This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pRK5-EGFP-Tau P301L
catalog :
46908
citations: 16
Reference
Cho H, Choi B, Shin Y, Suh S, Park S. Neuroinflammation-Modulating Agent SB1617 Enhances LC3-Associated Phagocytosis to Mitigate Tau Pathology. ACS Chem Neurosci. 2023;14:4139-4152 pubmed publisher
Bhagat R, Minaya M, Renganathan A, Mehra M, Marsh J, Martinez R, et al. Long non-coding RNA SNHG8 drives stress granule formation in tauopathies. medRxiv. 2023;: pubmed publisher
Hill S, Esquivel A, Ospina S, Rahal L, Dickey C, Blair L. Chaperoning activity of the cyclophilin family prevents tau aggregation. Protein Sci. 2022;31:e4448 pubmed publisher
Kim K, Park S, Hong J, Koh J, Cho D, Hwang J, et al. Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly. Front Cell Neurosci. 2022;16:895750 pubmed publisher
Iyaswamy A, Wang X, Krishnamoorthi S, Kaliamoorthy V, Sreenivasmurthy S, Kumar Durairajan S, et al. Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models. Redox Biol. 2022;51:102280 pubmed publisher
Torres Garcia L, P Domingues J, Brandi E, Haikal C, Mudannayake J, Brás I, et al. Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation. Sci Rep. 2022;12:2987 pubmed publisher
Yuste Checa P, Trinkaus V, Riera Tur I, Imamoglu R, Schaller T, Wang H, et al. The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Nat Commun. 2021;12:4863 pubmed publisher
Park L, Hochrainer K, Hattori Y, Ahn S, Anfray A, Wang G, et al. Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration. Nat Neurosci. 2020;23:1079-1089 pubmed publisher
Iyaswamy A, Krishnamoorthi S, Song J, Yang C, Kaliyamoorthy V, Zhang H, et al. NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models. J Food Drug Anal. 2020;28:132-146 pubmed publisher
Song J, Malampati S, Zeng Y, Durairajan S, Yang C, Tong B, et al. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2019;:e13069 pubmed publisher
Huang J, Huang F, Yang C. Moscatilin Ameliorates Tau Phosphorylation and Cognitive Deficits in Alzheimer's Disease Models. J Nat Prod. 2019;82:1979-1988 pubmed publisher
Lee H, Fan S, Huang F, Chao H, Hsu K, Lin T, et al. 5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes. J Med Chem. 2018;61:7087-7102 pubmed publisher
Fan S, Huang F, Liou J, Yang C. The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model. Cell Death Dis. 2018;9:655 pubmed publisher
Hassiotis S, Manavis J, Blumbergs P, Hattersley K, Carosi J, Kamei M, et al. Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus. Eur J Neurosci. 2018;47:1043-1053 pubmed publisher
Brunello C, Yan X, Huttunen H. Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules. Sci Rep. 2016;6:30498 pubmed publisher
Hoover B, Reed M, Su J, Penrod R, Kotilinek L, Grant M, et al. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. 2010;68:1067-81 pubmed publisher
product information
Catalog Number :
46908
Product Name :
pRK5-EGFP-Tau P301L
article :
doi10.1016/j.neuron.2010.11.030
id6986
pubmed_id21172610
bacterial resistance :
Ampicillin
cloning :
backbonepRK5
backbone_mutation
backbone_originClontech
backbone_size
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
WT htau construct (Addgene plasmid 46904) was used as a template to make mutations and contains human four-repeat tau lacking the N-terminal sequences (4R0N) and contains exons 1, 4 and 5, 7, and 9 13, intron 13, and exon 14.
growth strain :
expresses EGFP tagged Tau P301L in mammalian cells
origin :
37
pi :
alt_names
Tau
microtubule-associated protein tau
MAPT
cloning
clone_methodRestriction Enzyme
cloning_site_3SalI
cloning_site_5Cla1
promoterCMV
sequencing_primer_3SV40pA-R
sequencing_primer_5SP6
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesDDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, Tau-PHF6, tau-40
geneMAPT
id4137
genbank_ids
mutationP301L
nameTau P301L
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationN terminal on insert
tagEGFP
resistance markers :
1642
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA