This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pT3-N90-beta-catenin
catalog :
31785
citations: 17
Reference
Zhu C, Soto Feliciano Y, Morris J, Huang C, Koche R, Ho Y, et al. MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer. elife. 2023;12: pubmed publisher
Zhu G, Tang Z, Huang R, Qu W, Fang Y, Yang R, et al. CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor. Cell Discov. 2023;9:25 pubmed publisher
Tsai C, Chuang Y, Li X, Yu Y, Tzeng S, Teoh S, et al. Immunoediting instructs tumor metabolic reprogramming to support immune evasion. Cell Metab. 2023;35:118-133.e7 pubmed publisher
Sun X, Li K, Figueiredo M, Lin C, Li B, Yokota H. Generation of the Chondroprotective Proteomes by Activating PI3K and TNFα Signaling. Cancers (Basel). 2022;14: pubmed publisher
Zhu A, Abbas A, de Galarreta M, Guan Y, Lu S, Koeppen H, et al. Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma. Nat Med. 2022;: pubmed publisher
Sun X, Li K, Hase M, Zha R, Feng Y, Li B, et al. Suppression of breast cancer-associated bone loss with osteoblast proteomes via Hsp90ab1/moesin-mediated inhibition of TGFβ/FN1/CD44 signaling. Theranostics. 2022;12:929-943 pubmed publisher
Wei Y, Wang Y, Liu N, Qi R, Xu Y, Li K, et al. A FAK Inhibitor Boosts Anti-PD1 Immunotherapy in a Hepatocellular Carcinoma Mouse Model. Front Pharmacol. 2021;12:820446 pubmed publisher
Liu S, Sun X, Li K, Zha R, Feng Y, Sano T, et al. Generation of the tumor-suppressive secretome from tumor cells. Theranostics. 2021;11:8517-8534 pubmed publisher
Sun X, Li K, Zha R, Liu S, Fan Y, Wu D, et al. Preventing tumor progression to the bone by induced tumor-suppressing MSCs. Theranostics. 2021;11:5143-5159 pubmed publisher
Sano T, Sun X, Feng Y, Liu S, Hase M, Fan Y, et al. Inhibition of the Growth of Breast Cancer-Associated Brain Tumors by the Osteocyte-Derived Conditioned Medium. Cancers (Basel). 2021;13: pubmed publisher
Jiang T, Sanchez Rivera F, Soto Feliciano Y, Yang Q, Song C, Bhuatkar A, et al. Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function. Hepatology. 2021;74:233-247 pubmed publisher
Toh T, Lim J, Hooi L, Rashid M, Chow E. Targeting Jak/Stat pathway as a therapeutic strategy against SP/CD44+ tumorigenic cells in Akt/β-catenin-driven hepatocellular carcinoma. J Hepatol. 2020;72:104-118 pubmed publisher
Ruiz de Galarreta M, Bresnahan E, Molina Sánchez P, Lindblad K, Maier B, Sia D, et al. β-catenin activation promotes immune escape and resistance to anti-PD-1 therapy in hepatocellular carcinoma. Cancer Discov. 2019;: pubmed publisher
Zhang H, Hui H, Li Z, Pan J, Jiang X, Wei T, et al. Pigment epithelium-derived factor attenuates myocardial fibrosis via inhibiting Endothelial-to-Mesenchymal Transition in rats with acute myocardial infarction. Sci Rep. 2017;7:41932 pubmed publisher
Liu Z, Guo J, Wang Y, Weng Z, Huang B, Yu M, et al. CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development. Cell Death Differ. 2017;24:98-110 pubmed publisher
Shibayama Y, Fujimori T, Nguyen G, Hirose T, Totsune K, Ichihara A, et al. (Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma. Sci Rep. 2015;5:8854 pubmed publisher
Tward A, Jones K, Yant S, Cheung S, Fan S, Chen X, et al. Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A. 2007;104:14771-6 pubmed
product information
Catalog Number :
31785
Product Name :
pT3-N90-beta-catenin
article :
doi10.1073/pnas.0706578104
id4502
pubmed_id17785413
bacterial resistance :
Ampicillin
cloning :
backbonepT3-EF1a
backbone_mutation
backbone_origin
backbone_size7000
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
This plasmid is in the pT3-EF1a vector which contains loxP sites flanking the inverted repeats of SB (sleeping beauty) sequence. Therefore this plasmid cannot not used with Cre for in vivo studies.
origin :
37
pi :
alt_names
b-catenin
CTNNB1
cloning
clone_methodGateway Cloning
cloning_site_3
cloning_site_5
promoterEF1alpha
sequencing_primer_3
sequencing_primer_5EF-1a-Fwd
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCTNNB, EVR7, MRD19, NEDSDV, armadillo
geneCTNNB1
id1499
genbank_ids
mutationDeletion of aa 1-90- Constitutitvely Active
namebeta-catenin
shRNA_sequence
size2121
species
9606
Homo sapiens
tags
locationN terminal on insert
tagMyc
resistance markers :
1021
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA