This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pHM6-alphasynuclein-A53T
catalog :
40825
citations: 12
Reference
Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, et al. p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease. J Neuroinflammation. 2021;18:295 pubmed publisher
Wang C, Lau C, Ma F, Zheng C. Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Delaidelli A, Richner M, Jiang L, van der Laan A, Bergholdt Jul Christiansen I, Ferreira N, et al. α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response. Acta Neuropathol Commun. 2021;9:105 pubmed publisher
Lee B, Kim H, Kim H, Jeong H, Kim B, Lee H, et al. O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease. Brain. 2020;143:3699-3716 pubmed publisher
Hatstat A, Ahrendt H, Foster M, Mayne L, Moseley M, Englander S, et al. Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade. Cell Chem Biol. 2021;28:14-25.e9 pubmed publisher
Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, et al. Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease. Aging Cell. 2020;19:e13163 pubmed publisher
Gui C, Ren Y, Chen J, Wu X, Mao K, Li H, et al. p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T α-synuclein model of Parkinson's disease. Toxicol Appl Pharmacol. 2019;388:114874 pubmed publisher
Jan A, Jansonius B, Delaidelli A, Bhanshali F, An Y, Ferreira N, et al. Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity. Acta Neuropathol Commun. 2018;6:54 pubmed publisher
Shaltouki A, Hsieh C, Kim M, Wang X. Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models. Acta Neuropathol. 2018;136:607-620 pubmed publisher
Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, et al. Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease. Cell Death Dis. 2018;9:700 pubmed publisher
Jorge Finnigan A, Kleppe R, Jung Kc K, Ying M, Marie M, Rios Mondragon I, et al. Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. J Biol Chem. 2017;292:14092-14107 pubmed publisher
Furlong R, Narain Y, Rankin J, Wyttenbach A, Rubinsztein D. Alpha-synuclein overexpression promotes aggregation of mutant huntingtin. Biochem J. 2000;346 Pt 3:577-81 pubmed
product information
Catalog Number :
40825
Product Name :
pHM6-alphasynuclein-A53T
article :
doi10.1042/0264-6021:3460577
id5941
pubmed_id10698681
bacterial resistance :
Ampicillin
cloning :
backbonepHM6
backbone_mutation
backbone_originRoche
backbone_size5450
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
Alpha-synuclein
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5HindIII
promoterCMV
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesNACP, PARK1, PARK4, PD1
geneSNCA
id6622
genbank_ids
mutationA53T
nameSNCA
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagHA
locationC terminal on backbone
tag6x His
resistance markers :
1372
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA