| Reference |
|---|
Llamas E, Koyuncu S, Lee H, Wehrmann M, Gutiérrez García R, Dunken N, et al. In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation. Nat Aging. 2023;3:1345-1357 pubmed publisher
|
Lee D, Choi C, Sanders D, Beckers L, Riback J, Brangwynne C, et al. Size distributions of intracellular condensates reflect competition between coalescence and nucleation. Nat Phys. 2023;19:586-596 pubmed publisher
|
Pereira C, Medaglia N, Ureshino R, Bincoletto C, Antonioli M, Fimia G, et al. NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes. Int J Mol Sci. 2023;24: pubmed publisher
|
Mansky R, Greguske E, Yu D, Zarate N, Intihar T, Tsai W, et al. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease. Cell Rep. 2023;42:112198 pubmed publisher
|
Joshi B, Zuhorn I. Preparation of chaperone-loaded neural stem cell-derived extracellular vesicles to reduce protein aggregation in Huntington's disease cellular models. STAR Protoc. 2023;4:102134 pubmed publisher
|
Haver H, Wedemeyer M, Butcher E, Peterson F, Volkman B, Scaglione K. Mechanistic Insight into the Suppression of Polyglutamine Aggregation by SRCP1. ACS Chem Biol. 2023;18:549-560 pubmed publisher
|
Joshi B, Garcia Romeu H, Aliyandi A, de Vries M, Zuhorn I. DNAJB6-Containing Extracellular Vesicles as Chaperone Delivery Systems: A Proteomic Analysis. Pharmaceutics. 2022;14: pubmed publisher
|
Ahat E, Bui S, Zhang J, da Veiga Leprevost F, Sharkey L, Reid W, et al. GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin. J Biol Chem. 2022;:102219 pubmed publisher
|
Watabe K, Niida Kawaguchi M, Tada M, Kato Y, Murata M, Tanji K, et al. Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation. Neuropathology. 2022;: pubmed publisher
|
Peinado J, Chaplot K, Jarvela T, Barbieri E, Shorter J, Lindberg I. Sequestration of TDP-43216-414 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone. ACS Chem Neurosci. 2022;13:1651-1665 pubmed publisher
|
Palminha N, dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L, El Khamisy S. Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease. Cell Mol Life Sci. 2022;79:160 pubmed publisher
|
Qiu W, Ai W, Zhu F, Zhang Y, Guo M, Law B, et al. Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy. Free Radic Biol Med. 2021;179:76-94 pubmed publisher
|
Joshi B, Youssef S, Bron R, de Bruin A, Kampinga H, Zuhorn I. DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease. iScience. 2021;24:103282 pubmed publisher
|
Blumenstock S, Schulz Trieglaff E, Voelkl K, Bolender A, Lapios P, Lindner J, et al. Fluc-EGFP reporter mice reveal differential alterations of neuronal proteostasis in aging and disease. EMBO J. 2021;40:e107260 pubmed publisher
|
Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, et al. DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases. Neurotherapeutics. 2021;: pubmed publisher
|
de Armas Rillo S, Fumagallo Reading F, Luis Ravelo D, Abdul Jalbar B, Gonzalez Hernandez T, Lahoz F. Random Lasing Detection of Mutant Huntingtin Expression in Cells. Sensors (Basel). 2021;21: pubmed publisher
|
Kim Guisbert K, Mossiah I, Guisbert E. Titration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology. Int J Mol Sci. 2020;21: pubmed publisher
|
Aravindan S, Chen S, Choudhry H, Molfetta C, Chen K, Liu A. Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington's disease cell models. Sci Rep. 2020;10:15511 pubmed publisher
|
Rodríguez González C, Lin S, Arkan S, Hansen C. Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation. Sci Rep. 2020;10:8130 pubmed publisher
|
Glaser T, Shimojo H, Ribeiro D, Martins P, Beco R, Kosinski M, et al. ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. Mol Psychiatry. 2020;: pubmed publisher
|
Nath S, Lieberman M, Yu Z, Marchioretti C, Jones S, Danby E, et al. MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease. Acta Neuropathol. 2020;140:63-80 pubmed publisher
|
Nóbrega C, Conceição A, Costa R, Koppenol R, Sequeira R, Nunes R, et al. The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington's disease. BMC Res Notes. 2020;13:210 pubmed publisher
|
Pinho B, Reis S, Hartley R, Murphy M, Oliveira J. Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Free Radic Biol Med. 2019;130:318-327 pubmed publisher
|
Chang C, Lin T, Ho H, Kuo C, Li H, Korolenko T, et al. GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. Int J Mol Sci. 2018;19: pubmed publisher
|
Chen J, Parekh M, Seliman H, Bakshinskaya D, Dai W, Kwan K, et al. Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction. J Biol Chem. 2018;293:15581-15593 pubmed publisher
|
Jena K, Kolapalli S, Mehto S, Nath P, Das B, Sahoo P, et al. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018;37: pubmed publisher
|
Zeng Y, Jones A, Thomas E, Nassif B, Silberg J, Segatori L. A Split Transcriptional Repressor That Links Protein Solubility to an Orthogonal Genetic Circuit. ACS Synth Biol. 2018;7:2126-2138 pubmed publisher
|
Pierzynowska K, Gaffke L, Hać A, Mantej J, Niedziałek N, Brokowska J, et al. Correction of Huntington's Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model. Neuromolecular Med. 2018;20:112-123 pubmed publisher
|
Victor M, Richner M, Olsen H, Lee S, Monteys A, Ma C, et al. Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. Nat Neurosci. 2018;21:341-352 pubmed publisher
|
Tanji K, Mori F, Miki Y, Utsumi J, Sasaki H, Kakita A, et al. YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity. Neurobiol Dis. 2018;112:14-23 pubmed publisher
|
Al Ramahi I, Giridharan S, Chen Y, Patnaik S, Safren N, Hasegawa J, et al. Inhibition of PIP4K? ameliorates the pathological effects of mutant huntingtin protein. elife. 2017;6: pubmed publisher
|
Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, et al. A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell. 2017;171:1692-1706.e18 pubmed publisher
|
Aprile F, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C. The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Sci Rep. 2017;7:9039 pubmed publisher
|
Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, O Prey J, Clark W, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell. 2017;66:517-532.e9 pubmed publisher
|
Barakat D, Mendonca J, Barberi T, Zhang J, Kachhap S, Paz Priel I, et al. C/EBPβ regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion. Cancer Lett. 2016;375:152-161 pubmed publisher
|
Tanji K, Miki Y, Maruyama A, Mori F, Mimura J, Itoh K, et al. The role of NUB1 in α-synuclein degradation in Lewy body disease model mice. Biochem Biophys Res Commun. 2016;470:635-642 pubmed publisher
|
Yue F, Li W, Zou J, Chen Q, Xu G, Huang H, et al. Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin. Aging (Albany NY). 2015;7:839-53 pubmed
|
Narain Y, Wyttenbach A, Rankin J, Furlong R, Rubinsztein D. A molecular investigation of true dominance in Huntington's disease. J Med Genet. 1999;36:739-46 pubmed
|