This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pBabe EGFR(L858R/T790M)
catalog :
32073
citations: 8
Reference
Pan J, Xiong D, Zhang Q, Palen K, Shoemaker R, Johnson B, et al. Precision immunointerception of EGFR-driven tumorigenesis for lung cancer prevention. Front Immunol. 2023;14:1036563 pubmed publisher
Song X, Tang W, Peng H, Qi X, Li J. FGFR leads to sustained activation of STAT3 to mediate resistance to EGFR-TKIs treatment. Invest New Drugs. 2021;: pubmed publisher
Castellan M, Guarnieri A, Fujimura A, Zanconato F, Battilana G, Panciera T, et al. Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma. Nat Cancer. 2021;2:174-188 pubmed publisher
Nishiya N, Oku Y, Ishikawa C, Fukuda T, Dan S, Mashima T, et al. Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor. Cancer Sci. 2021;112:1963-1974 pubmed publisher
Quintanal Villalonga Á, Molina Pinelo S, Cirauqui C, Ojeda Márquez L, Marrugal A, Suarez R, et al. FGFR1 Cooperates with EGFR in Lung Cancer Oncogenesis, and Their Combined Inhibition Shows Improved Efficacy. J Thorac Oncol. 2019;14:641-655 pubmed publisher
Song X, Qi X, Wang Q, Zhu W, Li J. A novel multi-target inhibitor harboring selectivity of inhibiting EGFR T790M sparing wild-type EGFR. Am J Cancer Res. 2017;7:1884-1898 pubmed
Ku B, Bae Y, Koh J, Sun J, Lee S, Ahn J, et al. AZD9291 overcomes T790 M-mediated resistance through degradation of EGFR(L858R/T790M) in non-small cell lung cancer cells. Invest New Drugs. 2016;34:407-15 pubmed publisher
Yuza Y, Glatt K, Jiang J, Greulich H, Minami Y, Woo M, et al. Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors. Cancer Biol Ther. 2007;6:661-7 pubmed
product information
Catalog Number :
32073
Product Name :
pBabe EGFR(L858R/T790M)
article :
doi10.4161/cbt.6.5.4003
id4299
pubmed_id17495523
bacterial resistance :
Ampicillin
cloning :
backbonepBABEpuro
backbone_mutation
backbone_origin
backbone_size5169
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3SnaB1
cloning_site_5SnaB1
promoter
sequencing_primer_3
sequencing_primer_5pBABE 5'
site_3_destroyed1
site_5_destroyed1
entrez_gene
aliasesERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
geneEGFR
id1956
genbank_ids
mutationL858R/T790M
nameEGFR
shRNA_sequence
size3600
species
9606
Homo sapiens
tags
resistance markers :
338
tags :
High Copy
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA