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product summary
company name :
Addgene
product type :
cDNA
product name :
pCDH-puro-cMyc
catalog :
46970
citations: 37
Reference
Wang Y, Yao M, Li C, Yang K, Qin X, Xu L, et al. Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling. Exp Hematol Oncol. 2023;12:105 pubmed publisher
Kwon J, Zhang J, Mok B, Allsup S, Kim C, Toretsky J, et al. USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity. Mol Cancer. 2023;22:204 pubmed publisher
Wan L, Lin K, Rahman M, Ishigami Y, Wang Z, Jensen M, et al. Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer. Cancer Discov. 2023;13:1678-1695 pubmed publisher
Krohl P, Fine J, Yang H, VanDyke D, Ang Z, Kim K, et al. Discovery of antibodies targeting multipass transmembrane proteins using a suspension cell-based evolutionary approach. Cell Rep Methods. 2023;3:100429 pubmed publisher
Latorre Y, Torres M, Vergara M, Berrios J, Sampayo M, G xf6 decke N, et al. Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production. Sci Rep. 2023;13:1482 pubmed publisher
Gonzalez M, Olivas I, Bencomo Alvarez A, Rubio A, Barreto Vargas C, Lopez J, et al. Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism. Clin Transl Med. 2022;12:e1146 pubmed publisher
Sena L, Kumar R, Sanin D, Thompson E, Rosen D, Dalrymple S, et al. Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC. J Clin Invest. 2022;132: pubmed publisher
Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, et al. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain. 2022;145:4368-4384 pubmed publisher
Jiang H, Tang E, Chen Y, Liu H, Zhao Y, Lin M, et al. Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression. Cancer Sci. 2022;113:971-985 pubmed publisher
Guo H, Wu Y, Nouri M, Spisak S, Russo J, Sowalsky A, et al. Androgen receptor and MYC equilibration centralizes on developmental super-enhancer. Nat Commun. 2021;12:7308 pubmed publisher
Ogunnaike M, Wang H, Zempleni J. Bovine mammary alveolar MAC-T cells afford a tool for studies of bovine milk exosomes in drug delivery. Int J Pharm. 2021;610:121263 pubmed publisher
He L, Li H, Pan C, Hua Y, Peng J, Zhou Z, et al. Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. Cancer Commun (Lond). 2021;41:726-746 pubmed publisher
Jin X, Zhang Z, Nie Z, Wang C, Meng F, Yi Q, et al. An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function. J Biol Chem. 2021;296:100437 pubmed publisher
Shang C, Hassan B, Haque M, Song Y, Li J, Liu D, et al. Crizotinib Resistance Mediated by Autophagy Is Higher in the Stem-Like Cell Subset in ALK-Positive Anaplastic Large Cell Lymphoma, and This Effect Is MYC-Dependent. Cancers (Basel). 2021;13: pubmed publisher
Yan X, Wang X, Li Y, Zhou M, Li Y, Song L, et al. Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron. Nat Chem Biol. 2021;: pubmed publisher
Lin K, Rutter J, Xie A, Pardieu B, Winn E, Bello R, et al. Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. Nat Genet. 2020;52:408-417 pubmed publisher
Tanaka A, Watanabe A, Nakano Y, Matsumoto M, Okazaki Y, Miyajima A. Reversible expansion of pancreatic islet progenitors derived from human induced pluripotent stem cells. Genes Cells. 2020;25:302-311 pubmed publisher
Guo L, Li J, Zeng H, Guzman A, Li T, Lee M, et al. A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells. Nat Commun. 2020;11:740 pubmed publisher
Varum S, Baggiolini A, Zurkirchen L, Atak Z, Cantù C, Marzorati E, et al. Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell. 2019;24:637-653.e9 pubmed publisher
Best S, Hashiguchi T, Kittai A, Bruss N, Paiva C, Okada C, et al. Targeting ubiquitin-activating enzyme induces ER stress-mediated apoptosis in B-cell lymphoma cells. Blood Adv. 2019;3:51-62 pubmed publisher
Yu L, Wang L, Mao C, Duraki D, Kim J, Huang R, et al. Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations. Cancer Lett. 2019;442:373-382 pubmed publisher
Abdelfattah N, Rajamanickam S, Panneerdoss S, Timilsina S, Yadav P, Onyeagucha B, et al. MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma. Nat Commun. 2018;9:4541 pubmed publisher
Lee H, Cha J, Kim S, Park J, Song K, Kim P, et al. c-MYC Drives Breast Cancer Metastasis to the Brain, but Promotes Synthetic Lethality with TRAIL. Mol Cancer Res. 2019;17:544-554 pubmed publisher
Yang C, Stampouloglou E, Kingston N, Zhang L, Monti S, Varelas X. Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells. EMBO Rep. 2018;19: pubmed publisher
Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, et al. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. Cell. 2018;172:90-105.e23 pubmed publisher
Topper M, Vaz M, Chiappinelli K, Destefano Shields C, Niknafs N, Yen R, et al. Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer. Cell. 2017;171:1284-1300.e21 pubmed publisher
Salas S, Ng N, Gerami Naini B, Anchan R. Induced Pluripotent Stem Cells from Ovarian Tissue. Curr Protoc Hum Genet. 2017;95:21.10.1-21.10.22 pubmed publisher
Zhao L, Loewenstein P, Green M. Adenovirus E1A TRRAP-targeting domain-mediated enhancement of MYC association with the NuA4 complex activates a panel of MYC target genes enriched for gene expression and ribosome biogenesis. Virology. 2017;512:172-179 pubmed publisher
Kapil S, Sharma B, Patil M, Elattar S, Yuan J, Hou S, et al. The cell polarity protein Scrib functions as a tumor suppressor in liver cancer. Oncotarget. 2017;8:26515-26531 pubmed publisher
Gomes L, Menck C, Cuervo A. Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation. Autophagy. 2017;13:928-940 pubmed publisher
Lee H, Wang H, Baladandayuthapani V, Lin H, He J, Jones R, et al. RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma. Br J Haematol. 2017;177:80-94 pubmed publisher
Vanli G, Sempoux C, Widmann C. The caspase-3/p120 RasGAP stress-sensing module reduces liver cancer incidence but does not affect overall survival in gamma-irradiated and carcinogen-treated mice. Mol Carcinog. 2017;56:1680-1684 pubmed publisher
Rodina A, Wang T, Yan P, Gomes E, Dunphy M, Pillarsetty N, et al. The epichaperome is an integrated chaperome network that facilitates tumour survival. Nature. 2016;538:397-401 pubmed publisher
Zhao L, Loewenstein P, Green M. Ad E1A 243R oncoprotein promotes association of proto-oncogene product MYC with the NuA4/Tip60 complex via the E1A N-terminal repression domain. Virology. 2016;499:178-184 pubmed publisher
Shi X, Mihaylova V, Kuruvilla L, Chen F, Viviano S, Baldassarre M, et al. Loss of TRIM33 causes resistance to BET bromodomain inhibitors through MYC- and TGF-?-dependent mechanisms. Proc Natl Acad Sci U S A. 2016;113:E4558-66 pubmed publisher
Tateishi K, Iafrate A, Ho Q, Curry W, Batchelor T, Flaherty K, et al. Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma. Clin Cancer Res. 2016;22:4452-65 pubmed publisher
Cheng Z, Gong Y, Ma Y, Lu K, Lu X, Pierce L, et al. Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin Cancer Res. 2013;19:1748-59 pubmed publisher
product information
Catalog Number :
46970
Product Name :
pCDH-puro-cMyc
article :
doi10.1158/1078-0432.CCR-12-3066
id7005
pubmed_id23403638
bacterial resistance :
Ampicillin
cloning :
backbonePCDH-CMV-MCS-EF1-PURO
backbone_mutation
backbone_originSystem Biosciences
backbone_size
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Lentiviral
growth strain :
lentiviral expression of c-Myc
origin :
37
pi :
alt_names
v-myc avian myelocytomatosis viral oncogene homolog
c-MYC
MRTL
cloning
clone_methodRestriction Enzyme
cloning_site_3BamHI
cloning_site_5EcoRI
promoterCMV
sequencing_primer_3
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesMRTL, MYCC, bHLHe39, c-Myc
geneMYC
id4609
genbank_ids
mutation
nameMYC
shRNA_sequence
size1323
species
9606
Homo sapiens
tags
resistance markers :
1651
tags :
Unknown
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA