This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pAAV asyn WT
catalog :
36055
citations: 8
Reference
Dubey A, Mishra R, Jagtap Y, Kinger S, Kumar P, Dhiman R, et al. Itraconazole Confers Cytoprotection Against Neurodegenerative Disease-Associated Abnormal Protein Aggregation. Mol Neurobiol. 2023;60:2397-2412 pubmed publisher
Sandoval Pistorius S, Gerson J, Liggans N, Ryou J, Oak K, Li X, et al. Ubiquilin-2 regulates pathological alpha-synuclein. Sci Rep. 2023;13:293 pubmed publisher
Lashuel H, Mahul Mellier A, Novello S, Hegde R, Jasiqi Y, Altay M, et al. Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity. NPJ Parkinsons Dis. 2022;8:136 pubmed publisher
Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, et al. p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease. J Neuroinflammation. 2021;18:295 pubmed publisher
Frey B, AlOkda A, Jackson M, Riguet N, Duce J, Lashuel H. Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get. J Neurochem. 2020;: pubmed publisher
Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, et al. Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease. Cell Death Dis. 2018;9:700 pubmed publisher
Upadhyay A, Amanullah A, Mishra R, Kumar A, Mishra A. Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. Mol Neurobiol. 2018;55:1169-1182 pubmed publisher
Oueslati A, Paleologou K, Schneider B, Aebischer P, Lashuel H. Mimicking phosphorylation at serine 87 inhibits the aggregation of human ?-synuclein and protects against its toxicity in a rat model of Parkinson's disease. J Neurosci. 2012;32:1536-44 pubmed publisher
product information
Catalog Number :
36055
Product Name :
pAAV asyn WT
article :
doi10.1523/JNEUROSCI.3784-11.2012
id5222
pubmed_id22302797
bacterial resistance :
Ampicillin
cloning :
backbonepAAV-MCS
backbone_mutation
backbone_originStratagene
backbone_size4581
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
AAV
growth notes :
Lashuel Lab Plasmid #172
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3BglII
cloning_site_5ClaI
promoterCMV
sequencing_primer_3hGH rev (TAGGACAAGGCTGGTGGGCA)
sequencing_primer_5bglob fw (TCTTATCTTCCTCCCACAGC)
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesNACP, PARK1, PARK4, PD1
geneSNCA
id6622
genbank_ids
mutation
namealpha-synuclein WT
shRNA_sequence
size484
species
9606
Homo sapiens
tags
resistance markers :
1204
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA