This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pCAX APP 695
catalog :
30137
citations: 17
Reference
Brandimarti R, Irollo E, Meucci O. The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities. Mol Neurobiol. 2022;: pubmed publisher
Reinitz F, Chen E, Nicolis Di Robilant B, Chuluun B, Antony J, Jones R, et al. Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model. elife. 2022;11: pubmed publisher
Nowakowska Gołacka J, Czapiewska J, Sominka H, Sowa Rogozińska N, Słomińska Wojewódzka M. EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and Amyloid-β Production. Int J Mol Sci. 2021;23: pubmed publisher
Wilkins H, TROUTWINE B, Menta B, Manley S, Strope T, Lysaker C, et al. Mitochondrial Membrane Potential Influences Amyloid-β Protein Precursor Localization and Amyloid-β Secretion. J Alzheimers Dis. 2021;: pubmed publisher
Montesinos J, Pera M, Larrea D, Guardia Laguarta C, Agrawal R, Velasco K, et al. The Alzheimer's disease-associated C99 fragment of APP regulates cellular cholesterol trafficking. EMBO J. 2020;39:e103791 pubmed publisher
Iannuzzi F, Sirabella R, Canu N, Maier T, Annunziato L, Matrone C. Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer's Disease Patients. Cells. 2020;9: pubmed publisher
Cone A, Hurwitz S, Lee G, Yuan X, Zhou Y, Li Y, et al. Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. BMC Mol Cell Biol. 2020;21:58 pubmed publisher
Hayrabedyan S, Todorova K, Spinelli M, Barnea E, Mueller M. The core sequence of PIF competes for insulin/amyloid β in insulin degrading enzyme: potential treatment for Alzheimer's disease. Oncotarget. 2018;9:33884-33895 pubmed publisher
Velagapudi R, Ajileye O, Okorji U, Jain P, Aderogba M, Olajide O. Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells. Phytother Res. 2018;32:1957-1966 pubmed publisher
Velagapudi R, El Bakoush A, Olajide O. Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside. Mol Neurobiol. 2018;55:8103-8123 pubmed publisher
Hein L, Apaja P, Hattersley K, Grose R, Xie J, Proud C, et al. A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome. Biochim Biophys Acta Mol Cell Res. 2017;1864:1554-1565 pubmed publisher
Pahrudin Arrozi A, Shukri S, Wan Ngah W, Mohd Yusof Y, Ahmad Damanhuri M, Makpol S. Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheime. Appl Biochem Biotechnol. 2017;183:853-866 pubmed publisher
Swaminathan G, Zhu W, Plowey E. BECN1/Beclin 1 sorts cell-surface APP/amyloid ? precursor protein for lysosomal degradation. Autophagy. 2016;12:2404-2419 pubmed
Wegierski T, Gazda K, Kuznicki J. Microscopic analysis of Orai-mediated store-operated calcium entry in cells with experimentally altered levels of amyloid precursor protein. Biochem Biophys Res Commun. 2016;478:1087-92 pubmed publisher
Manocha G, Floden A, Rausch K, Kulas J, McGregor B, Rojanathammanee L, et al. APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease. J Neurosci. 2016;36:8471-86 pubmed publisher
Strilic B, Yang L, Albarrán Juárez J, Wachsmuth L, Han K, Müller U, et al. Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 2016;536:215-8 pubmed
Young Pearse T, Bai J, Chang R, Zheng J, LoTurco J, Selkoe D. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci. 2007;27:14459-69 pubmed
product information
Catalog Number :
30137
Product Name :
pCAX APP 695
article :
doi10.1523/JNEUROSCI.4701-07.2007
id4221
pubmed_id18160654
bacterial resistance :
Ampicillin
cloning :
backbonepCAX
backbone_mutation
backbone_origin
backbone_size1380
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
APP
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5EcoRV
promoter
sequencing_primer_3
sequencing_primer_5n/a
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, alpha-sAPP, preA4
geneAPP
id351
genbank_ids
mutationwild type splice variant 695
nameAmyloid Precursor Protein
shRNA_sequence
size2000
species
9606
Homo sapiens
tags
resistance markers :
959
958
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA