. Cancer Lett. 2018;433:117-130 pubmed  publisher | 
| Meyer N, Zielke S, Michaelis J, Linder B, Warnsmann V, Rakel S, et al . AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy. 2018;14:1693-1709 pubmed  publisher | 
| Oksuz O, Narendra V, Lee C, Descostes N, LeRoy G, Raviram R, et al . Capturing the Onset of PRC2-Mediated Repressive Domain Formation. Mol Cell. 2018;70:1149-1162.e5 pubmed  publisher | 
| Zhao C, Dong C, Frah M, Deng Y, Marie C, Zhang F, et al . Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Dev Cell. 2018;45:753-768.e8 pubmed  publisher | 
| Liu Q, Thoms J, Nunez A, Huang Y, Knezevic K, Packham D, et al . Disruption of a -35 kb Enhancer Impairs CTCF Binding and MLH1 Expression in Colorectal Cells. Clin Cancer Res. 2018;24:4602-4611 pubmed  publisher | 
| Zhang S, He Y, Sen B, Chen X, Xie Y, Keasling J, et al . Alleviation of reactive oxygen species enhances PUFA accumulation in Schizochytrium sp. through regulating genes involved in lipid metabolism. Metab Eng Commun. 2018;6:39-48 pubmed  publisher | 
| Marcassa E, Kallinos A, Jardine J, Rusilowicz Jones E, Martinez A, Kuehl S, et al . Dual role of USP30 in controlling basal pexophagy and mitophagy. EMBO Rep. 2018;19: pubmed  publisher | 
| Yasunaga K, Ito T, Miki M, Ueda K, Fujiyama T, Tachibana Y, et al . Using CRISPR/Cas9 to Knock out Amylase in Acinar Cells Decreases Pancreatitis-Induced Autophagy. Biomed Res Int. 2018;2018:8719397 pubmed  publisher | 
| Almeida Souza L, Frank R, García Nafría J, Colussi A, Gunawardana N, Johnson C, et al . A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits. Cell. 2018;174:325-337.e14 pubmed  publisher | 
| Luo J, Lu L, Gu Y, Huang R, Gui L, Li S, et al . Speed genome editing by transient CRISPR/Cas9 targeting and large DNA fragment deletion. J Biotechnol. 2018;281:11-20 pubmed  publisher | 
| Dovey C, Diep J, Clarke B, Hale A, McNamara D, Guo H, et al . MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol Cell. 2018;70:936-948.e7 pubmed  publisher | 
| Inamori K, Ito H, Tamura Y, Nitta T, Yang X, Nihei W, et al . Deficient ganglioside synthesis restores responsiveness to leptin and melanocortin signaling in obese KKAy mice. J Lipid Res. 2018;59:1472-1481 pubmed  publisher | 
| Højland Knudsen C, Ásgrímsdóttir E, Rahimi K, Gill K, Frandsen S, Hvolbøl Buchholdt S, et al . A Modified Monomeric Red Fluorescent Protein Reporter for Assessing CRISPR Activity. Front Cell Dev Biol. 2018;6:54 pubmed  publisher | 
| Lin Y, Seo J, Gao F, Feldman H, Wen H, Penney J, et al . APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types. Neuron. 2018;98:1141-1154.e7 pubmed  publisher | 
| György B, Lööv C, Zaborowski M, Takeda S, Kleinstiver B, Commins C, et al . CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Mol Ther Nucleic Acids. 2018;11:429-440 pubmed  publisher | 
| Fiddes I, Lodewijk G, Mooring M, Bosworth C, Ewing A, Mantalas G, et al . Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis. Cell. 2018;173:1356-1369.e22 pubmed  publisher | 
| Fiedler E, Bhutkar A, Lawler E, Besada R, Hemann M. In vivo RNAi screening identifies Pafah1b3 as a target for combination therapy with TKIs in BCR-ABL1+ BCP-ALL. Blood Adv. 2018;2:1229-1242 pubmed  publisher | 
| Eisenhut P, Klanert G, Weinguny M, Baier L, Jadhav V, Ivansson D, et al . A CRISPR/Cas9 based engineering strategy for overexpression of multiple genes in Chinese hamster ovary cells. Metab Eng. 2018;48:72-81 pubmed  publisher | 
| Kanatsu K, Hori Y, Ebinuma I, Chiu Y, Tomita T. Retrograde transport of ?-secretase from endosomes to the trans-Golgi network regulates A?42 production. J Neurochem. 2018;: pubmed  publisher | 
| Kobayashi K, Sudaka Y, Takashino A, Imura A, Fujii K, Koike S. Amino Acid Variation at VP1-145 of Enterovirus 71 Determines Attachment Receptor Usage and Neurovirulence in Human Scavenger Receptor B2 Transgenic Mice. J Virol. 2018;92: pubmed  publisher | 
| Weissmann S, Cloos P, Sidoli S, Jensen O, Pollard S, Helin K. The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation. Cancer Res. 2018;78:4114-4125 pubmed  publisher | 
| Lambrus B, Moyer T, Holland A. Applying the auxin-inducible degradation system for rapid protein depletion in mammalian cells. Methods Cell Biol. 2018;144:107-135 pubmed  publisher | 
| Marx N, Grünwald Gruber C, Bydlinski N, Dhiman H, Ngoc Nguyen L, Klanert G, et al . CRISPR-Based Targeted Epigenetic Editing Enables Gene Expression Modulation of the Silenced Beta-Galactoside Alpha-2,6-Sialyltransferase 1 in CHO Cells. Biotechnol J. 2018;13:e1700217 pubmed  publisher | 
| Diplas B, He X, Brosnan Cashman J, Liu H, Chen L, Wang Z, et al . The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma. Nat Commun. 2018;9:2087 pubmed  publisher | 
| Chen H, Li C, Zhou Z, Liang H. Fast-Evolving Human-Specific Neural Enhancers Are Associated with Aging-Related Diseases. Cell Syst. 2018;6:604-611.e4 pubmed  publisher | 
| Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N. Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J Cell Biol. 2018;217:2633-2645 pubmed  publisher | 
| Dedoni S, CAMPBELL L, Harvey B, Avdoshina V, Mocchetti I. The orphan G-protein-coupled receptor 75 signaling is activated by the chemokine CCL5. J Neurochem. 2018;146:526-539 pubmed  publisher | 
| Kumar S, Morrison J, Dingli D, Poeschla E. HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products. J Virol. 2018;92: pubmed  publisher | 
| Arshad N, Cresswell P. Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I. J Biol Chem. 2018;293:9555-9569 pubmed  publisher | 
| Lork M, Kreike M, Staal J, Beyaert R. Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKK?/TBK1 as a Case Study. Front Cell Dev Biol. 2018;6:40 pubmed  publisher | 
| Haabeth O, Fauskanger M, Manzke M, Lundin K, Corthay A, Bogen B, et al . CD4+ T-cell-Mediated Rejection of MHC Class II-Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs. Cancer Res. 2018;78:4573-4585 pubmed  publisher | 
| Yu Z, Surface L, Park C, Horlbeck M, Wyant G, Abu Remaileh M, et al . Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. elife. 2018;7: pubmed  publisher | 
| Parry A, Hoare M, Bihary D, Hänsel Hertsch R, Smith S, Tomimatsu K, et al . NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nat Commun. 2018;9:1840 pubmed  publisher | 
| Du Y, Zhao Y, Li C, Zheng Q, Tian J, Li Z, et al . Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes. J Exp Med. 2018;215:1665-1677 pubmed  publisher | 
| Chang J, Zhang W, Yeh H, Park M, Yao C, Shi Y, et al . An integrative model for alternative polyadenylation, IntMAP, delineates mTOR-modulated endoplasmic reticulum stress response. Nucleic Acids Res. 2018;46:5996-6008 pubmed  publisher | 
| Tröder S, Ebert L, Butt L, Assenmacher S, Schermer B, Zevnik B. An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes. PLoS ONE. 2018;13:e0196891 pubmed  publisher | 
| Peters Hall J, Coquelin M, Torres M, LaRanger R, Alabi B, Sho S, et al . Long-term culture and cloning of primary human bronchial basal cells that maintain multipotent differentiation capacity and CFTR channel function. Am J Physiol Lung Cell Mol Physiol. 2018;315:L313-L327 pubmed  publisher | 
| Guy J, Alexander Howden B, Fitzpatrick L, Desousa D, Koerner M, Selfridge J, et al . A mutation-led search for novel functional domains in MeCP2. Hum Mol Genet. 2018;27:2531-2545 pubmed  publisher | 
| Hegge B, Sjøttem E, Mikkola I. Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress. BMC Cancer. 2018;18:496 pubmed  publisher | 
| Yu J, Zhou J, Xu F, Bai W, Zhang W. High expression of Aurora-B is correlated with poor prognosis and drug resistance in non-small cell lung cancer. Int J Biol Markers. 2018;33:215-221 pubmed  publisher | 
| Nguyen Q, Nicoll R. The GABAA Receptor β Subunit Is Required for Inhibitory Transmission. Neuron. 2018;98:718-725.e3 pubmed  publisher | 
| Balestrieri C, Alfarano G, Milan M, Tosi V, Prosperini E, Nicoli P, et al . Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity. Cell. 2018;173:1150-1164.e14 pubmed  publisher | 
| Peng X, Xu X, Wang Y, Hawke D, Yu S, Han L, et al . A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer. Cancer Cell. 2018;33:817-828.e7 pubmed  publisher | 
| Seong H, Manoharan R, Ha H. Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity. Cell Death Dis. 2018;9:471 pubmed  publisher | 
| Mercado Matos J, Janusis J, Zhu S, Chen S, Shaw L. Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2. Mol Cell Biol. 2018;38: pubmed  publisher | 
| Wang W, Zheng W, Hu F, He X, Wu D, Zhang W, et al . Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9. ACS Synth Biol. 2018;7:1259-1268 pubmed  publisher | 
| Lin G, Zhang K, Peng R, Han Y, Xie J, Li J. Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/CRISPR-Associated Endonuclease Cas9-Mediated Homology-Independent Integration for Generating Quality Control Materials for Clinical Molecular Genetic Testing. J Mol Diagn. 2018;20:373-380 pubmed  publisher | 
| Takahashi C, Miyatake K, Kusakabe M, Nishida E. The atypical mitogen-activated protein kinase ERK3 is essential for establishment of epithelial architecture. J Biol Chem. 2018;293:8342-8361 pubmed  publisher | 
| Lee K, Chatterjee P, Choi E, Sung M, Oh J, Won H, et al . Selection on the regulation of sympathetic nervous activity in humans and chimpanzees. PLoS Genet. 2018;14:e1007311 pubmed  publisher | 
| Zhu S, Ward B, Yu J, Matthew Onabanjo A, Janusis J, Hsieh C, et al . IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma. JCI Insight. 2018;3: pubmed  publisher | 
| He X, Kläsener K, Iype J, Becker M, Maity P, Cavallari M, et al . Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells. EMBO J. 2018;37: pubmed  publisher | 
| Finley L, Vardhana S, Carey B, Alonso Curbelo D, Koche R, Chen Y, et al . Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity. Nat Cell Biol. 2018;20:565-574 pubmed  publisher | 
| Ding S, Diep J, Feng N, Ren L, Li B, Ooi Y, et al . STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. Nat Commun. 2018;9:1485 pubmed  publisher | 
| Yu X, Zhang Y, Ma X, Pertsemlidis A. miR-195 potentiates the efficacy of microtubule-targeting agents in non-small cell lung cancer. Cancer Lett. 2018;427:85-93 pubmed  publisher | 
| Moutal A, Sun L, Yang X, Li W, Cai S, Luo S, et al . CRMP2-Neurofibromin Interface Drives NF1-related Pain. Neuroscience. 2018;381:79-90 pubmed  publisher | 
| Mahen R. Stable centrosomal roots disentangle to allow interphase centriole independence. PLoS Biol. 2018;16:e2003998 pubmed  publisher | 
| Sanli I, Lalevée S, Cammisa M, Perrin A, Rage F, Lleres D, et al . Meg3 Non-coding RNA Expression Controls Imprinting by Preventing Transcriptional Upregulation in cis. Cell Rep. 2018;23:337-348 pubmed  publisher | 
| Anderson D, Kaplan D, Bell K, Koutsis K, Haynes J, Mills R, et al . NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. Nat Commun. 2018;9:1373 pubmed  publisher | 
| Liu B, Yang H, Taher L, Denz A, Grutzmann R, Pilarsky C, et al . Identification of Prognostic Biomarkers by Combined mRNA and miRNA Expression Microarray Analysis in Pancreatic Cancer. Transl Oncol. 2018;11:700-714 pubmed  publisher | 
| Lecuyer H, Virion Z, Barnier J, Matczak S, Bourdoulous S, Bianchini E, et al . An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. PLoS Pathog. 2018;14:e1006981 pubmed  publisher | 
| Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, et al . A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities. Mol Cell. 2018;70:408-421.e8 pubmed  publisher | 
| Chen W, Chen M, Xu Y, Chen X, Zhou P, Zhao X, et al . Long non-coding RNA THOR promotes human osteosarcoma cell growth in vitro and in vivo. Biochem Biophys Res Commun. 2018;499:913-919 pubmed  publisher | 
| Chen H, Li C, Peng X, Zhou Z, Weinstein J, Liang H. A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples. Cell. 2018;173:386-399.e12 pubmed  publisher | 
| Martyn G, Wienert B, Yang L, Shah M, Norton L, Burdach J, et al . Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding. Nat Genet. 2018;50:498-503 pubmed  publisher | 
| Bazzani L, Donnini S, Giachetti A, Christofori G, Ziche M. PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells. Oncotarget. 2018;9:14939-14958 pubmed  publisher | 
| Rosselli Murai L, Yates J, Yoshida S, Bourg J, Ho K, White M, et al . Loss of PTEN promotes formation of signaling-capable clathrin-coated pits. J Cell Sci. 2018;131: pubmed  publisher | 
| Nerys Junior A, Braga Dias L, Pezzuto P, Cotta de Almeida V, Tanuri A. Comparison of the editing patterns and editing efficiencies of TALEN and CRISPR-Cas9 when targeting the human CCR5 gene. Genet Mol Biol. 2018;41:167-179 pubmed  publisher | 
| Zhang L, Li J, Zhang P, Gao Z, Zhao Y, Qiao X, et al . PI4KII? regulates insulin secretion and glucose homeostasis via a PKD-dependent pathway. Biophys Rep. 2018;4:25-38 pubmed  publisher | 
| Sarin S, ZUNIGA SANCHEZ E, Kurmangaliyev Y, Cousins H, Patel M, Hernandez J, et al . Role for Wnt Signaling in Retinal Neuropil Development: Analysis via RNA-Seq and In Vivo Somatic CRISPR Mutagenesis. Neuron. 2018;98:109-126.e8 pubmed  publisher | 
| Hertzog J, Dias Júnior A, Rigby R, Donald C, Mayer A, Sezgin E, et al . Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling. Eur J Immunol. 2018;48:1120-1136 pubmed  publisher | 
| Qiang L, Wang J, Zhang Y, Ge P, Chai Q, Li B, et al . Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. Cell Mol Immunol. 2018;: pubmed  publisher | 
| Cheng L, Tang Y, Chen X, Zhao L, Liu S, Ma Y, et al . Deletion of MBD2 inhibits proliferation of chronic myeloid leukaemia blast phase cells. Cancer Biol Ther. 2018;19:676-686 pubmed  publisher | 
| Barbier J, Chen X, Sanchez G, Cai M, Helsmoortel M, Higuchi T, et al . An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression. Cell Res. 2018;28:556-571 pubmed  publisher | 
| Mazel Sanchez B, Boal Carvalho I, Silva F, Dijkman R, Schmolke M. H5N1 Influenza A Virus PB1-F2 Relieves HAX-1-Mediated Restriction of Avian Virus Polymerase PA in Human Lung Cells. J Virol. 2018;92: pubmed  publisher | 
| Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth C, et al . Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. J Biol Chem. 2018;293:7408-7422 pubmed  publisher | 
| Amaya Ramirez C, Hubbe P, Mandel N, Béthune J. 4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2. Nucleic Acids Res. 2018;46:5792-5808 pubmed  publisher | 
| Kanwal M, Ding X, Song X, Zhou G, Cao Y. MUC16 overexpression induced by gene mutations promotes lung cancer cell growth and invasion. Oncotarget. 2018;9:12226-12239 pubmed  publisher | 
| Perez García V, Fineberg E, Wilson R, Murray A, Mazzeo C, Tudor C, et al . Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018;555:463-468 pubmed  publisher | 
| Takaku M, Grimm S, Roberts J, Chrysovergis K, Bennett B, Myers P, et al . GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network. Nat Commun. 2018;9:1059 pubmed  publisher | 
| Pines A, Dijk M, Makowski M, Meulenbroek E, Vrouwe M, van der Weegen Y, et al . TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A. Nat Commun. 2018;9:1040 pubmed  publisher | 
| Zhang Y, Guan Q, Liu Y, Zhang Y, Chen Y, Chen J, et al . Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice. J Biol Chem. 2018;293:7894-7904 pubmed  publisher | 
| Horn M, Kroef V, Allmeroth K, Schüller N, Miethe S, Peifer M, et al . Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells. Oncotarget. 2018;9:9838-9851 pubmed  publisher | 
| Huang J, Li K, Cai W, Liu X, Zhang Y, Orkin S, et al . Dissecting super-enhancer hierarchy based on chromatin interactions. Nat Commun. 2018;9:943 pubmed  publisher | 
| Caprara G, Prosperini E, Piccolo V, Sigismondo G, Melacarne A, Cuomo A, et al . PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN-Inducible Proteins. J Immunol. 2018;200:2439-2454 pubmed  publisher | 
| Gao Z, Herrera Carrillo E, Berkhout B. Delineation of the Exact Transcription Termination Signal for Type 3 Polymerase III. Mol Ther Nucleic Acids. 2018;10:36-44 pubmed  publisher | 
| Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, et al . Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018;20:285-295 pubmed  publisher | 
| McArthur K, Whitehead L, Heddleston J, Li L, Padman B, Oorschot V, et al . BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science. 2018;359: pubmed  publisher | 
| Macheret M, Halazonetis T. Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress. Nature. 2018;555:112-116 pubmed  publisher | 
| Delorme Axford E, Abernathy E, Lennemann N, Bernard A, Ariosa A, Coyne C, et al . The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy. Autophagy. 2018;14:898-912 pubmed  publisher | 
| Kornete M, Marone R, Jeker L. Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells. J Immunol. 2018;200:2489-2501 pubmed  publisher | 
| Li R, Cauchy P, Ramamoorthy S, Boller S, Chavez L, Grosschedl R. Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming. Genes Dev. 2018;32:96-111 pubmed  publisher | 
| Bernkopf D, Jalal K, Brückner M, Knaup K, Gentzel M, Schambony A, et al . Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling. J Cell Biol. 2018;217:1383-1394 pubmed  publisher | 
| Kuliyev E, Gingras S, Guy C, Howell S, Vogel P, Pelletier S. Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. J Neurosci. 2018;38:2615-2630 pubmed  publisher | 
| Swindell W, Beamer M, Sarkar M, Loftus S, Fullmer J, Xing X, et al . RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature. Front Immunol. 2018;9:80 pubmed  publisher | 
| Meyer C, Garzia A, Mazzola M, Gerstberger S, Molina H, Tuschl T. The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression. Mol Cell. 2018;69:622-635.e6 pubmed  publisher | 
| Ebner P, Poetsch I, Deszcz L, Hoffmann T, Zuber J, Ikeda F. The IAP family member BRUCE regulates autophagosome-lysosome fusion. Nat Commun. 2018;9:599 pubmed  publisher | 
| Arnhold V, Schmelz K, Proba J, Winkler A, W nschel J, Toedling J, et al . Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma. Oncotarget. 2018;9:2304-2319 pubmed  publisher | 
| Yu X, Zhang Y, Cavazos D, Ma X, Zhao Z, Du L, et al . miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer. Cell Death Dis. 2018;9:193 pubmed  publisher | 
| Jafarnejad S, Chapat C, Matta Camacho E, Gelbart I, Hesketh G, Arguello M, et al . Translational control of ERK signaling through miRNA/4EHP-directed silencing. elife. 2018;7: pubmed  publisher | 
| Long C, Li H, Tiburcy M, Rodriguez Caycedo C, Kyrychenko V, Zhou H, et al . Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Sci Adv. 2018;4:eaap9004 pubmed  publisher | 
| Shen Y, Zhang J, Yu T, Qi C. Generation of PTEN knockout bone marrow mesenchymal stem cell lines by CRISPR/Cas9-mediated genome editing. Cytotechnology. 2018;70:783-791 pubmed  publisher | 
| Jia S, Zhang R, Lin G, Peng R, Gao P, Han Y, et al . A novel cell line generated using the CRISPR/Cas9 technology as universal quality control material for KRAS G12V mutation testing. J Clin Lab Anal. 2018;32:e22391 pubmed  publisher | 
| van Haren J, Charafeddine R, Ettinger A, Wang H, Hahn K, Wittmann T. Local control of intracellular microtubule dynamics by EB1 photodissociation. Nat Cell Biol. 2018;20:252-261 pubmed  publisher | 
| Khoshnejad M, Brenner J, Motley W, Parhiz H, Greineder C, Villa C, et al . Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9. Sci Rep. 2018;8:1760 pubmed  publisher | 
| Markmiller S, Soltanieh S, Server K, Mak R, Jin W, Fang M, et al . Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018;172:590-604.e13 pubmed  publisher | 
| Calo E, Gu B, Bowen M, Aryan F, Zalc A, Liang J, et al . Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature. 2018;554:112-117 pubmed  publisher | 
| de Groot R, Lüthi J, Lindsay H, Holtackers R, Pelkmans L. Large-scale image-based profiling of single-cell phenotypes in arrayed CRISPR-Cas9 gene perturbation screens. Mol Syst Biol. 2018;14:e8064 pubmed  publisher | 
| Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, et al . Lack of beta-arrestin signaling in the absence of active G proteins. Nat Commun. 2018;9:341 pubmed  publisher | 
| Cao S, Zhou K, Zhang Z, Luger K, Straight A. Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell. Mol Biol Cell. 2018;29:751-762 pubmed  publisher | 
| Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, et al . Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Nat Commun. 2018;9:242 pubmed  publisher | 
| Cormerais Y, Massard P, Vucetic M, Giuliano S, Tambutte E, Durivault J, et al . The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5). J Biol Chem. 2018;293:2877-2887 pubmed  publisher | 
| Fernández Barrera J, Bernabé Rubio M, Casares Arias J, Rangel L, Fernández Martín L, Correas I, et al . The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression. J Cell Biol. 2018;217:929-944 pubmed  publisher | 
| Fletcher K, Ulferts R, Jacquin E, Veith T, Gammoh N, Arasteh J, et al . The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes. EMBO J. 2018;37: pubmed  publisher | 
| Steyer B, Bu Q, Cory E, Jiang K, Duong S, Sinha D, et al . Scarless Genome Editing of Human Pluripotent Stem Cells via Transient Puromycin Selection. Stem Cell Reports. 2018;10:642-654 pubmed  publisher | 
| Anding A, Wang C, Chang T, Sliter D, Powers C, Hofmann K, et al . Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Curr Biol. 2018;28:287-295.e6 pubmed  publisher | 
| Wu W, Schecker J, Würstle S, Schneider F, Schönfelder M, Schlegel J. Aldehyde dehydrogenase 1A3 (ALDH1A3) is regulated by autophagy in human glioblastoma cells. Cancer Lett. 2018;417:112-123 pubmed  publisher | 
| Cleyrat C, Girard R, Choi E, Jeziorski E, Lavabre Bertrand T, Hermouet S, et al . Gene editing rescue of a novel MPL mutant associated with congenital amegakaryocytic thrombocytopenia. Blood Adv. 2017;1:1815-1826 pubmed  publisher | 
| Ji Y, Huang Z, Yang X, Wang X, Zhao L, Wang P, et al . The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat Med. 2018;24:213-223 pubmed  publisher | 
| Pusapati G, Kong J, Patel B, Krishnan A, Sagner A, Kinnebrew M, et al . CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog. Dev Cell. 2018;44:113-129.e8 pubmed  publisher | 
| Flores Pérez A, Elizondo G. Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. Chem Biol Interact. 2018;281:98-105 pubmed  publisher | 
| Corsinotti A, Wong F, Tatar T, Szczerbinska I, Halbritter F, Colby D, et al . Distinct SoxB1 networks are required for naïve and primed pluripotency. elife. 2017;6: pubmed  publisher | 
| Kim J, Sturgill D, Sebastian R, Khurana S, Tran A, Edwards G, et al . Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. Mol Cell. 2018;69:36-47.e7 pubmed  publisher | 
| Gao Y, Lee C, Song J, Li S, Cui Y, Liu Y, et al . Digenic mutations on SCAP and AGXT2 predispose to premature myocardial infarction. Oncotarget. 2017;8:100141-100149 pubmed  publisher | 
| Hosono Y, Niknafs Y, Prensner J, Iyer M, Dhanasekaran S, Mehra R, et al . Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA. Cell. 2017;171:1559-1572.e20 pubmed  publisher | 
| Zhu T, Yong X, Xia D, Widagdo J, Anggono V. Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein. J Mol Biol. 2018;430:363-371 pubmed  publisher | 
| Wang J, Hanada K, Gareri C, Rockman H. Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling. J Cell Biochem. 2018;119:3586-3597 pubmed  publisher | 
| Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, et al . A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Cell. 2018;172:373-386.e10 pubmed  publisher | 
| Tucker N, McLellan M, Hu D, Ye J, Parsons V, Mills R, et al . Novel Mutation in FLNC (Filamin C) Causes Familial Restrictive Cardiomyopathy. Circ Cardiovasc Genet. 2017;10: pubmed  publisher | 
| Adikusuma F, Pfitzner C, Thomas P. Versatile single-step-assembly CRISPR/Cas9 vectors for dual gRNA expression. PLoS ONE. 2017;12:e0187236 pubmed  publisher | 
| Xin Q, Kong S, Yan J, Qiu J, He B, Zhou C, et al . Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation. J Clin Invest. 2018;128:175-189 pubmed  publisher | 
| Taketani Y, Kitamoto K, Sakisaka T, Kimakura M, Toyono T, Yamagami S, et al . Repair of the TGFBI gene in human corneal keratocytes derived from a granular corneal dystrophy patient via CRISPR/Cas9-induced homology-directed repair. Sci Rep. 2017;7:16713 pubmed  publisher | 
| Wang Y, Yin B, Li D, Wang G, Han X, Sun X. GSDME mediates caspase-3-dependent pyroptosis in gastric cancer. Biochem Biophys Res Commun. 2018;495:1418-1425 pubmed  publisher | 
| Gurbuz F, Desai S, Diao F, Turkkahraman D, Wranitz F, Wood Trageser M, et al . Novel inactivating mutations of the DCAF17 gene in American and Turkish families cause male infertility and female subfertility in the mouse model. Clin Genet. 2018;93:853-859 pubmed  publisher | 
| Wang J, Hanada K, Staus D, Makara M, Dahal G, Chen Q, et al . Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. Nat Commun. 2017;8:1706 pubmed  publisher | 
| de Padua M, Delodi G, Vucetic M, Durivault J, Vial V, Bayer P, et al . Disrupting glucose-6-phosphate isomerase fully suppresses the "Warburg effect" and activates OXPHOS with minimal impact on tumor growth except in hypoxia. Oncotarget. 2017;8:87623-87637 pubmed  publisher | 
| Johnson A, Petrov A, Fuchs G, Majzoub K, Grosely R, Choi J, et al . Fluorescently-tagged human eIF3 for single-molecule spectroscopy. Nucleic Acids Res. 2018;46:e8 pubmed  publisher | 
| Mircetic J, Dietrich A, Paszkowski Rogacz M, Krause M, Buchholz F. Development of a genetic sensor that eliminates p53 deficient cells. Nat Commun. 2017;8:1463 pubmed  publisher | 
| Yuan C, Hu Y. A Transgenic Core Facility's Experience in Genome Editing Revolution. Adv Exp Med Biol. 2017;1016:75-90 pubmed  publisher | 
| Huang H, Dobrovolsky D, Paulk J, Yang G, Weisberg E, Doctor Z, et al . A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Cell Chem Biol. 2018;25:88-99.e6 pubmed  publisher | 
| Lee J, Jefcoate C. Monitoring of Dual CRISPR/Cas9-Mediated Steroidogenic Acute Regulatory Protein Gene Deletion and Cholesterol Accumulation Using High-Resolution Fluorescence In Situ Hybridization in a Single Cell. Front Endocrinol (Lausanne). 2017;8:289 pubmed  publisher | 
| Tamura N, Nishimura T, Sakamaki Y, Koyama Honda I, Yamamoto H, Mizushima N. Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets. FEBS Lett. 2017;591:3819-3830 pubmed  publisher | 
| Thomson B, Souma T, Tompson S, Onay T, Kizhatil K, Siggs O, et al . Angiopoietin-1 is required for Schlemm's canal development in mice and humans. J Clin Invest. 2017;127:4421-4436 pubmed  publisher | 
| Frejno M, Zenezini Chiozzi R, Wilhelm M, Koch H, Zheng R, Klaeger S, et al . Pharmacoproteomic characterisation of human colon and rectal cancer. Mol Syst Biol. 2017;13:951 pubmed  publisher | 
| De Tomasi L, David P, Humbert C, Silbermann F, Arrondel C, Tores F, et al . Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice. Am J Hum Genet. 2017;101:803-814 pubmed  publisher | 
| Berrens R, Andrews S, Spensberger D, Santos F, Dean W, Gould P, et al . An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells. Cell Stem Cell. 2017;21:694-703.e7 pubmed  publisher | 
| Wyler E, Menegatti J, Franke V, Kocks C, Boltengagen A, Hennig T, et al . Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection. Genome Biol. 2017;18:209 pubmed  publisher | 
| Jordi M, Marty J, Mordasini V, Lünemann A, McComb S, Bernasconi M, et al . IRAK4 is essential for TLR9-induced suppression of Epstein-Barr virus BZLF1 transcription in Akata Burkitt's lymphoma cells. PLoS ONE. 2017;12:e0186614 pubmed  publisher | 
| Yu Y, Scheel T, Luna J, Chung H, Nishiuchi E, Scull M, et al . miRNA independent hepacivirus variants suggest a strong evolutionary pressure to maintain miR-122 dependence. PLoS Pathog. 2017;13:e1006694 pubmed  publisher | 
| Schimmel J, Kool H, van Schendel R, Tijsterman M. Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells. EMBO J. 2017;36:3634-3649 pubmed  publisher | 
| Yik J, Crossley M, Quinlan K. Genome Editing of Erythroid Cell Culture Model Systems. Methods Mol Biol. 2018;1698:245-257 pubmed  publisher | 
| Duchêne B, Iyombe Engembe J, Rousseau J, Tremblay J, Ouellet D. From gRNA Identification to the Restoration of Dystrophin Expression: A Dystrophin Gene Correction Strategy for Duchenne Muscular Dystrophy Mutations Using the CRISPR-Induced Deletion Method. Methods Mol Biol. 2018;1687:267-283 pubmed  publisher | 
| Thompson E, Yeo J, Lee E, Kan Y, Raghunandan M, Wiek C, et al . FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response. Nucleic Acids Res. 2017;45:11837-11857 pubmed  publisher | 
| Goyal A, Fiskin E, Gutschner T, Polycarpou Schwarz M, Groß M, Neugebauer J, et al . A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression. Nucleic Acids Res. 2017;45:12496-12508 pubmed  publisher | 
| Malek M, Kielkowska A, Chessa T, Anderson K, Barneda D, Pir P, et al . PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Mol Cell. 2017;68:566-580.e10 pubmed  publisher | 
| Lehtimäki J, Fenix A, Kotila T, Balistreri G, Paavolainen L, Varjosalo M, et al . UNC-45a promotes myosin folding and stress fiber assembly. J Cell Biol. 2017;216:4053-4072 pubmed  publisher | 
| Lindström L, Alvarado Kristensson M. Characterization of gamma-tubulin filaments in mammalian cells. Biochim Biophys Acta Mol Cell Res. 2018;1865:158-171 pubmed  publisher | 
| Vonderstein K, Nilsson E, Hubel P, Nygård Skalman L, Upadhyay A, Pasto J, et al . Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles. J Virol. 2018;92: pubmed  publisher | 
| Walters D, Arendt B, Tschumper R, Wu X, Jelinek D. Characterization and use of the novel human multiple myeloma cell line MC-B11/14 to study biological consequences of CRISPR-mediated loss of immunoglobulin A heavy chain. Exp Hematol. 2018;57:42-49.e1 pubmed  publisher | 
| Wang H, Li S, Chao T, Wang X, Shi L, Zhang L, et al . A point mutation in the extracellular domain of CD4 completely abolishes CD4 T cell development in C57BL/6 mouse. Mol Immunol. 2017;92:12-20 pubmed  publisher | 
| Chen Y, Spitzer S, Agathou S, Karadottir R, Smith A. Gene Editing in Rat Embryonic Stem Cells to Produce In Vitro Models and In Vivo Reporters. Stem Cell Reports. 2017;9:1262-1274 pubmed  publisher | 
| Gressel S, Schwalb B, Decker T, Qin W, Leonhardt H, Eick D, et al . CDK9-dependent RNA polymerase II pausing controls transcription initiation. elife. 2017;6: pubmed  publisher | 
| Pu J, Keren Kaplan T, Bonifacino J. A Ragulator-BORC interaction controls lysosome positioning in response to amino acid availability. J Cell Biol. 2017;216:4183-4197 pubmed  publisher | 
| Abulaiti X, Zhang H, Wang A, Li N, Li Y, Wang C, et al . Phosphorylation of Threonine343 Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency. Stem Cell Reports. 2017;9:1630-1641 pubmed  publisher | 
| ter Huurne M, Chappell J, Dalton S, Stunnenberg H. Distinct Cell-Cycle Control in Two Different States of Mouse Pluripotency. Cell Stem Cell. 2017;21:449-455.e4 pubmed  publisher | 
| Maddox J, Khorsandi N, Gleason E. TRPC5 is required for the NO-dependent increase in dendritic Ca2+ and GABA release from chick retinal amacrine cells. J Neurophysiol. 2018;119:262-273 pubmed  publisher | 
| Schmieder V, Bydlinski N, Strasser R, Baumann M, Kildegaard H, Jadhav V, et al . Enhanced Genome Editing Tools For Multi-Gene Deletion Knock-Out Approaches Using Paired CRISPR sgRNAs in CHO Cells. Biotechnol J. 2018;13:e1700211 pubmed  publisher | 
| Tucker N, Dolmatova E, Lin H, Cooper R, Ye J, Hucker W, et al . Diminished PRRX1 Expression Is Associated With Increased Risk of Atrial Fibrillation and Shortening of the Cardiac Action Potential. Circ Cardiovasc Genet. 2017;10: pubmed  publisher | 
| Yau E, Kummetha I, Lichinchi G, Tang R, Zhang Y, Rana T. Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Cancer Res. 2017;77:6330-6339 pubmed  publisher | 
| Yeow I, Howard G, Chadwick J, Mendoza Topaz C, Hansen C, Nichols B, et al . EHD Proteins Cooperate to Generate Caveolar Clusters and to Maintain Caveolae during Repeated Mechanical Stress. Curr Biol. 2017;27:2951-2962.e5 pubmed  publisher | 
| Yang R, Chen L, Hansen L, Carpenter A, Moure C, Liu H, et al . Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation. Cancer Res. 2017;77:6097-6108 pubmed  publisher | 
| Ruiz Torres S, Benight N, Karns R, Lower E, Guan J, Waltz S. HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical ?-catenin signaling. Oncotarget. 2017;8:58918-58933 pubmed  publisher | 
| Mroczek S, Chlebowska J, Kulinski T, Gewartowska O, Gruchota J, Cysewski D, et al . The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. Nat Commun. 2017;8:619 pubmed  publisher | 
| Kyrychenko V, Kyrychenko S, Tiburcy M, Shelton J, Long C, Schneider J, et al . Functional correction of dystrophin actin binding domain mutations by genome editing. JCI Insight. 2017;2: pubmed  publisher | 
| Chung C, Wang Q, Yang S, Ponce S, Kirsch B, Zhang H, et al . Combinatorial genome and protein engineering yields monoclonal antibodies with hypergalactosylation from CHO cells. Biotechnol Bioeng. 2017;114:2848-2856 pubmed  publisher | 
| Moreno Fortuny A, Bragg L, Cossu G, Roostalu U. MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation. Biol Open. 2017;6:1592-1601 pubmed  publisher | 
| Zweemer A, French C, Mesfin J, Gordonov S, Meyer A, Lauffenburger D. Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells. Mol Cancer Res. 2017;15:1656-1666 pubmed  publisher | 
| Riffelmacher T, Clarke A, Richter F, Stranks A, Pandey S, Danielli S, et al . Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation. Immunity. 2017;47:466-480.e5 pubmed  publisher | 
| Blumer T, Coto Llerena M, Duong F, Heim M. SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)-induced gene expression in vivo. J Biol Chem. 2017;292:17928-17938 pubmed  publisher | 
| Burman J, Pickles S, Wang C, Sekine S, Vargas J, Zhang Z, et al . Mitochondrial fission facilitates the selective mitophagy of protein aggregates. J Cell Biol. 2017;216:3231-3247 pubmed  publisher | 
| Kang M, Li Y, Zhao Y, He S, Shi J. miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer. Clin Transl Oncol. 2018;20:457-466 pubmed  publisher | 
| Mettananda S, Fisher C, Hay D, Badat M, Quek L, Clark K, et al . Editing an ?-globin enhancer in primary human hematopoietic stem cells as a treatment for ?-thalassemia. Nat Commun. 2017;8:424 pubmed  publisher | 
| Schwartz S, Cleyrat C, Olah M, Relich P, Phillips G, Hlavacek W, et al . Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics. Mol Biol Cell. 2017;28:3397-3414 pubmed  publisher | 
| Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, et al . Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. J Biol Chem. 2017;292:17703-17717 pubmed  publisher | 
| Liu X, Zhang Y, Chen Y, Li M, Zhou F, Li K, et al . In Situ Capture of Chromatin Interactions by Biotinylated dCas9. Cell. 2017;170:1028-1043.e19 pubmed  publisher | 
| Reboud E, Bouillot S, Patot S, Béganton B, Attree I, Huber P. Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation. PLoS Pathog. 2017;13:e1006579 pubmed  publisher | 
| Aprile F, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C. The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Sci Rep. 2017;7:9039 pubmed  publisher | 
| Hashwah H, Schmid C, Kasser S, Bertram K, Stelling A, Manz M, et al . Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth. Proc Natl Acad Sci U S A. 2017;114:9701-9706 pubmed  publisher | 
| Jia R, Guardia C, Pu J, Chen Y, Bonifacino J. BORC coordinates encounter and fusion of lysosomes with autophagosomes. Autophagy. 2017;13:1648-1663 pubmed  publisher | 
| Moutal A, Yang X, Li W, Gilbraith K, Luo S, Cai S, et al . CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. Pain. 2017;158:2301-2319 pubmed  publisher | 
| Zwart N, Andringa D, de Leeuw W, Kojima H, Iida M, Houtman C, et al . Improved androgen specificity of AR-EcoScreen by CRISPR based glucocorticoid receptor knockout. Toxicol In Vitro. 2017;45:1-9 pubmed  publisher | 
| Postler T, Pantry S, Desrosiers R, Ghosh S. Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection. Virology. 2017;511:30-39 pubmed  publisher | 
| Miotti S, Gulino A, Ferri R, Parenza M, Chronowska A, Lecis D, et al . Antibody-mediated blockade of JMJD6 interaction with collagen I exerts antifibrotic and antimetastatic activities. FASEB J. 2017;31:5356-5370 pubmed  publisher | 
| Shao Y, Taniguchi K, Townshend R, Miki T, Gumucio D, Fu J. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun. 2017;8:208 pubmed  publisher | 
| Lai M, Realini N, La Ferla M, Passalacqua I, Matteoli G, Ganesan A, et al . Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells. Sci Rep. 2017;7:7411 pubmed  publisher | 
| Chakraborty D, Benham V, Bullard B, Kearney T, Hsia H, Gibbon D, et al . Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer. Oncogene. 2017;36:6668-6679 pubmed  publisher | 
| Khan M, Salomaa S, Jacquemet G, Butt U, Miihkinen M, Deguchi T, et al . The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex. J Cell Sci. 2017;130:3094-3107 pubmed  publisher | 
| Stewart S, Menzies S, Popa S, Savinykh N, Petrunkina Harrison A, Lehner P, et al . A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface. J Cell Sci. 2017;130:3234-3247 pubmed  publisher | 
| Schwerd T, Twigg S, Aschenbrenner D, Manrique S, Miller K, Taylor I, et al . A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis. J Exp Med. 2017;214:2547-2562 pubmed  publisher | 
| Lumb J, Li Q, Popov L, Ding S, Keith M, Merrill B, et al . DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes. Cell Rep. 2017;20:819-831 pubmed  publisher | 
| Luna J, Barajas J, Teng K, Sun H, Moore M, Rice C, et al . Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer. Mol Cell. 2017;67:400-410.e7 pubmed  publisher | 
| Maina P, Shao P, Jia X, Liu Q, Umesalma S, Marin M, et al . Histone demethylase PHF8 regulates hypoxia signaling through HIF1? and H3K4me3. Biochim Biophys Acta Gene Regul Mech. 2017;1860:1002-1012 pubmed  publisher | 
| Zhang C, Hawley S, Zong Y, Li M, Wang Z, Gray A, et al . Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. 2017;548:112-116 pubmed  publisher | 
| Liu J, Zhao Y, Li W, Hou Y, Li T, Zhao Z, et al . Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels. Proc Natl Acad Sci U S A. 2017;: pubmed  publisher | 
| Kohli P, Höhne M, Jüngst C, Bertsch S, Ebert L, Schauss A, et al . The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia. EMBO Rep. 2017;18:1521-1535 pubmed  publisher | 
| Nabet B, Qiu Y, Shabason J, Wu T, Yoon T, Kim B, et al . Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer. Cell. 2017;170:352-366.e13 pubmed  publisher | 
| Balatti V, Nigita G, Veneziano D, Drusco A, Stein G, Messier T, et al . tsRNA signatures in cancer. Proc Natl Acad Sci U S A. 2017;114:8071-8076 pubmed  publisher | 
| Lei Y, Zhang X, Su J, Jeong M, Gundry M, Huang Y, et al . Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nat Commun. 2017;8:16026 pubmed  publisher | 
| Niemz J, Kliche S, Pils M, Morrison E, Manns A, Freund C, et al . The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells. Eur J Microbiol Immunol (Bp). 2017;7:112-126 pubmed  publisher | 
| Flack J, Mieszczanek J, Novcic N, Bienz M. Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5. Mol Cell. 2017;67:181-193.e5 pubmed  publisher | 
| Zelensky A, Schimmel J, Kool H, Kanaar R, Tijsterman M. Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA. Nat Commun. 2017;8:66 pubmed  publisher | 
| Roman T, Cannon M, Vadlamudi S, Buchkovich M, Wolford B, Welch R, et al . A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus. Diabetes. 2017;66:2521-2530 pubmed  publisher | 
| Bharaj P, Atkins C, Luthra P, Giraldo M, Dawes B, Miorin L, et al . The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication. J Virol. 2017;91: pubmed  publisher | 
| Tang C, Shan L, Wang W, Lu G, Tare R, Lee K. Generation of a Bag1 homozygous knockout mouse embryonic stem cell line using CRISPR/Cas9. Stem Cell Res. 2017;21:29-31 pubmed  publisher | 
| Castaño J, Bueno C, Jiménez Delgado S, Roca Ho H, Fraga M, Fernandez A, et al . Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the "safe harbor" AAVS1 locus. Stem Cell Res. 2017;21:137-140 pubmed  publisher | 
| Biering S, Choi J, Halstrom R, Brown H, Beatty W, Lee S, et al . Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. Cell Host Microbe. 2017;22:74-85.e7 pubmed  publisher | 
| Hamey J, Wienert B, Quinlan K, Wilkins M. METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout. Mol Cell Proteomics. 2017;16:2229-2242 pubmed  publisher | 
| Wienert B, Martyn G, Kurita R, Nakamura Y, Quinlan K, Crossley M. KLF1 drives the expression of fetal hemoglobin in British HPFH. Blood. 2017;130:803-807 pubmed  publisher | 
| Hindriksen S, Bramer A, Truong M, Vromans M, Post J, Verlaan Klink I, et al . Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. PLoS ONE. 2017;12:e0179514 pubmed  publisher | 
| Ng H, Jennings S, Wang J, Molina P, Nelson S, Wang G. Non-canonical Glucocorticoid Receptor Transactivation of gilz by Alcohol Suppresses Cell Inflammatory Response. Front Immunol. 2017;8:661 pubmed  publisher | 
| Dagg R, Pickett H, Neumann A, Napier C, Henson J, Teber E, et al . Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres. Cell Rep. 2017;19:2544-2556 pubmed  publisher | 
| Bloh K, Bialk P, Gopalakrishnapillai A, Kolb E, Kmiec E. CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome. Mol Ther Nucleic Acids. 2017;7:288-298 pubmed  publisher | 
| Kuchay S, Giorgi C, Simoneschi D, Pagan J, Missiroli S, Saraf A, et al . PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth. Nature. 2017;546:554-558 pubmed  publisher | 
| Liu Q, Miller L, Blecha F, Sang Y. Reduction of infection by inhibiting mTOR pathway is associated with reversed repression of type I interferon by porcine reproductive and respiratory syndrome virus. J Gen Virol. 2017;98:1316-1328 pubmed  publisher | 
| Gao Z, Harwig A, Berkhout B, Herrera Carrillo E. Mutation of nucleotides around the +1 position of type 3 polymerase III promoters: The effect on transcriptional activity and start site usage. Transcription. 2017;8:275-287 pubmed  publisher | 
| Vigueira P, McCommis K, Hodges W, Schweitzer G, Cole S, Oonthonpan L, et al . The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol. 2017;102:985-999 pubmed  publisher | 
| Rodvold J, Chiu K, Hiramatsu N, Nussbacher J, Galimberti V, Mahadevan N, et al . Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal. 2017;10: pubmed  publisher | 
| Feng Y, Zhang Q, Fu M, Zhang Z, Wei M, Zhou J, et al . Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer. Oncol Rep. 2017;38:109-119 pubmed  publisher | 
| Gingras S, Kuliyev E, Pelletier S. SCYL1 does not regulate REST expression and turnover. PLoS ONE. 2017;12:e0178680 pubmed  publisher | 
| Quinn M, Goh Q, Kurosaka M, Gamage D, Petrany M, Prasad V, et al . Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development. Nat Commun. 2017;8:15665 pubmed  publisher | 
| Yost S, de Wolf B, Hanks S, Zachariou A, Marcozzi C, Clarke M, et al . Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation. Nat Genet. 2017;49:1148-1151 pubmed  publisher | 
| Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee J, et al . Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell. 2017;66:684-697.e9 pubmed  publisher | 
| Tang S, Wang X, Li W, Yang X, Li Z, Liu W, et al . Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella. Am J Hum Genet. 2017;100:854-864 pubmed  publisher | 
| Butler J, Santos R, Martens G, Ladowski J, Wang Z, Li P, et al . Efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombination. J Surg Res. 2017;212:238-245 pubmed  publisher | 
| Louis Sam Titus A, Yusuff T, Cassar M, Thomas E, Kretzschmar D, D Mello S. Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease. J Neurosci. 2017;37:6575-6587 pubmed  publisher | 
| Gomes Silva D, Srinivasan M, Sharma S, Lee C, Wagner D, Davis T, et al . CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies. Blood. 2017;130:285-296 pubmed  publisher | 
| Fish J, Cantu Gutierrez M, Dang L, Khyzha N, Chen Z, Veitch S, et al . Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development. 2017;144:2428-2444 pubmed  publisher | 
| Vanoli F, Jasin M. Generation of chromosomal translocations that lead to conditional fusion protein expression using CRISPR-Cas9 and homology-directed repair. Methods. 2017;121-122:138-145 pubmed  publisher | 
| Krivega I, Dean A. LDB1-mediated enhancer looping can be established independent of mediator and cohesin. Nucleic Acids Res. 2017;45:8255-8268 pubmed  publisher | 
| Liu Y, Conlon D, Bi X, Slovik K, Shi J, Edelstein H, et al . Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress. Cell Rep. 2017;19:1456-1466 pubmed  publisher | 
| Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, et al . MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Mol Cell. 2017;66:698-710.e5 pubmed  publisher | 
| Bednash J, Weathington N, Londino J, Rojas M, Gulick D, Fort R, et al . Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun. 2017;8:15203 pubmed  publisher | 
| Tammela T, Sanchez Rivera F, Cetinbas N, Wu K, Joshi N, Helenius K, et al . A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Nature. 2017;545:355-359 pubmed  publisher | 
| Sandweiss A, McIntosh M, Moutal A, Davidson Knapp R, Hu J, Giri A, et al . Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential. Mol Psychiatry. 2018;23:1745-1755 pubmed  publisher | 
| Narni Mancinelli E, Gauthier L, Baratin M, Guia S, Fenis A, Deghmane A, et al . Complement factor P is a ligand for the natural killer cell-activating receptor NKp46. Sci Immunol. 2017;2: pubmed  publisher | 
| Higashioka K, Koizumi N, Sakurai H, Sotozono C, Sato T. Myogenic Differentiation from MYOGENIN-Mutated Human iPS Cells by CRISPR/Cas9. Stem Cells Int. 2017;2017:9210494 pubmed  publisher | 
| Chen N, Uddin B, Hardt R, Ding W, Panic M, Lucibello I, et al . Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm. Proc Natl Acad Sci U S A. 2017;114:5201-5206 pubmed  publisher | 
| Galaz Montoya M, Wright S, Rodriguez G, Lichtarge O, Wensel T. ?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem. 2017;292:9967-9974 pubmed  publisher | 
| Zhang Y, Long C, Li H, McAnally J, Baskin K, Shelton J, et al . CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice. Sci Adv. 2017;3:e1602814 pubmed  publisher | 
| Diamantopoulou Z, White G, Fadlullah M, Dreger M, Pickering K, Maltas J, et al . TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell. 2017;31:621-634.e6 pubmed  publisher | 
| Bazzani L, Donnini S, Finetti F, Christofori G, Ziche M. PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells. Oncotarget. 2017;8:31270-31287 pubmed  publisher | 
| Yao C, Liu Y, Lee I, Wang Y, Wu P. A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis. PLoS Biol. 2017;15:e2000931 pubmed  publisher | 
| Kelton W, Waindok A, Pesch T, Pogson M, Ford K, Parola C, et al . Reprogramming MHC specificity by CRISPR-Cas9-assisted cassette exchange. Sci Rep. 2017;7:45775 pubmed  publisher | 
| Dallari S, Macal M, Loureiro M, Jo Y, Swanson L, Hesser C, et al . Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses. Nat Commun. 2017;8:14830 pubmed  publisher | 
| Matreyek K, Stephany J, Fowler D. A platform for functional assessment of large variant libraries in mammalian cells. Nucleic Acids Res. 2017;45:e102 pubmed  publisher | 
| Kage F, Winterhoff M, Dimchev V, Mueller J, Thalheim T, Freise A, et al . FMNL formins boost lamellipodial force generation. Nat Commun. 2017;8:14832 pubmed  publisher | 
| Vanoli F, Tomishima M, Feng W, Lamribet K, Babin L, Brunet E, et al . CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells. Proc Natl Acad Sci U S A. 2017;114:3696-3701 pubmed  publisher | 
| Xu J, Songyang Z, Liu D, Kim H. Analysis of Average Telomere Length in Human Telomeric Protein Knockout Cells Generated by CRISPR/Cas9. Methods Mol Biol. 2017;1587:15-28 pubmed  publisher | 
| Donato V, Bonora M, Simoneschi D, Sartini D, Kudo Y, Saraf A, et al . The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol. 2017;19:341-351 pubmed  publisher | 
| Gu J, Li T, Zhao L, Liang X, Fu X, Wang J, et al . Identification of Significant Pathways Induced by PAX5 Haploinsufficiency Based on Protein-Protein Interaction Networks and Cluster Analysis in Raji Cell Line. Biomed Res Int. 2017;2017:5326370 pubmed  publisher | 
| Shathasivam P, Kollara A, Spybey T, Park S, Clarke B, Ringuette M, et al . VEPH1 expression decreases vascularisation in ovarian cancer xenografts and inhibits VEGFA and IL8 expression through inhibition of AKT activation. Br J Cancer. 2017;116:1065-1076 pubmed  publisher | 
| Das K, Eisel D, Lenkl C, Goyal A, Diederichs S, Dickes E, et al . Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system. PLoS ONE. 2017;12:e0174077 pubmed  publisher | 
| Jacquin E, Leclerc Mercier S, Judon C, Blanchard E, Fraitag S, Florey O. Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation. Autophagy. 2017;13:854-867 pubmed  publisher | 
| Page S, Hamersky G, Gallo R, Rannals M, Calcaterra N, Campbell M, et al . The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner. Mol Psychiatry. 2018;23:304-315 pubmed  publisher | 
| Cui J, Chew S, Shi Y, Gong Z, Shen H. CRISPR system for genome engineering: the application for autophagy study. BMB Rep. 2017;50:247-256 pubmed | 
| Wrona D, Siler U, Reichenbach J. CRISPR/Cas9-generated p47phox-deficient cell line for Chronic Granulomatous Disease gene therapy vector development. Sci Rep. 2017;7:44187 pubmed  publisher | 
| Stallaert W, Van der Westhuizen E, Schönegge A, Plouffe B, Hogue M, Lukashova V, et al . Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells. Mol Pharmacol. 2017;91:533-544 pubmed  publisher | 
| Yamasaki T, Hoyos Ramirez E, Martenson J, Morimoto Tomita M, Tomita S. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Neuron. 2017;93:1138-1152.e6 pubmed  publisher | 
| Mittal K, Choi D, Ogden A, Donthamsetty S, Melton B, Gupta M, et al . Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells. Sci Rep. 2017;7:43984 pubmed  publisher | 
| Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al . The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed  publisher | 
| Schimmack G, Schorpp K, Kutzner K, Gehring T, Brenke J, Hadian K, et al . YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB. elife. 2017;6: pubmed  publisher | 
| Drané P, Brault M, Cui G, Meghani K, Chaubey S, Detappe A, et al . TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature. 2017;543:211-216 pubmed  publisher | 
| Luijsterburg M, Typas D, Caron M, Wiegant W, van den Heuvel D, Boonen R, et al . A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation. elife. 2017;6: pubmed  publisher | 
| Cahill T, Thomsen A, Tarrasch J, Plouffe B, Nguyen A, Yang F, et al . Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proc Natl Acad Sci U S A. 2017;114:2562-2567 pubmed  publisher | 
| Williamson L, Saponaro M, Boeing S, East P, Mitter R, Kantidakis T, et al . UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene. Cell. 2017;168:843-855.e13 pubmed  publisher | 
| Seong H, Manoharan R, Ha H. Zinc finger protein ZPR9 functions as an activator of AMPK-related serine/threonine kinase MPK38/MELK involved in ASK1/TGF-β/p53 signaling pathways. Sci Rep. 2017;7:42502 pubmed  publisher | 
| Dietsch F, Donzeau M, Cordonnier A, Weiss E, Chatton B, Vigneron M. A fast method for analyzing essential protein mutants in human cells. Biotechniques. 2017;62:80-82 pubmed  publisher | 
| Lau H, Tang J, Casey P, Wang M. Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms. Oncogene. 2017;36:3934-3942 pubmed  publisher | 
| Spraggon L, Martelotto L, Hmeljak J, Hitchman T, Wang J, Wang L, et al . Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair. J Pathol. 2017;242:102-112 pubmed  publisher | 
| Goyal A, Myacheva K, Groß M, Klingenberg M, Duran Arqué B, Diederichs S. Challenges of CRISPR/Cas9 applications for long non-coding RNA genes. Nucleic Acids Res. 2017;45:e12 pubmed  publisher | 
| Andretta E, Cartón García F, Martinez Barriocanal A, de Marcondes P, Jiménez Flores L, Macaya I, et al . Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer. Sci Rep. 2017;7:41576 pubmed  publisher | 
| Nounamo B, Li Y, O Byrne P, Kearney A, Khan A, Liu J. An interaction domain in human SAMD9 is essential for myxoma virus host-range determinant M062 antagonism of host anti-viral function. Virology. 2017;503:94-102 pubmed  publisher | 
| Gao Y, Wu H, Wang Y, Liu X, Chen L, Li Q, et al . Single Cas9 nickase induced generation of NRAMP1 knockin cattle with reduced off-target effects. Genome Biol. 2017;18:13 pubmed  publisher | 
| Wu W, Lu Z, Li F, Wang W, Qian N, Duan J, et al . Efficient in vivo gene editing using ribonucleoproteins in skin stem cells of recessive dystrophic epidermolysis bullosa mouse model. Proc Natl Acad Sci U S A. 2017;114:1660-1665 pubmed  publisher | 
| Hummel B, Hansen E, Yoveva A, Aprile Garcia F, Hussong R, Sawarkar R. The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses. Nat Struct Mol Biol. 2017;24:234-242 pubmed  publisher | 
| Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett E. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Mol Cell. 2017;65:751-760.e4 pubmed  publisher | 
| Yi X, Tao Y, Lin X, Dai Y, Yang T, Yue X, et al . Histone methyltransferase Setd2 is critical for the proliferation and differentiation of myoblasts. Biochim Biophys Acta Mol Cell Res. 2017;1864:697-707 pubmed  publisher | 
| Hong S, Yada R, Choi K, Carpentier A, Liang T, Merling R, et al . Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers. Mol Ther. 2017;25:44-53 pubmed  publisher | 
| Phillips A, Millet A, Tigano M, Dubois S, Crimmins H, Babin L, et al . Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion. Mol Cell. 2017;65:527-538.e6 pubmed  publisher | 
| Min J, Wright W, Shay J. Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Nucleic Acids Res. 2017;45:2615-2628 pubmed  publisher | 
| Parks S, Cormerais Y, Durivault J, Pouyssegur J. Genetic disruption of the pHi-regulating proteins Na+/H+ exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells. Oncotarget. 2017;8:10225-10237 pubmed  publisher | 
| Rivera Torres N, Banas K, Bialk P, Bloh K, Kmiec E. Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides. PLoS ONE. 2017;12:e0169350 pubmed  publisher | 
| Crefcoeur R, Zgheib O, Halazonetis T. A Model to Investigate Single-Strand DNA Responses in G1 Human Cells via a Telomere-Targeted, Nuclease-Deficient CRISPR-Cas9 System. PLoS ONE. 2017;12:e0169126 pubmed  publisher | 
| Mahajan A, Youssef L, Cleyrat C, Grattan R, Lucero S, Mattison C, et al . Allergen Valency, Dose, and FcεRI Occupancy Set Thresholds for Secretory Responses to Pen a 1 and Motivate Design of Hypoallergens. J Immunol. 2017;198:1034-1046 pubmed  publisher | 
| Kim E, Hurtz C, Koehrer S, Wang Z, Balasubramanian S, Chang B, et al . Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK. Blood. 2017;129:1155-1165 pubmed  publisher | 
| Ouellet D, Cherif K, Rousseau J, Tremblay J. Deletion of the GAA repeats from the human frataxin gene using the CRISPR-Cas9 system in YG8R-derived cells and mouse models of Friedreich ataxia. Gene Ther. 2017;24:265-274 pubmed  publisher | 
| Peters E, Schirris T, van Asbeck A, Gerretsen J, Eymael J, Ashikov A, et al . Effects of a human recombinant alkaline phosphatase during impaired mitochondrial function in human renal proximal tubule epithelial cells. Eur J Pharmacol. 2017;796:149-157 pubmed  publisher | 
| Van Nostrand E, Gelboin Burkhart C, Wang R, Pratt G, Blue S, Yeo G. CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins. Methods. 2017;118-119:50-59 pubmed  publisher | 
| Bonneau B, Ando H, Kawaai K, Hirose M, Takahashi Iwanaga H, Mikoshiba K. IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact. elife. 2016;5: pubmed  publisher | 
| Allen S, Chen Y, Madden J, Fournier C, Altemus M, Hiziroglu A, et al . Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling. Sci Rep. 2016;6:39190 pubmed  publisher | 
| Dibley M, Ryan M, Stroud D. A novel isoform of the human mitochondrial complex I subunit NDUFV3. FEBS Lett. 2017;591:109-117 pubmed  publisher | 
| Shah R, Cholewa Waclaw J, Davies F, Paton K, Chaligne R, Heard E, et al . Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders. Wellcome Open Res. 2016;1:13 pubmed  publisher | 
| Chung C, Wang Q, Yang S, Yin B, Zhang H, Betenbaugh M. Integrated Genome and Protein Editing Swaps ?-2,6 Sialylation for ?-2,3 Sialic Acid on Recombinant Antibodies from CHO. Biotechnol J. 2017;12: pubmed  publisher | 
| Couturier A, Fleury H, Patenaude A, Bentley V, Rodrigue A, Coulombe Y, et al . Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. Nucleic Acids Res. 2016;44:10879-10897 pubmed | 
| Termglinchan V, Seeger T, Chen C, Wu J, Karakikes I. Efficient Genome Editing in Induced Pluripotent Stem Cells with Engineered Nucleases In Vitro. Methods Mol Biol. 2017;1521:55-68 pubmed | 
| Li T, Liu D, Lei X, Jiang Q. Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway. Biochem Biophys Res Commun. 2017;482:1037-1041 pubmed  publisher | 
| Ye J, Tucker N, Weng L, Clauss S, Lubitz S, Ellinor P. A Functional Variant Associated with Atrial Fibrillation Regulates PITX2c Expression through TFAP2a. Am J Hum Genet. 2016;99:1281-1291 pubmed  publisher | 
| Nguyen T, Padman B, Usher J, Oorschot V, Ramm G, Lazarou M. Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation. J Cell Biol. 2016;215:857-874 pubmed | 
| Johnson G, Li J, Beaver L, Dashwood W, Sun D, Rajendran P, et al . A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells. Mol Nutr Food Res. 2017;61: pubmed  publisher | 
| Köferle A, Worf K, Breunig C, Baumann V, Herrero J, Wiesbeck M, et al . CORALINA: a universal method for the generation of gRNA libraries for CRISPR-based screening. BMC Genomics. 2016;17:917 pubmed | 
| Sekine Y, Zyryanova A, Crespillo Casado A, Amin Wetzel N, Harding H, Ron D. Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells. PLoS ONE. 2016;11:e0166278 pubmed  publisher | 
| Chande A, Cuccurullo E, Rosa A, Ziglio S, Carpenter S, Pizzato M. S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3. Proc Natl Acad Sci U S A. 2016;113:13197-13202 pubmed | 
| Verver D, Zheng Y, Speijer D, Hoebe R, Dekker H, Repping S, et al . Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress. Int J Mol Sci. 2016;17: pubmed | 
| Wein M, Liang Y, Göransson O, Sundberg T, Wang J, Williams E, et al . SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2016;7:13176 pubmed  publisher | 
| Gammons M, Rutherford T, Steinhart Z, Angers S, Bienz M. Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay. J Cell Sci. 2016;129:3892-3902 pubmed | 
| Sellou H, Lebeaupin T, Chapuis C, Smith R, Hegele A, Singh H, et al . The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage. Mol Biol Cell. 2016;27:3791-3799 pubmed | 
| Hore T, von Meyenn F, Ravichandran M, Bachman M, Ficz G, Oxley D, et al . Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms. Proc Natl Acad Sci U S A. 2016;113:12202-12207 pubmed | 
| Tadi S, Tellier Lebegue C, Nemoz C, Drevet P, Audebert S, Roy S, et al . PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF. Cell Rep. 2016;17:541-555 pubmed  publisher | 
| Stoyanova T, Riedinger M, Lin S, Faltermeier C, Smith B, Zhang K, et al . Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016;113:E6457-E6466 pubmed | 
| Chauhan S, Kumar S, Jain A, Ponpuak M, Mudd M, Kimura T, et al . TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Dev Cell. 2016;39:13-27 pubmed  publisher | 
| Vijai J, Topka S, Villano D, Ravichandran V, Maxwell K, Maria A, et al . A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer. Cancer Discov. 2016;6:1267-1275 pubmed | 
| Kim E, Page P, Dellefave Castillo L, McNally E, Wyatt E. Direct reprogramming of urine-derived cells with inducible MyoD for modeling human muscle disease. Skelet Muscle. 2016;6:32 pubmed  publisher | 
| Gabriel C, Gross F, Karl M, Stephanowitz H, Hennig A, Weber M, et al . Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. J Biol Chem. 2016;291:24172-24187 pubmed | 
| Tveita A, Fauskanger M, Bogen B, Haabeth O. Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display. Oncotarget. 2016;7:67175-67182 pubmed  publisher | 
| Stroud D, Surgenor E, Formosa L, Reljic B, Frazier A, Dibley M, et al . Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature. 2016;538:123-126 pubmed  publisher | 
| Bialk P, Sansbury B, Rivera Torres N, Bloh K, Man D, Kmiec E. Analyses of point mutation repair and allelic heterogeneity generated by CRISPR/Cas9 and single-stranded DNA oligonucleotides. Sci Rep. 2016;6:32681 pubmed  publisher | 
| Murray D, Jahnel M, Lauer J, Avellaneda M, Brouilly N, Cezanne A, et al . An endosomal tether undergoes an entropic collapse to bring vesicles together. Nature. 2016;537:107-111 pubmed  publisher | 
| Nguyen T, Park W, Park B, Kim C, Oh Y, Kim J, et al . PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. Proc Natl Acad Sci U S A. 2016;113:10091-6 pubmed  publisher | 
| Santos D, Kiskinis E, Eggan K, Merkle F. Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol. 2016;38:5B.6.1-5B.6.60 pubmed  publisher | 
| Pogson M, Parola C, Kelton W, Heuberger P, Reddy S. Immunogenomic engineering of a plug-and-(dis)play hybridoma platform. Nat Commun. 2016;7:12535 pubmed  publisher | 
| Montero J, Lopez de Silanes I, Grana O, Blasco M. Telomeric RNAs are essential to maintain telomeres. Nat Commun. 2016;7:12534 pubmed  publisher | 
| Kotzin J, Spencer S, McCright S, Kumar D, Collet M, Mowel W, et al . The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature. 2016;537:239-243 pubmed  publisher | 
| Traxler E, Yao Y, Wang Y, Woodard K, Kurita R, Nakamura Y, et al . A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition. Nat Med. 2016;22:987-90 pubmed  publisher | 
| Khanom R, Nguyen C, Kayamori K, Zhao X, Morita K, Miki Y, et al . Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. PLoS ONE. 2016;11:e0161163 pubmed  publisher | 
| Dubey R, Lebensohn A, Bahrami Nejad Z, Marceau C, Champion M, Gevaert O, et al . Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1. Cancer Res. 2016;76:5810-5821 pubmed | 
| Bluteau D, Masliah Planchon J, Clairmont C, Rousseau A, Ceccaldi R, Dubois d Enghien C, et al . Biallelic inactivation of REV7 is associated with Fanconi anemia. J Clin Invest. 2016;126:3580-4 pubmed  publisher | 
| Shy B, MacDougall M, Clarke R, Merrill B. Co-incident insertion enables high efficiency genome engineering in mouse embryonic stem cells. Nucleic Acids Res. 2016;44:7997-8010 pubmed  publisher | 
| Robijns J, Molenberghs F, Sieprath T, Corne T, Verschuuren M, De Vos W. In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells. Sci Rep. 2016;6:30325 pubmed  publisher | 
| Lambrus B, Daggubati V, Uetake Y, Scott P, Clutario K, Sluder G, et al . A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis. J Cell Biol. 2016;214:143-53 pubmed  publisher | 
| Jin H, Jung S, DebRoy A, Davuluri R. Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer. Oncotarget. 2016;7:54616-54626 pubmed  publisher | 
| Du J, Leung A, Trac C, Lee M, Parks B, Lusis A, et al . Chromatin variation associated with liver metabolism is mediated by transposable elements. Epigenetics Chromatin. 2016;9:28 pubmed  publisher | 
| Mahil S, Twelves S, Farkas K, Setta Kaffetzi N, Burden A, Gach J, et al . AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production. J Invest Dermatol. 2016;136:2251-2259 pubmed  publisher | 
| Schokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al . CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed  publisher | 
| Murphy M, Chatterjee S, Jain S, KATARI M, DasGupta R. TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3. Sci Rep. 2016;6:28299 pubmed  publisher | 
| Cheng M, Jin X, Mu L, Wang F, Li W, Zhong X, et al . Combination of the clustered regularly interspaced short palindromic repeats (CRISPR)-associated 9 technique with the piggybac transposon system for mouse in utero electroporation to study cortical development. J Neurosci Res. 2016;94:814-24 pubmed  publisher | 
| Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, et al . Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers. Nature. 2016;534:402-6 pubmed  publisher | 
| Tao G, Kahr P, Morikawa Y, Zhang M, Rahmani M, Heallen T, et al . Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature. 2016;534:119-23 pubmed  publisher | 
| Bell C, Amaral P, Kalsbeek A, Magor G, Gillinder K, Tangermann P, et al . The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation. Sci Rep. 2016;6:26657 pubmed  publisher | 
| Ho S, Zhang W, Tan N, Khatoo M, Suter M, Tripathi S, et al . The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells. Immunity. 2016;44:1177-89 pubmed  publisher | 
| Guo X, Chen P, Hou X, Xu W, Wang D, Wang T, et al . The recombined cccDNA produced using minicircle technology mimicked HBV genome in structure and function closely. Sci Rep. 2016;6:25552 pubmed  publisher | 
| Murray A, Sienerth A, Hemberger M. Plet1 is an epigenetically regulated cell surface protein that provides essential cues to direct trophoblast stem cell differentiation. Sci Rep. 2016;6:25112 pubmed  publisher | 
| Castaño J, Herrero A, Bursen A, Gonzalez F, Marschalek R, Gutierrez N, et al . Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair. Oncotarget. 2016;7:30440-52 pubmed  publisher | 
| Wang Y, Li Y, Guo C, Lu Q, Wang W, Jia Z, et al . ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells. Nucleic Acids Res. 2016;44:6741-55 pubmed  publisher | 
| Gerl M, Bittl V, Kirchner S, Sachsenheimer T, Brunner H, Lüchtenborg C, et al . Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions. PLoS ONE. 2016;11:e0153009 pubmed  publisher | 
| Huang Y, Askew E, Knudson C, Knudson W. CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention. Matrix Biol. 2016;56:74-94 pubmed  publisher | 
| Roehm P, Shekarabi M, Wollebo H, Bellizzi A, He L, Salkind J, et al . Inhibition of HSV-1 Replication by Gene Editing Strategy. Sci Rep. 2016;6:23146 pubmed  publisher | 
| Guerrera D, Shah J, Vasileva E, Sluysmans S, Méan I, Jond L, et al . PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins. J Biol Chem. 2016;291:11016-29 pubmed  publisher | 
| Nelles D, Fang M, O Connell M, Xu J, Markmiller S, Doudna J, et al . Programmable RNA Tracking in Live Cells with CRISPR/Cas9. Cell. 2016;165:488-96 pubmed  publisher | 
| Young N, Kamireddy A, Van Nostrand J, Eichner L, Shokhirev M, Dayn Y, et al . AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes. Genes Dev. 2016;30:535-52 pubmed  publisher | 
| Mavuluri J, Beesetti S, Surabhi R, Kremerskothen J, Venkatraman G, Rayala S. Phosphorylation-Dependent Regulation of the DNA Damage Response of Adaptor Protein KIBRA in Cancer Cells. Mol Cell Biol. 2016;36:1354-65 pubmed  publisher | 
| Nöske K, Stark H, Nevaril L, Berning M, Langbein L, Goyal A, et al . Mitotic Diversity in Homeostatic Human Interfollicular Epidermis. Int J Mol Sci. 2016;17: pubmed  publisher | 
| Pillay S, Meyer N, Puschnik A, Davulcu O, Diep J, Ishikawa Y, et al . An essential receptor for adeno-associated virus infection. Nature. 2016;530:108-12 pubmed  publisher | 
| Iyombe Engembe J, Ouellet D, Barbeau X, Rousseau J, Chapdelaine P, Lagüe P, et al . Efficient Restoration of the Dystrophin Gene Reading Frame and Protein Structure in DMD Myoblasts Using the CinDel Method. Mol Ther Nucleic Acids. 2016;5:e283 pubmed  publisher | 
| Hou S, Isaji T, Hang Q, Im S, Fukuda T, Gu J. Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells. Sci Rep. 2016;6:18430 pubmed  publisher | 
| Carroll K, Makarewich C, McAnally J, Anderson D, Zentilin L, Liu N, et al . A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9. Proc Natl Acad Sci U S A. 2016;113:338-43 pubmed  publisher | 
| Wang J, Xiao Y, Hsu C, Martinez Traverso I, Zhang M, Bai Y, et al . Yap and Taz play a crucial role in neural crest-derived craniofacial development. Development. 2016;143:504-15 pubmed  publisher | 
| Wojtal D, Kemaladewi D, Malam Z, Abdullah S, Wong T, Hyatt E, et al . Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders. Am J Hum Genet. 2016;98:90-101 pubmed  publisher | 
| Lukacs V, Mathur J, Mao R, Bayrak Toydemir P, Procter M, Cahalan S, et al . Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia. Nat Commun. 2015;6:8329 pubmed  publisher | 
| Hobbs R, DePianto D, Jacob J, Han M, Chung B, Batazzi A, et al . Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015;47:933-8 pubmed  publisher | 
| Whiting J, Nygren P, Tunquist B, Langeberg L, Seternes O, Scott J. Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220. J Biol Chem. 2015;290:19445-57 pubmed  publisher | 
| Bialk P, Rivera Torres N, Strouse B, Kmiec E. Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems. PLoS ONE. 2015;10:e0129308 pubmed  publisher | 
| Krentz N, Nian C, Lynn F. TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm. PLoS ONE. 2014;9:e114275 pubmed  publisher | 
| Findlay G, Boyle E, Hause R, Klein J, Shendure J. Saturation editing of genomic regions by multiplex homology-directed repair. Nature. 2014;513:120-3 pubmed  publisher | 
| Goubau D, Schlee M, Deddouche S, Pruijssers A, Zillinger T, Goldeck M, et al . Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates. Nature. 2014;514:372-375 pubmed  publisher | 
| Ran F, Hsu P, Wright J, Agarwala V, Scott D, Zhang F. Genome engineering using the CRISPR-Cas9 system. Nat Protoc. 2013;8:2281-2308 pubmed  publisher |