This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCW57.1-4EBP1_4xAla
catalog :
38240
citations: 11
Reference
Kantzer C, Yang W, Grommisch D, Vikhe Patil K, Mak K, Shirokova V, et al. ID1 and CEBPA coordinate epidermal progenitor cell differentiation. Development. 2022;149: pubmed publisher
Lee B, Boyer J, Burnett G, Thottumkara A, Tibrewal N, Wilson S, et al. Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth. Nat Chem Biol. 2021;: pubmed publisher
Zhang Y, Swanda R, Nie L, Liu X, Wang C, Lee H, et al. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021;12:1589 pubmed publisher
Lee H, Chin H, Kim H, Jung H, Lee D. STAT3-mediated MLST8 gene expression regulates cap-dependent translation in cancer cells. Mol Oncol. 2020;: pubmed publisher
Woodcock H, Eley J, Guillotin D, Platè M, Nanthakumar C, Martufi M, et al. The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis. Nat Commun. 2019;10:6 pubmed publisher
Figlia G, Norrmen C, Pereira J, Gerber D, Suter U. Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system. elife. 2017;6: pubmed publisher
Kang J, Kusnadi E, Ogden A, Hicks R, Bammert L, Kutay U, et al. Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription. Oncotarget. 2016;7:48887-48904 pubmed publisher
Olejniczak S, La Rocca G, Radler M, Egan S, Xiang Q, Garippa R, et al. Coordinated Regulation of Cap-Dependent Translation and MicroRNA Function by Convergent Signaling Pathways. Mol Cell Biol. 2016;36:2360-73 pubmed publisher
Llanos S, García Pedrero J, Morgado Palacin L, Rodrigo J, Serrano M. Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Nat Commun. 2016;7:10438 pubmed publisher
Grzmil M, Huber R, Hess D, Frank S, Hynx D, Moncayo G, et al. MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas. J Clin Invest. 2014;124:742-54 pubmed publisher
Thoreen C, Chantranupong L, Keys H, Wang T, Gray N, Sabatini D. A unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012;485:109-13 pubmed publisher
product information
Catalog Number :
38240
Product Name :
pCW57.1-4EBP1_4xAla
article :
doi10.1038/nature11083
id5626
pubmed_id22552098
bacterial resistance :
Ampicillin
cloning :
backbonepCW57.1
backbone_mutation
backbone_originBroad Insitute
backbone_size5000
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Lentiviral
Other
Doxycycline inducible
origin :
37
pi :
alt_names
Eif4Ebp1
cloning
clone_methodRestriction Enzyme
cloning_site_3BamH1
cloning_site_5Nhe1
promoterTet ON
sequencing_primer_3GGATGGATCCTTAAATGTCCATCTCAAACTG
sequencing_primer_5ATAAGCTAGCGATGTCCGGGGGCAGCAGCTGC
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesPHAS-I
geneEif4ebp1
id116636
genbank_ids
mutationT37A, T46A, S65A, T70A (dominant negative)
name4EBP1
shRNA_sequence
size357
species
10116
Rattus norvegicus
32644
Other
hybrid gene of rat and human
tags
resistance markers :
432
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA