This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCI-Caspase 1
catalog :
41552
citations: 6
Reference
Goh G, Ahn M, Zhu F, Lee L, Luo D, Irving A, et al. Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of dampened inflammation in bats. Proc Natl Acad Sci U S A. 2020;117:28939-28949 pubmed publisher
Mambwe B, Neo K, Javanmard Khameneh H, Leong K, Colantuoni M, Vacca M, et al. Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes. Front Immunol. 2019;10:1556 pubmed publisher
Mehto S, Jena K, Nath P, Chauhan S, Kolapalli S, Das S, et al. The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. Mol Cell. 2019;73:429-445.e7 pubmed publisher
Adams A, Weinman S, Wozniak A. Caspase-1 regulates cellular trafficking via cleavage of the Rab7 adaptor protein RILP. Biochem Biophys Res Commun. 2018;503:2619-2624 pubmed publisher
Zhong F, Mamaï O, Sborgi L, Boussofara L, Hopkins R, Robinson K, et al. Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation. Cell. 2016;167:187-202.e17 pubmed publisher
Hornung V, Ablasser A, Charrel Dennis M, Bauernfeind F, Horvath G, Caffrey D, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009;458:514-8 pubmed publisher
product information
Catalog Number :
41552
Product Name :
pCI-Caspase 1
article :
doi10.1038/nature07725
id3897
pubmed_id19158675
bacterial resistance :
Ampicillin
cloning :
backbonepCI
backbone_mutation
backbone_originPromega
backbone_size4006
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
CASP1
ICE
CASP1 caspase 1, apoptosis-related cysteine peptidase
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5EcoRI
promoterCMV immediate-early enhancer/promoter
sequencing_primer_3EBV-rev
sequencing_primer_5chim-int-F (TCTTACTGACATCCACTTTGCC)
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesICE, IL1BC, P45
geneCASP1
id834
genbank_ids
NM_033292.3
NP_150634.1
mutation
nameCaspase-1
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on insert
tagMyc
resistance markers :
872
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA