This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pcDNA-HDAC6-FLAG
catalog :
30482
citations: 12
Reference
Chiu Y, Medina C, Doyle C, Zhou M, Narahari A, Sandilos J, et al. Deacetylation as a receptor-regulated direct activation switch for pannexin channels. Nat Commun. 2021;12:4482 pubmed publisher
Urdiciain A, Erausquin E, Zelaya M, Zazpe I, Lanciego J, Melendez B, et al. Silencing of Histone Deacetylase 6 Decreases Cellular Malignancy and Contributes to Primary Cilium Restoration, Epithelial-to-Mesenchymal Transition Reversion, and Autophagy Inhibition in Glioblastoma Cell Lines. Biology (Basel). 2021;10: pubmed publisher
Chi Z, Le T, Lee S, Guo E, Kim D, Lee S, et al. Honokiol ameliorates angiotensin II-induced hypertension and endothelial dysfunction by inhibiting HDAC6-mediated cystathionine γ-lyase degradation. J Cell Mol Med. 2020;: pubmed publisher
Zhang M, Urabe G, Little C, Wang B, Kent A, Huang Y, et al. HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity. JACC Basic Transl Sci. 2018;3:782-795 pubmed publisher
Wang R, Tan J, Chen T, Han H, Tian R, Tan Y, et al. ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion. J Cell Biol. 2019;218:267-284 pubmed publisher
Li W, Yue F, Dai Y, Shi B, Xu G, Jiang X, et al. Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation. Cell Death Differ. 2018;: pubmed publisher
Yen C, Choy C, Huang W, Huang S, Lai P, Yu M, et al. A Novel Hydroxamate-Based Compound WMJ-J-09 Causes Head and Neck Squamous Cell Carcinoma Cell Death via LKB1-AMPK-p38MAPK-p63-Survivin Cascade. Front Pharmacol. 2018;9:167 pubmed publisher
Bitler B, Wu S, Park P, Hai Y, Aird K, Wang Y, et al. ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nat Cell Biol. 2017;19:962-973 pubmed publisher
Salemi L, Maitland M, Yefet E, Schild Poulter C. Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex. BMC Cancer. 2017;17:460 pubmed publisher
Chang I, Wang C. Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. J Biol Chem. 2016;291:18199-209 pubmed publisher
Schoepflin Z, Shapiro I, Risbud M. Class I and IIa HDACs Mediate HIF-1? Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1? Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc. J Bone Miner Res. 2016;31:1287-99 pubmed publisher
Kawaguchi Y, Kovacs J, McLaurin A, Vance J, Ito A, Yao T. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell. 2003;115:727-38 pubmed
product information
Catalog Number :
30482
Product Name :
pcDNA-HDAC6-FLAG
article :
doi10.1016/S0092-8674(03)00939-5
id4272
pubmed_id14675537
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5400
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodRestriction Enzyme
cloning_site_3
cloning_site_5
promoter
sequencing_primer_3SP6
sequencing_primer_5T7
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesCPBHM, HD6, JM21, KDAC6, PPP1R90
geneHDAC6
id10013
genbank_ids
mutation
nameHDAC6
shRNA_sequence
size
species
9606
Homo sapiens
tags
locationC terminal on insert
tagFLAG
resistance markers :
965
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA