This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pBS U3-hTR-500
catalog :
28170
citations: 4
Reference
Klump B, Perez G, Patrick E, Adams Boone K, Cohen S, Han L, et al. TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly. Cell Rep. 2023;42:112577 pubmed publisher
Kroustallaki P, Lirussi L, Carracedo S, You P, Esbensen Q, Götz A, et al. SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing. Cell Rep. 2019;28:1690-1702.e10 pubmed publisher
Stockklausner C, Raffel S, Klermund J, Bandapalli O, Beier F, Brümmendorf T, et al. A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition. Aging (Albany NY). 2015;7:911-27 pubmed
Fu D, Collins K. Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs. Mol Cell. 2003;11:1361-72 pubmed
product information
Catalog Number :
28170
Product Name :
pBS U3-hTR-500
article :
doi10.1016/S1097-2765(03)00196-5
id4054
pubmed_id12769858
bacterial resistance :
Ampicillin
cloning :
backbonepBS
backbone_mutation
backbone_origin
backbone_size2900
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth notes :
Note that BLAST results bring back one T->C nt change in the TERC, but this is the plasmid used in the associated article.
origin :
37
pi :
alt_names
human telomerase RNA
TER
TERC
cloning
clone_methodRestriction Enzyme
cloning_site_3BamHI
cloning_site_5SalI
promoter
sequencing_primer_3
sequencing_primer_5n/a
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesDKCA1, PFBMFT2, SCARNA19, TER, TR, TRC3, hTR
geneTERC
id7012
genbank_ids
mutation
nameU3-hTR-500
shRNA_sequence
size1300
species
9606
Homo sapiens
tags
resistance markers :
892
tags :
Unknown
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA