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product summary
company name :
Addgene
product type :
cDNA
product name :
8xGTIIC-luciferase
catalog :
34615
citations: 161
Reference
Ebrahimighaei R, Tarassova N, Bond S, McNeill M, Hathway T, Vohra H, et al. Extracellular matrix stiffness controls cardiac fibroblast proliferation via the nuclear factor-Y (NF-Y) transcription factor. Biochim Biophys Acta Mol Cell Res. 2024;1871:119640 pubmed publisher
Claude Taupin A, Isnard P, Bagattin A, Kuperwasser N, Roccio F, Ruscica B, et al. The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells. Nat Commun. 2023;14:8056 pubmed publisher
El Yousfi Y, Mora Molina R, L xf3 pez Rivas A, Yerbes R. Role of the YAP/TAZ-TEAD Transcriptional Complex in the Metabolic Control of TRAIL Sensitivity by the Mevalonate Pathway in Cancer Cells. Cells. 2023;12: pubmed publisher
Boogerd C, Perini I, Kyriakopoulou E, Han S, La P, van der Swaan B, et al. Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation. Nat Commun. 2023;14:4716 pubmed publisher
Lin W, Feathers R, Cooper L, Lewis Tuffin L, Chen J, Sarkaria J, et al. A Syx-RhoA-Dia1 signaling axis regulates cell cycle progression, DNA damage, and therapy resistance in glioblastoma. JCI Insight. 2023;8: pubmed publisher
Jiang M, Ding H, Huang Y, Cheng C, Lau C, Xia Y, et al. Thioridazine protects against disturbed flow-induced atherosclerosis by inhibiting RhoA/YAP-mediated endothelial inflammation. Acta Pharmacol Sin. 2023;44:1977-1988 pubmed publisher
Chu J, Li Y, He M, Zhang H, Yang L, Yang M, et al. Zinc finger and SCAN domain containing 1, ZSCAN1, is a novel stemness-related tumor suppressor and transcriptional repressor in breast cancer targeting TAZ. Front Oncol. 2023;13:1041688 pubmed publisher
Kang S, Kim J, Park A, Koh M, Shin W, Park G, et al. TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity. Nat Commun. 2023;14:700 pubmed publisher
Zhang S, Guo M, Jiang X, Tang L, Wu T, Bi G, et al. PXR triggers YAP-TEAD binding and Sirt2-driven YAP deacetylation and polyubiquitination to promote liver enlargement and regeneration in mice. Pharmacol Res. 2023;188:106666 pubmed publisher
Ippolito F, Consalvi V, Noce V, Battistelli C, Cicchini C, Tripodi M, et al. Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity. Cell Death Dis. 2023;14:32 pubmed publisher
Seavey C, Hallett A, Li S, Che K, Pobbati A, Ma S, et al. Loss of CDKN2A cooperates with WWTR1(TAZ)-CAMTA1 gene fusion to promote tumor progression in epithelioid hemangioendothelioma. Clin Cancer Res. 2023;: pubmed publisher
Csukasi F, Bosakova M, Bárta T, Martin J, Arcedo J, Barad M, et al. Skeletal diseases caused by mutations in PTH1R show aberrant differentiation of skeletal progenitors due to dysregulation of DEPTOR. Front Cell Dev Biol. 2022;10:963389 pubmed publisher
Ding H, Jiang M, Lau C, Luo J, Chan A, Wang L, et al. Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of the Src-YAP signalling axis. Br J Pharmacol. 2022;: pubmed publisher
Saini H, Choudhary M, Sharma H, Chowdhury S, Mukherjee S, Chowdhury R. Chloroquine induces transitory attenuation of proliferation of human lung cancer cells through regulation of mutant P53 and YAP. Mol Biol Rep. 2022;: pubmed publisher
Caire R, Audoux E, Thomas M, Dalix E, Peyron A, Rodriguez K, et al. YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro. Nat Commun. 2022;13:6995 pubmed publisher
Kim J, Luck C, Wu W, Ponce R, Lin Y, Gupta N, et al. Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer. Cell Rep. 2022;41:111443 pubmed publisher
Tchicaya Bouanga J, Hung Y, Schwartz J, Yoon D, Chotard E, Marty C, et al. A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases. Cell Death Dis. 2022;13:819 pubmed publisher
x160 vec J, x160 x165 astn xe1 M, Jane x10d kov xe1 L, Hr x10d kul xe1 k D, Vojt x11b chov xe1 M, Onhajzer J, et al. TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial-Mesenchymal Transition and Invasiveness. Cancers (Basel). 2022;14: pubmed publisher
Ballout F, Lu H, Chen L, Sriramajayam K, Que J, Meng Z, et al. APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett's-associated esophageal adenocarcinomas. J Exp Clin Cancer Res. 2022;41:264 pubmed publisher
Guo Y, Zhu Z, Huang Z, Cui L, Yu W, Hong W, et al. CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis. Nat Commun. 2022;13:4995 pubmed publisher
Li J, Dai Y, Ge H, Guo S, Zhang W, Wang Y, et al. The deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ. Cell Death Dis. 2022;13:677 pubmed publisher
Ebrahimighaei R, Sala Newby G, Hudson C, Kimura T, Hathway T, Hawkins J, et al. Combined role for YAP-TEAD and YAP-RUNX2 signalling in substrate-stiffness regulation of cardiac fibroblast proliferation. Biochim Biophys Acta Mol Cell Res. 2022;1869:119329 pubmed publisher
Thirusangu P, Ray U, Sarkar Bhattacharya S, Oien D, Jin L, Staub J, et al. PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma. Oncogene. 2022;41:4003-4017 pubmed publisher
Huang Y, Ahmad U, Rehman A, Uttagomol J, Wan H. YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions. Life (Basel). 2022;12: pubmed publisher
Choi S, Lee H, Cho N, Kim I, Cheon S, Park C, et al. RBFOX2-regulated TEAD1 alternative splicing plays a pivotal role in Hippo-YAP signaling. Nucleic Acids Res. 2022;: pubmed publisher
Rigiracciolo D, Nohata N, Lappano R, Cirillo F, Talia M, Adame García S, et al. Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC). J Exp Clin Cancer Res. 2022;41:193 pubmed publisher
Berthold R, Isfort I, Erkut C, Heinst L, Grünewald I, Wardelmann E, et al. Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma. Oncogenesis. 2022;11:20 pubmed publisher
Yu H, Yang Z, Xu M, Huang J, Yue Z, Guo B. Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2. Int J Biol Sci. 2022;18:2261-2276 pubmed publisher
Kim S, Basili T, Dopeso H, DA Cruz Paula A, Bi R, Issa Bhaloo S, et al. Recurrent WWTR1 S89W mutations and Hippo pathway deregulation in clear cell carcinomas of the cervix. J Pathol. 2022;: pubmed publisher
Sriramareddy S, Faião Flores F, Emmons M, Saha B, Chellappan S, Wyatt C, et al. HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma. Cancer Gene Ther. 2022;: pubmed publisher
Li L, Li R, Wang Y. Identification of Small-molecule YAP-TEAD inhibitors by High-throughput docking for the Treatment of colorectal cancer. Bioorg Chem. 2022;122:105707 pubmed publisher
García García M, Sánchez Perales S, Jarabo P, Calvo E, Huyton T, Fu L, et al. Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP. Nat Commun. 2022;13:1174 pubmed publisher
Zheng L, Luo C, Yang N, Pei H, Ji M, Shu Y, et al. Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction. Cell Death Dis. 2022;13:209 pubmed publisher
Zhao T, Wang Z, Fang J, Cheng W, Zhang Y, Huang J, et al. HTLV-1 activates YAP via NF-κB/p65 to promote oncogenesis. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
Xiao Y, Liu Q, Peng N, Li Y, Qiu D, Yang T, et al. Lovastatin Inhibits RhoA to Suppress Canonical Wnt/β-Catenin Signaling and Alternative Wnt-YAP/TAZ Signaling in Colon Cancer. Cell Transplant. 2022;31:9636897221075749 pubmed publisher
Tian Q, Gao H, Zhou Y, Zhu L, Yang J, Wang B, et al. RICH1 inhibits breast cancer stem cell traits through activating kinases cascade of Hippo signaling by competing with Merlin for binding to Amot-p80. Cell Death Dis. 2022;13:71 pubmed publisher
Guegan J, Lapouge M, Voisin L, Saba El Leil M, Tanguay P, Lévesque K, et al. Signaling by the tyrosine kinase Yes promotes liver cancer development. Sci Signal. 2022;15:eabj4743 pubmed publisher
Kumar B, Adebayo A, Prasad M, Capitano M, Wang R, Bhat Nakshatri P, et al. Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity. Sci Adv. 2022;8:eabh3375 pubmed publisher
Ahmad U, Parkinson E, Wan H. Desmoglein-3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells. Mol Oncol. 2022;16:1625-1649 pubmed publisher
Qin Y, Pei Z, Feng Z, Lin P, Wang S, Li Y, et al. Oncogenic Activation of YAP Signaling Sensitizes Ferroptosis of Hepatocellular Carcinoma via ALOXE3-Mediated Lipid Peroxidation Accumulation. Front Cell Dev Biol. 2021;9:751593 pubmed publisher
Park S, Frake R, Karabiyik C, Son S, Siddiqi F, Bento C, et al. Vinexin contributes to autophagic decline in brain ageing across species. Cell Death Differ. 2021;: pubmed publisher
Morice S, Danieau G, Tesfaye R, Mullard M, Brion R, Dupuy M, et al. Involvement of the TGF-β Signaling Pathway in the Development of YAP-Driven Osteosarcoma Lung Metastasis. Front Oncol. 2021;11:765711 pubmed publisher
Patrick S, Gowda P, Lathoria K, Suri V, Sen E. YAP1-mediated regulation of mitochondrial dynamics in IDH1 mutant gliomas. J Cell Sci. 2021;134: pubmed publisher
Xu S, Liu Y, Hu R, Wang M, Stöhr O, Xiong Y, et al. TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states. elife. 2021;10: pubmed publisher
Sun B, Zhong F, Xu C, Li Y, Zhao Y, Cao M, et al. Programmed cell death 10 promotes metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma via PP2Ac-mediated YAP activation. Cell Death Dis. 2021;12:849 pubmed publisher
Zhang S, Liang S, Wu D, Guo H, Ma K, Liu L. LncRNA coordinates Hippo and mTORC1 pathway activation in cancer. Cell Death Dis. 2021;12:822 pubmed publisher
Yang M, Han Y, Han Q, Rong X, Liu X, Ln X. KCTD11 inhibits progression of lung cancer by binding to β-catenin to regulate the activity of the Wnt and Hippo pathways. J Cell Mol Med. 2021;25:9411-9426 pubmed publisher
Mygland L, Brinch S, Strand M, Olsen P, Aizenshtadt A, Lund K, et al. Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. iScience. 2021;24:102807 pubmed publisher
Berlew E, Kuznetsov I, Yamada K, Bugaj L, Boerckel J, Chow B. Single-Component Optogenetic Tools for Inducible RhoA GTPase Signaling. Adv Biol (Weinh). 2021;5:e2100810 pubmed publisher
Jeon Y, Yoo J, Rhee H, Kim Y, Il Kim G, Chung T, et al. YAP inactivation in estrogen receptor alpha-positive hepatocellular carcinoma with less aggressive behavior. Exp Mol Med. 2021;53:1055-1067 pubmed publisher
Mickle M, Adhikary G, Shrestha S, Xu W, Eckert R. VGLL4 inhibits YAP1/TEAD signaling to suppress the epidermal squamous cell carcinoma cancer phenotype. Mol Carcinog. 2021;60:497-507 pubmed publisher
Huang Y, Jedlickova H, Cai Y, Rehman A, Gammon L, Ahmad U, et al. Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris. Front Immunol. 2021;12:649502 pubmed publisher
Park M, Kim J, Kim K, Kang S, Kim W, Kim J, et al. Circulating Small Extracellular Vesicles Activate TYRO3 to Drive Cancer Metastasis and Chemoresistance. Cancer Res. 2021;81:3539-3553 pubmed publisher
Li C, Li J, Gong S, Huang M, Li R, Xiong G, et al. Targeting the ILK/YAP axis by LFG-500 blocks epithelial-mesenchymal transition and metastasis. Acta Pharmacol Sin. 2021;: pubmed publisher
Han Q, Rong X, Lin X, Zhang X, Fan C, Zhao H, et al. WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression. Cell Death Dis. 2021;12:384 pubmed publisher
Bi Lin K, Seshachalam P, Tuoc T, Stoykova A, Ghosh S, Singh M. Critical role of the BAF chromatin remodeling complex during murine neural crest development. PLoS Genet. 2021;17:e1009446 pubmed publisher
Pavel M, Park S, Frake R, Son S, Manni M, Bento C, et al. α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation. Nat Commun. 2021;12:1703 pubmed publisher
Vrbsky J, Vinarsky V, Perestrelo A, De La Cruz J, Martino F, Pompeiano A, et al. Evidence for discrete modes of YAP1 signaling via mRNA splice isoforms in development and diseases. Genomics. 2021;113:1349-1365 pubmed publisher
Quinn N, García Gutiérrez L, Doherty C, von Kriegsheim A, Fallahi E, Sacks D, et al. IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway. Cells. 2021;10: pubmed publisher
Uneda A, Kurozumi K, Fujimura A, Fujii K, Ishida J, Shimazu Y, et al. Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration. Acta Neuropathol Commun. 2021;9:29 pubmed publisher
Dai Y, Kyoyama H, Yang Y, Wang Y, Liu S, Wang Y, et al. A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells. Oncotarget. 2021;12:173-184 pubmed publisher
Delgado E, Erickson H, Tao J, Monga S, Duncan A, Anakk S. Scaffolding Protein IQGAP1 is Dispensable But Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling. Mol Cell Biol. 2021;: pubmed publisher
Morice S, Mullard M, Brion R, Dupuy M, Renault S, Tesfaye R, et al. The YAP/TEAD Axis as a New Therapeutic Target in Osteosarcoma: Effect of Verteporfin and CA3 on Primary Tumor Growth. Cancers (Basel). 2020;12: pubmed publisher
Kong H, Kwon E, Kwon O, Lee H, Choi J, Kim Y, et al. Crosstalk between YAP and TGFβ regulates SERPINE1 expression in mesenchymal lung cancer cells. Int J Oncol. 2020;: pubmed publisher
Kim J, Kang W, Kang S, Park S, Kim J, Yang S, et al. Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis. Sci Rep. 2020;10:21018 pubmed publisher
Bruschi F, Tardelli M, Einwallner E, Claudel T, Trauner M. PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells. Int J Mol Sci. 2020;21: pubmed publisher
Wei L, Li P, Luo Y, Zhang M, Yan T, Yang Y, et al. PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin. Onco Targets Ther. 2020;13:10025-10037 pubmed publisher
Li Y, Chen M, Hu J, Sheng R, Lin Q, He X, et al. Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling. Cell Stem Cell. 2021;28:63-78.e7 pubmed publisher
Lorenzo Martín L, Fernández Parejo N, Menacho Márquez M, Rodríguez Fdez S, Robles Valero J, Zumalave S, et al. VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. Nat Commun. 2020;11:4788 pubmed publisher
Yang H, Hu J, Chen J, Chen Z, Jiao F, Cui J, et al. RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer. Med Oncol. 2020;37:84 pubmed publisher
Cao D, Zhu G, Lu Y, Yang A, Chen D, Huang H, et al. Luteolin suppresses epithelial-mesenchymal transition and migration of triple-negative breast cancer cells by inhibiting YAP/TAZ activity. Biomed Pharmacother. 2020;129:110462 pubmed publisher
Meinhardt G, Haider S, Kunihs V, Saleh L, Pollheimer J, Fiala C, et al. Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta. Proc Natl Acad Sci U S A. 2020;117:13562-13570 pubmed publisher
Wu X, Wang Y, Zhong W, Cheng H, Tian Z. The Long Non-Coding RNA MALAT1 Enhances Ovarian Cancer Cell Stemness by Inhibiting YAP Translocation from Nucleus to Cytoplasm. Med Sci Monit. 2020;26:e922012 pubmed publisher
Waaler J, Mygland L, Tveita A, Strand M, Solberg N, Olsen P, et al. Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Commun Biol. 2020;3:196 pubmed publisher
Rigiracciolo D, Nohata N, Lappano R, Cirillo F, Talia M, Scordamaglia D, et al. IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells. Cells. 2020;9: pubmed publisher
Guo Q, Quan M, Dong J, Bai J, Wang J, Han R, et al. The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy. Theranostics. 2020;10:4422-4436 pubmed publisher
Li Q, Sun Y, Jarugumilli G, Liu S, Dang K, Cotton J, et al. Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. Cell Stem Cell. 2020;26:675-692.e8 pubmed publisher
Sun H, Men J, Liu H, Liu M, Zhang H. FOXM1 facilitates breast cancer cell stemness and migration in YAP1-dependent manner. Arch Biochem Biophys. 2020;685:108349 pubmed publisher
Yuan Y, Park J, Feng A, Awasthi P, Wang Z, Chen Q, et al. YAP1/TAZ-TEAD transcriptional networks maintain skin homeostasis by regulating cell proliferation and limiting KLF4 activity. Nat Commun. 2020;11:1472 pubmed publisher
Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, et al. Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin. elife. 2020;9: pubmed publisher
McNeill M, Wray J, Sala Newby G, Hindmarch C, Smith S, Ebrahimighaei R, et al. Nuclear actin regulates cell proliferation and migration via inhibition of SRF and TEAD. Biochim Biophys Acta Mol Cell Res. 2020;1867:118691 pubmed publisher
Nguyen T, Ralbovska A, Kugler J. RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1. G3 (Bethesda). 2020;10:1319-1325 pubmed publisher
Irie K, Nagai T, Mizuno K. Furry protein suppresses nuclear localization of yes-associated protein (YAP) by activating NDR kinase and binding to YAP. J Biol Chem. 2020;295:3017-3028 pubmed publisher
Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, et al. YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nat Commun. 2020;11:507 pubmed publisher
Quan M, Chen Z, Jiao F, Xiao X, Xia Q, Chen J, et al. Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression. J Exp Clin Cancer Res. 2020;39:13 pubmed publisher
You E, Ko P, Jeong J, Keum S, Kim J, Seo Y, et al. Dynein-mediated nuclear translocation of yes-associated protein through microtubule acetylation controls fibroblast activation. Cell Mol Life Sci. 2020;: pubmed publisher
Rodríguez Núñez P, Romero Pérez L, Amaral A, Puerto Camacho P, Jordán C, Marcilla D, et al. Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma. J Pathol. 2019;: pubmed publisher
Isfort I, Elges S, Cyra M, Berthold R, Renner M, Mechtersheimer G, et al. Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone. Sci Rep. 2019;9:19704 pubmed publisher
Yin X, Choudhury M, Kang J, Schaefbauer K, Jung M, Andrianifahanana M, et al. Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β. Sci Signal. 2019;12: pubmed publisher
Li H, Li Q, Dang K, Ma S, Cotton J, Yang S, et al. YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression. Cell Rep. 2019;29:3200-3211.e4 pubmed publisher
Jimenez Martinez M, Ostalé C, van der Burg L, Galán Martínez J, Hardwick J, López Pérez R, et al. DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression. Cancers (Basel). 2019;11: pubmed publisher
Sayedyahossein S, Hedman A, Sacks D. Insulin suppresses transcriptional activity of yes-associated protein in insulin target cells. Mol Biol Cell. 2020;31:131-141 pubmed publisher
Giraud J, Molina Castro S, Seeneevassen L, Sifré E, Izotte J, Tiffon C, et al. Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells. Int J Cancer. 2020;146:2255-2267 pubmed publisher
Costa R, Peruzzo R, Bachmann M, Montà G, Vicario M, Santinon G, et al. Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction. Cell Rep. 2019;28:1949-1960.e6 pubmed publisher
Sethunath V, Hu H, De Angelis C, Veeraraghavan J, Qin L, WANG N, et al. Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer. Mol Cancer Res. 2019;17:2318-2330 pubmed publisher
Aureille J, Buffière Ribot V, Harvey B, Boyault C, Pernet L, Andersen T, et al. Nuclear envelope deformation controls cell cycle progression in response to mechanical force. EMBO Rep. 2019;20:e48084 pubmed publisher
Wu J, Minikes A, Gao M, Bian H, Li Y, Stockwell B, et al. Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling. Nature. 2019;572:402-406 pubmed publisher
Li J, Yao M, Zhu X, Li Q, He J, Chen L, et al. YAP-Induced Endothelial-Mesenchymal Transition in Oral Submucous Fibrosis. J Dent Res. 2019;98:920-929 pubmed publisher
Hennigan R, Fletcher J, Guard S, Ratner N. Proximity biotinylation identifies a set of conformation-specific interactions between Merlin and cell junction proteins. Sci Signal. 2019;12: pubmed publisher
Isfort I, Cyra M, Elges S, Kailayangiri S, Altvater B, Rossig C, et al. SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma. Clin Cancer Res. 2019;25:3718-3731 pubmed publisher
Cui J, Zhou Z, Yang H, Jiao F, Li N, Gao Y, et al. MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis. Mol Cancer Res. 2019;17:1316-1325 pubmed publisher
Feng X, Arang N, Rigiracciolo D, Lee J, Yeerna H, Wang Z, et al. A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell. 2019;35:457-472.e5 pubmed publisher
Smith S, Sessions R, Shoemark D, Williams C, Ebrahimighaei R, McNeill M, et al. Anti-proliferative and anti-migratory effects of a novel YAP-TEAD interaction inhibitor identified using in silico molecular docking. J Med Chem. 2019;: pubmed publisher
Ferrari N, Ranftl R, Chicherova I, Slaven N, Moeendarbary E, Farrugia A, et al. Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts. Nat Commun. 2019;10:130 pubmed publisher
Escot S, Willnow D, Naumann H, Di Francescantonio S, Spagnoli F. Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors. Nat Commun. 2018;9:5082 pubmed publisher
Li Y, Xu J, Zhu G, Huang Z, Lu Y, Li X, et al. Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity. Cell Death Discov. 2018;4:105 pubmed publisher
Moreno Vicente R, Pavón D, Martin Padura I, Català Montoro M, Díez Sánchez A, Quílez Álvarez A, et al. Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP. Cell Rep. 2018;25:1622-1635.e6 pubmed publisher
Choi H, Kim N, Kim B, Seo M, Heo J. TNF-α-Induced YAP/TAZ Activity Mediates Leukocyte-Endothelial Adhesion by Regulating VCAM1 Expression in Endothelial Cells. Int J Mol Sci. 2018;19: pubmed publisher
Mohamed A, Shah N, Hettmer S, Vargesson N, Wackerhage H. Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma. Sci Rep. 2018;8:15674 pubmed publisher
Lopez Almeida L, Sebbagh M, Bertucci F, Finetti P, Wicinski J, Marchetto S, et al. The SCRIB Paralog LANO/LRRC1 Regulates Breast Cancer Stem Cell Fate through WNT/β-Catenin Signaling. Stem Cell Reports. 2018;11:1040-1050 pubmed publisher
Melhuish T, Kowalczyk I, Manukyan A, Zhang Y, Shah A, Abounader R, et al. Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression. Biochim Biophys Acta Gene Regul Mech. 2018;1861:983-995 pubmed publisher
Li J, Wang H, Wang L, Tan R, Zhu M, Zhong X, et al. Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway. Phytother Res. 2018;32:2456-2465 pubmed publisher
Gao F, Yu X, Meng R, Wang J, Jia L. STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cells. Onco Targets Ther. 2018;11:5371-5381 pubmed publisher
Gegenfurtner F, Zisis T, Al Danaf N, Schrimpf W, Kliesmete Z, Ziegenhain C, et al. Transcriptional effects of actin-binding compounds: the cytoplasm sets the tone. Cell Mol Life Sci. 2018;75:4539-4555 pubmed publisher
Gao J, Rong Y, Huang Y, Shi P, Wang X, Meng X, et al. Cirrhotic stiffness affects the migration of hepatocellular carcinoma cells and induces sorafenib resistance through YAP. J Cell Physiol. 2019;234:2639-2648 pubmed publisher
Pavel M, Renna M, Park S, Menzies F, Ricketts T, Füllgrabe J, et al. Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis. Nat Commun. 2018;9:2961 pubmed publisher
Martin D, Degese M, Vitale Cross L, Iglesias Bartolomé R, Valera J, Wang Z, et al. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nat Commun. 2018;9:2372 pubmed publisher
Xiong S, Lorenzen K, Couzens A, Templeton C, Rajendran D, Mao D, et al. Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Structure. 2018;26:1101-1115.e6 pubmed publisher
Gao L, Cheng X, Cao H. LncRNA THOR attenuates cisplatin sensitivity of nasopharyngeal carcinoma cells via enhancing cells stemness. Biochimie. 2018;152:63-72 pubmed publisher
Sun J, Wang X, Tang B, Liu H, Zhang M, Wang Y, et al. A tightly controlled Src-YAP signaling axis determines therapeutic response to dasatinib in renal cell carcinoma. Theranostics. 2018;8:3256-3267 pubmed publisher
Qin J, Shi H, Xu Y, Zhao F, Wang Q. Tanshinone IIA inhibits cervix carcinoma stem cells migration and invasion via inhibiting YAP transcriptional activity. Biomed Pharmacother. 2018;105:758-765 pubmed publisher
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product information
Catalog Number :
34615
Product Name :
8xGTIIC-luciferase
article :
doi10.1038/nature10137
id4963
pubmed_id21654799
bacterial resistance :
Ampicillin
cloning :
backbonepGL3b
backbone_mutation
backbone_origin
backbone_size4800
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Luciferase
growth notes :
Addgene sequencing detected a 7 nucleotide insertion at position 107 relative to the author's insert sequence. This results in the loss of a MscI restriction site but does not alter the function of the plasmid. Please click http://www.addgene.org/34615/notes/ for general advice and technical tips on how to monitor YAP/TAZ regulation and activity in cell culture by 8xGTIIC lux.
growth strain :
YAP/TAZ-responsive synthetic promoter driving luciferase expression
origin :
37
pi :
alt_names
YAP/TAZ luciferase reporter
contains the minimal chicken TnT promoter
cloning
clone_methodRestriction Enzyme
cloning_site_3NcoI
cloning_site_5NheI
promoter
sequencing_primer_3luciferase-rev
sequencing_primer_5RVprimer3
site_3_destroyed
site_5_destroyed
entrez_gene
genbank_ids
mutation
namesynthetic TEAD luciferase reporter
shRNA_sequence
size360
species
tags
plasmid copy :
The plasmid was derived from the 4XGTIIC-lux made from Ian Farrance, by adding 4 more TEAD binding sites (ACATTCCA).
resistance markers :
391
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA