This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pShuttle-FEN1hWT
catalog :
35027
citations: 5
Reference
Lainšček D, Forstnerič V, Mikolič V, Malenšek Š, Pečan P, Bencina M, et al. Coiled-coil heterodimer-based recruitment of an exonuclease to CRISPR/Cas for enhanced gene editing. Nat Commun. 2022;13:3604 pubmed publisher
Schilling E, Scherer M, Rothemund F, Stamminger T. Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks. PLoS Pathog. 2021;17:e1009460 pubmed publisher
Flach K, Periyasamy M, Jadhav A, Dorjsuren D, Siefert J, Hickey T, et al. Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer. Cancer Res. 2020;80:1914-1926 pubmed publisher
Deshmukh A, Chandra S, Singh D, Siddiqi M, Banerjee D. Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening. Mol Biosyst. 2017;13:1630-1639 pubmed publisher
Saharia A, Teasley D, Duxin J, Dao B, Chiappinelli K, Stewart S. FEN1 ensures telomere stability by facilitating replication fork re-initiation. J Biol Chem. 2010;285:27057-66 pubmed publisher
product information
Catalog Number :
35027
Product Name :
pShuttle-FEN1hWT
article :
doi10.1074/jbc.M110.112276
id5067
pubmed_id20551483
bacterial resistance :
Kanamycin
cloning :
backbonepShuttle
backbone_mutation
backbone_originStratgene
backbone_size7500
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Adenoviral
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRV
cloning_site_5EcoRV
promoterCMV
sequencing_primer_3CTGatcataatcagccataccac
sequencing_primer_5GGTctatataagcagagctg
site_3_destroyed1
site_5_destroyed1
entrez_gene
aliasesFEN-1, MF1, RAD2
geneFEN1
id2237
genbank_ids
mutation
nameFEN1
shRNA_sequence
size1500
species
9606
Homo sapiens
tags
locationN terminal on insert
tagFlag
resistance markers :
502
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA