This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCXN2-BCL6 (CXN-BCL6)
catalog :
40346
citations: 3
Reference
Zeng X, Zhao F, Jia J, Ma X, Jiang Q, Zhang R, et al. Targeting BCL6 in Gastrointestinal Stromal Tumor Promotes p53-Mediated Apoptosis to Enhance the Antitumor Activity of Imatinib. Cancer Res. 2023;83:3624-3635 pubmed publisher
Dhar S, Zhao D, Lin T, Gu B, Pal K, Wu S, et al. MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes. Mol Cell. 2018;70:825-841.e6 pubmed publisher
Vasanwala F, Kusam S, Toney L, Dent A. Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. J Immunol. 2002;169:1922-9 pubmed
product information
Catalog Number :
40346
Product Name :
pCXN2-BCL6 (CXN-BCL6)
article :
doi
id5860
pubmed_id12165517
bacterial resistance :
Ampicillin
cloning :
backbonepCXN2
backbone_mutation
backbone_originNiwa, Yamamura, and Miyazaki (PMID: 1660837)
backbone_size5200
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
CXN-BCL-6 was constructed by inserting the human BCL-6 cDNA from pBS-BCL-6 full length (FL) via SalI ends into the XhoI site in the pCXN2 expression vector. The pCXN2 (CXN) vector was obtained from Dr. K. Ozato (National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD) and consists of the human BCL-6 cDNA driven by a hybrid  -actin-CMV promoter.
origin :
37
pi :
alt_names
BCL-6
B-cell CLL/lymphoma 6
cloning
clone_methodRestriction Enzyme
cloning_site_3SalI/XhoI
cloning_site_5XhoI/SalI
promoterpCAG
sequencing_primer_3Bglob-pA-R (ttttggcagagggaaaaaga)
sequencing_primer_5pCAG-F
site_3_destroyed1
site_5_destroyed1
entrez_gene
aliasesBCL5, BCL6A, LAZ3, ZBTB27, ZNF51
geneBCL6
id604
genbank_ids
mutation
nameBCL6
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on insert
tagFLAG
resistance markers :
1357
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA