This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pBABEpuro-ERBB2
catalog :
40978
citations: 17
Reference
Montero Vergara J, Plachetta K, Kinch L, Bernhardt S, Kashyap K, Levine B, et al. GRB2 is a BECN1 interacting protein that regulates autophagy. Cell Death Dis. 2024;15:14 pubmed publisher
McKernan C, Khatri A, Hannigan M, Child J, Chen Q, Mayro B, et al. ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain. Cell Rep. 2022;40:111268 pubmed publisher
Song X, Tang W, Peng H, Qi X, Li J. FGFR leads to sustained activation of STAT3 to mediate resistance to EGFR-TKIs treatment. Invest New Drugs. 2021;: pubmed publisher
Akhand S, Chen H, Purdy S, Liu Z, Anderson J, Willey C, et al. Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy. NPJ Breast Cancer. 2021;7:5 pubmed publisher
Reche Perez F, Plesselova S, De Los Reyes Berbel E, Ortega Muñoz M, López Jaramillo F, Hernandez Mateo F, et al. Single chain variable fragment fused to maltose binding protein: a modular nanocarrier platform for the targeted delivery of antitumorals. Biomater Sci. 2021;: pubmed publisher
Piasecka D, Braun M, Mieszkowska M, Kowalczyk L, Kopczynski J, Kordek R, et al. Upregulation of HIF1-α via an NF-κB/COX2 pathway confers proliferative dominance of HER2-negative ductal carcinoma in situ cells in response to inflammatory stimuli. Neoplasia. 2020;22:576-589 pubmed publisher
Kutys M, Polacheck W, Welch M, Gagnon K, Koorman T, Kim S, et al. Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Nat Commun. 2020;11:3377 pubmed publisher
DiScala M, Najor M, Yung T, Morgan D, Abukhdeir A, Cobleigh M. Loss of STAT6 leads to anchorage-independent growth and trastuzumab resistance in HER2+ breast cancer cells. PLoS ONE. 2020;15:e0234146 pubmed publisher
Wang M, LAW M, Davis B, Yaaghubi E, Ghilardi A, Ferreira R, et al. Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway. Cell Death Discov. 2019;5:153 pubmed publisher
Robichaux J, Elamin Y, Vijayan R, Nilsson M, Hu L, He J, et al. Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity. Cancer Cell. 2019;36:444-457.e7 pubmed publisher
Shin D, Jo J, Han J. Dual Targeting of ERBB2/ERBB3 for the Treatment of SLC3A2-NRG1-Mediated Lung Cancer. Mol Cancer Ther. 2018;17:2024-2033 pubmed publisher
Kitowska K, Kowalska A, Mieszkowska M, Piasecka D, Skladanowski A, Romanska H, et al. Progesterone impairs Herceptin effect on breast cancer cells. Oncol Lett. 2018;15:1817-1822 pubmed publisher
Thaler S, Schmidt M, Roβwag S, Thiede G, Schad A, Sleeman J. Proteasome inhibitors prevent bi-directional HER2/estrogen-receptor cross-talk leading to cell death in endocrine and lapatinib-resistant HER2+/ER+ breast cancer cells. Oncotarget. 2017;8:72281-72301 pubmed publisher
Papadakis E, Barker C, Syed H, Reeves T, Schwaiger S, Stuppner H, et al. The Bag-1 inhibitor, Thio-2, reverses an atypical 3D morphology driven by Bag-1L overexpression in a MCF-10A model of ductal carcinoma in situ. Oncogenesis. 2016;5:e215 pubmed publisher
Huang W, Burnouf P, Su Y, Chen B, Chuang K, Lee C, et al. Engineering Chimeric Receptors To Investigate the Size- and Rigidity-Dependent Interaction of PEGylated Nanoparticles with Cells. ACS Nano. 2016;10:648-62 pubmed publisher
Garay C, Judge G, Lucarelli S, Bautista S, Pandey R, Singh T, et al. Epidermal growth factor-stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis. Mol Biol Cell. 2015;26:3504-19 pubmed publisher
Greulich H, Kaplan B, Mertins P, Chen T, Tanaka K, Yun C, et al. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A. 2012;109:14476-81 pubmed publisher
product information
Catalog Number :
40978
Product Name :
pBABEpuro-ERBB2
article :
doi10.1073/pnas.1203201109
id5985
pubmed_id22908275
bacterial resistance :
Ampicillin
cloning :
backbonepBABE-puro
backbone_mutationpBABE-puro vector was modified to be compatible with Gateway cloning
backbone_origin
backbone_size5200
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
origin :
37
pi :
alt_names
HER2
cloning
clone_methodGateway Cloning
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3gcatacttctgcctgctg
sequencing_primer_5tttgtacaccctaagcctc
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2)
geneERBB2
id2064
genbank_ids
M11730.1
mutation
nameERBB2
shRNA_sequence
size3768
species
9606
Homo sapiens
tags
resistance markers :
338
tags :
High Copy
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA