This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pEGFP-Q23
catalog :
40261
citations: 17
Reference
Mansky R, Greguske E, Yu D, Zarate N, Intihar T, Tsai W, et al. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease. Cell Rep. 2023;42:112198 pubmed publisher
Ahat E, Bui S, Zhang J, da Veiga Leprevost F, Sharkey L, Reid W, et al. GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin. J Biol Chem. 2022;:102219 pubmed publisher
Watabe K, Niida Kawaguchi M, Tada M, Kato Y, Murata M, Tanji K, et al. Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation. Neuropathology. 2022;: pubmed publisher
Palminha N, dos Santos Souza C, Griffin J, Liao C, Ferraiuolo L, El Khamisy S. Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease. Cell Mol Life Sci. 2022;79:160 pubmed publisher
de Armas Rillo S, Fumagallo Reading F, Luis Ravelo D, Abdul Jalbar B, Gonzalez Hernandez T, Lahoz F. Random Lasing Detection of Mutant Huntingtin Expression in Cells. Sensors (Basel). 2021;21: pubmed publisher
Kim Guisbert K, Mossiah I, Guisbert E. Titration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology. Int J Mol Sci. 2020;21: pubmed publisher
Sarraf S, Shah H, Kanfer G, Pickrell A, Holtzclaw L, Ward M, et al. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Mol Cell. 2020;80:779-795.e10 pubmed publisher
Aravindan S, Chen S, Choudhry H, Molfetta C, Chen K, Liu A. Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington's disease cell models. Sci Rep. 2020;10:15511 pubmed publisher
Glaser T, Shimojo H, Ribeiro D, Martins P, Beco R, Kosinski M, et al. ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research. Mol Psychiatry. 2020;: pubmed publisher
Pinho B, Reis S, Hartley R, Murphy M, Oliveira J. Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. Free Radic Biol Med. 2019;130:318-327 pubmed publisher
Chang C, Lin T, Ho H, Kuo C, Li H, Korolenko T, et al. GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling. Int J Mol Sci. 2018;19: pubmed publisher
Chen J, Parekh M, Seliman H, Bakshinskaya D, Dai W, Kwan K, et al. Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction. J Biol Chem. 2018;293:15581-15593 pubmed publisher
Zeng Y, Jones A, Thomas E, Nassif B, Silberg J, Segatori L. A Split Transcriptional Repressor That Links Protein Solubility to an Orthogonal Genetic Circuit. ACS Synth Biol. 2018;7:2126-2138 pubmed publisher
Victor M, Richner M, Olsen H, Lee S, Monteys A, Ma C, et al. Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. Nat Neurosci. 2018;21:341-352 pubmed publisher
Al Ramahi I, Giridharan S, Chen Y, Patnaik S, Safren N, Hasegawa J, et al. Inhibition of PIP4K? ameliorates the pathological effects of mutant huntingtin protein. elife. 2017;6: pubmed publisher
Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, et al. A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell. 2017;171:1692-1706.e18 pubmed publisher
Narain Y, Wyttenbach A, Rankin J, Furlong R, Rubinsztein D. A molecular investigation of true dominance in Huntington's disease. J Med Genet. 1999;36:739-46 pubmed
product information
Catalog Number :
40261
Product Name :
pEGFP-Q23
article :
doi10.1136/jmg.36.10.739
id5830
pubmed_id10528852
bacterial resistance :
Kanamycin
cloning :
backbonepEGFP-C1
backbone_mutation
backbone_originClontech
backbone_size4700
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
huntingtin
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5BglII
promoterCMV
sequencing_primer_3SV40pA-R
sequencing_primer_5EGFP-C
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesHD, IT15, LOMARS
geneHTT
id3064
genbank_ids
mutationexpanded poly-Q
nameHTT partial exon 1 Q23
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagEGFP
resistance markers :
1372
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA