This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pEGFP-parkin WT
catalog :
45875
citations: 23
Reference
Mishra S, Behera B, Singh V, Mahapatra K, Mundkinajeddu D, Bhat D, et al. Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma. Phytomedicine. 2024;123:155157 pubmed publisher
Peng W, Schr xf6 der L, Song P, Wong Y, Krainc D. Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease. Sci Adv. 2023;9:eadh3347 pubmed publisher
Panigrahi D, Praharaj P, Behera B, Patra S, Patil S, Patro B, et al. The inner mitochondrial membrane fission protein MTP18 serves as a mitophagy receptor to prevent apoptosis in oral cancer. J Cell Sci. 2023;136: pubmed publisher
Tang W, Thundyil J, Lim G, Tng T, Yeow S, Nair A, et al. Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease. Hum Mol Genet. 2023;32:1466-1482 pubmed publisher
Sauv xe9 V, Sung G, MacDougall E, Kozlov G, Saran A, Fakih R, et al. Structural basis for feedforward control in the PINK1/Parkin pathway. EMBO J. 2022;41:e109460 pubmed publisher
Kapadia B, Roychowdhury A, Kayastha F, Nanaji N, Gartenhaus R. PARK2 regulates eIF4B-driven lymphomagenesis. Mol Cancer Res. 2022;: pubmed publisher
Ma K, Fokkens M, van Laar T, Verbeek D. Systematic analysis of PINK1 variants of unknown significance shows intact mitophagy function for most variants. NPJ Parkinsons Dis. 2021;7:113 pubmed publisher
Rouland L, Duplan E, Ramos Dos Santos L, Bernardin A, Katula K, Manfioletti G, et al. Therapeutic potential of parkin as a tumor suppressor via transcriptional control of cyclins in glioblastoma cell and animal models. Theranostics. 2021;11:10047-10063 pubmed publisher
Ma K, Fokkens M, Reggiori F, Mari M, Verbeek D. Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy. Transl Neurodegener. 2021;10:19 pubmed publisher
Kara E, Crimi A, Wiedmer A, Emmenegger M, Manzoni C, Bandrés Ciga S, et al. An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein. Cell Rep. 2021;35:109189 pubmed publisher
Chen H, Li Y, Li Y, Chen Z, Xie L, Li W, et al. PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2. Theranostics. 2020;10:9984-10000 pubmed publisher
Dannheisig D, Beck E, Calzia E, Walther P, Behrends C, Pfister A. Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux. Cells. 2019;8: pubmed publisher
Yi W, MacDougall E, Tang M, Krahn A, Gan Or Z, Trempe J, et al. The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson's disease. Hum Mol Genet. 2019;28:2811-2825 pubmed publisher
Cho H, Ryu J, Jo Y, Seo T, Choi Y, Kim J, et al. Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System. Mol Cell. 2019;73:364-376.e8 pubmed publisher
Cummins N, Tweedie A, Zuryn S, Bertran Gonzalez J, Götz J. Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria. EMBO J. 2019;38: pubmed publisher
Zhu M, Cortese G, Waites C. Parkinson's disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons. BMC Biol. 2018;16:100 pubmed publisher
Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, et al. Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease. Cell Death Dis. 2018;9:700 pubmed publisher
Lahuerta M, Aguado C, Sánchez Martín P, Sanz P, Knecht E. Degradation of altered mitochondria by autophagy is impaired in Lafora disease. FEBS J. 2018;285:2071-2090 pubmed publisher
Kruppa A, Kishi Itakura C, Masters T, Rorbach J, Grice G, Kendrick Jones J, et al. Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria. Dev Cell. 2018;44:484-499.e6 pubmed publisher
Lai H, Li J, Wang M, Huang H, Croce C, Sun H, et al. HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis. J Clin Invest. 2018;128:625-643 pubmed publisher
Lindqvist L, Frank D, McArthur K, Dite T, Lazarou M, Oakhill J, et al. Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion. Cell Death Differ. 2018;25:782-794 pubmed publisher
Panda P, Naik P, Meher B, Das D, Mukhopadhyay S, Praharaj P, et al. PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation. Biochim Biophys Acta Mol Cell Res. 2018;1865:480-495 pubmed publisher
Trempe J, Sauvé V, Grenier K, Seirafi M, Tang M, Ménade M, et al. Structure of parkin reveals mechanisms for ubiquitin ligase activation. Science. 2013;340:1451-5 pubmed publisher
product information
Catalog Number :
45875
Product Name :
pEGFP-parkin WT
article :
doi10.1126/science.1237908
id6823
pubmed_id23661642
bacterial resistance :
Kanamycin
cloning :
backbonepEGFP-C2
backbone_mutation
backbone_origin
backbone_size4731
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
PARK2
cloning
clone_methodRestriction Enzyme
cloning_site_3SalI
cloning_site_5EcoRI
promoterCMV
sequencing_primer_3
sequencing_primer_5EGFP_C_primer
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAR-JP, LPRS2, PARK2, PDJ
genePRKN
id5071
genbank_ids
NM_004562.2
mutation
nameParkin
shRNA_sequence
size1398
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagEGFP
plasmid copy :
Lab of Heidi McBride
resistance markers :
1596
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA