This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
HA-p62
catalog :
28027
citations: 46
Reference
Qiang L, Zhao B, Ming M, Wang N, He T, Hwang S, et al. Autophagy regulates tumor growth and metastasis. bioRxiv. 2023;: pubmed publisher
Xue R, Fan X, Yang Q, Yu C, Lu T, Wan G. Protective effect of ethyl ferulate against hypoxic injury in retinal cells and retinal neovascularization in an oxygen-induced retinopathy model. Phytomedicine. 2023;121:155097 pubmed publisher
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Bonavita R, Scerra G, Di Martino R, Nuzzo S, Polishchuk E, Di Gennaro M, et al. The HSPB1-p62/SQSTM1 functional complex regulates the unconventional secretion and transcellular spreading of the HD-associated mutant huntingtin protein. Hum Mol Genet. 2023;32:2269-2291 pubmed publisher
Baron D, Fenton A, Saez Atienzar S, Giampetruzzi A, Sreeram A, Shankaracharya -, et al. ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function. Cell Rep. 2022;39:110598 pubmed publisher
Lin J, McCann A, Sereesongsaeng N, Burden J, Alsa d A, Burden R, et al. USP17 is required for peripheral trafficking of lysosomes. EMBO Rep. 2022;23:e51932 pubmed publisher
Kim M, Choi B, Kim J, Min Y, Kwon D, Son J, et al. USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-κB activation and autophagy induction by TLR4. Transl Oncol. 2022;15:101250 pubmed publisher
Valionyte E, Yang Y, Griffiths S, Bone A, Barrow E, Sharma V, et al. The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner. Cell Death Differ. 2021;: pubmed publisher
Kannangara A, Poole D, McEwan C, Youngs J, Weerasekara V, Thornock A, et al. BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters. EMBO Rep. 2021;:e51136 pubmed publisher
Ylä Anttila P, Masucci M. Inhibition of selective autophagy by members of the herpesvirus ubiquitin-deconjugase family. Biochem J. 2021;478:2297-2308 pubmed publisher
Torrino S, Tiroille V, Dolfi B, Dufies M, Hinault C, Bonesso L, et al. UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling. elife. 2021;10: pubmed publisher
Cui Y, Yang S, Wei J, Shea C, Zhong W, Wang F, et al. Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Nat Commun. 2021;12:2183 pubmed publisher
Lee M, Nam H, Kang H, Lee W, Lee G, Sung G, et al. Epigenetic regulation of p62/SQSTM1 overcomes the radioresistance of head and neck cancer cells via autophagy-dependent senescence induction. Cell Death Dis. 2021;12:250 pubmed publisher
Singh S, Bano A, Saraya A, Das P, Sharma R. iTRAQ-based analysis for the identification of MARCH8 targets in human esophageal squamous cell carcinoma. J Proteomics. 2021;236:104125 pubmed publisher
Li X, Xia Q, Mao M, Zhou H, Zheng L, Wang Y, et al. Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy. Sci Adv. 2021;7: pubmed publisher
Ylä Anttila P, Gupta S, Masucci M. The Epstein-Barr virus deubiquitinase BPLF1 targets SQSTM1/p62 to inhibit selective autophagy. Autophagy. 2021;:1-15 pubmed publisher
Wakula M, Balcerak A, Rubel T, Chmielarczyk M, Konopinski R, Lyczek F, et al. The interactome of multifunctional HAX1 protein suggests its role in the regulation of energy metabolism, de-aggregation, cytoskeleton organization and RNA-processing. Biosci Rep. 2020;40: pubmed publisher
Friesen E, Zhang Y, Earnshaw R, De Snoo M, O Hara D, Agapova V, et al. BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62. Front Cell Dev Biol. 2020;8:716 pubmed publisher
Blazquez C, Ruiz Calvo A, Bajo Grañeras R, Baufreton J, Resel E, Varilh M, et al. Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination. elife. 2020;9: pubmed publisher
Damiano V, Spessotto P, Vanin G, Perin T, Maestro R, Santarosa M. The Autophagy Machinery Contributes to E-cadherin Turnover in Breast Cancer. Front Cell Dev Biol. 2020;8:545 pubmed publisher
Wang Y, Zhu F, Zhang Y, Chen C, Lai Y, Sun J, et al. Shikonin suppresses trophoblast cell growth via regulation of GLI1, and p62 mediated caspase 8 activation. Reprod Toxicol. 2020;95:104-112 pubmed publisher
Morita M, Kajiye M, Sakurai C, Kubo S, Takahashi M, Kinoshita D, et al. Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages. Biol Open. 2020;9: pubmed publisher
Kim M, Min Y, Im J, Son J, Lee J, Lee K. p62 is Negatively Implicated in the TRAF6-BECN1 Signaling Axis for Autophagy Activation and Cancer Progression by Toll-Like Receptor 4 (TLR4). Cells. 2020;9: pubmed publisher
Ye J, Cheung J, Gerbino V, Ahlsen G, Zimanyi C, Hirsh D, et al. Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity. Proc Natl Acad Sci U S A. 2019;116:24517-24526 pubmed publisher
Wang K, Tu Y, Wan J, Chen M, He C. Synergistic anti-breast cancer effect of pulsatilla saponin D and camptothecin through interrupting autophagic-lysosomal function and promoting p62-mediated ubiquitinated protein aggregation. Carcinogenesis. 2019;: pubmed publisher
Waisner H, Kalamvoki M. The ICP0 Protein of Herpes Simplex Virus 1 (HSV-1) Downregulates Major Autophagy Adaptor Proteins Sequestosome 1 and Optineurin during the Early Stages of HSV-1 Infection. J Virol. 2019;93: pubmed publisher
Ivanova S, Polajnar M, Narbona Pérez Á, Hernández Alvarez M, Frager P, Slobodnyuk K, et al. Regulation of death receptor signaling by the autophagy protein TP53INP2. EMBO J. 2019;38: pubmed publisher
Gupta M, Gordon J, Glauser G, Myers V, Feldman A, Cheung J, et al. Lamin B is a target for selective nuclear PQC by BAG3: implication for nuclear envelopathies. Cell Death Dis. 2019;10:23 pubmed publisher
Li Y, Merkel C, Zeng X, Heier J, Cantrell P, Sun M, et al. The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics. J Cell Sci. 2019;132: pubmed publisher
Zhang H, Zhang Y, Zhu X, Chen C, Zhang C, Xia Y, et al. DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1. Hepatology. 2019;69:1046-1063 pubmed publisher
Jamilloux Y, Lagrange B, Di Micco A, Bourdonnay E, Provost A, Tallant R, et al. A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate. J Biol Chem. 2018;293:12563-12575 pubmed publisher
Kalogeropulou A, Zhao J, Bolliger M, Memou A, Narasimha S, Molitor T, et al. P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity. Biochem J. 2018;475:1271-1293 pubmed publisher
Guilbert S, Lambert H, Rodrigue M, Fuchs M, Landry J, Lavoie J. HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency. FASEB J. 2018;32:3518-3535 pubmed publisher
Sample A, Zhao B, Qiang L, He Y. Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. J Biol Chem. 2017;292:14786-14795 pubmed publisher
Ha S, Jeong S, Yi K, Chung K, Hong C, Kim S, et al. Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells. J Biol Chem. 2017;292:13795-13808 pubmed publisher
Liu L, He J, Wei X, Wan G, Lao Y, Xu W, et al. MicroRNA-20a-mediated loss of autophagy contributes to breast tumorigenesis by promoting genomic damage and instability. Oncogene. 2017;36:5874-5884 pubmed publisher
Nakayama S, Karasawa H, Suzuki T, Yabuuchi S, Takagi K, Aizawa T, et al. p62/sequestosome 1 in human colorectal carcinoma as a potent prognostic predictor associated with cell proliferation. Cancer Med. 2017;6:1264-1274 pubmed publisher
Xiao B, Deng X, Lim G, Zhou W, Saw W, Zhou Z, et al. p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization. Biochim Biophys Acta Mol Cell Res. 2017;1864:1308-1317 pubmed publisher
Villar V, Nguyen T, Delcroix V, Terés S, Bouchecareilh M, Salin B, et al. mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. Nat Commun. 2017;8:14124 pubmed publisher
Keane H, Ryan B, Jackson B, Whitmore A, Wade Martins R. Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's disease. Sci Rep. 2015;5:17004 pubmed publisher
Zhang J, Tripathi D, Jing J, Alexander A, Kim J, Powell R, et al. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat Cell Biol. 2015;17:1259-1269 pubmed publisher
Coutts A, La Thangue N. Actin nucleation by WH2 domains at the autophagosome. Nat Commun. 2015;6:7888 pubmed publisher
Rui Y, Xu Z, Chen Z, Zhang S. The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells. Autophagy. 2015;11:812-32 pubmed publisher
Dunlop E, Seifan S, Claessens T, Behrends C, Kamps M, Rozycka E, et al. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy. 2014;10:1749-60 pubmed publisher
Wei H, Wang C, Croce C, Guan J. p62/SQSTM1 synergizes with autophagy for tumor growth in vivo. Genes Dev. 2014;28:1204-16 pubmed publisher
Fan W, Tang Z, Chen D, Moughon D, Ding X, Chen S, et al. Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy. 2010;6:614-21 pubmed publisher
product information
Catalog Number :
28027
Product Name :
HA-p62
article :
doi10.4161/auto.6.5.12189
id4025
pubmed_id20495340
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA4/TO
backbone_mutation
backbone_originInvitrogen
backbone_size5078
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
growth strain :
Mammalian expression of HA tagged human p62
origin :
37
pi :
alt_names
SQSTM1
sequestosome
cloning
clone_methodRestriction Enzyme
cloning_site_3NotI
cloning_site_5EcoRI
promoter
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesA170, DMRV, FTDALS3, NADGP, OSIL, PDB3, ZIP3, p60, p62, p62B
geneSQSTM1
id8878
genbank_ids
mutation
namep62
shRNA_sequence
size1070
species
9606
Homo sapiens
tags
locationC terminal on insert
tagHA
resistance markers :
696
tags :
High Copy
terms :
Zeocin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA