This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pEGFP-parkin C431S
catalog :
45877
citations: 7
Reference
Peng W, Schr xf6 der L, Song P, Wong Y, Krainc D. Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease. Sci Adv. 2023;9:eadh3347 pubmed publisher
Zhang Z, Yi J, Xie B, Chen J, Zhang X, Wang L, et al. Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells. Curr Issues Mol Biol. 2022;44:2759-2771 pubmed publisher
Kapadia B, Roychowdhury A, Kayastha F, Nanaji N, Gartenhaus R. PARK2 regulates eIF4B-driven lymphomagenesis. Mol Cancer Res. 2022;: pubmed publisher
Esser L, Branchi V, Shakeri F, Simon A, Stephan C, Kristiansen G, et al. Overexpression of Parkin in clear cell renal cell carcinoma decreases tumor aggressiveness by regulating CKS2 levels. Int J Oncol. 2022;60: pubmed publisher
Zhu M, Cortese G, Waites C. Parkinson's disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons. BMC Biol. 2018;16:100 pubmed publisher
Lai H, Li J, Wang M, Huang H, Croce C, Sun H, et al. HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis. J Clin Invest. 2018;128:625-643 pubmed publisher
Trempe J, Sauvé V, Grenier K, Seirafi M, Tang M, Ménade M, et al. Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science. 2013;340:1451-5 pubmed publisher
product information
Catalog Number :
45877
Product Name :
pEGFP-parkin C431S
article :
doi10.1126/science.1237908
id6823
pubmed_id23661642
bacterial resistance :
Kanamycin
cloning :
backbonepEGFP-C2
backbone_mutation
backbone_origin
backbone_size4731
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
PARK2
cloning
clone_methodRestriction Enzyme
cloning_site_3SalI
cloning_site_5EcoRI
promoterCMV
sequencing_primer_3
sequencing_primer_5EGFP_C_primer
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAR-JP, LPRS2, PARK2, PDJ
genePRKN
id5071
genbank_ids
NM_004562.2
mutationC431S mutation (ubiquitin acceptor site)
nameParkin
shRNA_sequence
size1398
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagEGFP
resistance markers :
1596
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA