This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCAX APP Swe/Ind
catalog :
30145
citations: 19
Reference
Um J, Shin D, Choi S, Nathan A, Kim Y, Lee D, et al. Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease models. Theranostics. 2024;14:56-74 pubmed publisher
Iyaswamy A, Thakur A, Guan X, Krishnamoorthi S, Fung T, Lu K, et al. Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease. Signal Transduct Target Ther. 2023;8:404 pubmed publisher
Ricciardi N, Modarresi F, Lohse I, Andrade N, Newman I, Brown J, et al. Investigating the Synergistic Potential of Low-Dose HDAC3 Inhibition and Radiotherapy in Alzheimer's Disease Models. Mol Neurobiol. 2023;60:4811-4827 pubmed publisher
Park J, Choe K, Khan A, Jo M, Park H, Kang M, et al. Establishing Co-Culture Blood-Brain Barrier Models for Different Neurodegeneration Conditions to Understand Its Effect on BBB Integrity. Int J Mol Sci. 2023;24: pubmed publisher
Reinitz F, Chen E, Nicolis Di Robilant B, Chuluun B, Antony J, Jones R, et al. Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model. elife. 2022;11: pubmed publisher
Nowakowska Gołacka J, Czapiewska J, Sominka H, Sowa Rogozińska N, Słomińska Wojewódzka M. EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production. Int J Mol Sci. 2021;23: pubmed publisher
Yuan Y, Chen J, Ge X, Deng J, Xu X, Zhao Y, et al. Activation of ERK-Drp1 signaling promotes hypoxia-induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity. FEBS Open Bio. 2021;11:2740-2755 pubmed publisher
Ali T, Rehman S, Khan A, Badshah H, Abid N, Kim M, et al. Adiponectin-mimetic novel nonapeptide rescues aberrant neuronal metabolic-associated memory deficits in Alzheimer's disease. Mol Neurodegener. 2021;16:23 pubmed publisher
Romani M, Sorrentino V, Oh C, Li H, de Lima T, Zhang H, et al. NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell Rep. 2021;34:108660 pubmed publisher
Cone A, Hurwitz S, Lee G, Yuan X, Zhou Y, Li Y, et al. Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. BMC Mol Cell Biol. 2020;21:58 pubmed publisher
Iyaswamy A, Krishnamoorthi S, Song J, Yang C, Kaliyamoorthy V, Zhang H, et al. NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models. J Food Drug Anal. 2020;28:132-146 pubmed publisher
Song J, Malampati S, Zeng Y, Durairajan S, Yang C, Tong B, et al. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2019;:e13069 pubmed publisher
Fan W, Sun Y, Shi Z, Wang H, Deng J. Mouse induced pluripotent stem cells-derived Alzheimer's disease cerebral organoid culture and neural differentiation disorders. Neurosci Lett. 2019;711:134433 pubmed publisher
Velagapudi R, Ajileye O, Okorji U, Jain P, Aderogba M, Olajide O. Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells. Phytother Res. 2018;32:1957-1966 pubmed publisher
Velagapudi R, El Bakoush A, Olajide O. Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside. Mol Neurobiol. 2018;55:8103-8123 pubmed publisher
Yoon G, Shah S, Ali T, Kim M. The Adiponectin Homolog Osmotin Enhances Neurite Outgrowth and Synaptic Complexity via AdipoR1/NgR1 Signaling in Alzheimer's Disease. Mol Neurobiol. 2018;55:6673-6686 pubmed publisher
Pahrudin Arrozi A, Shukri S, Wan Ngah W, Mohd Yusof Y, Ahmad Damanhuri M, Makpol S. Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheime. Appl Biochem Biotechnol. 2017;183:853-866 pubmed publisher
Wegierski T, Gazda K, Kuznicki J. Microscopic analysis of Orai-mediated store-operated calcium entry in cells with experimentally altered levels of amyloid precursor protein. Biochem Biophys Res Commun. 2016;478:1087-92 pubmed publisher
Young Pearse T, Bai J, Chang R, Zheng J, LoTurco J, Selkoe D. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci. 2007;27:14459-69 pubmed
product information
Catalog Number :
30145
Product Name :
pCAX APP Swe/Ind
article :
doi10.1523/JNEUROSCI.4701-07.2007
id4221
pubmed_id18160654
bacterial resistance :
Ampicillin
cloning :
backbonepCAX
backbone_mutation
backbone_origin
backbone_size4731
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
amyloid precursor protein
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRV
cloning_site_5EcoRV
promoter
sequencing_primer_3
sequencing_primer_5n/a
site_3_destroyed
site_5_destroyed1
entrez_gene
aliasesAAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, alpha-sAPP, preA4
geneAPP
id351
genbank_ids
mutationSwedish and Indiana; K595N, M596L and V642F
namehuman APP 695 Swedish/Indiana mutation
shRNA_sequence
size2000
species
9606
Homo sapiens
tags
resistance markers :
959
958
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA