This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
HA Nprl3 pRK5
catalog :
46330
citations: 6
Reference
Yin S, Liu L, Ball L, Wang Y, Bedford M, Duncan S, et al. CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. Cell Rep. 2023;42:112316 pubmed publisher
Figlia G, M xfc ller S, Hagenston A, Kleber S, Roiuk M, Quast J, et al. Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition. Nat Cell Biol. 2022;24:1407-1421 pubmed publisher
Dawson R, Nieto Guil A, Robertson L, Piltz S, Hughes J, Thomas P. Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy. Neurobiol Dis. 2019;134:104640 pubmed publisher
Pal R, Palmieri M, Chaudhury A, Klisch T, di Ronza A, Neilson J, et al. Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Nat Commun. 2018;9:4351 pubmed publisher
Shen K, Choe A, Sabatini D. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Mol Cell. 2017;68:552-565.e8 pubmed publisher
Bar Peled L, Chantranupong L, Cherniack A, Chen W, Ottina K, Grabiner B, et al. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013;340:1100-6 pubmed publisher
product information
Catalog Number :
46330
Product Name :
HA Nprl3 pRK5
article :
doi10.1126/science.1232044
id6899
pubmed_id23723238
bacterial resistance :
Ampicillin
cloning :
backbonepRK5
backbone_mutation
backbone_origin
backbone_size
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3BamHI
cloning_site_5SalI
promoter
sequencing_primer_3SV40pA-R
sequencing_primer_5SP6
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesC16orf35, CGTHBA, FFEVF3, HS-40, MARE, NPR3, RMD11
geneNPRL3
id8131
genbank_ids
mutation
nameNprl3
shRNA_sequence
size1710
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagHA
resistance markers :
432
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA